{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:21:45Z","timestamp":1784978505942,"version":"3.55.0"},"reference-count":212,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004412","name":"Human Frontier Science Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.pharmthera.2020.107673","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T11:33:41Z","timestamp":1599824021000},"page":"107673","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["A natural product solution to aging and aging-associated diseases"],"prefix":"10.1016","volume":"216","author":[{"given":"Chuanbin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoduo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2020.107673_bb0005","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.pharep.2015.03.002","article-title":"Berberine and neurodegeneration: A review of literature","volume":"67","author":"Ahmed","year":"2015","journal-title":"Pharmacological Reports : PR"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0010","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.critrevonc.2013.01.005","article-title":"The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer","volume":"87","author":"Anisimov","year":"2013","journal-title":"Critical Reviews in Oncology\/Hematology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0015","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1101\/gad.1255404","article-title":"The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans","volume":"18","author":"Apfeld","year":"2004","journal-title":"Genes & Development"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0020","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","article-title":"The epidemiology of Parkinson\u2019s disease: Risk factors and prevention","volume":"15","author":"Ascherio","year":"2016","journal-title":"The Lancet. Neurology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0025","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ncb1744","article-title":"Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency","volume":"10","author":"Baker","year":"2008","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0030","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1141448","article-title":"Adapting proteostasis for disease intervention","volume":"319","author":"Balch","year":"2008","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0035","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1111\/dom.12354","article-title":"Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls","volume":"16","author":"Bannister","year":"2014","journal-title":"Diabetes, Obesity & Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0040","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3389\/fendo.2018.00790","article-title":"Hallmarks of aging: An Autophagic perspective","volume":"9","author":"Barbosa","year":"2018","journal-title":"Frontiers in Endocrinology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0045","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(15)00516-4","article-title":"The world report on ageing and health: A policy framework for healthy ageing","volume":"387","author":"Beard","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0050","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s10654-012-9714-6","article-title":"Use of glucosamine and chondroitin in relation to mortality","volume":"27","author":"Bell","year":"2012","journal-title":"European Journal of Epidemiology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0055","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart disease and stroke Statistics-2018 update: A report from the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0060","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.bbadis.2015.01.012","article-title":"Lifespan and healthspan extension by resveratrol","volume":"1852","author":"Bhullar","year":"2015","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0065","doi-asserted-by":"crossref","first-page":"35492","DOI":"10.18632\/oncotarget.18033","article-title":"From rapalogs to anti-aging formula","volume":"8","author":"Blagosklonny","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0070","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1126\/science.1078223","article-title":"Extended longevity in mice lacking the insulin receptor in adipose tissue","volume":"299","author":"Bl\u00fcher","year":"2003","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0075","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrm.2016.93","article-title":"Slowing ageing by design: The rise of NAD(+) and sirtuin-activating compounds","volume":"17","author":"Bonkowski","year":"2016","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0040295","article-title":"Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells","volume":"4","author":"Bordone","year":"2006","journal-title":"PLoS Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0085","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.smim.2018.10.011","article-title":"Aging, inflammation and cancer","volume":"40","author":"Bottazzi","year":"2018","journal-title":"Seminars in Immunology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20071523","article-title":"Resveratrol and its effects on the vascular system","volume":"20","author":"Breuss","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0095","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/20014091111730","article-title":"Hormesis: A generalizable and unifying hypothesis","volume":"31","author":"Calabrese","year":"2001","journal-title":"Critical Reviews in Toxicology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0100","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.bbadis.2011.11.002","article-title":"Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity","volume":"1822","author":"Calabrese","year":"2012","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0105","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1159\/000225957","article-title":"The shock of aging: Molecular chaperones and the heat shock response in longevity and aging--a mini-review","volume":"55","author":"Calderwood","year":"2009","journal-title":"Gerontology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0110","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1093\/eurheartj\/ehv587","article-title":"Molecular mechanism of endothelial and vascular aging: Implications for cardiovascular disease","volume":"36","author":"Camici","year":"2015","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.arr.2017.08.003","article-title":"Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis","volume":"40","author":"Campbell","year":"2017","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0120","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev-physiol-030212-183653","article-title":"Aging, cellular senescence, and cancer","volume":"75","author":"Campisi","year":"2013","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0125","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41586-019-1365-2","article-title":"From discoveries in ageing research to therapeutics for healthy ageing","volume":"571","author":"Campisi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0130","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1101\/gad.265462.115","article-title":"Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol","volume":"29","author":"Cao","year":"2015","journal-title":"Genes & Development"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0135","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1080\/10408398.2018.1492900","article-title":"Dietary polyphenols and type 2 diabetes: Human study and clinical trial","volume":"59","author":"Cao","year":"2019","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0140","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neulet.2018.12.030","article-title":"\u03b1-Synuclein in salivary extracellular vesicles as a potential biomarker of Parkinson\u2019s disease","volume":"696","author":"Cao","year":"2019","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0145","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ceb.2017.01.005","article-title":"AMPK signalling in health and disease","volume":"45","author":"Carling","year":"2017","journal-title":"Current Opinion in Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4155\/fmc-2016-0186","article-title":"Quercetin and derivatives: Useful tools in inflammation and pain management","volume":"9","author":"Carullo","year":"2017","journal-title":"Future Medicinal Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0155","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.biotechadv.2018.03.012","article-title":"Natural products with anti-aging potential: Affected targets and molecular mechanisms","volume":"36","author":"C\u0103tan\u0103","year":"2018","journal-title":"Biotechnology Advances"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0160","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1254\/jphs.08215FP","article-title":"Rapamycin protects against high fat diet-induced obesity in C57BL\/6J mice","volume":"109","author":"Chang","year":"2009","journal-title":"Journal of Pharmacological Sciences"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0165","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1742-7843.2009.00427.x","article-title":"Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK\/HlJ mice","volume":"105","author":"Chang","year":"2009","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0170","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1139\/bcb-2014-0107","article-title":"Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies","volume":"93","author":"Chang","year":"2015","journal-title":"Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0175","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12874","article-title":"The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms","volume":"18","author":"Chellappa","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0180","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fphar.2018.00104","article-title":"A mechanistic overview of Triptolide and Celastrol, natural products from Tripterygium wilfordii hook F","volume":"9","author":"Chen","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0185","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: From mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0190","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/nrd.2017.116","article-title":"Senescent cells: An emerging target for diseases of ageing","volume":"16","author":"Childs","year":"2017","journal-title":"Nature Reviews. Drug Discovery"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.arr.2016.06.005","article-title":"A synopsis on aging-theories, mechanisms and future prospects","volume":"29","author":"da Costa","year":"2016","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102288","article-title":"Dietary Quercetin and Kaempferol: Bioavailability and potential cardiovascular-related bioactivity in humans","volume":"11","author":"Dabeek","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13060","article-title":"Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression","volume":"19","author":"Dang","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0210","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1074\/jbc.M113.521062","article-title":"Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: Potential role of attenuated oxidative stress and altered contractile protein expression","volume":"289","author":"Das","year":"2014","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/nu11092147","article-title":"Dietary curcumin: Correlation between bioavailability and health potential","volume":"11","author":"Dei Cas","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0220","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/bjh.14520","article-title":"The aspirin story - from willow to wonder drug","volume":"177","author":"Desborough","year":"2017","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102426","article-title":"Curcumin, gut microbiota, and neuroprotection","volume":"11","author":"Di Meo","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1146\/annurev-biochem-061516-044908","article-title":"Proteasomal and Autophagic degradation systems","volume":"86","author":"Dikic","year":"2017","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0235","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0240","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.exger.2018.09.019","article-title":"Resveratrol and Alzheimer's disease. From molecular pathophysiology to clinical trials","volume":"113","author":"Drygalski","year":"2018","journal-title":"Experimental Gerontology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0245","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cell.2010.12.016","article-title":"The cell-non-autonomous nature of electron transport chain-mediated longevity","volume":"144","author":"Durieux","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20040904","article-title":"The effects of resveratrol in patients with cardiovascular disease and heart failure: A narrative review","volume":"20","author":"Dyck","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0255","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1007\/s00018-014-1677-1","article-title":"Longevity, aging and rapamycin","volume":"71","author":"Ehninger","year":"2014","journal-title":"Cellular and Molecular Life Sciences : CMLS"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0260","doi-asserted-by":"crossref","first-page":"101030","DOI":"10.1016\/j.plipres.2020.101030","article-title":"Lipid-based biomarkers for CVD, COPD, and aging - a translational perspective","volume":"78","author":"Ekroos","year":"2020","journal-title":"Progress in Lipid Research"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0265","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13028","article-title":"Reversal of epigenetic aging and immunosenescent trends in humans","volume":"18","author":"Fahy","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0270","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0275","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.7150\/thno.30787","article-title":"Berberine in cardiovascular and metabolic diseases: From mechanisms to therapeutics","volume":"9","author":"Feng","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0280","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.3233\/JAD-161221","article-title":"The DNA damage response in neurons: Die by apoptosis or survive in a senescence-like state?","volume":"60","author":"Fielder","year":"2017","journal-title":"Journal of Alzheimer\u2019s Disease\u202f: JAD"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0285","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.ijcard.2012.10.046","article-title":"Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations","volume":"168","author":"Finegold","year":"2013","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0290","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/10409238.2017.1291577","article-title":"Integrating the UPR(mt) into the mitochondrial maintenance network","volume":"52","author":"Fiorese","year":"2017","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0295","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1038\/s41467-017-02183-y","article-title":"Identification and characterization of two functional variants in the human longevity gene FOXO3","volume":"8","author":"Flachsbart","year":"2017","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0300","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/acel.12109","article-title":"Late-life rapamycin treatment reverses age-related heart dysfunction","volume":"12","author":"Flynn","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0305","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.cmet.2014.09.018","article-title":"Metformin: From mechanisms of action to therapies","volume":"20","author":"Foretz","year":"2014","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0310","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.molcel.2017.05.031","article-title":"The UPR(ER): Sensor and coordinator of organismal homeostasis","volume":"66","author":"Frakes","year":"2017","journal-title":"Molecular Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0315","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.arr.2018.11.008","article-title":"Reversibility of irreversible aging","volume":"49","author":"Galkin","year":"2019","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20121098","article-title":"Amino acid sensing in dietary-restriction-mediated longevity: Roles of signal-transducing kinases GCN2 and TOR","volume":"449","author":"Gallinetti","year":"2013","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0325","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1080\/15548627.2015.1067364","article-title":"Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease","volume":"11","author":"Gan-Or","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0330","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1093\/brain\/awy197","article-title":"Genetic variation within endolysosomal system is associated with late-onset Alzheimer's disease","volume":"141","author":"Gao","year":"2018","journal-title":"Brain : A Journal of Neurology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0335","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12707","article-title":"Overexpression of PGC-1\u03b1 in aging muscle enhances a subset of young-like molecular patterns","volume":"17","author":"Garcia","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0340","doi-asserted-by":"crossref","DOI":"10.3390\/cells9040933","article-title":"Protein and mitochondria quality control mechanisms and cardiac aging","volume":"9","author":"Ghosh","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0345","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0009-9120(02)00397-1","article-title":"Absorption of three wine-related polyphenols in three different matrices by healthy subjects","volume":"36","author":"Goldberg","year":"2003","journal-title":"Clinical Biochemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0350","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Research and Clinical Practice"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0355","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1039\/C7MD00474E","article-title":"Synthesis and biological evaluation of rapamycin-derived, next generation small molecules","volume":"9","author":"Guduru","year":"2018","journal-title":"MedChemComm"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0360","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1476-5381.2009.00572.x","article-title":"Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine","volume":"159","author":"Guha","year":"2010","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0365","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cmet.2007.01.001","article-title":"The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid","volume":"5","author":"Guo","year":"2007","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0370","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1039\/c1np00051a","article-title":"Multitargeting by curcumin as revealed by molecular interaction studies","volume":"28","author":"Gupta","year":"2011","journal-title":"Natural Product Reports"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0375","series-title":"Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme","article-title":"PGC-1\u03b1-mediated regulation of mitochondrial function and physiological implications","author":"Halling","year":"2020"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0380","series-title":"Everolimus. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer","first-page":"101","volume":"211","author":"Hasskarl","year":"2018"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0385","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in health and disease","volume":"169","author":"He","year":"2017","journal-title":"Cell"},{"issue":"Suppl. 1","key":"10.1016\/j.pharmthera.2020.107673_bb0390","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/dom.12719","article-title":"Effects of ageing and senescence on pancreatic \u03b2-cell function","volume":"18","author":"Helman","year":"2016","journal-title":"Diabetes, Obesity & Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0395","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41589-019-0326-2","article-title":"Pharmacological targeting of the unfolded protein response for disease intervention","volume":"15","author":"Hetz","year":"2019","journal-title":"Nature Chemical Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0400","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0405","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2125.2012.04340.x","article-title":"Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man","volume":"75","author":"Hoffmann","year":"2013","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0410","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nature Reviews. Neurology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0415","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.2337\/db09-1324","article-title":"Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue","volume":"59","author":"Houde","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0420","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1231097","article-title":"Evidence for a common mechanism of SIRT1 regulation by allosteric activators","volume":"339","author":"Hubbard","year":"2013","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0425","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0430","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/ptr.6252","article-title":"Berberine and barberry (Berberis vulgaris): A clinical review","volume":"33","author":"Imenshahidi","year":"2019","journal-title":"Phytotherapy Research : PTR"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0435","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3945\/ajcn.113.073106","article-title":"Flavonoid intake and all-cause mortality","volume":"101","author":"Ivey","year":"2015","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0440","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1017\/S0007114517001325","article-title":"Association of flavonoid-rich foods and flavonoids with risk of all-cause mortality","volume":"117","author":"Ivey","year":"2017","journal-title":"The British Journal of Nutrition"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0445","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature11861","article-title":"mTOR is a key modulator of ageing and age-related disease","volume":"493","author":"Johnson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0450","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCRESAHA.117.308903","article-title":"Reducing the global burden of cardiovascular disease, part 1: The epidemiology and risk factors","volume":"121","author":"Joseph","year":"2017","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0455","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11357-018-0042-y","article-title":"A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: Report from the TAME biomarkers workgroup","volume":"40","author":"Justice","year":"2018","journal-title":"GeroScience"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0460","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar4289","article-title":"Rapamycin and Alzheimer\u2019s disease: Time for a clinical trial?","volume":"11","author":"Kaeberlein","year":"2019","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0465","first-page":"821","article-title":"Senolytics and Senostatics: A two-pronged approach to target cellular senescence for delaying aging and age-related diseases","volume":"42","author":"Kang","year":"2019","journal-title":"Molecules and Cells"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0470","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.15252\/embj.201797135","article-title":"Modulating NAD(+) metabolism, from bench to bedside","volume":"36","author":"Katsyuba","year":"2017","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0475","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/nm.4001","article-title":"Proteostasis and aging","volume":"21","author":"Kaushik","year":"2015","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0480","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.cmet.2016.05.009","article-title":"The mechanistic target of rapamycin: The grand ConducTOR of metabolism and aging","volume":"23","author":"Kennedy","year":"2016","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0485","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/366461a0","article-title":"A C. elegans mutant that lives twice as long as wild type","volume":"366","author":"Kenyon","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0490","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature08980","article-title":"The genetics of ageing","volume":"464","author":"Kenyon","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0495","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000090364","article-title":"Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis","volume":"2","author":"Kiaei","year":"2005","journal-title":"Neuro-Degenerative Diseases"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0500","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/ajcn\/nqy102","article-title":"Higher spermidine intake is linked to lower mortality: A prospective population-based study","volume":"108","author":"Kiechl","year":"2018","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0505","doi-asserted-by":"crossref","first-page":"12844","DOI":"10.18632\/aging.102557","article-title":"Targeting senescent cells: Approaches, opportunities, challenges","volume":"11","author":"von Kobbe","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0510","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm1135","article-title":"Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins","volume":"10","author":"Kong","year":"2004","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0515","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging","volume":"114","author":"Krishnamurthy","year":"2004","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0520","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2020.04.001","article-title":"Benefits of metformin in attenuating the hallmarks of aging","volume":"32","author":"Kulkarni","year":"2020","journal-title":"Cell Metabolism."},{"key":"10.1016\/j.pharmthera.2020.107673_bb0525","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev-biochem-060614-033955","article-title":"The biology of proteostasis in aging and disease","volume":"84","author":"Labbadia","year":"2015","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0530","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1172\/JCI64099","article-title":"Rapalogs and mTOR inhibitors as anti-aging therapeutics","volume":"123","author":"Lamming","year":"2013","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0535","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jep.2014.09.049","article-title":"Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension","volume":"161","author":"Lan","year":"2015","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0540","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/ncomms3267","article-title":"The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans","volume":"4","author":"Lapierre","year":"2013","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0545","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson's disease","volume":"5","author":"de Lau","year":"2006","journal-title":"The Lancet. Neurology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0550","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1124\/pr.113.007757","article-title":"Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: Focus on the nervous system","volume":"66","author":"Lee","year":"2014","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0555","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2337\/db07-1795","article-title":"Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway","volume":"58","author":"Lee","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0560","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41556-018-0249-2","article-title":"The dynamic nature of senescence in cancer","volume":"21","author":"Lee","year":"2019","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0565","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: One drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0570","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.tcb.2017.08.002","article-title":"Rethinking HSF1 in stress, development, and organismal health","volume":"27","author":"Li","year":"2017","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0575","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrendo.2009.101","article-title":"SIRT1 and insulin resistance","volume":"5","author":"Liang","year":"2009","journal-title":"Nature Reviews. Endocrinology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0580","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051395","article-title":"A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers","volume":"7","author":"Libri","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0585","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.05.011","article-title":"Treatment of obesity with celastrol","volume":"161","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0590","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/acel.12338","article-title":"Interventions to slow aging in humans: Are we ready?","volume":"14","author":"Longo","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0595","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0600","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/gerona\/glt162","article-title":"Heterogeneity in healthy aging","volume":"69","author":"Lowsky","year":"2014","journal-title":"The journals of gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0605","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.arr.2018.03.004","article-title":"PGC-1\u03b1 sparks the fire of neuroprotection against neurodegenerative disorders","volume":"44","author":"Lv","year":"2018","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0610","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.biopha.2017.08.085","article-title":"The anti-tumor effect of aspirin: What we know and what we expect","volume":"95","author":"Ma","year":"2017","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0615","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.cmet.2015.08.005","article-title":"Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1\u03b1 transcriptional Axis","volume":"22","author":"Ma","year":"2015","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0620","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrm2672","article-title":"Molecular mechanisms of mTOR-mediated translational control","volume":"10","author":"Ma","year":"2009","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0625","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cmet.2019.01.018","article-title":"Caloric restriction mimetics against age-associated disease: Targets, mechanisms, and therapeutic potential","volume":"29","author":"Madeo","year":"2019","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0630","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1172\/JCI73946","article-title":"Essential role for autophagy in life span extension","volume":"125","author":"Madeo","year":"2015","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0635","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1124\/pr.110.004499","article-title":"Genome-environment interactions that modulate aging: Powerful targets for drug discovery","volume":"64","author":"de Magalh\u00e3es","year":"2012","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0640","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nature09706","article-title":"Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB","volume":"470","author":"Mair","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0645","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1007\/s11095-017-2199-y","article-title":"Metformin - a future therapy for neurodegenerative diseases\u202f: Theme: Drug discovery, development and delivery in Alzheimer\u2019s disease guest editor: Davide Brambilla","volume":"34","author":"Markowicz-Piasecka","year":"2017","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0650","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nrendo.2016.142","article-title":"Anti-obesogenic and antidiabetic effects of plants and mushrooms","volume":"13","author":"Martel","year":"2017","journal-title":"Nature Reviews. Endocrinology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0655","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.tem.2019.04.001","article-title":"Hormetic effects of phytochemicals on health and longevity","volume":"30","author":"Martel","year":"2019","journal-title":"Trends in Endocrinology and Metabolism: TEM"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0660","doi-asserted-by":"crossref","DOI":"10.1002\/med.21702","article-title":"Emerging use of senolytics and senomorphics against aging and chronic diseases","author":"Martel","year":"2020","journal-title":"Medicinal Research Reviews."},{"key":"10.1016\/j.pharmthera.2020.107673_bb0665","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/nph.14730","article-title":"Medicine is not health care, food is health care: Plant metabolic engineering, diet and human health","volume":"216","author":"Martin","year":"2017","journal-title":"The New Phytologist"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0670","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/acel.12427","article-title":"Long live FOXO: Unraveling the role of FOXO proteins in aging and longevity","volume":"15","author":"Martins","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0675","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.18632\/aging.101250","article-title":"Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs","volume":"9","author":"McCubrey","year":"2017","journal-title":"Aging"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0680","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1097\/CCM.0000000000000949","article-title":"The selective Sirtuin 1 activator SRT2104 reduces endotoxin-induced cytokine release and coagulation activation in humans","volume":"43","author":"van der Meer","year":"2015","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0685","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuron.2017.01.022","article-title":"Autophagy and neurodegeneration: Pathogenic mechanisms and therapeutic opportunities","volume":"93","author":"Menzies","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0690","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/acel.12220","article-title":"SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass","volume":"13","author":"Mercken","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0695","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature25167","article-title":"Senescence-associated reprogramming promotes cancer stemness","volume":"553","author":"Milanovic","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0700","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature06261","article-title":"Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0705","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/srep00070","article-title":"SRT1720 improves survival and healthspan of obese mice","volume":"1","author":"Minor","year":"2011","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0710","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.celrep.2014.01.031","article-title":"The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet","volume":"6","author":"Mitchell","year":"2014","journal-title":"Cell Reports"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0715","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1074\/jbc.TM117.000893","article-title":"Mitochondrial proteostasis in the context of cellular and organismal health and aging","volume":"294","author":"Moehle","year":"2019","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0720","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2018.10.008","article-title":"The first 3500 years of aspirin history from its roots - a concise summary","volume":"113","author":"Montinari","year":"2019","journal-title":"Vascular Pharmacology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0725","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41568-018-0074-8","article-title":"mTOR signalling and cellular metabolism are mutual determinants in cancer","volume":"18","author":"Mossmann","year":"2018","journal-title":"Nature Reviews. Cancer"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0730","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.semcancer.2019.07.003","article-title":"mTOR: Role in cancer, metastasis and drug resistance","volume":"59","author":"Murugan","year":"2019","journal-title":"Seminars in Cancer Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0735","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.4155\/fmc-2018-0234","article-title":"The emerging field of senotherapeutic drugs","volume":"10","author":"Myrianthopoulos","year":"2018","journal-title":"Future Medicinal Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0740","first-page":"65","article-title":"Autophagy and longevity","volume":"41","author":"Nakamura","year":"2018","journal-title":"Molecules and Cells"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0745","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4236\/ajps.2012.327123","article-title":"Berberine prolongs life span and stimulates locomotor activity of Drosophila melanogaster","volume":"3","author":"Navrotskaya","year":"2012","journal-title":"American Journal of Plant Sciences"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0750","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0755","doi-asserted-by":"crossref","first-page":"R741","DOI":"10.1016\/j.cub.2012.07.024","article-title":"Ageing as a risk factor for disease","volume":"22","author":"Niccoli","year":"2012","journal-title":"Current Biology\u202f: CB"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0760","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2015.01.002","article-title":"Resveratrol supplementation: Where are we now and where should we go?","volume":"21","author":"Novelle","year":"2015","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0765","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.biopha.2017.08.070","article-title":"Resveratrol and diabetes: A critical review of clinical studies","volume":"95","author":"Ozturk","year":"2017","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0770","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.jacc.2017.01.064","article-title":"The aging cardiovascular system: Understanding it at the cellular and clinical levels","volume":"69","author":"Paneni","year":"2017","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0775","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jacc.2016.05.083","article-title":"Aspirin and cancer","volume":"68","author":"Patrignani","year":"2016","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0780","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1126\/science.1082889","article-title":"Mitochondrial dysfunction in the elderly: Possible role in insulin resistance","volume":"300","author":"Petersen","year":"2003","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0785","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.celrep.2018.02.024","article-title":"Aspirin recapitulates features of caloric restriction","volume":"22","author":"Pietrocola","year":"2018","journal-title":"Cell Reports"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0790","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000109998","article-title":"Prevalence of dementia in the United States: The aging, demographics, and memory study","volume":"29","author":"Plassman","year":"2007","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0795","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3945\/ajcn.2009.28639","article-title":"Total mortality risk in relation to use of less-common dietary supplements","volume":"91","author":"Pocobelli","year":"2010","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0800","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cmet.2012.04.003","article-title":"SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function","volume":"15","author":"Price","year":"2012","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0805","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3389\/fphar.2016.00505","article-title":"Geroprotective and Radioprotective activity of quercetin, (\u2212)-Epicatechin, and ibuprofen in Drosophila melanogaster","volume":"7","author":"Proshkina","year":"2016","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0810","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cell.2019.08.003","article-title":"Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy","volume":"178","author":"Pryor","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0815","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13086","article-title":"Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment","volume":"19","author":"Quarles","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0820","doi-asserted-by":"crossref","first-page":"13500","DOI":"10.1074\/jbc.R117.791061","article-title":"The mitochondrial unfolded protein response: Signaling from the powerhouse","volume":"292","author":"Qureshi","year":"2017","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0825","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1080\/10408398.2016.1263597","article-title":"Resveratrol as an anti-cancer agent: A review","volume":"58","author":"Rauf","year":"2018","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0830","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00125-017-4342-z","article-title":"The mechanisms of action of metformin","volume":"60","author":"Rena","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0835","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature03205","article-title":"Regulation of cap-dependent translation by eIF4E inhibitory proteins","volume":"433","author":"Richter","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0840","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nm.4132","article-title":"Urolithin a induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents","volume":"22","author":"Ryu","year":"2016","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0845","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1074\/jbc.270.2.815","article-title":"Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells","volume":"270","author":"Sabers","year":"1995","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0850","doi-asserted-by":"crossref","first-page":"11849","DOI":"10.1021\/acsomega.0c01818","article-title":"Therapeutic potential of quercetin: New insights and perspectives for human health","volume":"5","author":"Salehi","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0855","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1080\/17460441.2017.1349750","article-title":"Novel strategies for anti-aging drug discovery","volume":"12","author":"Saraswat","year":"2017","journal-title":"Expert Opinion on Drug Discovery"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0860","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11357-018-0017-z","article-title":"Efficacy of curcumin for age-associated cognitive decline: A narrative review of preclinical and clinical studies","volume":"40","author":"Sarker","year":"2018","journal-title":"GeroScience"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0865","first-page":"1435","article-title":"[insulin\/IGF-1 signaling and aging]. Nihon rinsho","volume":"74","author":"Sasako","year":"2016","journal-title":"Japanese Journal of Clinical Medicine"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0870","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.mad.2008.07.001","article-title":"Quercetin-mediated longevity in Caenorhabditis elegans: Is DAF-16 involved?","volume":"129","author":"Saul","year":"2008","journal-title":"Mechanisms of Ageing and Development"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0875","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR Signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0880","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1038\/s41467-019-11174-0","article-title":"A novel rapamycin analog is highly selective for mTORC1 in vivo","volume":"10","author":"Schreiber","year":"2019","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0885","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1113\/jphysiol.2014.282665","article-title":"Physiological geroscience: Targeting function to increase healthspan and achieve optimal longevity","volume":"594","author":"Seals","year":"2016","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0890","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1126\/science.1177221","article-title":"Ribosomal protein S6 kinase 1 signaling regulates mammalian life span","volume":"326","author":"Selman","year":"2009","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0895","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002713","article-title":"Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials","volume":"5","author":"Serban","year":"2016","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.pharmthera.2020.107673_bb5000","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbadis.2016.09.010","article-title":"Re-expression of cell cycle markers in aged neurons and muscles: Whether cells should divide or die?","volume":"1863","author":"Sharma","year":"2017","journal-title":"Biochimica et Biophysica Acta - Molecular Basis of Disease"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0900","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.tibs.2013.09.003","article-title":"Less is more: Improving proteostasis by translation slow down","volume":"38","author":"Sherman","year":"2013","journal-title":"Trends in Biochemical Sciences"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0905","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11156","article-title":"Salicylate, diflunisal and their metabolites inhibit CBP\/p300 and exhibit anticancer activity","volume":"5","author":"Shirakawa","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0910","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrm.2017.110","article-title":"The mitochondrial UPR: Mechanisms, physiological functions and implications in ageing","volume":"19","author":"Shpilka","year":"2018","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0915","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00011.2008","article-title":"AMPK in health and disease","volume":"89","author":"Steinberg","year":"2009","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0920","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.foodchem.2006.01.047","article-title":"A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine","volume":"101","author":"Stervbo","year":"2007","journal-title":"Food Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0925","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23040835","article-title":"Therapeutic potential and recent advances of curcumin in the treatment of aging-associated diseases","volume":"23","author":"Sundar Dhilip Kumar","year":"2018","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0930","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.bbadis.2014.10.013","article-title":"Resveratrol and diabetes: From animal to human studies","volume":"1852","author":"Szkudelski","year":"2015","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0935","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/dc07-1443","article-title":"Effect of aging on glucose homeostasis: Accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance","volume":"31","author":"Szoke","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0940","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.1057987","article-title":"A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function","volume":"292","author":"Tatar","year":"2001","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0945","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1158\/1055-9965.EPI-15-0578","article-title":"Global Cancer incidence and mortality rates and trends--An update","volume":"25","author":"Torre","year":"2016","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0950","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1002\/anie.201601967","article-title":"Artemisinin-a gift from traditional Chinese medicine to the world (Nobel lecture)","volume":"55","author":"Tu","year":"2016","journal-title":"Angewandte Chemie (International Ed. in English)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0955","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/db07-1552","article-title":"Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action","volume":"57","author":"Turner","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0960","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","article-title":"A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0965","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11357-017-9972-z","article-title":"A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs","volume":"39","author":"Urfer","year":"2017","journal-title":"GeroScience"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0970","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.arr.2017.01.001","article-title":"Gut microbiota: A player in aging and a target for anti-aging intervention","volume":"35","author":"Vaiserman","year":"2017","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0975","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/426620a","article-title":"Genetics: influence of TOR kinase on lifespan in C. elegans","volume":"426","author":"Vellai","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0980","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000042","article-title":"Cardiovascular effects of a novel SIRT1 activator, SRT2104, in otherwise healthy cigarette smokers","volume":"2","author":"Venkatasubramanian","year":"2013","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0985","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/978-3-319-41334-1_12","article-title":"Celastrol and its role in controlling chronic diseases","volume":"928","author":"Venkatesha","year":"2016","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0990","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1038\/ncomms6659","article-title":"The role of protein clearance mechanisms in organismal ageing and age-related diseases","volume":"5","author":"Vilchez","year":"2014","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107673_bb0995","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","article-title":"High absorption but very low bioavailability of oral resveratrol in humans","volume":"32","author":"Walle","year":"2004","journal-title":"Drug Metabolism and Disposition: The Biological Fate of Chemicals"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1000","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.arr.2017.08.001","article-title":"Sirtuins, epigenetics and longevity","volume":"40","author":"W\u0105troba","year":"2017","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1005","doi-asserted-by":"crossref","first-page":"56053","DOI":"10.1074\/jbc.M409267200","article-title":"Celastrols as inducers of the heat shock response and cytoprotection","volume":"279","author":"Westerheide","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1010","first-page":"51","article-title":"Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: Controversies and clinical implications","volume":"17","author":"Willcox","year":"2014","journal-title":"Current Opinion in Clinical Nutrition and Metabolic Care"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1015","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/1541-4337.12351","article-title":"The bioavailability, transport, and bioactivity of dietary flavonoids: A review from a historical perspective","volume":"17","author":"Williamson","year":"2018","journal-title":"Comprehensive Reviews in Food Science and Food Safety"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1020","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1530\/JOE-16-0021","article-title":"PGC-1\u03b1, glucose metabolism and type 2 diabetes mellitus","volume":"229","author":"Wu","year":"2016","journal-title":"The Journal of Endocrinology"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1025","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jash.2017.07.004","article-title":"Celastrol synergizes with oral nifedipine to attenuate hypertension in preeclampsia: A randomized, placebo-controlled, and double blinded trial","volume":"11","author":"Xiao","year":"2017","journal-title":"Journal of the American Society of Hypertension\u202f: JASH"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1030","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1035","doi-asserted-by":"crossref","first-page":"760","DOI":"10.14336\/AD.2016.0620","article-title":"Rhizoma Coptidis and Berberine as a natural drug to combat aging and aging-related diseases via anti-oxidation and AMPK activation","volume":"8","author":"Xu","year":"2017","journal-title":"Aging and Disease"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2018.05.006","article-title":"NAD metabolism: Implications in aging and longevity","volume":"47","author":"Yaku","year":"2018","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1045","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ccell.2018.01.002","article-title":"Targeting the senescence-overriding cooperative activity of structurally unrelated H3K9 demethylases in melanoma","volume":"33","author":"Yu","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1050","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21050559","article-title":"The traditional medicine and modern medicine from natural products","volume":"21","author":"Yuan","year":"2016","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.pharmthera.2020.107673_bb1055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","article-title":"mTOR: From growth signal integration to cancer, diabetes and ageing","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nature Reviews. Molecular Cell Biology"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725820302035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725820302035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:11:38Z","timestamp":1759011098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725820302035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":212,"alternative-id":["S0163725820302035"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107673","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A natural product solution to aging and aging-associated diseases","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107673","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107673"}}