{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:47:52Z","timestamp":1789177672471,"version":"build-2803163510"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"am","delay-in-days":345,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100012482","name":"University of Michigan Comprehensive Cancer Center","doi-asserted-by":"publisher","award":["CCSG P30 CA118100"],"award-info":[{"award-number":["CCSG P30 CA118100"]}],"id":[{"id":"10.13039\/100012482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007179","name":"University of New Mexico","doi-asserted-by":"publisher","award":["UL1TR001449"],"award-info":[{"award-number":["UL1TR001449"]}],"id":[{"id":"10.13039\/100007179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20 GM121176"],"award-info":[{"award-number":["P20 GM121176"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HL007736"],"award-info":[{"award-number":["T32 HL007736"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.pharmthera.2019.03.009","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T12:05:35Z","timestamp":1552910735000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Clioquinol: To harm or heal"],"prefix":"10.1016","volume":"199","author":[{"given":"Dominique R.","family":"Perez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry A.","family":"Sklar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Chigaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2019.03.009_bb0005","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1124\/jpet.108.136523","article-title":"The human multidrug resistance protein 4 (MRP4, ABCC4): Functional analysis of a highly polymorphic gene","volume":"325","author":"Abla","year":"2008","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0010","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.expneurol.2007.08.011","article-title":"Modulation of the cAMP signaling pathway after traumatic brain injury","volume":"208","author":"Atkins","year":"2007","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0015","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2012.10.558","article-title":"Metallostasis in Alzheimer's disease","volume":"62","author":"Ayton","year":"2013","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0020","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s13311-014-0312-z","article-title":"Biometals and their therapeutic implications in Alzheimer's disease","volume":"12","author":"Ayton","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0025","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s00535-010-0248-y","article-title":"The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease","volume":"45","author":"Ban","year":"2010","journal-title":"Journal of Gastroenterology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0030","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0092-8674(02)00657-8","article-title":"Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture","volume":"108","author":"Barco","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10549-010-1292-2","article-title":"No evidence for an association between the earwax-associated polymorphism in ABCC11 and breast cancer risk in Caucasian women","volume":"126","author":"Beesley","year":"2011","journal-title":"Breast Cancer Research and Treatment"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0040","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1021\/acschemneuro.5b00305","article-title":"Effects of neonatal Iron feeding and chronic Clioquinol administration on the parkinsonian human A53T transgenic mouse","volume":"7","author":"Billings","year":"2016","journal-title":"ACS Chemical Neuroscience"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0045","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nm0409-356","article-title":"The curious case of clioquinol","volume":"15","author":"Cahoon","year":"2009","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0050","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1007\/s12035-017-0473-y","article-title":"Inhibition of intracellular type 10 adenylyl cyclase protects cortical neurons against reperfusion-induced mitochondrial injury and apoptosis","volume":"55","author":"Chagtoo","year":"2018","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0055","doi-asserted-by":"crossref","first-page":"11390","DOI":"10.1523\/JNEUROSCI.0757-12.2012","article-title":"Alzheimer's beta-secretase (BACE1) regulates the cAMP\/PKA\/CREB pathway independently of beta-amyloid","volume":"32","author":"Chen","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0060","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(01)00317-8","article-title":"Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice","volume":"30","author":"Cherny","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0065","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fphar.2015.00134","article-title":"Does aberrant membrane transport contribute to poor outcome in adult acute myeloid leukemia?","volume":"6","author":"Chigaev","year":"2015","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0070","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fimmu.2012.00242","article-title":"Aspects of VLA-4 and LFA-1 regulation that may contribute to rolling and firm adhesion","volume":"3","author":"Chigaev","year":"2012","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1091\/mbc.e14-06-1050","article-title":"FRET detection of lymphocyte function-associated antigen-1 conformational extension","volume":"26","author":"Chigaev","year":"2015","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12865-014-0052-1","article-title":"Carbon monoxide down-regulates alpha4beta1 integrin-specific ligand binding and cell adhesion: A possible mechanism for cell mobilization","volume":"15","author":"Chigaev","year":"2014","journal-title":"BMC Immunology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0085","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2172-9-26","article-title":"Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: A possible mechanism for cell de-adhesion","volume":"9","author":"Chigaev","year":"2008","journal-title":"BMC Immunology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0090","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1074\/jbc.M110.166868","article-title":"Multidrug resistance protein 4 (MRP4\/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation","volume":"286","author":"Copsel","year":"2011","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0095","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0165-0173(02)00219-9","article-title":"Zinc takes the center stage: Its paradoxical role in Alzheimer's disease","volume":"41","author":"Cuajungco","year":"2003","journal-title":"Brain Research. Brain Research Reviews"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0100","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/j.bbadis.2013.03.004","article-title":"Cyclophilin D deficiency rescues Abeta-impaired PKA\/CREB signaling and alleviates synaptic degeneration","volume":"1842","author":"Du","year":"2014","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0105","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0047-6374(79)90106-4","article-title":"Aging, genetics, and the environment: Potential of errors introduced into genetic information transfer by metal ions","volume":"9","author":"Eichhorn","year":"1979","journal-title":"Mechanisms of Ageing and Development"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0110","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/acschemneuro.5b00253","article-title":"Clioquinol improves cognitive, motor function, and microanatomy of the alpha-Synuclein hA53T transgenic mice","volume":"7","author":"Finkelstein","year":"2016","journal-title":"ACS Chemical Neuroscience"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrc2789","article-title":"ABC transporters in cancer: More than just drug efflux pumps","volume":"10","author":"Fletcher","year":"2010","journal-title":"Nature Reviews. Cancer"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0120","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3233\/JAD-130719","article-title":"Trends in diet and Alzheimer's disease during the nutrition transition in Japan and developing countries","volume":"38","author":"Grant","year":"2014","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0125","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1002\/chem.201002809","article-title":"Copper(I) and copper(II) inhibit Abeta peptides proteolysis by insulin-degrading enzyme differently: Implications for metallostasis alteration in Alzheimer's disease","volume":"17","author":"Grasso","year":"2011","journal-title":"Chemistry"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0130","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1158\/1078-0432.CCR-08-0442","article-title":"Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: Relation to long-term survival","volume":"15","author":"Guo","year":"2009","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0135","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1039\/C6MT00019C","article-title":"Lead and manganese levels in serum and erythrocytes in Alzheimer's disease and mild cognitive impairment: Results from the Australian imaging, biomarkers and lifestyle flagship study of ageing","volume":"8","author":"Hare","year":"2016","journal-title":"Metallomics"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0140","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2174\/138920111795164020","article-title":"ABC transporters in the CNS - an inventory","volume":"12","author":"Hartz","year":"2011","journal-title":"Current Pharmaceutical Biotechnology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0145","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1126\/science.290.5495.1273a","article-title":"Neuroscience. An antibiotic to treat Alzheimer's?","volume":"290","author":"Helmuth","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0150","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1515\/acph-2015-0034","article-title":"Induction of cell cycle arrest via the p21, p27-cyclin E,A\/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol","volume":"65","author":"Huang","year":"2015","journal-title":"Acta Pharmaceutica"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0155","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1474-4422(14)70262-5","article-title":"Safety, tolerability, and efficacy of PBT2 in Huntington's disease: A phase 2, randomised, double-blind, placebo-controlled trial","volume":"14","author":"Huntington Study Group Reach, H. D. I","year":"2015","journal-title":"Lancet Neurology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0160","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/humu.20694","article-title":"6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4","volume":"29","author":"Janke","year":"2008","journal-title":"Human Mutation"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0165","first-page":"195","article-title":"Subacute myelo-optico-neuropathy, a new neurological disease prevailing in Japan","volume":"24","author":"Kono","year":"1971","journal-title":"Japanese Journal of Medical Science & Biology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0170","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.expneurol.2013.03.026","article-title":"The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis","volume":"247","author":"Kraft","year":"2013","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0175","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1158\/0008-5472.CAN-07-6790","article-title":"Transporter-mediated protection against thiopurine-induced hematopoietic toxicity","volume":"68","author":"Krishnamurthy","year":"2008","journal-title":"Cancer Research"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0180","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10549-011-1613-0","article-title":"The earwax-associated SNP c.538G>A (G180R) in ABCC11 is not associated with breast cancer risk in Europeans","volume":"129","author":"Lang","year":"2011","journal-title":"Breast Cancer Research and Treatment"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0185","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1474-4422(08)70167-4","article-title":"Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial","volume":"7","author":"Lannfelt","year":"2008","journal-title":"Lancet Neurology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0190","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrc.2017.53","article-title":"Targeting autophagy in cancer","volume":"17","author":"Levy","year":"2017","journal-title":"Nature Reviews. Cancer"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0195","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.neuron.2012.12.040","article-title":"Environmental novelty activates beta2-adrenergic signaling to prevent the impairment of hippocampal LTP by Abeta oligomers","volume":"77","author":"Li","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0200","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1021\/acsmedchemlett.5b00281","article-title":"Novel fluorinated 8-Hydroxyquinoline based metal Ionophores for exploring the metal hypothesis of Alzheimer's disease","volume":"6","author":"Liang","year":"2015","journal-title":"ACS Medicinal Chemistry Letters"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0205","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1111\/j.1471-4159.2007.04942.x","article-title":"Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain","volume":"103","author":"Liang","year":"2007","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0210","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0006-8993(99)01981-2","article-title":"Increased cerebrospinal fluid cAMP levels in Alzheimer's disease","volume":"846","author":"Martinez","year":"1999","journal-title":"Brain Research"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0215","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0006-8993(01)03009-8","article-title":"Increased cAMP immunostaining in cerebral vessels in Alzheimer's disease","volume":"922","author":"Martinez","year":"2001","journal-title":"Brain Research"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0220","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neures.2011.02.006","article-title":"Stabilising influence: Integrins in regulation of synaptic plasticity","volume":"70","author":"McGeachie","year":"2011","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0225","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11095-018-2377-6","article-title":"Ionophore and biometal modulation of P-glycoprotein expression and function in human brain microvascular endothelial cells","volume":"35","author":"McInerney","year":"2018","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0230","first-page":"157","article-title":"Subacute myelo-optic neuropathy and clioquinol. An epidemiological case-history for diagnosis","volume":"29","author":"Meade","year":"1975","journal-title":"British Journal of Preventive & Social Medicine"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0235","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2009.01.013","article-title":"Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro","volume":"452","author":"Mei","year":"2009","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0240","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-2010-1221","article-title":"Alzheimer's disease and the amyloid-beta peptide","volume":"19","author":"Murphy","year":"2010","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0245","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2156-10-42","article-title":"A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene","volume":"10","author":"Nakano","year":"2009","journal-title":"BMC Genetics"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0250","first-page":"5189","article-title":"Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11","volume":"30","author":"Ota","year":"2010","journal-title":"Anticancer Research"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0255","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.nbd.2011.01.009","article-title":"Clioquinol induces autophagy in cultured astrocytes and neurons by acting as a zinc ionophore","volume":"42","author":"Park","year":"2011","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0260","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-1-4939-3673-1_15","article-title":"A High-throughput flow cytometry assay for identification of inhibitors of 3\u2032,5'-cyclic adenosine monophosphate efflux","volume":"1439","author":"Perez","year":"2016","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0265","doi-asserted-by":"crossref","first-page":"33960","DOI":"10.18632\/oncotarget.8986","article-title":"Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia","volume":"7","author":"Perez","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0270","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.173.3994.347","article-title":"Cerumen genetics and human breast cancer","volume":"173","author":"Petrakis","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuroscience.2012.05.050","article-title":"Synaptic changes in Alzheimer's disease and its models","volume":"251","author":"Pozueta","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0280","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/cpt.435","article-title":"Transporters as drug targets in neurological diseases","volume":"100","author":"Qosa","year":"2016","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0285","doi-asserted-by":"crossref","first-page":"45597","DOI":"10.18632\/oncotarget.10056","article-title":"The metabolic\/pH sensor soluble adenylyl cyclase is a tumor suppressor protein","volume":"7","author":"Ramos-Espiritu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0290","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s40478-016-0390-8","article-title":"Rubidium and potassium levels are altered in Alzheimer's disease brain and blood but not in cerebrospinal fluid","volume":"4","author":"Roberts","year":"2016","journal-title":"Acta Neuropathologica Communications"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0295","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bcp.2011.11.009","article-title":"Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics","volume":"83","author":"Scott Bitner","year":"2012","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0300","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1016\/j.neurobiolaging.2015.09.006","article-title":"The zinc ionophore clioquinol reverses autophagy arrest in chloroquine-treated ARPE-19 cells and in APP\/mutant presenilin-1-transfected Chinese hamster ovary cells","volume":"36","author":"Seo","year":"2015","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0305","doi-asserted-by":"crossref","first-page":"14639","DOI":"10.1074\/jbc.M110.204453","article-title":"Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: A mechanism involved in tau pathology of Alzheimer disease","volume":"286","author":"Shi","year":"2011","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0310","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2741\/3938","article-title":"Metals in Alzheimer's disease: A systemic perspective","volume":"17","author":"Squitti","year":"2012","journal-title":"Frontiers in Bioscience (Landmark Ed)"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0315","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/jhg.2009.62","article-title":"Japanese map of the earwax gene frequency: A nationwide collaborative study by Super Science High School consortium","volume":"54","author":"Super Science High School","year":"2009","journal-title":"Journal of Human Genetics"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0320","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/tpj.2014.74","article-title":"Multidrug resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during maintenance therapy in Japanese childhood acute lymphoblastic leukemia","volume":"15","author":"Tanaka","year":"2015","journal-title":"The Pharmacogenomics Journal"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0325","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"Tanida","year":"2008","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0330","doi-asserted-by":"crossref","first-page":"7670483","DOI":"10.1155\/2016\/7670483","article-title":"Diagnosis of human axillary Osmidrosis by genotyping of the human ABCC11 gene: Clinical practice and basic scientific evidence","volume":"2016","author":"Toyoda","year":"2016","journal-title":"BioMed Research International"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0335","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2174\/187152010794473975","article-title":"Pharmacogenomics of human ABC transporter ABCC11 (MRP8): Potential risk of breast cancer and chemotherapy failure","volume":"10","author":"Toyoda","year":"2010","journal-title":"Anti-Cancer Agents in Medicinal Chemistry"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0340","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1096\/fj.09-129098","article-title":"Earwax, osmidrosis, and breast cancer: Why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?","volume":"23","author":"Toyoda","year":"2009","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0345","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1111\/j.1349-7006.2010.01690.x","article-title":"ABCC11\/MRP8 confers pemetrexed resistance in lung cancer","volume":"101","author":"Uemura","year":"2010","journal-title":"Cancer Science"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0350","doi-asserted-by":"crossref","first-page":"13217","DOI":"10.1073\/pnas.172504199","article-title":"Amyloid beta -peptide inhibition of the PKA\/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling","volume":"99","author":"Vitolo","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0355","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.neurobiolaging.2007.03.018","article-title":"Alpha v integrins mediate beta-amyloid induced inhibition of long-term potentiation","volume":"29","author":"Wang","year":"2008","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0360","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.neurobiolaging.2007.12.004","article-title":"Inhibition of LTP by beta-amyloid is prevented by activation of beta2 adrenoceptors and stimulation of the cAMP\/PKA signalling pathway","volume":"30","author":"Wang","year":"2009","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0365","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.brainres.2010.08.034","article-title":"ABC efflux transporters in brain vasculature of Alzheimer's subjects","volume":"1358","author":"Wijesuriya","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0370","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10549-012-2398-5","article-title":"High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival","volume":"137","author":"Yamada","year":"2013","journal-title":"Breast Cancer Research and Treatment"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0375","first-page":"652","article-title":"Earwax type and osmidrosis: Prognostic factor for breast cancer? Response to letter to the editor","volume":"138","author":"Yamada","year":"2013","journal-title":"Breast Cancer Research and Treatment"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0380","doi-asserted-by":"crossref","first-page":"P518","DOI":"10.1016\/j.jalz.2014.05.805","article-title":"Protein And Metal Alterations In Platelets Of Alzheimer's Disease Patients","volume":"10","author":"Yevenes Ugarte","year":"2014","journal-title":"Alzheimer's & Dementia: The Journal of the Alzheimer's Association"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0385","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.3390\/molecules17033524","article-title":"Terpenoids as potential anti-Alzheimer's disease therapeutics","volume":"17","author":"Yoo","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0390","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/ng1733","article-title":"A SNP in the ABCC11 gene is the determinant of human earwax type","volume":"38","author":"Yoshiura","year":"2006","journal-title":"Nature Genetics"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0395","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2174\/138920007780655441","article-title":"Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier","volume":"8","author":"Yu","year":"2007","journal-title":"Current Drug Metabolism"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0400","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2011.08.036","article-title":"Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice","volume":"1417","author":"Zeitlin","year":"2011","journal-title":"Brain Research"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0405","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3109\/13880209.2015.1027408","article-title":"Salvia miltiorrhiza: A source for anti-Alzheimer's disease drugs","volume":"54","author":"Zhang","year":"2016","journal-title":"Pharmaceutical Biology"},{"key":"10.1016\/j.pharmthera.2019.03.009_bb0410","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1474-9726.2007.00352.x","article-title":"Amyloid beta-peptide 31-35-induced neuronal apoptosis is mediated by caspase-dependent pathways via cAMP-dependent protein kinase a activation","volume":"7","author":"Zhao","year":"2008","journal-title":"Aging Cell"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725819300488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725819300488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:03:03Z","timestamp":1777492983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725819300488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":82,"alternative-id":["S0163725819300488"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2019.03.009","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clioquinol: To harm or heal","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2019.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}