{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:17:09Z","timestamp":1791472629077,"version":"4.3.4"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.pharmthera.2020.107613","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T11:29:09Z","timestamp":1592393349000},"page":"107613","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"special_numbering":"C","title":["Therapeutic potential of resveratrol against emerging respiratory viral infections"],"prefix":"10.1016","volume":"214","author":[{"given":"Simone","family":"Filardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Di Pietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Mastromarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2020.107613_bb0005","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/184241","article-title":"Antiviral activity of resveratrol against human and animal viruses","volume":"2015","author":"Abba","year":"2015","journal-title":"Adv Virol"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jcv.2017.07.019","article-title":"Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe","volume":"95","author":"Alimi","year":"2017","journal-title":"Journal of Clinical Virology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0015","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: The in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nature Reviews. Drug Discovery"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0020","article-title":"The therapeutic potential of resveratrol: A review of clinical trials","volume":"1","author":"Berman","year":"2017","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0025","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.3390\/ijms21082945","article-title":"Resveratrol in cancer patients: From bench to bedside","volume":"21","author":"Berretta","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0030","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.nutres.2012.06.003","article-title":"Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus","volume":"32","author":"Bhatt","year":"2012","journal-title":"Nutrition Research"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/nyas.13401","article-title":"Resveratrol derivatives as a pharmacological tool","volume":"1403","author":"Biasutto","year":"2017","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0040","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.phrs.2016.08.010","article-title":"Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial","volume":"111","author":"Bo","year":"2016","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0045","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3945\/ajcn.112.049379","article-title":"In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota","volume":"97","author":"Bode","year":"2013","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0050","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3389\/fimmu.2019.00452","article-title":"Contribution of cytokines to tissue damage during human respiratory syncytial virus infection","volume":"10","author":"Bohmwald","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0055","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1158\/1055-9965.EPI-07-0022","article-title":"Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent","volume":"16","author":"Boocock","year":"2007","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0060","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/j.semdp.2019.04.006","article-title":"Emerging respiratory infections: The infectious disease pathology of SARS, MERS, pandemic influenza, and Legionella","volume":"36","author":"Bradley","year":"2019","journal-title":"Seminars in Diagnostic Pathology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0065","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3390\/ijms20071523","article-title":"Resveratrol and its effects on the vascular system","volume":"20","author":"Breuss","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0070","doi-asserted-by":"crossref","first-page":"R209","DOI":"10.1530\/ERC-13-0171","article-title":"Resveratrol and cancer: Focus on in vivo evidence","volume":"21","author":"Carter","year":"2014","journal-title":"Endocrine-Related Cancer"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0075","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ccm.2018.07.005","article-title":"Influenza and Viral Pneumonia","volume":"39","author":"Cavallazzi","year":"2018","journal-title":"Clinics in Chest Medicine"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2005.07.010","article-title":"Dosage effects of resveratrol on ethanol-induced cell death in the human K562 cell line","volume":"161","author":"Chan","year":"2006","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0085","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.4161\/auto.26336","article-title":"Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway","volume":"9","author":"Chen","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0090","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/bph.14801","article-title":"Pharmacological basis and new insights of resveratrol action in the cardiovascular system","volume":"177","author":"Cheng","year":"2020","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0095","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3390\/ijms20061381","article-title":"Progress to improve Oral bioavailability and beneficial effects of resveratrol","volume":"20","author":"Chimento","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0100","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200900437","article-title":"Resveratrol bioavailability and toxicity in humans","volume":"54","author":"Cottart","year":"2010","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0105","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/jim-2018-000712","article-title":"Viral pneumonia: Etiologies and treatment","volume":"66","author":"Dandachi","year":"2018","journal-title":"Journal of Investigative Medicine"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/00325481.2019.1592400","article-title":"Pulmonary complications of influenza infection: A targeted narrative review","volume":"131","author":"Daoud","year":"2019","journal-title":"Postgraduate Medicine"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0115","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.3389\/fimmu.2018.01946","article-title":"Treating influenza infection, from now and into the future","volume":"9","author":"Davidson","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0120","first-page":"509","article-title":"Resveratrol in Chlamydia pneumoniae-induced foam cell formation and interleukin-17A synthesis","volume":"27","author":"Di Pietro","year":"2013","journal-title":"Journal of Biological Regulators and Homeostatic Agents"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112459","article-title":"Infectious agents in atherosclerotic cardiovascular diseases through oxidative stress","volume":"18","author":"Di Pietro","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbrc.2008.06.113","article-title":"Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice","volume":"374","author":"Do","year":"2008","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0135","article-title":"Adamantane-resistant influenza A viruses in the world (1902-2013): Frequency and distribution of M2 gene mutations","volume":"10","author":"Dong","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0140","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1086\/649559","article-title":"The interleukin 6174 C\/C genotype predicts greater rhinovirus illness","volume":"201","author":"Doyle","year":"2010","journal-title":"The Journal of Infectious Diseases"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0145","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1053\/spid.2002.122999","article-title":"Antiviral therapy of influenza","volume":"13","author":"Englund","year":"2002","journal-title":"Seminars in Pediatric Infectious Diseases"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0150","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/10408363.2013.805182","article-title":"Pterostilbene: Biomedical applications","volume":"50","author":"Estrela","year":"2013","journal-title":"Critical Reviews in Clinical Laboratory Sciences"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13034-7","article-title":"Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae","volume":"7","author":"Euba","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0160","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00705-019-04300-2","article-title":"Epidemiology of respiratory viruses in Saudi Arabia: Toward a complete picture","volume":"164","author":"Farrag","year":"2019","journal-title":"Archives of Virology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0165","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1016\/j.bmc.2012.05.062","article-title":"Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action","volume":"20","author":"Fioravanti","year":"2012","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0170","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/jf404155e","article-title":"Improved stability of trans-resveratrol in aqueous solutions by carboxymethylated (1,3\/1,6)-\u03b2-D-glucan","volume":"62","author":"Francioso","year":"2014","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0175","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.drudis.2010.07.005","article-title":"Resveratrol and derivatives for the prevention and treatment of cancer","volume":"15","author":"Fulda","year":"2010","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/837042","article-title":"Properties of resveratrol: In vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans","volume":"2015","author":"Gambini","year":"2015","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0185","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1034\/j.1399-3038.2002.01093.x","article-title":"Relationships among specific viral pathogens, virus-induced interleukin-8, and respiratory symptoms in infancy","volume":"13","author":"Gern","year":"2002","journal-title":"Pediatric Allergy and Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0190","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/1479164113520332","article-title":"Resveratrol ameliorates diabetic vascular inflammation and macrophage infiltration in db\/db mice by inhibiting the NF-kappaB pathway","volume":"11","author":"Guo","year":"2014","journal-title":"Diabetes & Vascular Disease Research"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0195","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.medmal.2018.01.008","article-title":"Respiratory syncytial virus infection in elderly adults","volume":"48","author":"Haber","year":"2018","journal-title":"M\u00e9decine et Maladies Infectieuses"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0200","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1128\/JVI.03275-14","article-title":"Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication","volume":"89","author":"Hastings","year":"2015","journal-title":"Journal of Virology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0205","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3389\/fimmu.2019.00566","article-title":"Role of type I interferon (IFN) in the respiratory syncytial virus (RSV) immune response and disease severity","volume":"10","author":"Hijano","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0210","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/CMR.00077-12","article-title":"Human rhinoviruses","volume":"26","author":"Jacobs","year":"2013","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0215","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-019-2539-x","article-title":"Influenza virus-related critical illness: Pathophysiology and epidemiology","volume":"23","author":"Kalil","year":"2019","journal-title":"Critical Care"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0220","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00280-010-1525-4","article-title":"Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats","volume":"68","author":"Kapetanovic","year":"2011","journal-title":"Cancer Chemotherapy and Pharmacology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0225","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.antiviral.2010.08.016","article-title":"Inhibition of influenza virus replication by plant-derived isoquercetin","volume":"88","author":"Kim","year":"2010","journal-title":"Antiviral Research"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0230","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1210\/jc.2016-2160","article-title":"No beneficial effects of resveratrol on the metabolic syndrome: A randomized placebo-controlled clinical trial","volume":"102","author":"Kjaer","year":"2017","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0235","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.3390\/ijms18122589","article-title":"The role of resveratrol in Cancer therapy","volume":"18","author":"Ko","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0240","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.idc.2017.07.006","article-title":"Respiratory syncytial virus and other noninfluenza respiratory viruses in older adults","volume":"31","author":"Kodama","year":"2017","journal-title":"Infectious Disease Clinics of North America"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0245","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virusres.2015.01.018","article-title":"Role of dietary antioxidants in human metapneumovirus infection","volume":"200","author":"Komaravelli","year":"2015","journal-title":"Virus Research"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0250","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00705-018-3708-y","article-title":"The emerging influenza virus threat: Status and new prospects for its therapy and control","volume":"163","author":"Kumar","year":"2018","journal-title":"Archives of Virology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105924","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges","volume":"55","author":"Lai","year":"2020","journal-title":"International Journal of Antimicrobial Agents"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0260","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a038505","article-title":"The structure, function, and pathobiology of the influenza A and B virus ion channels","author":"Lamb","year":"2020","journal-title":"Cold Spring Harb Perspect Med pii"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0265","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1042\/BST0351156","article-title":"Resveratrol as an antioxidant and pro-oxidant agent: Mechanisms and clinical implications","volume":"35","author":"de la Lastra","year":"2007","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0270","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1099\/vir.0.055533-0","article-title":"Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: Implications for pathogenesis and treatment","volume":"94","author":"Lau","year":"2013","journal-title":"The Journal of General Virology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0275","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1080\/08927014.2019.1657418","article-title":"The anti-biofilm and anti-virulence activities of trans-resveratrol and oxyresveratrol against uropathogenic Escherichia coli","volume":"35","author":"Lee","year":"2019","journal-title":"Biofouling"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0280","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0285","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.foodchem.2012.05.043","article-title":"Hypohalous acid-mediated halogenation of resveratrol and its role in antioxidant and antimicrobial activities","volume":"135","author":"Li","year":"2012","journal-title":"Food Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0290","article-title":"Characterization of signaling pathways regulating the expression of pro-inflammatory long form thymic stromal lymphopoietin upon human metapneumovirus infection","volume":"17","author":"Li","year":"2018","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0295","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.ejmech.2006.03.024","article-title":"Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication","volume":"41","author":"Li","year":"2006","journal-title":"European Journal of Medicinal Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0300","article-title":"Polygonum cuspidatum and its active components inhibit replication of the influenza virus through toll-like receptor 9-induced interferon beta expression","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0305","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/22221751.2020.1746199","article-title":"Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia","volume":"9","author":"Lin","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0310","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-017-2253-8","article-title":"Effective inhibition of MERS-CoV infection by resveratrol","volume":"17","author":"Lin","year":"2017","journal-title":"BMC Infectious Diseases"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0315","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1055\/s-0030-1250030","article-title":"In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum","volume":"76","author":"Liu","year":"2010","journal-title":"Planta Medica"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0320","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jmv.25709","article-title":"Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV","volume":"92","author":"Liu","year":"2020","journal-title":"Journal of Medical Virology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0325","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1128\/JVI.03637-13","article-title":"Resveratrol inhibits the TRIF-dependent pathway by upregulating sterile alpha and armadillo motif protein, contributing to anti-inflammatory effects after respiratory syncytial virus infection","volume":"88","author":"Liu","year":"2014","journal-title":"Journal of Virology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0330","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00430-016-0459-9","article-title":"NK cells contribute to persistent airway inflammation and AHR during the later stage of RSV infection in mice","volume":"205","author":"Long","year":"2016","journal-title":"Medical Microbiology and Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0335","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5582\/bst.2020.01020","article-title":"Drug treatment options for the 2019-new coronavirus (2019-nCoV)","volume":"16","author":"Lu","year":"2020","journal-title":"Bioscience Trends"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0340","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11357-019-00116-9","article-title":"Nanodelivery of phytobioactive compounds for treating aging-associated disorders","volume":"42","author":"Lushchak","year":"2020","journal-title":"Geroscience"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0345","series-title":"Recent advances in understanding rhinovirus immunity. F1000Res","author":"Makris","year":"2018"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0350","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.antiviral.2015.08.010","article-title":"Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia","volume":"123","author":"Mastromarino","year":"2015","journal-title":"Antiviral Research"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0355","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/S2213-2600(15)00255-6","article-title":"Lower respiratory tract infection caused by respiratory syncytial virus: Current management and new therapeutics","volume":"3","author":"Mazur","year":"2015","journal-title":"The Lancet Respiratory Medicine"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0360","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01174-14","article-title":"Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses","volume":"5","author":"Menachery","year":"2014","journal-title":"MBio"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0365","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3390\/foods9030340","article-title":"Health benefits and molecular mechanisms of resveratrol: A narrative review","volume":"9","author":"Meng","year":"2020","journal-title":"Foods"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0370","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ajpath.2015.09.014","article-title":"Dipeptidyl peptidase 4 distribution in the human respiratory tract: implications for the Middle East respiratory syndrome","volume":"186","author":"Meyerholz","year":"2016","journal-title":"Am J Pathol"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0375","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.nut.2012.07.006","article-title":"Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life","volume":"29","author":"Militaru","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0380","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/pai.12279","article-title":"Resveratrol plus carboxymethyl-\u03b2-glucan may affect respiratory infections in children with allergic rhinitis","volume":"25","author":"Miraglia Del Giudice","year":"2014","journal-title":"Pediatric Allergy and Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0385","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/intimm\/dxv018","article-title":"Resveratrol inhibits the acetylated \u03b1-tubulin-mediated assembly of the NLRP3-inflammasome","volume":"27","author":"Misawa","year":"2015","journal-title":"International Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0390","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3390\/nu9111188","article-title":"Therapeutic versatility of resveratrol derivatives","volume":"9","author":"Nawaz","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0395","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1093\/infdis\/jiy056","article-title":"Respiratory syncytial virus seasonality: A global overview","volume":"217","author":"Obando-Pacheco","year":"2018","journal-title":"The Journal of Infectious Diseases"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0400","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1086\/429694","article-title":"Inhibition of influenza a virus replication by resveratrol","volume":"191","author":"Palamara","year":"2005","journal-title":"The Journal of Infectious Diseases"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0405","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.biopha.2018.11.075","article-title":"Resveratrol: From enhanced biosynthesis and bioavailability to multitargeting chronic diseases","volume":"109","author":"Pannu","year":"2019","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0410","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/resp.13558","article-title":"Respiratory infections assembly of the APSR. Emerging respiratory infections threatening public health in the Asia-Pacific region: A position paper of the Asian Pacific Society of Respirology","volume":"24","author":"Park","year":"2019","journal-title":"Respirology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0415","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0140-6736(17)30129-0","article-title":"Influenza","volume":"390","author":"Paules","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0420","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.fct.2015.01.017","article-title":"Resveratrol alters human endothelial cells redox state and causes mitochondrial-dependent cell death","volume":"78","author":"Posadino","year":"2015","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0425","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1080\/21645515.2017.1337614","article-title":"Product review on the monoclonal antibody palivizumab for prevention of respiratory syncytial virus infection","volume":"13","author":"Resch","year":"2017","journal-title":"Human Vaccines & Immunotherapeutics"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0430","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/pai.12716","article-title":"Respiratory syncytial virus-host interaction in the pathogenesis of bronchiolitis and its impact on respiratory morbidity in later life","volume":"28","author":"Rossi","year":"2017","journal-title":"Pediatric Allergy and Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0435","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1128\/CMR.00090-16","article-title":"The human immune response to respiratory syncytial virus infection","volume":"30","author":"Russell","year":"2017","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0440","doi-asserted-by":"crossref","first-page":"E109","DOI":"10.3390\/pathogens9020109","article-title":"Human Metapneumovirus: A largely unrecognized threat to human health","volume":"9","author":"Russell","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0445","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.colsurfb.2019.04.030","article-title":"Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity","volume":"180","author":"Santos","year":"2019","journal-title":"Colloids and Surfaces. B, Biointerfaces"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0450","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12013-012-9407-5","article-title":"Moderate red wine and grape juice consumption modulates the hydrolysis of the adenine nucleotides and decreases platelet aggregation in streptozotocin-induced diabetic rats","volume":"65","author":"Schmatz","year":"2013","journal-title":"Cell Biochemistry and Biophysics"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0455","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-017-1823-z","article-title":"Resveratrol distinctively modulates the inflammatory profiles of immune and endothelial cells","volume":"17","author":"Schwager","year":"2017","journal-title":"BMC Complementary and Alternative Medicine"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0460","doi-asserted-by":"crossref","first-page":"240","DOI":"10.12998\/wjcc.v2.i7.240","article-title":"Infectious burden and atherosclerosis: A clinical issue","volume":"2","author":"Sessa","year":"2014","journal-title":"World Journal of Clinical Cases"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0470","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.3390\/ijms21062084","article-title":"Potential adverse effects of resveratrol: A literature review","volume":"21","author":"Shaito","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0475","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.3389\/fimmu.2018.02466","article-title":"Human metapneumovirus: Mechanisms and molecular targets used by the virus to avoid the immune system","volume":"9","author":"Soto","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0480","first-page":"1","article-title":"Phenolic substances of white hellebore (Veratrum grandiflorum Loes. fil.)","volume":"3","author":"Takaoka","year":"1940","journal-title":"J Faculty Sci"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0485","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3390\/cells8090986","article-title":"RNA sequencing of H3N2 influenza virus-infected human nasal epithelial cells from multiple subjects reveals molecular pathways associated with tissue injury and complications","volume":"8","author":"Tan","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0490","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/mnfr.201100673","article-title":"Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial","volume":"56","author":"Tome-Carneiro","year":"2012","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0495","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.amjcard.2012.03.030","article-title":"One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease","volume":"110","author":"Tome-Carneiro","year":"2012","journal-title":"The American Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0500","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.phrs.2013.03.011","article-title":"One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease","volume":"72","author":"Tome-Carneiro","year":"2013","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0505","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejps.2016.02.018","article-title":"Co-spray dried resveratrol and budesonide inhalation formulation for reducing inflammation and oxidative stress in rat alveolar macrophages","volume":"86","author":"Trotta","year":"2016","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0510","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3390\/v11060521","article-title":"Impact of rhinovirus infections in children","volume":"11","author":"Vandini","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0515","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.3389\/fimmu.2019.01154","article-title":"Cytokines in the respiratory airway as biomarkers of severity and prognosis for respiratory syncytial virus infection: An update","volume":"10","author":"V\u00e1zquez","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0520","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ijantimicag.2019.02.015","article-title":"Antibacterial and antifungal properties of resveratrol","volume":"53","author":"Vestergaard","year":"2019","journal-title":"International Journal of Antimicrobial Agents"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0525","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","article-title":"High absorption but very low bioavailability of oral resveratrol in humans","volume":"32","author":"Walle","year":"2004","journal-title":"Drug Metabolism and Disposition"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.11.032","article-title":"Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein","author":"Walls","year":"2020","journal-title":"Cell."},{"key":"10.1016\/j.pharmthera.2020.107613_bb0535","article-title":"Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures","author":"Wang","year":"2020","journal-title":"Journal of Medical Virology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0540","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/bph.13492","article-title":"Antioxidant effects of resveratrol in the cardiovascular system","volume":"174","author":"Xia","year":"2017","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0545","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1007\/s10753-012-9452-7","article-title":"Resveratrol inhibits respiratory syncytial virus-induced IL-6 production, decreases viral replication, and downregulates TRIF expression in airway epithelial cells","volume":"35","author":"Xie","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0550","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1271\/bbb.90549","article-title":"Evaluation of resveratrol oxidation in vitro and the crucial role of bicarbonate ions","volume":"74","author":"Yang","year":"2010","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0555","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/resp.13196","article-title":"MERS, SARS and other coronaviruses as causes of pneumonia","volume":"23","author":"Yin","year":"2018","journal-title":"Respirology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0560","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.2337\/db05-1188","article-title":"Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice","volume":"55","author":"Zang","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0565","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.intimp.2015.05.031","article-title":"Resveratrol suppresses persistent airway inflammation and hyperresponsivess might partially via nerve growth factor in respiratory syncytial virus-infected mice","volume":"28","author":"Zang","year":"2015","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0570","doi-asserted-by":"crossref","first-page":"13061","DOI":"10.1128\/JVI.05869-11","article-title":"Resveratrol-mediated gamma interferon reduction prevents airway inflammation and airway hyperresponsiveness in respiratory syncytial virus-infected immunocompromised mice","volume":"85","author":"Zang","year":"2011","journal-title":"Journal of Virology"},{"key":"10.1016\/j.pharmthera.2020.107613_bb0575","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejpb.2015.04.002","article-title":"Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature","volume":"93","author":"Zupan\u010di\u010d","year":"2015","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725820301431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725820301431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:05:01Z","timestamp":1759010701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725820301431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":114,"alternative-id":["S0163725820301431"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107613","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of resveratrol against emerging respiratory viral infections","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107613","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107613"}}