{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:51:21Z","timestamp":1793641881193,"version":"4.5.1"},"reference-count":449,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL09502"],"award-info":[{"award-number":["HL09502"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL114570"],"award-info":[{"award-number":["HL114570"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL128363"],"award-info":[{"award-number":["HL128363"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL130167"],"award-info":[{"award-number":["HL130167"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17GRNT33660671"],"award-info":[{"award-number":["17GRNT33660671"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AHA Career Development Award","award":["18CDA34110359"],"award-info":[{"award-number":["18CDA34110359"]}],"id":[{"id":"https:\/\/ror.org\/02xjhr934","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.pharmthera.2018.11.003","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T22:12:55Z","timestamp":1542060775000},"page":"15-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":160,"special_numbering":"C","title":["Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics"],"prefix":"10.1016","volume":"196","author":[{"given":"Suowen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Kamato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Pelisek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng Gen","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2018.11.003_bb0005","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/eurheartj\/ehu437","article-title":"Global DNA methylation analysis of human atherosclerotic plaques reveals extensive genomic hypomethylation and reactivation at imprinted locus 14q32 involving induction of a miRNA cluster","volume":"36","author":"Aavik","year":"2015","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0010","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s12272-017-0973-3","article-title":"Epigenetic modifications of gene expression by lifestyle and environment","volume":"40","author":"Abdul","year":"2017","journal-title":"Archives of Pharmacal Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0015","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature23876","article-title":"Ascorbate regulates haematopoietic stem cell function and leukaemogenesis","volume":"549","author":"Agathocleous","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/mnfr.201300528","article-title":"Epigenetic regulation of miRNA-cancer stem cells nexus by nutraceuticals","volume":"58","author":"Ahmad","year":"2014","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0025","doi-asserted-by":"crossref","first-page":"E8660","DOI":"10.1073\/pnas.1803725115","article-title":"Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells","volume":"115","author":"Ahmed","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/8580b50a-1556-4c86-aeb6-a88af839297a","article-title":"Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation","volume":"7","author":"Aljubran","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0035","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2353\/ajpath.2010.090031","article-title":"Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature","volume":"176","author":"Alkemade","year":"2010","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1124\/jpet.117.242081","article-title":"Pleiotropic and Adverse Effects of Statins-Do Epigenetics Play a Role?","volume":"362","author":"Allen","year":"2017","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0045","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.atherosclerosis.2017.10.012","article-title":"Long non-coding RNAs in the atherosclerotic plaque","volume":"266","author":"Arslan","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0050","article-title":"Non-coding RNA regulation of endothelial and macrophage functions during atherosclerosis","author":"Aryal","year":"2018","journal-title":"Vascular Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0055","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/CIRCRESAHA.108.184663","article-title":"Hemizygous deficiency of Kruppel-like factor 2 augments experimental atherosclerosis","volume":"103","author":"Atkins","year":"2008","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0060","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/eurheartj\/ehx628","article-title":"European society of cardiology: Cardiovascular disease statistics 2017","volume":"39","author":"Atlas Writing","year":"2018","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0065","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1161\/STROKEAHA.114.007213","article-title":"Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1","volume":"46","author":"Azghandi","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0070","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/CIRCGENETICS.110.958744","article-title":"Cardiovascular epigenetics: Basic concepts and results from animal and human studies","volume":"3","author":"Baccarelli","year":"2010","journal-title":"Circulation. Cardiovascular Genetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0075","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.jacc.2010.02.035","article-title":"RVX-208: A small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo","volume":"55","author":"Bailey","year":"2010","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0080","doi-asserted-by":"crossref","first-page":"51163","DOI":"10.1074\/jbc.M409024200","article-title":"Curcumin, a novel p300\/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone\/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription","volume":"279","author":"Balasubramanyam","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0085","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.2337\/db14-1149","article-title":"Sirtuin 6 expression and inflammatory activity in diabetic atherosclerotic plaques: Effects of incretin treatment","volume":"64","author":"Balestrieri","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0090","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1161\/CIRCULATIONAHA.115.021019","article-title":"Smooth muscle enriched long noncoding RNA (SMILR) regulates cell proliferation","volume":"133","author":"Ballantyne","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0095","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1124\/mol.117.110650","article-title":"Long noncoding RNA LINC00657 acting as a miR-590-3p sponge to facilitate low concentration oxidized low-density lipoprotein-induced angiogenesis","volume":"93","author":"Bao","year":"2018","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.atherosclerosis.2008.08.041","article-title":"Identification of trichostatin A as a novel transcriptional up-regulator of scavenger receptor BI both in HepG2 and RAW 264.7 cells","volume":"204","author":"Bao","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0021-9150(02)00387-8","article-title":"Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: Potential role of simvastatin-mediated inhibition of Egr-1 expression and activation","volume":"167","author":"Bea","year":"2003","journal-title":"Atherosclerosis"},{"issue":"135\u2013146","key":"10.1016\/j.pharmthera.2018.11.003_bb0110","article-title":"Metabolic induction of trained immunity through the mevalonate pathway","volume":"172","author":"Bekkering","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0115","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1128\/CVI.00349-16","article-title":"In vitro experimental model of trained innate immunity in human primary monocytes","volume":"23","author":"Bekkering","year":"2016","journal-title":"Clinical and Vaccine Immunology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0120","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/MOL.0000000000000023","article-title":"Trained innate immunity and atherosclerosis","volume":"24","author":"Bekkering","year":"2013","journal-title":"Current Opinion in Lipidology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0125","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/ATVBAHA.114.303887","article-title":"Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes","volume":"34","author":"Bekkering","year":"2014","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0130","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/ATVBAHA.114.303240","article-title":"Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA","volume":"34","author":"Bell","year":"2014","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0135","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke statistics-2018 update: A report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0140","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-pharmtox-010716-105106","article-title":"Targeting epigenetics in cancer","volume":"58","author":"Bennett","year":"2018","journal-title":"Annual Review of Pharmacology and Toxicology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0145","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of plaque formation and rupture","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0150","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.jnutbio.2012.11.009","article-title":"Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice","volume":"24","author":"Berbee","year":"2013","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0155","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1161\/CIRCRESAHA.114.302937","article-title":"Induction of atherosclerosis in mice and hamsters without germline genetic engineering","volume":"114","author":"Bjorklund","year":"2014","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0160","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1016\/j.jacc.2016.09.949","article-title":"Long noncoding RNA Meg3 controls endothelial cell aging and function: Implications for regenerative angiogenesis","volume":"68","author":"Boon","year":"2016","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0165","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.jacc.2015.12.051","article-title":"Long noncoding RNAs: From clinical genetics to therapeutic targets?","volume":"67","author":"Boon","year":"2016","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0170","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/mt.2016.41","article-title":"A role for the long noncoding RNA SENCR in commitment and function of endothelial cells","volume":"24","author":"Boulberdaa","year":"2016","journal-title":"Molecular Therapy"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0175","doi-asserted-by":"crossref","first-page":"330","DOI":"10.2353\/ajpath.2009.080385","article-title":"Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: Evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis","volume":"174","author":"Bowes","year":"2009","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0180","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.plipres.2016.10.002","article-title":"The role of DNA methylation in dyslipidaemia: A systematic review","volume":"64","author":"Braun","year":"2016","journal-title":"Progress in Lipid Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0185","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.molcel.2014.08.024","article-title":"NF-kappaB directs dynamic super enhancer formation in inflammation and atherogenesis","volume":"56","author":"Brown","year":"2014","journal-title":"Molecular Cell"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0190","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002360","article-title":"Circulating \"LncPPARdelta\" from monocytes as a novel biomarker for coronary artery diseases","volume":"95","author":"Cai","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0195","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/cvr\/cvw022","article-title":"Circulating 'lncRNA OTTHUMT00000387022' from monocytes as a novel biomarker for coronary artery disease","volume":"112","author":"Cai","year":"2016","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0200","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1161\/ATVBAHA.114.303393","article-title":"Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development","volume":"34","author":"Cao","year":"2014","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0205","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1210\/en.2014-1595","article-title":"Inhibiting DNA Methylation by 5-Aza-2\u2032-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation","volume":"155","author":"Cao","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0210","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.redox.2017.05.027","article-title":"SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease","volume":"13","author":"Chan","year":"2017","journal-title":"Redox Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0215","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tem.2013.12.001","article-title":"SIRT1 and other sirtuins in metabolism","volume":"25","author":"Chang","year":"2014","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0220","article-title":"NEAT1 contributes to ox-LDL-induced inflammation and oxidative stress in macrophages through inhibiting miR-128","author":"Chen","year":"2018","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0225","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1161\/CIRCRESAHA.116.308895","article-title":"Age-associated Sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm","volume":"119","author":"Chen","year":"2016","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0230","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.atherosclerosis.2016.12.007","article-title":"Histone demethylase KDM3a, a novel regulator of vascular smooth muscle cells, controls vascular neointimal hyperplasia in diabetic rats","volume":"257","author":"Chen","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0235","article-title":"Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway","volume":"2015","author":"Chen","year":"2015","journal-title":"BioMed Research International"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0240","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.bbrc.2015.08.066","article-title":"The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE(\u2212)\/(\u2212) mice through inhibiting vascular inflammatory response","volume":"465","author":"Chen","year":"2015","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0245","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12940-016-0202-4","article-title":"Long-term outdoor air pollution and DNA methylation in circulating monocytes: Results from the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"15","author":"Chi","year":"2016","journal-title":"Environmental Health"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0250","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3892\/ijmm.2014.1868","article-title":"The anti-atherogenic effects of berberine on foam cell formation are mediated through the upregulation of sirtuin 1","volume":"34","author":"Chi","year":"2014","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0255","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/01.ATV.0000184758.07257.88","article-title":"Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice","volume":"25","author":"Choi","year":"2005","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"162\u2013175","key":"10.1016\/j.pharmthera.2018.11.003_bb0260","article-title":"Western diet triggers NLRP3-dependent innate immune reprogramming","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"},{"issue":"1079\u20131095","key":"10.1016\/j.pharmthera.2018.11.003_bb0265","article-title":"Restoration of TET2 function blocks aberrant self-renewal and leukemia progression","volume":"170","author":"Cimmino","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0270","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bbrc.2012.02.050","article-title":"CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC","volume":"419","author":"Congrains","year":"2012","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0275","article-title":"Epigenetics and precision medicine in cardiovascular patients: From basic concepts to the clinical arena","author":"Costantino","year":"2017","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0280","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1074\/jbc.RA117.000698","article-title":"Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells","volume":"293","author":"Cribbs","year":"2018","journal-title":"The Journal of Biological Chemistry"},{"issue":"56\u201370","key":"10.1016\/j.pharmthera.2018.11.003_bb0285","article-title":"Tet2 restrains inflammatory gene expression in macrophages","volume":"55","author":"Cull","year":"2017","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0290","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.redox.2018.03.003","article-title":"MicroRNA-98 regulates foam cell formation and lipid accumulation through repression of LOX-1","volume":"16","author":"Dai","year":"2018","journal-title":"Redox Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0295","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fcvm.2018.00073","article-title":"Deciphering non-coding RNAs in cardiovascular health and disease","volume":"5","author":"Das","year":"2018","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0300","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11010-005-9070-x","article-title":"Effect of ascorbic acid on prevention of hypercholesterolemia induced atherosclerosis","volume":"285","author":"Das","year":"2006","journal-title":"Molecular and Cellular Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0305","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1161\/ATVBAHA.117.310663","article-title":"Diabetes mellitus-induced long noncoding RNA Dnm3os regulates macrophage functions and inflammation via nuclear mechanisms","volume":"38","author":"Das","year":"2018","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0310","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/s41467-017-01629-7","article-title":"Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells","volume":"8","author":"Das","year":"2017","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0315","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1161\/01.CIR.94.8.2013","article-title":"Stability and instability: Two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995","volume":"94","author":"Davies","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0320","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1038\/emboj.2009.271","article-title":"Jmjd3 contributes to the control of gene expression in LPS-activated macrophages","volume":"28","author":"De Santa","year":"2009","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0325","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2007.08.019","article-title":"The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing","volume":"130","author":"De Santa","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0330","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13059-016-1000-6","article-title":"Blood lipids influence DNA methylation in circulating cells","volume":"17","author":"Dekkers","year":"2016","journal-title":"Genome Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0335","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/jcp.21678","article-title":"Epigenetic control","volume":"219","author":"Delcuve","year":"2009","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0340","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1242\/dev.112607","article-title":"Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature","volume":"141","author":"Delgado-Olguin","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0345","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1093\/hmg\/ddv161","article-title":"Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci","volume":"24","author":"Demerath","year":"2015","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0350","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13148-018-0443-x","article-title":"Genomic 5-mC contents in peripheral blood leukocytes were independent protective factors for coronary artery disease with a specific profile in different leukocyte subtypes","volume":"10","author":"Deng","year":"2018","journal-title":"Clinical Epigenetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0355","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1007\/s00018-016-2316-9","article-title":"Diabetes propels the risk for cardiovascular disease: Sweet monocytes becoming aggressive?","volume":"73","author":"van Diepen","year":"2016","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0360","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/carcin\/bgp305","article-title":"Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells","volume":"31","author":"Dimri","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0365","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1158\/1541-7786.MCR-07-0324","article-title":"Histone deacetylase inhibitors: Overview and perspectives","volume":"5","author":"Dokmanovic","year":"2007","journal-title":"Molecular Cancer Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0370","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yjmcc.2018.08.004","article-title":"The salient role of microRNAs in atherogenesis","volume":"122","author":"Donaldson","year":"2018","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0375","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1089\/ars.2017.7178","article-title":"SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection","volume":"28","author":"D'Onofrio","year":"2018","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0380","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.bbadis.2015.03.001","article-title":"Sirtuins in vascular diseases: Emerging roles and therapeutic potential","volume":"1852","author":"D'Onofrio","year":"2015","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0385","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1161\/HYPERTENSIONAHA.112.191098","article-title":"Epigenetic regulation of cell adhesion and communication by enhancer of zeste homolog 2 in human endothelial cells","volume":"60","author":"Dreger","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0390","article-title":"Sulfhydrated Sirtuin-1 increasing Its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide","author":"Du","year":"2018","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0395","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1002\/jcp.26622","article-title":"MiR-181a inhibits vascular inflammation induced by ox-LDL via targeting TLR4 in human macrophages","volume":"233","author":"Du","year":"2018","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0400","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1172\/JCI74792","article-title":"Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis","volume":"124","author":"Dunn","year":"2014","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0405","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/CIRCRESAHA.116.309318","article-title":"MicroRNA-210 enhances fibrous cap stability in advanced atherosclerotic lesions","volume":"120","author":"Eken","year":"2017","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0410","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1084\/jem.20081188","article-title":"Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia","volume":"205","author":"El-Osta","year":"2008","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0415","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejphar.2017.05.010","article-title":"Animal models of atherosclerosis","volume":"816","author":"Emini Veseli","year":"2017","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0420","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/med.21438","article-title":"Atheroprotective effects and molecular targets of tanshinones derived from herbal medicine danshen","volume":"38","author":"Fang","year":"2018","journal-title":"Medicinal Research Reviews"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0425","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCRESAHA.115.306300","article-title":"MicroRNA regulation of atherosclerosis","volume":"118","author":"Feinberg","year":"2016","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0430","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective inhibition of BET bromodomains","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0435","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature08197","article-title":"Recent progress in the biology and physiology of sirtuins","volume":"460","author":"Finkel","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0440","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1161\/ATVBAHA.108.179739","article-title":"Concept of vulnerable\/unstable plaque","volume":"30","author":"Finn","year":"2010","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0445","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: Regulation and function","volume":"33","author":"Forstermann","year":"2012","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0450","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/HYPERTENSIONAHA.116.07622","article-title":"Vascular smooth muscle Sirtuin-1 Protects Against Diet-Induced aortic stiffness","volume":"68","author":"Fry","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0455","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002384","article-title":"Vascular smooth muscle Sirtuin-1 protects against aortic dissection during angiotensin II-induced hypertension","volume":"4","author":"Fry","year":"2015","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0460","doi-asserted-by":"crossref","DOI":"10.1038\/s41401-018-0045-3","article-title":"Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability","author":"Fu","year":"2018","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0465","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.1574","article-title":"Circular RNAs in hepatocellular carcinoma: Functions and implications","author":"Fu","year":"2018","journal-title":"Cancer Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0470","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/00001721-200408000-00001","article-title":"Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice","volume":"15","author":"Fukao","year":"2004","journal-title":"Blood Coagulation & Fibrinolysis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0475","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice","volume":"355","author":"Fuster","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0480","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2009.02.015","article-title":"Sexual dimorphism in environmental epigenetic programming","volume":"304","author":"Gabory","year":"2009","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0485","article-title":"Immune system-mediated atherosclerosis caused by deficiency of long noncoding RNA MALAT1 in ApoE\u2212\/\u2212 mice","author":"Gast","year":"2018","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0490","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/cvr\/cvy036","article-title":"Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity","volume":"114","author":"Gaul","year":"2018","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0495","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108577","article-title":"Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR\u2212\/\u2212 mice\u2014Role of intestinal permeability and macrophage activation","volume":"9","author":"Ghosh","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0500","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.atherosclerosis.2016.01.036","article-title":"RVX-208, a BET-inhibitor for treating atherosclerotic cardiovascular disease, raises ApoA-I\/HDL and represses pathways that contribute to cardiovascular disease","volume":"247","author":"Gilham","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0505","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/CIRCRESAHA.116.303630","article-title":"Readers, writers, and erasers: Chromatin as the whiteboard of heart disease","volume":"116","author":"Gillette","year":"2015","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0510","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.atherosclerosis.2016.06.011","article-title":"A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification","volume":"251","author":"Goettsch","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0515","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.omtn.2017.07.014","article-title":"The function and therapeutic potential of long non-coding RNAs in cardiovascular development and disease","volume":"8","author":"Gomes","year":"2017","journal-title":"Molecular Therapy--Nucleic Acids"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0520","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1161\/CIRCULATIONAHA.112.124404","article-title":"Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis","volume":"127","author":"Gorenne","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0525","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0002-9343(51)90107-6","article-title":"Lipid metabolism and atherosclerosis","volume":"11","author":"Gould","year":"1951","journal-title":"The American Journal of Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0530","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1186\/s12864-017-4193-5","article-title":"Physical activity in the prevention of human diseases: Role of epigenetic modifications","volume":"18","author":"Grazioli","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0535","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.carpath.2015.11.001","article-title":"Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques","volume":"25","author":"Greissel","year":"2016","journal-title":"Cardiovascular Pathology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0540","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1160\/TH14-10-0852","article-title":"Alternation of histone and DNA methylation in human atherosclerotic carotid plaques","volume":"114","author":"Greissel","year":"2015","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0545","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1194\/jlr.M600181-JLR200","article-title":"Lipopolysaccharide-induced gene expression in murine macrophages is enhanced by prior exposure to oxLDL","volume":"47","author":"Groeneweg","year":"2006","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0550","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1172\/JCI93025","article-title":"CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis","volume":"128","author":"Guo","year":"2018","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0555","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1741-7015-10-70","article-title":"Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke","volume":"10","author":"Hacke","year":"2012","journal-title":"BMC Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0560","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2741\/4428","article-title":"HDAC9 regulates ox-LDL-induced endothelial cell apoptosis by participating in inflammatory reactions","volume":"21","author":"Han","year":"2016","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0565","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molimm.2017.11.017","article-title":"Silencing of H19 inhibits the adipogenesis and inflammation response in ox-LDL-treated Raw264.7 cells by up-regulating miR-130b","volume":"93","author":"Han","year":"2018","journal-title":"Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0570","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/humupd\/dmy021","article-title":"Epigenetic regulation in development: Is the mouse a good model for the human?","volume":"24","author":"Hanna","year":"2018","journal-title":"Human Reproduction Update"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0575","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ni.2001","article-title":"The immune system in atherosclerosis","volume":"12","author":"Hansson","year":"2011","journal-title":"Nature Immunology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0580","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.pathol.1.110304.100100","article-title":"Inflammation and atherosclerosis","volume":"1","author":"Hansson","year":"2006","journal-title":"Annual Review of Pathology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0585","doi-asserted-by":"crossref","first-page":"7A","DOI":"10.1016\/S0002-9149(02)03144-2","article-title":"Role of oxidative stress in atherosclerosis","volume":"91","author":"Harrison","year":"2003","journal-title":"The American Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0590","article-title":"Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4","volume":"7","author":"Hartmann","year":"2016","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0595","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1128\/MMBR.00040-05","article-title":"Nuclear ADP-ribosylation reactions in mammalian cells: Where are we today and where are we going?","volume":"70","author":"Hassa","year":"2006","journal-title":"Microbiology and Molecular Biology Reviews"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0600","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cyto.2018.03.016","article-title":"TET-2 up-regulation is associated with the anti-inflammatory action of Vicenin-2","volume":"108","author":"Hassan","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0605","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1161\/01.ATV.17.11.2744","article-title":"Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation","volume":"17","author":"Hayek","year":"1997","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0610","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/febs.14055","article-title":"SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition","volume":"284","author":"He","year":"2017","journal-title":"The FEBS Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0615","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2217\/epi-2017-0176","article-title":"Uncovering novel landscape of cardiovascular diseases and therapeutic targets for cardioprotection via long noncoding RNA-miRNA-mRNA axes","volume":"10","author":"He","year":"2018","journal-title":"Epigenomics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0620","doi-asserted-by":"crossref","DOI":"10.1038\/srep14368","article-title":"Lysine Methyltransferase SETD7 (SET7\/9) Regulates ROS Signaling through mitochondria and NFE2L2\/ARE pathway","volume":"5","author":"He","year":"2015","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0625","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.2174\/13816128113196660745","article-title":"Regulation of eNOS enzyme activity by posttranslational modification","volume":"20","author":"Heiss","year":"2014","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0630","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1161\/ATVBAHA.116.307841","article-title":"Resveratrol inhibits aortic root dilatation in the Fbn1C1039G\/+ Marfan mouse model","volume":"36","author":"Hibender","year":"2016","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0635","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.15252\/emmm.201404170","article-title":"Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions","volume":"6","author":"Hoeksema","year":"2014","journal-title":"EMBO Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0640","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12429","article-title":"Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans","volume":"7","author":"Holdt","year":"2016","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0645","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005814","article-title":"MUSASHI-mediated expression of JMJD3, a H3K27me3 demethylase, is involved in foamy macrophage generation during mycobacterial infection","volume":"12","author":"Holla","year":"2016","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0650","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0655","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/ATVBAHA.114.304296","article-title":"RP5-833A20.1\/miR-382-5p\/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction","volume":"35","author":"Hu","year":"2015","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0660","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.atherosclerosis.2017.09.034","article-title":"4-phenylbutyrate and valproate treatment attenuates the progression of atherosclerosis and stabilizes existing plaques","volume":"266","author":"Huang","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0665","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1089\/dna.2016.3422","article-title":"Long noncoding RNA HOXC-AS1 suppresses Ox-LDL-induced cholesterol accumulation through promoting HOXC6 expression in THP-1 macrophages","volume":"35","author":"Huang","year":"2016","journal-title":"DNA and Cell Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0670","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1152\/physiolgenomics.00132.2016","article-title":"LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1","volume":"49","author":"Huang","year":"2017","journal-title":"Physiological Genomics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0675","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1745-7270.2007.00251.x","article-title":"Different effects of homocysteine and oxidized low density lipoprotein on methylation status in the promoter region of the estrogen receptor alpha gene","volume":"39","author":"Huang","year":"2007","journal-title":"Acta Biochimica et Biophysica Sinica Shanghai"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0680","first-page":"3092","article-title":"Neat1 regulates oxidized low-density lipoprotein-induced inflammation and lipid uptake in macrophages via paraspeckle formation","volume":"17","author":"Huang-Fu","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0685","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.bbrc.2017.12.086","article-title":"LncRNA MALAT1 regulates oxLDL-induced CD36 expression via activating beta-catenin","volume":"495","author":"Huangfu","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0690","doi-asserted-by":"crossref","first-page":"e324","DOI":"10.1038\/emm.2017.11","article-title":"Writing, erasing and reading histone lysine methylations","volume":"49","author":"Hyun","year":"2017","journal-title":"Experimental & Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0695","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1182\/blood-2009-04-217620","article-title":"Epigenetic regulation of the alternatively activated macrophage phenotype","volume":"114","author":"Ishii","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0700","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1002\/ijc.28672","article-title":"Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer","volume":"135","author":"Ishikawa","year":"2014","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0705","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbrc.2017.09.053","article-title":"M2b macrophage polarization accompanied with reduction of long noncoding RNA GAS5","volume":"493","author":"Ito","year":"2017","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0710","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.atherosclerosis.2014.06.008","article-title":"A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice","volume":"236","author":"Jahagirdar","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0715","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"377","author":"Jaiswal","year":"2017","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0720","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.tibs.2014.05.002","article-title":"New concepts in DNA methylation","volume":"39","author":"Jeltsch","year":"2014","journal-title":"Trends in Biochemical Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0725","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.canlet.2016.08.009","article-title":"Long non-coding RNA H19 regulates glioma angiogenesis and the biological behavior of glioma-associated endothelial cells by inhibiting microRNA-29a","volume":"381","author":"Jia","year":"2016","journal-title":"Cancer Letters"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0730","doi-asserted-by":"crossref","first-page":"781","DOI":"10.15252\/embr.201643179","article-title":"TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response","volume":"18","author":"Jiang","year":"2017","journal-title":"EMBO Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0735","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCRESAHA.115.303883","article-title":"Hemodynamic disturbed flow induces differential DNA methylation of endothelial Kruppel-Like Factor 4 promoter in vitro and in vivo","volume":"115","author":"Jiang","year":"2014","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0740","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ymthe.2018.01.011","article-title":"Local delivery of miR-21 stabilizes fibrous caps in vulnerable atherosclerotic lesions","volume":"26","author":"Jin","year":"2018","journal-title":"Molecular Therapy"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0745","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/CIRCGENETICS.116.001506","article-title":"Epigenetic signatures of cigarette smoking","volume":"9","author":"Joehanes","year":"2016","journal-title":"Circulation. Cardiovascular Genetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0750","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCRESAHA.110.222968","article-title":"Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase","volume":"107","author":"Jung","year":"2010","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0755","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.atherosclerosis.2004.08.005","article-title":"Effects of statin therapy on the progression of carotid atherosclerosis: A systematic review and meta-analysis","volume":"177","author":"Kang","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0760","article-title":"Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress","volume":"7","author":"Kassan","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0765","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.08.009","article-title":"Differential expression of microRNAs in severely calcified carotid plaques","volume":"27","author":"Katano","year":"2018","journal-title":"Journal of Stroke and Cerebrovascular Diseases"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0770","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1007\/s00018-014-1651-y","article-title":"Deep sequencing reveals novel Set7 networks","volume":"71","author":"Keating","year":"2014","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0775","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1073\/pnas.0904715106","article-title":"Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression","volume":"106","author":"Khalil","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0780","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.molmed.2017.02.004","article-title":"Epigenetics of atherosclerosis: Emerging mechanisms and methods","volume":"23","author":"Khyzha","year":"2017","journal-title":"Trends in Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0785","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.bbrc.2018.07.057","article-title":"Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells","volume":"503","author":"Kim","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0790","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm.4036","article-title":"Targeting EZH2 in cancer","volume":"22","author":"Kim","year":"2016","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0795","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vph.2015.04.015","article-title":"SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells","volume":"72","author":"Kim","year":"2015","journal-title":"Vascular Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0800","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.18632\/aging.101068","article-title":"The protective role of Sirt1 in vascular tissue: Its relationship to vascular aging and atherosclerosis","volume":"8","author":"Kitada","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0805","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1161\/01.CIR.0000086460.55494.AF","article-title":"Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin","volume":"108","author":"Kleemann","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0810","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/CIRCULATIONAHA.115.020406","article-title":"Shared Risk Factors in Cardiovascular Disease and Cancer","volume":"133","author":"Koene","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0815","doi-asserted-by":"crossref","first-page":"30306","DOI":"10.1074\/jbc.M115.686865","article-title":"Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 protein interaction with peroxisome proliferator-activated receptor (PPAR)-gamma in CD36 protein expression and foam cell formation","volume":"290","author":"Kotla","year":"2015","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0820","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.redox.2016.12.005","article-title":"ROS via BTK-p300-STAT1-PPARgamma signaling activation mediates cholesterol crystals-induced CD36 expression and foam cell formation","volume":"11","author":"Kotla","year":"2017","journal-title":"Redox Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0825","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nature11262","article-title":"A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response","volume":"488","author":"Kruidenier","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0830","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1139\/cjpp-2015-0215","article-title":"Vicenin-2 and scolymoside inhibit high-glucose-induced vascular inflammation in vitro and in vivo","volume":"94","author":"Ku","year":"2016","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0835","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-380866-0.60002-2","article-title":"DNA methylation and cancer","volume":"70","author":"Kulis","year":"2010","journal-title":"Advances in Genetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0840","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1161\/ATVBAHA.113.301765","article-title":"Histone and DNA methylation-mediated epigenetic downregulation of endothelial Kruppel-like factor 2 by low-density lipoprotein cholesterol","volume":"33","author":"Kumar","year":"2013","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0845","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/labinvest.2017.47","article-title":"Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation","volume":"97","author":"Kumar","year":"2017","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0850","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1073\/pnas.1614112114","article-title":"Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction","volume":"114","author":"Kumar","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0855","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/cvr\/cvu183","article-title":"Histone deacetylase 5 interacts with Kruppel-like factor 2 and inhibits its transcriptional activity in endothelium","volume":"104","author":"Kwon","year":"2014","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0860","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cjca.2017.01.001","article-title":"MicroRNAs in the pathobiology and therapy of atherosclerosis","volume":"33","author":"Laffont","year":"2017","journal-title":"The Canadian Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0865","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00213.2018","article-title":"Atheroprone flow enhances the endothelial-to-mesenchymal transition","author":"Lai","year":"2018","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0870","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1161\/STROKEAHA.109.556563","article-title":"Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray","volume":"40","author":"Lanktree","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0875","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/j.1530-0277.2010.01238.x","article-title":"Quercetin and ethanol attenuate the progression of atherosclerotic plaques with concomitant up regulation of paraoxonase1 (PON1) gene expression and PON1 activity in LDLR\u2212\/\u2212 mice","volume":"34","author":"Leckey","year":"2010","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0880","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1471-4159.2012.07786.x","article-title":"Molecular mechanism of Jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury","volume":"122","author":"Lee","year":"2012","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0885","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1124\/mol.104.008367","article-title":"Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids","volume":"68","author":"Lee","year":"2005","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0890","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.2337\/db16-1446","article-title":"Myeloid Sirtuin 6 deficiency causes insulin resistance in high-fat diet-fed mice by eliciting macrophage polarization toward an M1 phenotype","volume":"66","author":"Lee","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0895","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/CIRCRESAHA.117.312465","article-title":"Trained innate immunity as a novel mechanism linking infection and the development of atherosclerosis","volume":"122","author":"Leentjens","year":"2018","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0900","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/cvr\/cvx249","article-title":"Non-coding RNAs: Key regulators of smooth muscle cell fate in vascular disease","volume":"114","author":"Leeper","year":"2018","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0905","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.116.026991","article-title":"Long noncoding RNA MANTIS facilitates endothelial angiogenic function","volume":"136","author":"Leisegang","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0910","doi-asserted-by":"crossref","first-page":"H711","DOI":"10.1152\/ajpheart.00724.2016","article-title":"Cystathionine gamma-lyase protects vascular endothelium: A role for inhibition of histone deacetylase 6","volume":"312","author":"Leucker","year":"2017","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0915","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.112.300849","article-title":"Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells","volume":"113","author":"Leung","year":"2013","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0920","first-page":"1165","article-title":"DNA hydroxymethylase 10-11 translocation 2 (TET2) inhibits mouse macrophage activation and polarization","volume":"33","author":"Li","year":"2017","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0925","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.biopha.2017.09.064","article-title":"Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis","volume":"95","author":"Li","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0930","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.117.032184","article-title":"H19 Induces Abdominal Aortic Aneurysm Development and Progression","volume":"138","author":"Li","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0935","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.117.305844","article-title":"Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-kappaB-driven inflammation and atherosclerosis","volume":"117","author":"Li","year":"2015","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0940","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/abbs\/gmq104","article-title":"SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy","volume":"43","author":"Li","year":"2011","journal-title":"Acta Biochimica et Biophysica Sinica Shanghai"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0945","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.atherosclerosis.2018.06.866","article-title":"Characterization of LncRNA expression profile and identification of novel LncRNA biomarkers to diagnose coronary artery disease","volume":"275","author":"Li","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0950","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1161\/CIRCRESAHA.110.237875","article-title":"SIRT1 acts as a modulator of neointima formation following vascular injury in mice","volume":"108","author":"Li","year":"2011","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0955","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1089\/jir.2014.0172","article-title":"High glucose increases the expression of inflammatory cytokine genes in macrophages through H3K9 methyltransferase mechanism","volume":"36","author":"Li","year":"2016","journal-title":"Journal of Interferon & Cytokine Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0960","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1016\/j.bbrc.2018.08.049","article-title":"MicroRNA-30c-5p inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis through FOXO3 down-regulation in atherosclerosis","volume":"503","author":"Li","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0965","first-page":"2876","article-title":"SRT1720, a SIRT1 specific activator, protected H2O2-induced senescent endothelium","volume":"8","author":"Li","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0970","first-page":"859","article-title":"The potential inhibitory effects of miR19b on vulnerable plaque formation via the suppression of STAT3 transcriptional activity","volume":"41","author":"Li","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0975","doi-asserted-by":"crossref","first-page":"48145","DOI":"10.18632\/oncotarget.18308","article-title":"Circulating microRNAs as potential biomarkers for coronary plaque rupture","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0980","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.numecd.2018.06.017","article-title":"The suppression of ox-LDL-induced inflammatory cytokine release and apoptosis of HCAECs by long non-coding RNA-MALAT1 via regulating microRNA-155\/SOCS1 pathway","volume":"28","author":"Li","year":"2018","journal-title":"Nutrition, Metabolism, and Cardiovascular Diseases"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0985","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jaut.2017.02.007","article-title":"Demethylase Kdm6a epigenetically promotes IL-6 and IFN-beta production in macrophages","volume":"80","author":"Li","year":"2017","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0990","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molcel.2007.07.032","article-title":"SIRT1 deacetylates and positively regulates the nuclear receptor LXR","volume":"28","author":"Li","year":"2007","journal-title":"Molecular Cell"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb0995","doi-asserted-by":"crossref","first-page":"393","DOI":"10.5603\/CJ.a2017.0133","article-title":"Identification of a peripheral blood long non-coding RNA (Upperhand) as a potential diagnostic marker of coronary artery disease","volume":"25","author":"Li","year":"2018","journal-title":"Cardiology Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1000","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3892\/ijo.2014.2757","article-title":"Paeonol suppresses lipid accumulation in macrophages via upregulation of the ATPbinding cassette transporter A1 and downregulation of the cluster of differentiation 36","volume":"46","author":"Li","year":"2015","journal-title":"International Journal of Oncology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1005","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/15384101.2018.1426413","article-title":"Icariin improves Fanconi anemia hematopoietic stem cell function through SIRT6-mediated NF-kappa B inhibition","volume":"17","author":"Li","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1010","doi-asserted-by":"crossref","first-page":"26771","DOI":"10.1074\/jbc.M802800200","article-title":"Role of the histone H3 lysine 4 methyltransferase, SET7\/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation","volume":"283","author":"Li","year":"2008","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1015","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.molimm.2016.07.018","article-title":"SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells","volume":"77","author":"Li","year":"2016","journal-title":"Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1020","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.imbio.2016.11.002","article-title":"Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells","volume":"222","author":"Li","year":"2017","journal-title":"Immunobiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1025","first-page":"4645","article-title":"Inhibition of miR34a prevents endothelial cell apoptosis by directly targeting HDAC1 in the setting of atherosclerosis","volume":"17","author":"Li","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1030","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1073\/pnas.1313768111","article-title":"The long noncoding RNA THRIL regulates TNFalpha expression through its interaction with hnRNPL","volume":"111","author":"Li","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1035","doi-asserted-by":"crossref","first-page":"9007","DOI":"10.1002\/jcp.26846","article-title":"SIRT1 inhibits TGF-beta-induced endothelial-mesenchymal transition in human endothelial cells with Smad4 deacetylation","volume":"233","author":"Li","year":"2018","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1040","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1002\/jcb.26854","article-title":"The anti-inflammatory effect of microRNA-383-3p interacting with IL1R2 against homocysteine-induced endothelial injury in rat coronary arteries","volume":"119","author":"Lian","year":"2018","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1045","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1002\/jcb.26448","article-title":"Long noncoding RNA HOTTIP promotes endothelial cell proliferation and migration via activation of the Wnt\/beta-catenin pathway","volume":"119","author":"Liao","year":"2018","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1050","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1055","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1161\/CIRCRESAHA.114.302699","article-title":"Inflammation and its resolution as determinants of acute coronary syndromes","volume":"114","author":"Libby","year":"2014","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143686","article-title":"Simvastatin attenuates oxidative stress, NF-kappaB activation, and artery calcification in LDLR\u2212\/\u2212 mice fed with high fat diet via down-regulation of tumor necrosis factor-alpha and TNF receptor 1","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1065","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/dna.2015.2866","article-title":"Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells","volume":"34","author":"Lin","year":"2015","journal-title":"DNA and Cell Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1070","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.2337\/db09-1003","article-title":"Epigenetics: A molecular link between environmental factors and type 2 diabetes","volume":"58","author":"Ling","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1075","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97493","article-title":"Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm","volume":"3","author":"Lino Cardenas","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1080","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/MOL.0b013e32830dd7c4","article-title":"Hyperelongated biglycan: The surreptitious initiator of atherosclerosis","volume":"19","author":"Little","year":"2008","journal-title":"Current Opinion in Lipidology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1085","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3892\/ijmm.2013.1609","article-title":"Enhancement in efferocytosis of oxidized low-density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy","volume":"33","author":"Liu","year":"2014","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1090","article-title":"Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-alpha-treated endothelial cells: Evidence for an anti-inflammatory cascade mediated by the miR-221\/222\/AMPK\/p38\/NF-kappaB pathway","volume":"7","author":"Liu","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1095","doi-asserted-by":"crossref","first-page":"e1827","DOI":"10.1038\/cddis.2015.193","article-title":"Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1100","article-title":"Silence of long intergenic noncoding RNA HOTAIR ameliorates oxidative stress and inflammation response in ox-LDL-treated human macrophages by upregulating miR-330-5p","author":"Liu","year":"2018","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1105","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1161\/CIRCULATIONAHA.113.002887","article-title":"Ten-eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity","volume":"128","author":"Liu","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1110","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00011-014-0758-9","article-title":"Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage","volume":"63","author":"Liu","year":"2014","journal-title":"Inflammation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1115","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/dna.2017.4118","article-title":"TET2: A novel epigenetic regulator and potential intervention target for atherosclerosis","volume":"37","author":"Liu","year":"2018","journal-title":"DNA and Cell Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1120","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1084\/jem.20151794","article-title":"Calorie restriction protects against experimental abdominal aortic aneurysms in mice","volume":"213","author":"Liu","year":"2016","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1125","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1194\/jlr.M040394","article-title":"Tanshinone IIA suppresses cholesterol accumulation in human macrophages: Role of heme oxygenase-1","volume":"55","author":"Liu","year":"2014","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1130","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.trsl.2016.02.005","article-title":"Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice","volume":"172","author":"Liu","year":"2016","journal-title":"Translational Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1135","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.bmcl.2008.12.041","article-title":"Curcumin is a potent DNA hypomethylation agent","volume":"19","author":"Liu","year":"2009","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1140","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/MOL.0000000000000338","article-title":"Early nutrition, epigenetics, and cardiovascular disease","volume":"27","author":"Loche","year":"2016","journal-title":"Current Opinion in Lipidology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1145","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/acel.12253","article-title":"Premature aging induced by radiation exhibits pro-atherosclerotic effects mediated by epigenetic activation of CD44 expression","volume":"13","author":"Lowe","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ccr.2010.06.016","article-title":"Regulation of tumor angiogenesis by EZH2","volume":"18","author":"Lu","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1155","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1172\/JCI68552","article-title":"Kruppel-like factor 15 is critical for vascular inflammation","volume":"123","author":"Lu","year":"2013","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1160","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/CIRCRESAHA.117.311311","article-title":"RNA therapeutics in cardiovascular disease","volume":"123","author":"Lucas","year":"2018","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1165","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvy176","article-title":"Critical role of histone demethylase JMJD3 in the regulation of neointima formation following vascular injury","author":"Luo","year":"2018","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2018.2.JNS171899","article-title":"Association between low levels of serum miR-638 and atherosclerotic plaque vulnerability in patients with high-grade carotid stenosis","author":"Luque","year":"2018","journal-title":"Journal of Neurosurgery"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1175","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1180","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tig.2012.03.001","article-title":"Genetics of atherosclerosis","volume":"28","author":"Lusis","year":"2012","journal-title":"Trends in Genetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157265","article-title":"Histone methyltransferase enhancer of zeste homolog 2-mediated ABCA1 promoter DNA methylation contributes to the progression of atherosclerosis","volume":"11","author":"Lv","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1190","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/978-1-4613-0325-1_17","article-title":"Ascorbic acid and atherosclerotic cardiovascular disease","volume":"25","author":"Lynch","year":"1996","journal-title":"Sub-Cellular Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1195","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.bbrc.2017.09.013","article-title":"Long-term exposure to PM2.5 lowers influenza virus resistance via down-regulating pulmonary macrophage Kdm6a and mediates histones modification in IL-6 and IFN-beta promoter regions","volume":"493","author":"Ma","year":"2017","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1200","article-title":"Ginkgolide B reduces LOX-1 expression by inhibiting Akt phosphorylation and increasing Sirt1 expression in oxidized LDL-stimulated human umbilical vein endothelial cells","volume":"8","author":"Ma","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1205","article-title":"E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis","volume":"6","author":"Ma","year":"2016","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1210","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.3892\/mmr.2017.7753","article-title":"Homocysteineinduced oxidative stress through TLR4\/NFkappaB\/DNMT1mediated LOX1 DNA methylation in endothelial cells","volume":"16","author":"Ma","year":"2017","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1215","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1089\/dna.2015.3203","article-title":"Long noncoding RNA highly upregulated in liver cancer regulates the tumor necrosis factor-alpha-induced apoptosis in human vascular endothelial cells","volume":"35","author":"Ma","year":"2016","journal-title":"DNA and Cell Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10456-015-9485-2","article-title":"The decrease in histone methyltransferase EZH2 in response to fluid shear stress alters endothelial gene expression and promotes quiescence","volume":"19","author":"Maleszewska","year":"2016","journal-title":"Angiogenesis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1225","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1073\/pnas.1616301114","article-title":"Common coding variant in SERPINA1 increases the risk for large artery stroke","volume":"114","author":"Malik","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1230","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1073\/pnas.1715182115","article-title":"Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA","volume":"115","author":"Man","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161632","article-title":"Differential expression of MicroRNAs in endarterectomy specimens taken from patients with asymptomatic and symptomatic carotid plaques","volume":"11","author":"Markus","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1240","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/STROKEAHA.111.000217","article-title":"Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis","volume":"44","author":"Markus","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1245","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrm1761","article-title":"The diverse functions of histone lysine methylation","volume":"6","author":"Martin","year":"2005","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1250","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/CIRCRESAHA.107.171025","article-title":"Epigenetic regulation of vascular endothelial gene expression","volume":"102","author":"Matouk","year":"2008","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139262","article-title":"Genome-wide association study of peripheral arterial disease in a japanese population","volume":"10","author":"Matsukura","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1260","doi-asserted-by":"crossref","first-page":"14855","DOI":"10.1073\/pnas.0704329104","article-title":"SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase","volume":"104","author":"Mattagajasingh","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1265","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature11606","article-title":"EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations","volume":"492","author":"McCabe","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083190","article-title":"RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist","volume":"8","author":"McLure","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1275","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.gene.2017.11.058","article-title":"microRNA-212 promotes lipid accumulation and attenuates cholesterol efflux in THP-1 human macrophages by targeting SIRT1","volume":"643","author":"Miao","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1280","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41467-017-02113-y","article-title":"Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function","volume":"9","author":"Miao","year":"2018","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1285","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1161\/CIRCRESAHA.114.303265","article-title":"Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth","volume":"114","author":"Michalik","year":"2014","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1290","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/eurheartj\/ehu095","article-title":"The Sirt1 activator SRT3025 provides atheroprotection in Apoe\u2212\/\u2212 mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression","volume":"36","author":"Miranda","year":"2015","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1295","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13148-016-0223-4","article-title":"Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy","volume":"8","author":"Morera","year":"2016","journal-title":"Clinical Epigenetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1300","first-page":"17","article-title":"Vitamin C and heart health: A review based on findings from epidemiologic studies","author":"Moser","year":"2016","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1305","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.3390\/molecules20033898","article-title":"Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents","volume":"20","author":"Mottamal","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1310","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ijcard.2016.03.062","article-title":"The role of epigenetic modifications in cardiovascular disease: A systematic review","volume":"212","author":"Muka","year":"2016","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1315","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1021\/bi00889a003","article-title":"THE OCCURRENCE OF EPSILON-N-METHYL LYSINE IN HISTONES","volume":"3","author":"Murray","year":"1964","journal-title":"Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1320","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1177\/0271678X17701156","article-title":"Dexamethasone suppresses JMJD3 gene activation via a putative negative glucocorticoid response element and maintains integrity of tight junctions in brain microvascular endothelial cells","volume":"37","author":"Na","year":"2017","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1325","doi-asserted-by":"crossref","first-page":"H1535","DOI":"10.1152\/ajpheart.00510.2009","article-title":"Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis","volume":"297","author":"Nam","year":"2009","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1330","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1038\/s41467-018-05065-z","article-title":"miR-103 promotes endothelial maladaptation by targeting lncWDR59","volume":"9","author":"Natarelli","year":"2018","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1335","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1084\/jem.20180479","article-title":"Repressing the repressor: Ezh2 mediates macrophage activation","volume":"215","author":"Neele","year":"2018","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1340","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.atherosclerosis.2018.05.052","article-title":"Myeloid Kdm6b deficiency results in advanced atherosclerosis","volume":"275","author":"Neele","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1345","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2217\/epi-2016-0152","article-title":"Macrophage Kdm6b controls the pro-fibrotic transcriptome signature of foam cells","volume":"9","author":"Neele","year":"2017","journal-title":"Epigenomics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1350","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1182\/blood-2017-10-811455","article-title":"Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells","volume":"131","author":"Neo","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1355","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.atherosclerosis.2003.08.009","article-title":"Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-E-deficient mice","volume":"171","author":"Nespereira","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1360","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41467-017-02431-1","article-title":"The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2","volume":"9","author":"Neumann","year":"2018","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1365","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s40256-017-0250-3","article-title":"Selective BET protein inhibition with apabetalone and cardiovascular events: A pooled analysis of trials in patients with coronary artery disease","volume":"18","author":"Nicholls","year":"2018","journal-title":"American Journal of Cardiovascular Drugs"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1370","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.atherosclerosis.2006.05.047","article-title":"Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice","volume":"191","author":"Norata","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1375","doi-asserted-by":"crossref","first-page":"528","DOI":"10.14348\/molcells.2015.0026","article-title":"The histone methyltransferase inhibitor bix01294 inhibits HIF-1alpha stability and angiogenesis","volume":"38","author":"Oh","year":"2015","journal-title":"Molecules and Cells"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1380","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5551\/jat.13.183","article-title":"Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1)","volume":"13","author":"Okamoto","year":"2006","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1385","first-page":"322","article-title":"LncRNA H19 promotes atherosclerosis by regulating MAPK and NF-kB signaling pathway","volume":"21","author":"Pan","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1390","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3389\/fphar.2018.00195","article-title":"(\u2212)-Epigallocatechin-3-Gallate ameliorates atherosclerosis and modulates hepatic lipid metabolic gene expression in Apolipoprotein E knockout mice: Involvement of TTC39B","volume":"9","author":"Pan","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1395","article-title":"Resveratrol protects against TNF-alpha-induced injury in human umbilical endothelial cells through promoting Sirtuin-1-Induced repression of NF-KB and p38 MAPK","volume":"11","author":"Pan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1400","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.yjmcc.2015.01.019","article-title":"NEDDylation promotes endothelial dysfunction: A role for HDAC2","volume":"81","author":"Pandey","year":"2015","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1405","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1161\/ATVBAHA.114.303685","article-title":"Transcriptional regulation of endothelial arginase 2 by histone deacetylase 2","volume":"34","author":"Pandey","year":"2014","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1410","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.jacc.2017.01.064","article-title":"The aging cardiovascular system: Understanding It at the Cellular and Clinical Levels","volume":"69","author":"Paneni","year":"2017","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1415","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fphar.2017.00486","article-title":"TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE\/H2S System","volume":"8","author":"Peng","year":"2017","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1420","doi-asserted-by":"crossref","first-page":"76423","DOI":"10.18632\/oncotarget.13121","article-title":"Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE\u2212\/\u2212 mice","volume":"7","author":"Peng","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1425","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20170351","article-title":"Thymic stromal lymphopoietin-induced HOTAIR activation promotes endothelial cell proliferation and migration in atherosclerosis","volume":"37","author":"Peng","year":"2017","journal-title":"Bioscience Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1430","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.molmed.2011.02.003","article-title":"Balancing histone methylation activities in psychiatric disorders","volume":"17","author":"Peter","year":"2011","journal-title":"Trends in Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1435","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1093\/eurheartj\/ehx165","article-title":"Non-coding RNAs in cardiovascular diseases: Diagnostic and therapeutic perspectives","volume":"39","author":"Poller","year":"2018","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1440","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/eurheartj\/ehn603","article-title":"Epigenetic histone acetylation modifiers in vascular remodelling: New targets for therapy in cardiovascular disease","volume":"30","author":"Pons","year":"2009","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1445","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cmet.2011.10.007","article-title":"Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation","volume":"14","author":"Qiang","year":"2011","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1450","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1152\/physiolgenomics.00025.2016","article-title":"Deep transcriptomic profiling reveals the similarity between endothelial cells cultured under static and oscillatory shear stress conditions","volume":"48","author":"Qiao","year":"2016","journal-title":"Physiological Genomics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1455","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1159\/000490932","article-title":"MicroRNA-142-3p induces atherosclerosis-associated endothelial cell apoptosis by directly targeting rictor","volume":"47","author":"Qin","year":"2018","journal-title":"Cellular Physiology and Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1460","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ijbiomac.2017.02.025","article-title":"Vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells","volume":"98","author":"Qu","year":"2017","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1465","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1038\/s41598-018-22388-5","article-title":"Natural polyphenols as sirtuin 6 modulators","volume":"8","author":"Rahnasto-Rilla","year":"2018","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1470","doi-asserted-by":"crossref","DOI":"10.3390\/md15060190","article-title":"The identification of a SIRT6 activator from brown algae fucus distichus","volume":"15","author":"Rahnasto-Rilla","year":"2017","journal-title":"Marine Drugs"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1475","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/ATVBAHA.108.179150","article-title":"Role of Src tyrosine kinase in the atherogenic effects of the 12\/15-lipoxygenase pathway in vascular smooth muscle cells","volume":"29","author":"Reddy","year":"2009","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1480","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.atherosclerosis.2015.12.018","article-title":"Management of residual risk after statin therapy","volume":"245","author":"Reith","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1485","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1490","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014An inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1495","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.biochem.70.1.81","article-title":"Histone acetyltransferases","volume":"70","author":"Roth","year":"2001","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1500","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.gene.2018.01.072","article-title":"Knockdown of long noncoding RNA MEG3 impairs VEGF-stimulated endothelial sprouting angiogenesis via modulating VEGFR2 expression in human umbilical vein endothelial cells","volume":"649","author":"Ruan","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1505","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nm.4479","article-title":"Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA","volume":"24","author":"Sallam","year":"2018","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1510","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature17674","article-title":"Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis","volume":"534","author":"Sallam","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1515","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1161\/01.CIR.0000050626.25057.51","article-title":"Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study","volume":"107","author":"Salonen","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1520","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2017.12.037","article-title":"Tet2-mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1beta\/NLRP3 inflammasome","volume":"71","author":"Sano","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1525","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1681\/ASN.2014090850","article-title":"Inhibition of SET domain-containing lysine methyltransferase 7\/9 ameliorates renal fibrosis","volume":"27","author":"Sasaki","year":"2016","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1530","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nature Immunology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1535","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1146\/annurev-pathol-012615-044135","article-title":"Mechanisms of MicroRNAs in atherosclerosis","volume":"11","author":"Schober","year":"2016","journal-title":"Annual Review of Pathology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1540","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1128\/MCB.00657-10","article-title":"Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress","volume":"30","author":"Schug","year":"2010","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1545","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1084\/jem.20031132","article-title":"KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation","volume":"199","author":"SenBanerjee","year":"2004","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1550","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1161\/CIRCULATIONAHA.117.033249","article-title":"Defective base excision repair of oxidative DNA damage in vascular smooth muscle cells promotes Atherosclerosis","volume":"138","author":"Shah","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1555","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/carcin\/bgp220","article-title":"Epigenetics in cancer","volume":"31","author":"Sharma","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1560","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.freeradbiomed.2013.08.185","article-title":"Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for heme oxygenase-1","volume":"65","author":"Shen","year":"2013","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1565","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","article-title":"Histone demethylation mediated by the nuclear amine oxidase homolog LSD1","volume":"119","author":"Shi","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1570","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9174926","article-title":"EZH2 inhibition ameliorates transverse aortic constriction-induced pulmonary arterial hypertension in mice","volume":"2018","author":"Shi","year":"2018","journal-title":"Canadian Respiratory Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1575","article-title":"HDAC9 polymorphism alters blood gene expression in patients with large vessel atherosclerotic stroke","author":"Shroff","year":"2018","journal-title":"Translational Stroke Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1580","article-title":"LncRNAs in vascular biology and disease","author":"Simion","year":"2018","journal-title":"Vascular Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1585","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1242\/dev.134932","article-title":"Ezh2 restricts the smooth muscle lineage during mouse lung mesothelial development","volume":"143","author":"Snitow","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1590","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1159\/000478918","article-title":"Effect of circular ANRIL on the inflammatory response of vascular endothelial cells in a rat model of coronary atherosclerosis","volume":"42","author":"Song","year":"2017","journal-title":"Cellular Physiology and Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1595","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.atherosclerosis.2017.08.027","article-title":"The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis","volume":"265","author":"Sosnowska","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1600","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/cvr\/cvx253","article-title":"Endothelial-mesenchymal transition in atherosclerosis","volume":"114","author":"Souilhol","year":"2018","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1605","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1093\/eurheartj\/ehq107","article-title":"SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis","volume":"31","author":"Stein","year":"2010","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1610","doi-asserted-by":"crossref","first-page":"353","DOI":"10.18632\/aging.100162","article-title":"SIRT1 reduces endothelial activation without affecting vascular function in ApoE\u2212\/\u2212 mice","volume":"2","author":"Stein","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1615","first-page":"1405","article-title":"Long noncoding RNA SENCR alleviates the inhibitory effects of rapamycin on human umbilical vein endothelial cells","volume":"18","author":"Sun","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1620","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCRESAHA.113.302089","article-title":"Systemic delivery of microRNA-181b inhibits nuclear factor-kappaB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice","volume":"114","author":"Sun","year":"2014","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1625","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrg.2016.114","article-title":"Detecting circular RNAs: Bioinformatic and experimental challenges","volume":"17","author":"Szabo","year":"2016","journal-title":"Nature Reviews. Genetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1630","first-page":"1899","article-title":"Metformin inhibits ovarian cancer via decreasing H3K27 trimethylation","volume":"52","author":"Tang","year":"2018","journal-title":"International Journal of Oncology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1640","first-page":"17","article-title":"The Bromodomain and Extra-Terminal Domain (BET) Family: Functional anatomy of BET paralogous proteins","author":"Taniguchi","year":"2016","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1645","doi-asserted-by":"crossref","first-page":"29252","DOI":"10.1074\/jbc.M113.481473","article-title":"FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin\/kexin type 9 (Pcsk9) gene expression","volume":"288","author":"Tao","year":"2013","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1650","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1194\/jlr.M039339","article-title":"Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6","volume":"54","author":"Tao","year":"2013","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1655","doi-asserted-by":"crossref","first-page":"H533","DOI":"10.1152\/ajpheart.00871.2013","article-title":"Age-related loss of SirT1 expression results in dysregulated human vascular smooth muscle cell function","volume":"307","author":"Thompson","year":"2014","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb6005","series-title":"Targeting LOX-1 in Atherosclerosis and Vasculopathy: Current Knowledge and Future Perspectives","author":"Tian","year":"2018"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1660","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/CIRCULATIONAHA.117.029002","article-title":"Long noncoding RNA facilitated gene therapy reduces atherosclerosis in a murine model of familial hypercholesterolemia","volume":"136","author":"Tontonoz","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1665","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1161\/ATVBAHA.117.309923","article-title":"Perinatal hypercholesterolemia exacerbates atherosclerosis lesions in offspring by altering metabolism of trimethylamine-N-Oxide And Bile acids","volume":"37","author":"Trenteseaux","year":"2017","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1670","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700928","article-title":"Chlorogenic acid protects against oxLDL-Induced oxidative damage and mitochondrial dysfunction by modulating SIRT1 in endothelial cells","volume":"62","author":"Tsai","year":"2018","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1675","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/CIRCRESAHA.116.302521","article-title":"Long noncoding RNAs in cardiovascular diseases","volume":"116","author":"Uchida","year":"2015","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1680","doi-asserted-by":"crossref","first-page":"643","DOI":"10.15252\/emmm.201506031","article-title":"Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice","volume":"8","author":"Ulrich","year":"2016","journal-title":"EMBO Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1685","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbrc.2014.11.029","article-title":"Inhibiting epigenetic enzymes to improve atherogenic macrophage functions","volume":"455","author":"Van den Bossche","year":"2014","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1690","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000042","article-title":"Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers","volume":"2","author":"Venkatasubramanian","year":"2013","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1695","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2016-000402","article-title":"Effects of the small molecule SIRT1 activator, SRT2104 on arterial stiffness in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus","volume":"3","author":"Venkatasubramanian","year":"2016","journal-title":"Open Heart"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1700","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13059-015-0863-2","article-title":"IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation","volume":"17","author":"Vento-Tormo","year":"2016","journal-title":"Genome Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1705","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/ml3003346","article-title":"Identification of potent, selective, cell-active inhibitors of the histone lysine methyltransferase EZH2","volume":"3","author":"Verma","year":"2012","journal-title":"ACS Medicinal Chemistry Letters"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1710","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1073\/pnas.0803623105","article-title":"Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes","volume":"105","author":"Villeneuve","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1715","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.arr.2016.10.008","article-title":"Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases","volume":"35","author":"Vitiello","year":"2017","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1720","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13148-016-0170-0","article-title":"Epigenetic associations in relation to cardiovascular prevention and therapeutics","volume":"8","author":"Voelter-Mahlknecht","year":"2016","journal-title":"Clinical Epigenetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1725","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/MOL.0000000000000339","article-title":"Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization","volume":"27","author":"de Vries","year":"2016","journal-title":"Current Opinion in Lipidology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1730","series-title":"The epigenotype. Endeavour","first-page":"18","volume":"Vol. 1","author":"Waddington","year":"1942"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1735","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1093\/nar\/gkw093","article-title":"LncDisease: A sequence based bioinformatics tool for predicting lncRNA-disease associations","volume":"44","author":"Wang","year":"2016","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1740","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nature20602","article-title":"Integrin-YAP\/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow","volume":"540","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1745","article-title":"Blockade of NEAT1 represses inflammation response and lipid uptake via modulating miR-342-3p in human macrophages THP-1 cells","author":"Wang","year":"2018","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1750","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.3892\/mmr.2017.7027","article-title":"SIRT1 activation inhibits hyperglycemia-induced apoptosis by reducing oxidative stress and mitochondrial dysfunction in human endothelial cells","volume":"16","author":"Wang","year":"2017","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1755","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1182\/blood-2009-05-224824","article-title":"Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS","volume":"115","author":"Wang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1760","doi-asserted-by":"crossref","first-page":"114442","DOI":"10.18632\/oncotarget.17748","article-title":"Identification of the histone lysine demethylase KDM4A\/JMJD2A as a novel epigenetic target in M1 macrophage polarization induced by oxidized LDL","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1765","article-title":"HDAC9 Variant Rs2107595 modifies susceptibility to coronary artery disease and the severity of coronary atherosclerosis in a Chinese Han population","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1770","doi-asserted-by":"crossref","first-page":"89055","DOI":"10.18632\/oncotarget.21649","article-title":"ACAT-1 gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: A case-control study","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1775","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2012.12.006","article-title":"Transcriptional and epigenetic regulation of human microRNAs","volume":"331","author":"Wang","year":"2013","journal-title":"Cancer Letters"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1780","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbrc.2018.01.121","article-title":"SMAD7 methylation as a novel marker in atherosclerosis","volume":"496","author":"Wei","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1785","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3389\/fphys.2018.00522","article-title":"Long Non-coding RNAs in endothelial biology","volume":"9","author":"Weirick","year":"2018","journal-title":"Frontiers in Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1790","doi-asserted-by":"crossref","first-page":"E2420","DOI":"10.1073\/pnas.1309354110","article-title":"Ca2+\/calmodulin-dependent protein kinase kinase beta phosphorylation of Sirtuin 1 in endothelium is atheroprotective","volume":"110","author":"Wen","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1795","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/SLA.0000000000001466","article-title":"Inhibition of MicroRNA-494 reduces carotid artery atherosclerotic lesion development and increases plaque stability","volume":"262","author":"Wezel","year":"2015","journal-title":"Annals of Surgery"},{"issue":"3\u20139","key":"10.1016\/j.pharmthera.2018.11.003_bb1800","article-title":"Global histone H3 lysine 27 triple methylation levels are reduced in vessels with advanced atherosclerotic plaques","volume":"129","author":"Wierda","year":"2015","journal-title":"Life Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1805","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1093\/eurheartj\/ehv290","article-title":"Protective effects of sirtuins in cardiovascular diseases: From bench to bedside","volume":"36","author":"Winnik","year":"2015","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1810","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00395-013-0399-0","article-title":"Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: Implications for cardiovascular risk factor development","volume":"109","author":"Winnik","year":"2014","journal-title":"Basic Research in Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1815","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00395-016-0552-7","article-title":"Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: Protective role of a novel C\/EBP-beta-dependent feedback regulation of SOD2","volume":"111","author":"Winnik","year":"2016","journal-title":"Basic Research in Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1820","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3390\/ijms17040451","article-title":"Epigenetic modifications in essential hypertension","volume":"17","author":"Wise","year":"2016","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1825","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.phrs.2017.10.014","article-title":"Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells","volume":"128","author":"Wojtala","year":"2018","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1830","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25217","article-title":"HIF-1alpha is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium","volume":"6","author":"Wu","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1835","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1161\/CIRCULATIONAHA.114.011675","article-title":"LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity","volume":"130","author":"Wu","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1840","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrg.2017.33","article-title":"TET-mediated active DNA demethylation: Mechanism, function and beyond","volume":"18","author":"Wu","year":"2017","journal-title":"Nature Reviews. Genetics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1845","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1139\/cjpp-2016-0367","article-title":"Icariin improves eNOS\/NO pathway to prohibit the atherogenesis of apolipoprotein E-null mice","volume":"95","author":"Xiao","year":"2017","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1850","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167744","article-title":"Hyperhomocysteinemia in ApoE\u2212\/\u2212 mice leads to overexpression of enhancer of zeste homolog 2 via miR-92a regulation","volume":"11","author":"Xiaoling","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1855","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.tem.2016.07.004","article-title":"Sirtuins in cardiovascular health and diseases","volume":"27","author":"Xu","year":"2016","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1860","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/med.21300","article-title":"Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: From molecular mechanisms to therapeutic implications","volume":"34","author":"Xu","year":"2014","journal-title":"Medicinal Research Reviews"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1865","doi-asserted-by":"crossref","first-page":"37622","DOI":"10.18632\/oncotarget.9376","article-title":"A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis","volume":"7","author":"Xu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1870","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ijcard.2014.01.068","article-title":"Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis","volume":"172","author":"Xu","year":"2014","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1875","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1007\/s00018-012-1194-z","article-title":"LOX-1 in atherosclerosis: Biological functions and pharmacological modifiers","volume":"70","author":"Xu","year":"2013","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1880","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.tem.2018.04.007","article-title":"Atherosclerosis is an epigenetic disease","volume":"29","author":"Xu","year":"2018","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1885","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.7150\/thno.21966","article-title":"Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects","volume":"8","author":"Xu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1890","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.18632\/aging.100975","article-title":"SIRT6 protects against endothelial dysfunction and atherosclerosis in mice","volume":"8","author":"Xu","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1895","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1161\/ATVBAHA.107.151704","article-title":"Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy","volume":"27","author":"Xu","year":"2007","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1900","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.bbrc.2018.06.042","article-title":"Knockdown of long noncoding RNA XIST alleviates oxidative low-density lipoprotein-mediated endothelial cells injury through modulation of miR-320\/NOD2 axis","volume":"503","author":"Xu","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1905","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007134","article-title":"Suberanilohydroxamic acid as a pharmacological kruppel-like Factor 2 activator that represses vascular inflammation and atherosclerosis","volume":"6","author":"Xu","year":"2017","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1910","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1161\/CIRCRESAHA.116.305510","article-title":"lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA","volume":"116","author":"Yan","year":"2015","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1915","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.cellsig.2014.03.025","article-title":"Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages","volume":"26","author":"Yan","year":"2014","journal-title":"Cellular Signalling"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb6000","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s10753-017-0599-0","article-title":"Lipopolysaccharide downregulates kruppel-like factor 2 (KLF2) via inducing DNMT1-mediated hypermethylation in endothelial cells","volume":"40","author":"Yan","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1920","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1161\/CIRCULATIONAHA.117.027799","article-title":"miR-22 Is a novel mediator of vascular smooth muscle cell phenotypic modulation and neointima formation","volume":"137","author":"Yang","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1925","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1007\/s10439-015-1491-4","article-title":"Low shear stress inhibited endothelial cell autophagy through TET2 downregulation","volume":"44","author":"Yang","year":"2016","journal-title":"Annals of Biomedical Engineering"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1930","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-2184.2012.00828.x","article-title":"BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells","volume":"45","author":"Yang","year":"2012","journal-title":"Cell Proliferation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1935","first-page":"725","article-title":"Apelin\/APJ axis improves angiotensin II-induced endothelial cell senescence through AMPK\/SIRT1 signaling pathway","volume":"14","author":"Yang","year":"2018","journal-title":"Archives of Medical Science"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1940","first-page":"1659","article-title":"Sirt1 inhibited oxidized low-density lipoprotein induced smooth muscle cells inflammatory response","volume":"97","author":"Yang","year":"2017","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1945","article-title":"Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction","volume":"12","author":"Yang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1950","doi-asserted-by":"crossref","first-page":"51447","DOI":"10.18632\/oncotarget.17691","article-title":"SIRT1 inhibition promotes atherosclerosis through impaired autophagy","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1955","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41422-018-0040-8","article-title":"Dynamic transcriptomic m(6)A decoration: Writers, erasers, readers and functions in RNA metabolism","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1960","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.bbadis.2017.12.033","article-title":"Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway","volume":"1864","author":"Yang","year":"2018","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1965","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1097\/HJH.0000000000001304","article-title":"Profiles of long noncoding RNAs in hypertensive rats: long noncoding RNA XR007793 regulates cyclic strain-induced proliferation and migration of vascular smooth muscle cells","volume":"35","author":"Yao","year":"2017","journal-title":"Journal of Hypertension"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1970","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000010473","article-title":"LncRNA ENST00113 promotes proliferation, survival, and migration by activating PI3K\/Akt\/mTOR signaling pathway in atherosclerosis","volume":"97","author":"Yao","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1975","first-page":"561","article-title":"Varinostat alters gene expression profiles in aortic tissues from ApoE\u2212\/\u2212 mice","volume":"32","author":"Ye","year":"2018","journal-title":"Human Gene Therapy Clinical Development"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1980","first-page":"561","article-title":"Circulating microRNAs as novel biomarkers for atherosclerosis","volume":"32","author":"Yilmaz","year":"2018","journal-title":"In Vivo"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1985","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000464288","article-title":"Downregulations of CD36 and Calpain-1, inflammation, and atherosclerosis by simvastatin in Apolipoprotein E knockout mice","volume":"54","author":"Yin","year":"2017","journal-title":"Journal of Vascular Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1990","doi-asserted-by":"crossref","first-page":"10396","DOI":"10.1021\/ja4028346","article-title":"Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals","volume":"135","author":"Yin","year":"2013","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb1995","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jnutbio.2016.01.011","article-title":"Fucoidan alleviates high-fat diet-induced dyslipidemia and atherosclerosis in ApoE(shl) mice deficient in apolipoprotein E expression","volume":"32","author":"Yokota","year":"2016","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2000","doi-asserted-by":"crossref","first-page":"C1175","DOI":"10.1152\/ajpcell.00288.2008","article-title":"Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids","volume":"295","author":"Yoshida","year":"2008","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2005","article-title":"DNMT1-PPARgamma pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice","volume":"6","author":"Yu","year":"2016","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbrc.2017.02.020","article-title":"The regulation of Jmjd3 upon the expression of NF-kappaB downstream inflammatory genes in LPS activated vascular endothelial cells","volume":"485","author":"Yu","year":"2017","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2015","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3892\/ijmm.2017.2920","article-title":"Ulinastatin protects against lipopolysaccharide-induced cardiac microvascular endothelial cell dysfunction via downregulation of lncRNA MALAT1 and EZH2 in sepsis","volume":"39","author":"Yu","year":"2017","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2020","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1101\/gad.262766.115","article-title":"RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation","volume":"29","author":"Yue","year":"2015","journal-title":"Genes & Development"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2025","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/abbs\/gmy086","article-title":"MiR-147b influences vascular smooth muscle cell proliferation and migration via targeting YY1 and modulating Wnt\/beta-catenin activities","volume":"50","author":"Yue","year":"2018","journal-title":"Acta Biochimica et Biophysica Sinica Shanghai"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/CIRCULATIONAHA.109.890491","article-title":"Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow","volume":"121","author":"Zampetaki","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2035","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3892\/mmr.2013.1460","article-title":"SIRT1 prevents atherosclerosis via liverXreceptor and NFkappaB signaling in a U937 cell model","volume":"8","author":"Zeng","year":"2013","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2040","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1083\/jcb.200605113","article-title":"HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells","volume":"174","author":"Zeng","year":"2006","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2045","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.biopha.2017.11.061","article-title":"SIRT2 decreases atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice by modulating macrophage polarization","volume":"97","author":"Zhang","year":"2018","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2050","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.biopha.2017.07.099","article-title":"Long intergenic noncoding RNA 00305 sponges miR-136 to regulate the hypoxia induced apoptosis of vascular endothelial cells","volume":"94","author":"Zhang","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2055","article-title":"Long noncoding RNA LINC00305 promotes inflammation by activating the AHRR-NF-kappaB pathway in human monocytes","volume":"7","author":"Zhang","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2060","article-title":"Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1\/p300\/p53\/p21 Pathway","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2065","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.18632\/aging.101541","article-title":"Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits","volume":"10","author":"Zhang","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2070","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3892\/mmr.2015.4558","article-title":"A regulatory circuit involving miR-143 and DNMT3a mediates vascular smooth muscle cell proliferation induced by homocysteine","volume":"13","author":"Zhang","year":"2016","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12929-018-0418-4","article-title":"H19 knockdown suppresses proliferation and induces apoptosis by regulating miR-148b\/WNT\/beta-catenin in ox-LDL -stimulated vascular smooth muscle cells","volume":"25","author":"Zhang","year":"2018","journal-title":"Journal of Biomedical Science"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2080","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.carpath.2017.11.004","article-title":"TUG1 knockdown ameliorates atherosclerosis via up-regulating the expression of miR-133a target gene FGF1","volume":"33","author":"Zhang","year":"2018","journal-title":"Cardiovascular Pathology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00418-016-1408-9","article-title":"Impaired SIRT1 promotes the migration of vascular smooth muscle cell-derived foam cells","volume":"146","author":"Zhang","year":"2016","journal-title":"Histochemistry and Cell Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2090","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature15252","article-title":"Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/cvr\/cvn224","article-title":"Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice","volume":"80","author":"Zhang","year":"2008","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2100","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1021\/acs.jafc.7b04260","article-title":"Curcumin Protects against Atherosclerosis in Apolipoprotein E-Knockout Mice by Inhibiting Toll-like Receptor 4 Expression","volume":"66","author":"Zhang","year":"2018","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2105","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.15252\/embr.201540945","article-title":"The interplay of histone modifications - writers that read","volume":"16","author":"Zhang","year":"2015","journal-title":"EMBO Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2110","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7543973","article-title":"Sirt1 inhibits oxidative stress in vascular endothelial cells","volume":"2017","author":"Zhang","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2115","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4082102","article-title":"Sirt1 protects endothelial cells against lps-induced barrier dysfunction","volume":"2017","author":"Zhang","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2120","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1055\/s-0032-1328551","article-title":"Icariin attenuates the enhanced prothrombotic state in atherosclerotic rabbits independently of its lipid-lowering effects","volume":"79","author":"Zhang","year":"2013","journal-title":"Planta Medica"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2125","article-title":"Non-coding RNAs in lipid metabolism","author":"Zhang","year":"2018","journal-title":"Vascular Pharmacology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2130","article-title":"Long Non-Coding RNA Malat1 regulates angiogenesis in hindlimb ischemia","volume":"19","author":"Zhang","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2135","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1084\/jem.20171417","article-title":"Macrophage\/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3","volume":"215","author":"Zhang","year":"2018","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2140","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/abbs\/gmr100","article-title":"Lysine methylation: Beyond histones","volume":"44","author":"Zhang","year":"2012","journal-title":"Acta Biochimica et Biophysica Sinica Shanghai"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2145","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7589813","article-title":"Resveratrol enhances autophagic flux and promotes Ox-LDL degradation in HUVECs via upregulation of SIRT1","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2150","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12449","article-title":"Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3\/miR-223\/NLRP3 axis","volume":"64","author":"Zhang","year":"2018","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2155","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1161\/ATVBAHA.111.237453","article-title":"AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300","volume":"31","author":"Zhang","year":"2011","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2160","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.3945\/jn.113.177451","article-title":"Supplementation of cyanidin-3-O-beta-glucoside promotes endothelial repair and prevents enhanced atherogenesis in diabetic apolipoprotein E-deficient mice","volume":"143","author":"Zhang","year":"2013","journal-title":"The Journal of Nutrition"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2165","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.1002\/jcp.26576","article-title":"Let-7e inhibits TNF-alpha expression by targeting the methyl transferase EZH2 in DENV2-infected THP-1 cells","volume":"233","author":"Zhang","year":"2018","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2175","doi-asserted-by":"crossref","first-page":"7491","DOI":"10.1038\/s41598-017-07611-z","article-title":"Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population","volume":"7","author":"Zhang","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2180","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1146\/annurev-anchem-071213-020216","article-title":"High-throughput proteomics","volume":"7","author":"Zhang","year":"2014","journal-title":"Annual Review of Analytical Chemistry (Palo Alto, California)"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2185","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jgg.2018.01.002","article-title":"Mouse macrophage specific knockout of SIRT1 influences macrophage polarization and promotes angiotensin II-induced abdominal aortic aneurysm formation","volume":"45","author":"Zhang","year":"2018","journal-title":"Journal of Genetics and Genomics"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2190","article-title":"Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice","volume":"6","author":"Zhang","year":"2016","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2195","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1161\/ATVBAHA.116.307879","article-title":"MYOSLID Is a Novel serum response factor-dependent long noncoding RNA that amplifies the vascular smooth muscle differentiation program","volume":"36","author":"Zhao","year":"2016","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2200","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1002\/jcb.26126","article-title":"miR-34a targets HDAC1-regulated H3K9 acetylation on lipid accumulation induced by homocysteine in foam cells","volume":"118","author":"Zhao","year":"2017","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2205","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/CIRCRESAHA.115.305206","article-title":"The Role of DNA methylation in cardiovascular risk and disease: Methodological aspects, study design, and data analysis for epidemiological studies","volume":"118","author":"Zhong","year":"2016","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2210","first-page":"1134","article-title":"Downregulation of microRNA34a inhibits oxidized lowdensity lipoproteininduced apoptosis and oxidative stress in human umbilical vein endothelial cells","volume":"42","author":"Zhong","year":"2018","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2215","first-page":"6138","article-title":"Curcumin increases cholesterol efflux via heme oxygenase1mediated ABCA1 and SRBI expression in macrophages","volume":"17","author":"Zhong","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2220","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s12195-014-0325-z","article-title":"Epigenetic mechanism in regulation of endothelial function by disturbed flow: Induction of DNA hypermethylation by DNMT1","volume":"7","author":"Zhou","year":"2014","journal-title":"Cellular and Molecular Bioengineering"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2225","doi-asserted-by":"crossref","first-page":"609","DOI":"10.5551\/jat.36897","article-title":"CDKN2B methylation and aortic arch calcification in patients with ischemic stroke","volume":"24","author":"Zhou","year":"2017","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2230","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s12967-016-1093-4","article-title":"CDKN2B methylation is associated with carotid artery calcification in ischemic stroke patients","volume":"14","author":"Zhou","year":"2016","journal-title":"Journal of Translational Medicine"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2235","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1476-511X-13-134","article-title":"Notable epigenetic role of hyperhomocysteinemia in atherogenesis","volume":"13","author":"Zhou","year":"2014","journal-title":"Lipids in Health and Disease"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2240","doi-asserted-by":"crossref","first-page":"8513","DOI":"10.3892\/mmr.2017.7623","article-title":"Long intergenic noncoding RNA p21 mediates oxidized LDLinduced apoptosis and expression of LOX1 in human coronary artery endothelial cells","volume":"16","author":"Zhou","year":"2017","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2018.11.003_bb2245","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/ATVBAHA.116.307923","article-title":"The yin-yang dynamics of DNA methylation Is the key regulator for smooth muscle cell phenotype switch and vascular remodeling","volume":"37","author":"Zhuang","year":"2017","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725818302006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725818302006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T17:35:48Z","timestamp":1662399348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725818302006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":449,"alternative-id":["S0163725818302006"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2018.11.003","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2018.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}