{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:21:02Z","timestamp":1791418862774,"version":"4.3.3"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.pharmthera.2016.06.020","type":"journal-article","created":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T14:15:51Z","timestamp":1468160151000},"page":"128-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Cortisol and CBG \u2014 Getting cortisol to the right place at the right time"],"prefix":"10.1016","volume":"166","author":[{"given":"David","family":"Henley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stafford","family":"Lightman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Carrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2016.06.020_bb0005","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-642-81265-1_2","article-title":"Delivery and transport of glucocorticoids to target cells","volume":"12","author":"Ballard","year":"1979","journal-title":"Monogr Endocrinol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0010","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1182\/blood.V92.8.2696","article-title":"Antithrombins Wibble and Wobble (T85M\/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation","volume":"92","author":"Beauchamp","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0015","first-page":"770","article-title":"Corticosteroid-binding globulin influences kinetic parameters of plasma cortisol transport and clearance","volume":"80","author":"Bright","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0020","first-page":"764","article-title":"Corticosteroid-binding globulin modulates cortisol concentration responses to a given production rate","volume":"80","author":"Bright","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0025","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1210\/jc.2010-0942","article-title":"Temperature-responsive release of cortisol from its binding globulin: a protein thermocouple","volume":"95","author":"Cameron","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0030","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/317730a0","article-title":"Plakalbumin, alpha 1-antitrypsin, antithrombin and the mechanism of inflammatory thrombosis","volume":"317","author":"Carrell","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0035","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/353576a0","article-title":"Mobile reactive centre of serpins and the control of thrombosis","volume":"353","author":"Carrell","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0040","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.febslet.2008.06.021","article-title":"Serpins show structural basis for oligomer toxicity and amyloid ubiquity","volume":"582","author":"Carrell","year":"2008","journal-title":"FEBS Lett"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0045","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1210\/jc.2012-4280","article-title":"How changes in affinity of corticosteroid-binding globulin modulate free cortisol concentration","volume":"98","author":"Chan","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113402","article-title":"Towards engineering hormone-binding globulins as drug delivery agents","volume":"9","author":"Chan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0055","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1373\/clinchem.2009.134593","article-title":"Inaccuracies in free thyroid hormone measurement by ultrafiltration and tandem mass spectrometry","volume":"55","author":"Christofides","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0060","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nsb0395-196","article-title":"Hormone binding site of corticosteroid binding globulin","volume":"2","author":"Edgar","year":"1995","journal-title":"Nat Struct Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0065","doi-asserted-by":"crossref","first-page":"7708","DOI":"10.1073\/pnas.83.20.7708","article-title":"Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases","volume":"83","author":"Flink","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052759","article-title":"Corticosteroid-binding globulin: structure\u2013function implications from species differences","volume":"7","author":"Gardill","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0075","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/CCM.0000000000000773","article-title":"Dynamic pituitary\u2013adrenal interactions in response to cardiac surgery","volume":"43","author":"Gibbison","year":"2015","journal-title":"Crit Care Med"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1056-8719(03)00058-3","article-title":"An automated blood sampler for simultaneous sampling of systemic blood and brain microdialysates for drug absorption, distribution, metabolism, and elimination studies","volume":"49","author":"Gunaratna","year":"2004","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0085","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1210\/edrv-11-1-65","article-title":"Molecular properties of corticosteroid binding globulin and the sex-steroid binding proteins","volume":"11","author":"Hammond","year":"1990","journal-title":"Endocr Rev"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0090","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1073\/pnas.84.15.5153","article-title":"Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors","volume":"84","author":"Hammond","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0095","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1210\/jcem-71-1-34","article-title":"A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils","volume":"71","author":"Hammond","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0100","first-page":"50","article-title":"Suggested limits to the use of the hot tub and sauna by pregnant women","volume":"125","author":"Harvey","year":"1981","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2011.02.053","article-title":"New insights into corticosteroid-binding globulin and glucocorticoid delivery","volume":"180","author":"Henley","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0110","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1210\/jc.2009-1174","article-title":"Hypothalamic\u2013pituitary\u2013adrenal axis activation in obstructive sleep apnea: the effect of continuous positive airway pressure therapy","volume":"94","author":"Henley","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1210\/jc.2005-0265","article-title":"Septic shock and sepsis: a comparison of total and free plasma cortisol levels","volume":"91","author":"Ho","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0120","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1073\/pnas.83.10.3253","article-title":"Specific binding of human corticosteroid-binding globulin to cell membranes","volume":"83","author":"Hryb","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0125","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1021\/bi00449a001","article-title":"Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins","volume":"28","author":"Huber","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0130","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/35038119","article-title":"Structure of a serpin\u2013protease complex shows inhibition by deformation","volume":"407","author":"Huntington","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0135","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1373\/clinchem.2008.118752","article-title":"Correlations of free thyroid hormones measured by tandem mass spectrometry and immunoassay with thyroid-stimulating hormone across 4 patient populations","volume":"55","author":"Jonklaas","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0140","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0304-4165(68)90012-3","article-title":"Steroid\u2013protein interactions. XIX. Complex formation between alpha 1-acid glycoprotein and steroid hormones","volume":"170","author":"Kerkay","year":"1968","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0145","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0022-4731(84)90142-0","article-title":"Human corticosteroid binding globulin is secreted by a hepatoma-derived cell line","volume":"20","author":"Khan","year":"1984","journal-title":"J Steroid Biochem"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0150","doi-asserted-by":"crossref","first-page":"29594","DOI":"10.1074\/jbc.M705014200","article-title":"Corticosteroid-binding globulin, a structural basis for steroid transport and proteinase-triggered release","volume":"282","author":"Klieber","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0155","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.jmb.2009.01.028","article-title":"The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin","volume":"386","author":"Langdown","year":"2009","journal-title":"J Mol Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0160","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jsbmb.2011.08.006","article-title":"Corticosteroid-binding globulin reactive centre loop antibodies recognise only the intact natured protein: elastase cleaved and uncleaved CBG may coexist in circulation","volume":"127","author":"Lewis","year":"2011","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0165","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cca.2012.11.016","article-title":"Intact or \u201cactive\u201d corticosteroid-binding globulin (CBG) and total CBG in plasma: determination by parallel ELISAs using monoclonal antibodies","volume":"416","author":"Lewis","year":"2013","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0170","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cccn.2005.03.044","article-title":"Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin","volume":"359","author":"Lewis","year":"2005","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jsbmb.2015.01.020","article-title":"The half-lives of intact and elastase cleaved human corticosteroid-binding globulin (CBG) are identical in the rabbit","volume":"149","author":"Lewis","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0180","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jsbmb.2016.01.013","article-title":"Corticosteroid-binding globulin (CBG) reactive centre loop antibodies and surface plasmon resonance interrogate the proposed heat dependent \u201cflip-flop\u201d mechanism of human CBG","volume":"158","author":"Lewis","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0185","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/0470870796.ch14","article-title":"Significance of pulsatility in the HPA axis","volume":"227","author":"Lightman","year":"2000","journal-title":"Novartis Found Symp"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0190","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mce.2009.06.015","article-title":"Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin","volume":"316","author":"Lin","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0195","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1210\/endo.133.4.8404624","article-title":"Corticosteroid-binding globulin receptor of the rat hepatic membrane: solubilization, partial characterization, and the effect of steroids on binding","volume":"133","author":"Maitra","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0200","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1021\/bi00524a047","article-title":"Steroid\u2013protein interactions. Human corticosteroid binding globulin: some physicochemical properties and binding specificity","volume":"20","author":"Mickelson","year":"1981","journal-title":"Biochemistry"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0205","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1021\/bi00533a010","article-title":"Steroid\u2013protein interactions. Human corticosteroid-binding globulin: characterization of dimer and electrophoretic variants","volume":"21","author":"Mickelson","year":"1982","journal-title":"Biochemistry"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0210","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nrendo.2012.134-c1","article-title":"CBG: a cortisol reservoir rather than a transporter","volume":"9","author":"Moisan","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0215","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/S0006-291X(88)81329-9","article-title":"Induction of adenylate cyclase in a mammary carcinoma cell line by human corticosteroid-binding globulin","volume":"153","author":"Nakhla","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0220","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/cen.12680","article-title":"Depletion of high-affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications","volume":"82","author":"Nenke","year":"2015","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0225","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cca.2015.10.028","article-title":"Corticosteroid-binding globulin cleavage is paradoxically reduced in alpha-1 antitrypsin deficiency: implications for cortisol homeostasis","volume":"452","author":"Nenke","year":"2016","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0230","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jsbmb.2013.12.015","article-title":"Development of a formula for estimating plasma free cortisol concentration from a measured total cortisol concentration when elastase-cleaved and intact corticosteroid binding globulin coexist","volume":"141","author":"Nguyen","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0235","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1165\/rcmb.2003-0276OC","article-title":"Inhibiting polymerization: new therapeutic strategies for Z alpha1-antitrypsin-related emphysema","volume":"31","author":"Parfrey","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0240","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/336257a0","article-title":"Hormone binding globulins undergo serpin conformational change in inflammation","volume":"336","author":"Pemberton","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0245","doi-asserted-by":"crossref","first-page":"7236","DOI":"10.1128\/MCB.00400-06","article-title":"Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin","volume":"26","author":"Petersen","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0250","doi-asserted-by":"crossref","first-page":"16163","DOI":"10.1074\/jbc.M110.171082","article-title":"Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins","volume":"286","author":"Qi","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0255","doi-asserted-by":"crossref","first-page":"20132747","DOI":"10.1098\/rspb.2013.2747","article-title":"Temperature-responsive release of thyroxine and its environmental adaptation in Australians","volume":"281","author":"Qi","year":"2014","journal-title":"Proc Biol Sci"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0260","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1210\/edrv-11-1-80","article-title":"The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances","volume":"11","author":"Rosner","year":"1990","journal-title":"Endocr Rev"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0265","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1749-6632.1988.tb48859.x","article-title":"Are corticosteroid-binding globulin and sex hormone-binding globulin hormones?","volume":"538","author":"Rosner","year":"1988","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0270","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/clinchem\/38.6.880","article-title":"Is free thyroxine accurately measurable at room temperature?","volume":"38","author":"Ross","year":"1992","journal-title":"Clin Chem"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1432-1033.1990.tb19425.x","article-title":"Structural transition of alpha 1-antitrypsin by a peptide sequentially similar to beta-strand s4A","volume":"194","author":"Schulze","year":"1990","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0280","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1210\/endo-122-1-89","article-title":"Characteristics of the binding of corticosteroid-binding globulin to rat cell membranes","volume":"122","author":"Singer","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0285","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ncb1922","article-title":"Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription","volume":"11","author":"Stavreva","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0290","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/347099a0","article-title":"Crystal structure of ovalbumin as a model for the reactive centre of serpins","volume":"347","author":"Stein","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0295","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1472-6904-10-13","article-title":"Pharmacokinetic comparability of Prolastin(R)-C to Prolastin(R) in alpha(1)-antitrypsin deficiency: a randomized study","volume":"10","author":"Stocks","year":"2010","journal-title":"BMC Clin Pharmacol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0300","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0960-0760(91)90305-O","article-title":"Interaction of human CBG with cell membranes","volume":"40","author":"Strel'chyonok","year":"1991","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0305","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1373\/clinchem.2009.140228","article-title":"Report of the IFCC Working Group for Standardization of Thyroid Function Tests; part 3: total thyroxine and total triiodothyronine","volume":"56","author":"Thienpont","year":"2010","journal-title":"Clin Chem"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0310","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/clinchem\/38.7.1327","article-title":"Temperature effects on free-thyroxine measurements: analytical and clinical consequences","volume":"38","author":"van der Sluijs Veer","year":"1992","journal-title":"Clin Chem"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-82486-9_1","article-title":"Steroid-protein interactions II","volume":"27","author":"Westphal","year":"1986","journal-title":"Monogr Endocrinol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0320","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mce.2009.07.021","article-title":"Cellular uptake of steroid carrier proteins\u2014mechanisms and implications","volume":"316","author":"Willnow","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0325","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1365-2826.2001.00715.x","article-title":"Increased corticosterone pulse frequency during adjuvant-induced arthritis and its relationship to alterations in stress responsiveness","volume":"13","author":"Windle","year":"2001","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0330","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.yfrne.2004.07.001","article-title":"Cortisol pulsatility and its role in stress regulation and health","volume":"25","author":"Young","year":"2004","journal-title":"Front Neuroendocrinol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0335","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jmb.2004.07.078","article-title":"How small peptides block and reverse serpin polymerisation","volume":"342","author":"Zhou","year":"2004","journal-title":"J Mol Biol"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0340","doi-asserted-by":"crossref","first-page":"13321","DOI":"10.1073\/pnas.0604080103","article-title":"Structural mechanism for the carriage and release of thyroxine in the blood","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.pharmthera.2016.06.020_bb0345","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jmb.2008.05.012","article-title":"The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release","volume":"380","author":"Zhou","year":"2008","journal-title":"J Mol Biol"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725816301127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725816301127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T18:52:16Z","timestamp":1600887136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725816301127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":69,"alternative-id":["S0163725816301127"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2016.06.020","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cortisol and CBG \u2014 Getting cortisol to the right place at the right time","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2016.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}