{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:22:40Z","timestamp":1789903360984,"version":"4.0.1"},"reference-count":111,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26293187"],"award-info":[{"award-number":["26293187"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26670400"],"award-info":[{"award-number":["26670400"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japanese Ministry of Health, Labor and Welfare"},{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.pharmthera.2015.02.001","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T15:45:10Z","timestamp":1423323910000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The organ-protective effect of N-type Ca2+ channel blockade"],"prefix":"10.1016","volume":"151","author":[{"given":"Koichiro","family":"Kuwahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2015.02.001_bb0005","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.bbamem.2013.01.019","article-title":"Mechanisms of conotoxin inhibition of N-type (CaV2.2) calcium channels","volume":"1828","author":"Adams","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0010","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2174\/1573402110666140131155331","article-title":"L-\/N-type calcium channel blockers and proteinuria","volume":"9","author":"Ando","year":"2013","journal-title":"Curr Hypertens Rev"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0015","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.7150\/ijms.5508","article-title":"Comparison of the antialbuminuric effects of L-\/N-type and L-type calcium channel blockers in hypertensive patients with diabetes and microalbuminuria: the study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial","volume":"10","author":"Ando","year":"2013","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0020","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF00580957","article-title":"Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons. Differential sensitivity to dihydropyridines and omega-conotoxin GVIA","volume":"414","author":"Aosaki","year":"1989","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0025","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/hr.2010.191","article-title":"Expression of N-type calcium channels in human adrenocortical cells and their contribution to corticosteroid synthesis","volume":"34","author":"Aritomi","year":"2011","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0030","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1146\/annurev.ne.10.030187.003221","article-title":"Calcium action in synaptic transmitter release","volume":"10","author":"Augustine","year":"1987","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0035","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.2337\/diabetes.49.9.1500","article-title":"Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting \u03b1-cells","volume":"49","author":"Barg","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0014-2999(92)90163-X","article-title":"The effect of calcium channel modulators on blood pressure and pressor responses to noradrenaline in the guinea-pig","volume":"218","author":"Bond","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0045","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMoa011161","article-title":"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy","volume":"345","author":"Brenner","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0050","doi-asserted-by":"crossref","first-page":"865965","DOI":"10.1155\/2013\/865965","article-title":"Obesity-related metabolic syndrome: mechanisms of sympathetic overactivity","volume":"2013","author":"Canale","year":"2013","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0055","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/310501a0","article-title":"A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neurones","volume":"310","author":"Carbone","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0060","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.1073\/pnas.1403731111","article-title":"Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary \u03b12\u03b4-1 subunits","volume":"111","author":"Cassidy","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0065","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1161\/CIRCRESAHA.108.184051","article-title":"The CaV3.2 T-type Ca2+ channel is required for pressure overload-induced cardiac hypertrophy in mice","volume":"104","author":"Chiang","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1476-5381.1989.tb11789.x","article-title":"Inhibition of noradrenaline release by omega-conotoxin GVIA in the rat tail artery","volume":"96","author":"Clasbrummel","year":"1989","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0075","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJM198409273111303","article-title":"Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure","volume":"311","author":"Cohn","year":"1984","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0080","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0014-2999(88)90572-9","article-title":"Omega-conotoxin GVIA and pharmacological modulation of hippocampal noradrenaline release","volume":"148","author":"Dooley","year":"1988","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0085","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0014-2999(89)90318-X","article-title":"Omega-conotoxin GVIA blocks synaptic transmission in the CA1 field of the hippocampus","volume":"174","author":"Dutar","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0090","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1161\/CIRCULATIONAHA.106.655688","article-title":"The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease)","volume":"114","author":"Dzau","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0095","doi-asserted-by":"crossref","first-page":"940","DOI":"10.2215\/CJN.00240106","article-title":"Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes","volume":"1","author":"Epstein","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0100","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.tins.2006.08.006","article-title":"Presynaptic Ca2+ channels\u2013integration centers for neuronal signaling pathways","volume":"29","author":"Evans","year":"2006","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0105","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1097\/HJH.0b013e328336ade3","article-title":"Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte","volume":"28","author":"Fan","year":"2010","journal-title":"J Hypertens"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0110","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1987.sp016865","article-title":"Single-channel recordings of three types of calcium channels in chick sensory neurones","volume":"394","author":"Fox","year":"1987","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0115","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0022-3565(24)36515-2","article-title":"Effect of cilnidipine, a novel dihydropyridine Ca++-channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons","volume":"280","author":"Fujii","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0120","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/sj.ki.5002623","article-title":"Antiproteinuric effect of the calcium channel blocker cilnidipine added to renin\u2013angiotensin inhibition in hypertensive patients with chronic renal disease","volume":"72","author":"Fujita","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0125","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0896-6273(93)90162-K","article-title":"Primary structure and functional expression of the omega-conotoxin-sensitive N-type calcium channel from rabbit brain","volume":"10","author":"Fujita","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1085\/jgp.110.3.217","article-title":"Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels","volume":"110","author":"Gromada","year":"1997","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0135","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1097\/00001756-200108080-00027","article-title":"Differential nociceptive responses in mice lacking the \u03b11B subunit of N-type Ca2+ channels","volume":"12","author":"Hatakeyama","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0140","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1161\/01.RES.0000256155.31133.49","article-title":"Ca2+ channel subtypes and pharmacology in the kidney","volume":"100","author":"Hayashi","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/BF00169204","article-title":"Investigations of the roles of dihydropyridine and omega-conotoxin-sensitive calcium channels in mediating depolarisation-evoked endogenous dopamine release from striatal slices","volume":"340","author":"Herdon","year":"1989","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0150","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1126\/science.2447647","article-title":"Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons","volume":"239","author":"Hirning","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0155","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1097\/00004872-199715120-00015","article-title":"Beta-adrenergic stimulation of renin expression in vivo","volume":"15","author":"Holmer","year":"1997","journal-title":"J Hypertens"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0160","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1523\/JNEUROSCI.08-02-00463.1988","article-title":"Characterization of the electrically evoked release of substance P from dorsal root ganglion neurons: methods and dihydropyridine sensitivity","volume":"8","author":"Holz","year":"1988","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0165","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.1995.tb16375.x","article-title":"Calcium channel subtypes for the sympathetic and parasympathetic nerves of guinea-pig atria","volume":"116","author":"Hong","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0170","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1111\/j.1476-5381.1991.tb09855.x","article-title":"The effect of omega-conotoxin GVIA on synaptic transmission within the nucleus accumbens and hippocampus of the rat in vitro","volume":"103","author":"Horne","year":"1991","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0175","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1073\/pnas.081089398","article-title":"Functional disorders of the sympathetic nervous system in mice lacking the \u03b11B subunit (CaV 2.2) of N-type calcium channels","volume":"98","author":"Ino","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0180","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1097\/00001756-199508000-00008","article-title":"Regional difference of high voltage-activated Ca2+ channels in rat CNS neurones","volume":"6","author":"Ishibashi","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0185","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1113\/jphysiol.2005.089912","article-title":"Presynaptic N-type and P\/Q-type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice","volume":"568","author":"Ishikawa","year":"2005","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0190","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1523\/JNEUROSCI.20-01-00059.2000","article-title":"Developmental changes in calcium channel types mediating central synaptic transmission","volume":"20","author":"Iwasaki","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0195","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/B:HREV.0000046366.31764.ca","article-title":"The effects of beta blockers on morbidity and mortality in heart failure","volume":"9","author":"Jafri","year":"2004","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0200","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/01.HYP.21.6.886","article-title":"Corcoran lecture. Sympathetic hyperactivity and coronary risk in hypertension","volume":"21","author":"Julius","year":"1993","journal-title":"Hypertension"},{"issue":"Suppl. 3","key":"10.1016\/j.pharmthera.2015.02.001_bb0205","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1097\/00005344-198800120-00017","article-title":"Sympathetic hyperactivity in early stages of hypertension: the Ann Arbor data set","volume":"12","author":"Julius","year":"1988","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0210","doi-asserted-by":"crossref","first-page":"R2214","DOI":"10.1152\/ajpregu.2000.279.6.R2214","article-title":"Autonomic cardiovascular control in conscious mice","volume":"279","author":"Just","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0215","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1111\/j.1460-9568.2005.03984.x","article-title":"Presynaptic \u2018Ca2.3-containing\u2019 E-type Ca channels share dual roles during neurotransmitter release","volume":"21","author":"Kamp","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0220","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.ki.5000349","article-title":"Comparison between valsartan and valsartan plus cilnidipine in type II diabetics with normo- and microalbuminuria","volume":"70","author":"Katayama","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0225","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-2999(88)90501-8","article-title":"Autoradiographic localization of calcium channels with [125I]\u03c9-conotoxin in rat brain","volume":"146","author":"Kerr","year":"1988","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0230","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/mcne.2001.1013","article-title":"Altered nociceptive response in mice deficient in the \u03b11B subunit of the voltage-dependent calcium channel","volume":"18","author":"Kim","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0235","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.109.857011","article-title":"T-type Ca2+ channel blockade prevents sudden death in mice with heart failure","volume":"120","author":"Kinoshita","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0240","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1291\/hypres.27.379","article-title":"Comparison between cilnidipine and amlodipine besilate with respect to proteinuria in hypertensive patients with renal diseases","volume":"27","author":"Kojima","year":"2004","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0245","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1210\/endo-125-4-2008","article-title":"Pharmacological characterization of the voltage-dependent calcium channel of pancreatic B-cell","volume":"125","author":"Komatsu","year":"1989","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0250","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.1323145","article-title":"Selective role of N-type calcium channels in neuronal migration","volume":"257","author":"Komuro","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0255","first-page":"33","article-title":"Neural control of renal circulation","volume":"15","author":"Kon","year":"1989","journal-title":"Miner Electrolyte Metab"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0260","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000210396","article-title":"Different effects of L\/N-type and L-type calcium channel blockers on the renin\u2013angiotensin\u2013aldosterone system in SHR\/Izm","volume":"30","author":"Konda","year":"2009","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000085713","article-title":"The N- and L-type calcium channel blocker cilnidipine suppresses renal injury in dahl rats fed a high-sucrose diet, an experimental model of metabolic syndrome","volume":"101","author":"Konda","year":"2005","journal-title":"Nephron Physiol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0270","doi-asserted-by":"crossref","first-page":"6310","DOI":"10.1093\/emboj\/cdg601","article-title":"NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function","volume":"22","author":"Kuwahara","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0275","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1254\/jphs.FMJ05002X4","article-title":"Pathophysiological significance of T-type Ca2+ channels: transcriptional regulation of T-type Ca2+ channel-regulation of CACNA1H by neuron-restrictive silencer factor","volume":"99","author":"Kuwahara","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0280","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/cvr\/cvr082","article-title":"Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice","volume":"91","author":"Le Quang","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0285","doi-asserted-by":"crossref","first-page":"606","DOI":"10.2174\/1570159X11311060005","article-title":"Pharmacological inhibition of voltage-gated Ca2+ channels for chronic pain relief","volume":"11","author":"Lee","year":"2013","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0290","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1056\/NEJM199311113292004","article-title":"The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group","volume":"329","author":"Lewis","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0295","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1056\/NEJMoa011303","article-title":"Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes","volume":"345","author":"Lewis","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0300","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0896-6273(93)90119-C","article-title":"Multiple calcium channel types control glutamatergic synaptic transmission in the hippocampus","volume":"11","author":"Luebke","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0305","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0304-3940(90)90072-H","article-title":"Neurochemical evidence for the involvement of N-type calcium channels in transmitter secretion from peripheral endings of sensory nerves in guinea pigs","volume":"114","author":"Maggi","year":"1990","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0310","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00424-014-1482-6","article-title":"T-type channels in the sino-atrial and atrioventricular pacemaker mechanism","volume":"466","author":"Mesirca","year":"2014","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0315","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1126\/science.2432656","article-title":"Multiple calcium channels and neuronal function","volume":"235","author":"Miller","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0320","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1523\/JNEUROSCI.14-11-06815.1994","article-title":"N-type Ca2+ channels are located on somata, dendrites, and a subpopulation of dendritic spines on live hippocampal pyramidal neurons","volume":"14","author":"Mills","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0325","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1254\/jjp.72.83","article-title":"Molecular pharmacology of voltage-dependent calcium channels","volume":"72","author":"Mori","year":"1996","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0330","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1050-1738(02)00173-1","article-title":"Ca2+ channel \u03b11B subunit (CaV 2.2) knockout mouse reveals a predominant role of N-type channels in the sympathetic regulation of the circulatory system","volume":"12","author":"Mori","year":"2002","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0335","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.bbrc.2007.01.087","article-title":"Modified sympathetic regulation in N-type calcium channel null-mouse","volume":"354","author":"Murakami","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0340","first-page":"248","article-title":"Characterization of the renal action of pranidipine in the rat","volume":"50","author":"Nagahama","year":"2000","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0345","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1291\/hypres.28.361","article-title":"Cilnidipine, an N+L-type dihydropyridine Ca channel blocker, suppresses the occurrence of ischemia\/reperfusion arrhythmia in a rabbit model of myocardial infarction","volume":"28","author":"Nagai","year":"2005","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0350","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1172\/JCI39724","article-title":"Alpha1g-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice","volume":"119","author":"Nakayama","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cvr\/cvu197","article-title":"N-type calcium channel blockade: a new approach to preventing sudden cardiac death?","volume":"104","author":"Nattel","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0360","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbrc.2013.03.040","article-title":"Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice","volume":"434","author":"Nishida","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0365","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/316440a0","article-title":"Three types of neuronal calcium channel with different calcium agonist sensitivity","volume":"316","author":"Nowycky","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0370","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.4071055","article-title":"Peptide neurotoxins from fish-hunting cone snails","volume":"230","author":"Olivera","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0375","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0304-3959(99)00254-7","article-title":"Adverse effects associated with the intrathecal administration of ziconotide","volume":"85","author":"Penn","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0380","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physrev.00018.2002","article-title":"Molecular physiology of low-voltage-activated t-type calcium channels","volume":"83","author":"Perez-Reyes","year":"2003","journal-title":"Physiol Rev"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0385","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/00005344-199010000-00022","article-title":"Omega-conotoxin GVIA, the N-type calcium channel inhibitor, is sympatholytic but not vagolytic: consequences for hemodynamics and autonomic reflexes in conscious rabbits","volume":"16","author":"Pruneau","year":"1990","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0390","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0143-4160(94)90065-5","article-title":"\u03c9-conotoxin inhibits glucose- and arachidonic acid-induced rises in intracellular [Ca2+] in rat pancreatic islet beta-cells","volume":"15","author":"Ramanadham","year":"1994","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0395","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1291\/hypres.24.377","article-title":"Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis","volume":"24","author":"Rose","year":"2001","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0400","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/emboj\/20.10.2349","article-title":"Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel","volume":"20","author":"Saegusa","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0405","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0304-3940(92)90039-A","article-title":"Release of calcitonin gene-related peptide like-immunoreactivity induced by electrical field stimulation from rat spinal afferents is mediated by conotoxin-sensitive calcium channels","volume":"136","author":"Santicioli","year":"1992","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0410","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1476-5381.1996.tb15735.x","article-title":"Effect of amlodipine on renin secretion and renin gene expression in rats","volume":"119","author":"Schricker","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0415","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/sj.bjp.0702629","article-title":"Role of N-type calcium channels in autonomic neurotransmission in guinea-pig isolated left atria","volume":"127","author":"Serone","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0420","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1161\/01.HYP.31.2.603","article-title":"Mechanism of epinephrine-induced platelet aggregation","volume":"31","author":"Spalding","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0425","doi-asserted-by":"crossref","first-page":"III154","DOI":"10.1161\/01.HYP.5.5_Pt_2.III154","article-title":"Hemodynamic and humoral interactions between captopril and nifedipine","volume":"5","author":"Stornello","year":"1983","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0430","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1291\/hypres.26.743","article-title":"Neuronal Ca2+ channel blocking action of an antihypertensive drug, cilnidipine, in IMR-32 human neuroblastoma cells","volume":"26","author":"Takahara","year":"2003","journal-title":"Hypertens Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0435","first-page":"937","article-title":"Increased glucose tolerance in N-type Ca2+ channel \u03b11B-subunit gene-deficient mice","volume":"15","author":"Takahashi","year":"2005","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0440","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0306-4522(89)90089-4","article-title":"Distribution of the \u03c9-conotoxin receptor in rat brain. An autoradiographic mapping","volume":"32","author":"Takemura","year":"1989","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0445","doi-asserted-by":"crossref","first-page":"E900","DOI":"10.1152\/ajpendo.00101.2005","article-title":"Role of high-voltage-activated calcium channels in glucose-regulated beta-cell calcium homeostasis and insulin release","volume":"289","author":"Taylor","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0450","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/364635a0","article-title":"Mechanism of presynaptic inhibition by neuropeptide Y at sympathetic nerve terminals","volume":"364","author":"Toth","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0455","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1073\/pnas.90.20.9518","article-title":"Multiple Ca2+ channel types coexist to regulate synaptosomal neurotransmitter release","volume":"90","author":"Turner","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0460","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/sj.bjp.0701342","article-title":"Blockade of N-type Ca2+ current by cilnidipine (FRC-8653) in acutely dissociated rat sympathetic neurones","volume":"122","author":"Uneyama","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0465","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0014-2999(99)00237-X","article-title":"Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels","volume":"373","author":"Uneyama","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0470","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0165-6147(00)88977-4","article-title":"Molecular determinants of Ca2+ channel function and drug action","volume":"16","author":"Varadi","year":"1995","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0475","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0014-2999(95)00032-G","article-title":"Effects of omega-toxins on noradrenergic neurotransmission in beating guinea pig atria","volume":"276","author":"Vega","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0480","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1113\/jphysiol.2005.102368","article-title":"Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells","volume":"572","author":"Vignali","year":"2006","journal-title":"J Physiol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0485","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1254\/fpj.106.393","article-title":"Effect of cilnidipine (FRC-8653) on autoregulation of cerebral blood flow","volume":"106","author":"Watanabe","year":"1995","journal-title":"Nihon Yakurigaku Zasshi"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0490","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/BF00180653","article-title":"Differential effects of calcium channel antagonists (omega-conotoxin GVIA, nifedipine, verapamil) on the electrically-evoked release of [3H]acetylcholine from the myenteric plexus, phrenic nerve and neocortex of rats","volume":"341","author":"Wessler","year":"1990","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0495","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/01.HYP.0000067463.13172.EA","article-title":"Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension","volume":"41","author":"White","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0500","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0014-2999(96)00592-4","article-title":"Distribution of N-type Ca2+ channel binding sites in rabbit brain following central administration of omega-conotoxin GVIA","volume":"315","author":"Whorlow","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0505","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1126\/science.1321501","article-title":"Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel","volume":"257","author":"Williams","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0510","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0896-6273(92)90109-Q","article-title":"Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype","volume":"8","author":"Williams","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0515","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0006-8993(88)90207-7","article-title":"Differential sensitivity of synaptosomal calcium entry and endogenous dopamine release to omega-conotoxin","volume":"475","author":"Woodward","year":"1988","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0520","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1001\/jama.288.19.2421","article-title":"Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial","volume":"288","author":"Wright","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0525","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0165-1838(97)00120-3","article-title":"Effects of omega-conotoxin GVIA on cardiac sympathetic nerve function","volume":"68","author":"Yahagi","year":"1998","journal-title":"J Auton Nerv Syst"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0530","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/cvr\/cvu185","article-title":"Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure","volume":"104","author":"Yamada","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0535","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/156802609788317838","article-title":"Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke","volume":"9","author":"Yamamoto","year":"2009","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0540","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0006-8993(97)00443-5","article-title":"omega-conotoxin GVIA and desipramine insensitive norepinephrine efflux from cardiac sympathetic nerve terminal","volume":"761","author":"Yamazaki","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0545","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1152\/ajpendo.00042.2004","article-title":"Beta-cell CaV channel regulation in physiology and pathophysiology","volume":"288","author":"Yang","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0550","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0028-3908(93)90003-L","article-title":"Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons","volume":"32","author":"Zhang","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2015.02.001_bb0555","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1097\/00004872-200205000-00035","article-title":"N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME\/SHR model","volume":"20","author":"Zhou","year":"2002","journal-title":"J Hypertens"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725815000455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725815000455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T13:36:43Z","timestamp":1747575403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725815000455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":111,"alternative-id":["S0163725815000455"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2015.02.001","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The organ-protective effect of N-type Ca2+ channel blockade","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2015.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}