{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T03:44:08Z","timestamp":1787283848138,"version":"build-2736575974"},"reference-count":176,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T00:00:00Z","timestamp":1641686400000},"content-version":"am","delay-in-days":342,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003750","name":"Association France Alzheimer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.pharmthera.2020.107681","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T20:29:54Z","timestamp":1600547394000},"page":"107681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Tubulin modifying enzymes as target for the treatment of tau-related diseases"],"prefix":"10.1016","volume":"218","author":[{"given":"Krzysztof","family":"Rogowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Hached","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Crozet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siem","family":"van der Laan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.pharmthera.2020.107681_bb0005","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41594-019-0254-6","article-title":"Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1\u2013SVBP","volume":"26","author":"Adamopoulos","year":"2019","journal-title":"Nature Structural & Molecular Biology"},{"issue":"2","key":"10.1016\/j.pharmthera.2020.107681_bb0010","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1083\/jcb.145.2.305","article-title":"An essential role for Katanin in severing microtubules in the neuron","volume":"145","author":"Ahmad","year":"1999","journal-title":"Journal of Cell Biology"},{"issue":"6369","key":"10.1016\/j.pharmthera.2020.107681_bb0015","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1126\/science.aao4165","article-title":"Vasohibins\/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation","volume":"358","author":"Aillaud","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0020","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fncel.2018.00338","article-title":"Hyperphosphorylation of tau associates with changes in its function beyond microtubule stability","volume":"12","author":"Alonso","year":"2018","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"40","key":"10.1016\/j.pharmthera.2020.107681_bb0025","doi-asserted-by":"crossref","first-page":"30851","DOI":"10.1074\/jbc.M110.110957","article-title":"Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration","volume":"285","author":"Alonso","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"issue":"43","key":"10.1016\/j.pharmthera.2020.107681_bb0030","doi-asserted-by":"crossref","first-page":"10626","DOI":"10.1021\/bi00158a027","article-title":"Structure and novel exons of the human tau gene","volume":"31","author":"Andreadis","year":"1992","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0035","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s004010100423","article-title":"Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer\u2019s disease","volume":"103","author":"Augustinack","year":"2002","journal-title":"Acta Neuropathologica"},{"issue":"2","key":"10.1016\/j.pharmthera.2020.107681_bb0040","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1083\/jcb.111.2.495","article-title":"Individual microtubules in the axon consist of domains that differ in both composition and stability","volume":"111","author":"Baas","year":"1990","journal-title":"The Journal of Cell Biology"},{"issue":"9","key":"10.1016\/j.pharmthera.2020.107681_bb0045","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/cm.21286","article-title":"Stability properties of neuronal microtubules: Stability properties of neuronal microtubules","volume":"73","author":"Baas","year":"2016","journal-title":"Cytoskeleton"},{"issue":"11","key":"10.1016\/j.pharmthera.2020.107681_bb0050","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1091\/mbc.e11-11-0931","article-title":"CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development","volume":"23","author":"Backer","year":"2012","journal-title":"Molecular Biology of the Cell"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2020.107681_bb0055","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0006-8993(89)91396-6","article-title":"Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer\u2019s disease","volume":"477","author":"Bancher","year":"1989","journal-title":"Brain Research"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0060","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/0006-291X(74)90351-9","article-title":"Some common properties of the protein that incorporates tyrosine as a single unit and the microtubule proteins","volume":"60","author":"Barra","year":"1974","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"21","key":"10.1016\/j.pharmthera.2020.107681_bb0065","doi-asserted-by":"crossref","first-page":"7137","DOI":"10.1523\/JNEUROSCI.0188-12.2012","article-title":"Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027","volume":"32","author":"Barten","year":"2012","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0070","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41591-020-0781-z","article-title":"A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer\u2019s disease","volume":"26","author":"Barth\u00e9lemy","year":"2020","journal-title":"Nature Medicine"},{"issue":"2","key":"10.1016\/j.pharmthera.2020.107681_bb0075","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3233\/JAD-2008-15213","article-title":"Why do so many drugs for Alzheimer\u2019s disease fail in development? Time for new methods and new practices?","volume":"15","author":"Becker","year":"2008","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"9","key":"10.1016\/j.pharmthera.2020.107681_bb0080","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.1074\/jbc.M111.309138","article-title":"Cytosolic carboxypeptidase 1 is involved in processing alpha- and beta-tubulin","volume":"287","author":"Berezniuk","year":"2012","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.conb.2016.02.003","article-title":"Neuronal polarity: Remodeling microtubule organization","volume":"39","author":"van Beuningen","year":"2016","journal-title":"Current Opinion in Neurobiology"},{"issue":"18","key":"10.1016\/j.pharmthera.2020.107681_bb0090","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1016\/S0021-9258(17)39233-5","article-title":"Tubulin, hybrid dimers, and tubulin S. stepwise charge reduction and polymerization","volume":"260","author":"Bhattacharyya","year":"1985","journal-title":"The Journal of Biological Chemistry"},{"issue":"7","key":"10.1016\/j.pharmthera.2020.107681_bb0095","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1083\/jcb.200809190","article-title":"CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1\/tubulin-binding sites","volume":"183","author":"Bieling","year":"2008","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0100","series-title":"Biogen and Eisai to Discontinue Phase 3 ENGAGE and EMERGE Trials of aducanumab in Alzheimer\u2019s Disease","author":"Biogen press release","year":"2019"},{"issue":"10","key":"10.1016\/j.pharmthera.2020.107681_bb0105","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1016\/j.celrep.2018.10.095","article-title":"CSAP acts as a regulator of TTLL-mediated microtubule glutamylation","volume":"25","author":"Bompard","year":"2018","journal-title":"Cell Reports"},{"issue":"16","key":"10.1016\/j.pharmthera.2020.107681_bb0110","doi-asserted-by":"crossref","first-page":"12839","DOI":"10.1074\/jbc.M011380200","article-title":"Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation","volume":"276","author":"Bonnet","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0115","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathologica"},{"key":"10.1016\/j.pharmthera.2020.107681_bb4001","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.nbd.2016.12.021","article-title":"Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs","volume":"105","author":"Brunden","year":"2017","journal-title":"Neurobiol Dis."},{"issue":"10","key":"10.1016\/j.pharmthera.2020.107681_bb0120","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nrd2959","article-title":"Advances in tau-focused drug discovery for Alzheimer\u2019s disease and related tauopathies","volume":"8","author":"Brunden","year":"2009","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0125","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/bies.950130605","article-title":"Stabilization of post-translational modification of microtubules during cellular morphogenesis","volume":"13","author":"Bulinski","year":"1991","journal-title":"Bioessays"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0130","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/cm.970080309","article-title":"Acetylated and detyrosinated\u202f?-tubulins are co-localized in stable microtubules in rat meningeal fibroblasts","volume":"8","author":"Cambray-Deakin","year":"1987","journal-title":"Cell Motility and the Cytoskeleton"},{"issue":"5957","key":"10.1016\/j.pharmthera.2020.107681_bb0135","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1126\/science.1178955","article-title":"Haploid genetic screens in human cells identify host factors used by pathogens","volume":"326","author":"Carette","year":"2009","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0140","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/S0002-9440(10)64296-4","article-title":"Microtubule reduction in Alzheimer\u2019s disease and aging is independent of tau filament formation","volume":"162","author":"Cash","year":"2003","journal-title":"The American Journal of Pathology"},{"issue":"12","key":"10.1016\/j.pharmthera.2020.107681_bb0145","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrneurol.2010.160","article-title":"Chemotherapy-induced peripheral neurotoxicity","volume":"6","author":"Cavaletti","year":"2010","journal-title":"Nature Reviews Neurology"},{"issue":"10","key":"10.1016\/j.pharmthera.2020.107681_bb0150","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/cm.21290","article-title":"The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease","volume":"73","author":"Chakraborti","year":"2016","journal-title":"Cytoskeleton (Hoboken, N.J.)"},{"issue":"34","key":"10.1016\/j.pharmthera.2020.107681_bb0155","doi-asserted-by":"crossref","first-page":"30690","DOI":"10.1074\/jbc.M204930200","article-title":"Alteration of the C-terminal amino acid of tubulin specifically inhibits myogenic differentiation","volume":"277","author":"Chang","year":"2002","journal-title":"The Journal of Biological Chemistry"},{"issue":"6405","key":"10.1016\/j.pharmthera.2020.107681_bb0160","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/360674a0","article-title":"Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons","volume":"360","author":"Chen","year":"1992","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.pharmthera.2020.107681_bb0165","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1523\/JNEUROSCI.3986-15.2016","article-title":"Tau accumulation, altered phosphorylation, and missorting promote neurodegeneration in glaucoma","volume":"36","author":"Chiasseu","year":"2016","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12701\/yujm.2018.35.1.1","article-title":"Beta-amyloid imaging in dementia","volume":"35","author":"Chun","year":"2018","journal-title":"Yeungnam University Journal of Medicine"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0175","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cell.2008.03.020","article-title":"Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex","volume":"133","author":"Ciferri","year":"2008","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.pharmthera.2020.107681_bb0180","doi-asserted-by":"crossref","first-page":"R368","DOI":"10.1016\/S0960-9822(98)70239-8","article-title":"Nucleocytoplasmic transport: Driving and directing transport","volume":"8","author":"Cole","year":"1998","journal-title":"Current Biology: CB"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0185","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrn2631","article-title":"Microtubule assembly, organization and dynamics in axons and dendrites","volume":"10","author":"Conde","year":"2009","journal-title":"Nature Reviews Neuroscience"},{"issue":"7","key":"10.1016\/j.pharmthera.2020.107681_bb0190","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41582-018-0013-z","article-title":"Tau-targeting therapies for Alzheimer disease","volume":"14","author":"Congdon","year":"2018","journal-title":"Nature Reviews. Neurology"},{"issue":"10","key":"10.1016\/j.pharmthera.2020.107681_bb0195","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1073\/pnas.89.10.4378","article-title":"Primary structure of high molecular weight tau present in the peripheral nervous system","volume":"89","author":"Couchie","year":"1992","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0200","doi-asserted-by":"crossref","first-page":"9659","DOI":"10.1038\/srep09659","article-title":"Role of the tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms","volume":"5","author":"Derisbourg","year":"2015","journal-title":"Scientific Reports"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0205","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s12031-011-9589-0","article-title":"Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau)","volume":"45","author":"Dickson","year":"2011","journal-title":"Journal of Molecular Neuroscience"},{"issue":"4938","key":"10.1016\/j.pharmthera.2020.107681_bb4003","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1967194","article-title":"Posttranslational glutamylation of alpha-tubulin","volume":"247","author":"Edd\u00e9","year":"1990","journal-title":"Science"},{"issue":"43","key":"10.1016\/j.pharmthera.2020.107681_bb0220","doi-asserted-by":"crossref","first-page":"13166","DOI":"10.1021\/bi001290z","article-title":"Structural and functional implications of tau hyperphosphorylation: Information from phosphorylation-mimicking mutated tau proteins","volume":"39","author":"Eidenm\u00fcller","year":"2000","journal-title":"Biochemistry"},{"issue":"22","key":"10.1016\/j.pharmthera.2020.107681_bb0225","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.1073\/pnas.0409626102","article-title":"A vital role of tubulin-tyrosine-ligase for neuronal organization","volume":"102","author":"Erck","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0230","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1083\/jcb.201604108","article-title":"Motor axon navigation relies on Fidgetin-like 1\u2013driven microtubule plus end dynamics","volume":"217","author":"Fassier","year":"2018","journal-title":"Journal of Cell Biology"},{"issue":"9","key":"10.1016\/j.pharmthera.2020.107681_bb0235","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1172\/JCI0215451","article-title":"Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo","volume":"110","author":"Fellner","year":"2002","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0240","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1242\/jcs.00986","article-title":"Roles of microtubules, cell polarity and adhesion in electric-field-mediated motility of 3T3 fibroblasts","volume":"117","author":"Finkelstein","year":"2004","journal-title":"Journal of Cell Science"},{"issue":"9","key":"10.1016\/j.pharmthera.2020.107681_bb0245","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1083\/jcb.201612050","article-title":"Tubulin glycylation controls primary cilia length","volume":"216","author":"Gadadhar","year":"2017","journal-title":"Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0250","series-title":"Current topics in developmental biology","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0070-2153(08)00804-1","article-title":"Chapter 4 Ciliary tubulin and its post-translational modifications","volume":"Vol. 85","author":"Gaertig","year":"2008"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0255","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2015.04.003","article-title":"Multivalent microtubule recognition by tubulin tyrosine ligase-like family glutamylases","volume":"161","author":"Garnham","year":"2015","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.pharmthera.2020.107681_bb0260","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1523\/JNEUROSCI.4486-15.2016","article-title":"Promotion of functional nerve regeneration by inhibition of microtubule detyrosination","volume":"36","author":"Gobrecht","year":"2016","journal-title":"The Journal of Neuroscience"},{"issue":"13","key":"10.1016\/j.pharmthera.2020.107681_bb0265","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1002\/j.1460-2075.1990.tb07870.x","article-title":"Expression of separate isoforms of human tau protein: Correlation with the tau pattern in brain and effects on tubulin polymerization","volume":"9","author":"Goedert","year":"1990","journal-title":"The EMBO Journal"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0270","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1073\/pnas.89.5.1983","article-title":"Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system","volume":"89","author":"Goedert","year":"1992","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0275","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","article-title":"Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer\u2019s disease","volume":"3","author":"Goedert","year":"1989","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.pharmthera.2020.107681_bb0280","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/j.1460-2075.1989.tb03390.x","article-title":"Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: Differential expression of tau protein mRNAs in human brain","volume":"8","author":"Goedert","year":"1989","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0285","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12915-015-0115-7","article-title":"The dynamics of growth cone morphology","volume":"13","author":"Goodhill","year":"2015","journal-title":"BMC Biology"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0290","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022608","article-title":"Microtubules and microtubule-associated proteins","volume":"10","author":"Goodson","year":"2018","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0295","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuropharm.2013.08.016","article-title":"The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions","volume":"76","author":"Gornstein","year":"2014","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0300","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1083\/jcb.102.3.1118","article-title":"Distribution of tyrosinated and nontyrosinated alpha-tubulin during mitosis","volume":"102","author":"Gundersen","year":"1986","journal-title":"The Journal of Cell Biology"},{"issue":"16","key":"10.1016\/j.pharmthera.2020.107681_bb0305","doi-asserted-by":"crossref","first-page":"5946","DOI":"10.1073\/pnas.85.16.5946","article-title":"Selective stabilization of microtubules oriented toward the direction of cell migration","volume":"85","author":"Gundersen","year":"1988","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0310","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1091\/mbc.e09-01-0044","article-title":"Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons","volume":"21","author":"Hammond","year":"2010","journal-title":"Molecular Biology of the Cell"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0315","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1083\/jcb.200110134","article-title":"MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction","volume":"158","author":"Harada","year":"2002","journal-title":"The Journal of Cell Biology"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0320","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1038\/s41467-018-05867-1","article-title":"Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules","volume":"9","author":"He","year":"2018","journal-title":"Nature Communications"},{"issue":"7089","key":"10.1016\/j.pharmthera.2020.107681_bb0325","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature04736","article-title":"The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends","volume":"441","author":"Helenius","year":"2006","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0330","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.tins.2007.04.001","article-title":"The centrosome in neuronal development","volume":"30","author":"Higginbotham","year":"2007","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0335","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-981-32-9358-8_18","article-title":"Tau PET Imaging","volume":"1184","author":"Higuchi","year":"2019","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"5395","key":"10.1016\/j.pharmthera.2020.107681_bb0340","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1126\/science.282.5395.1914","article-title":"Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17","volume":"282","author":"Hong","year":"1998","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0345","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2010.11.030","article-title":"Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration","volume":"68","author":"Hoover","year":"2010","journal-title":"Neuron"},{"issue":"6962","key":"10.1016\/j.pharmthera.2020.107681_bb0350","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"Huangfu","year":"2003","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0355","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5213\/inj.2014.18.4.171","article-title":"Microtubule-targeting agents enter the central nervous system (CNS): Double-edged swords for treating CNS injury and disease","volume":"18","author":"Hur","year":"2014","journal-title":"International Neurourology Journal"},{"issue":"6686","key":"10.1016\/j.pharmthera.2020.107681_bb0360","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/31508","article-title":"Association of missense and 5\u2032-splice-site mutations in tau with the inherited dementia FTDP-17","volume":"393","author":"Hutton","year":"1998","journal-title":"Nature"},{"issue":"41","key":"10.1016\/j.pharmthera.2020.107681_bb0365","doi-asserted-by":"crossref","first-page":"30707","DOI":"10.1074\/jbc.M603984200","article-title":"TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites","volume":"281","author":"Ikegami","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"issue":"8504","key":"10.1016\/j.pharmthera.2020.107681_bb0370","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0140-6736(86)92134-3","article-title":"Defective brain microtubule assembly in Alzheimer\u2019s disease","volume":"2","author":"Iqbal","year":"1986","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.pharmthera.2020.107681_bb0375","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/s41436-018-0415-8","article-title":"Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia","volume":"21","author":"Iqbal","year":"2019","journal-title":"Genetics in Medicine"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0380","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.parkreldis.2015.09.020","article-title":"Tauopathies as clinicopathological entities","volume":"22","author":"Irwin","year":"2016","journal-title":"Parkinsonism & Related Disorders"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0385","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2010.06.036","article-title":"Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer\u2019s disease mouse models","volume":"142","author":"Ittner","year":"2010","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.pharmthera.2020.107681_bb0390","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1021\/bi00552a027","article-title":"Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins","volume":"19","author":"Jameson","year":"1980","journal-title":"Biochemistry"},{"issue":"5729","key":"10.1016\/j.pharmthera.2020.107681_bb0395","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1126\/science.1113010","article-title":"Tubulin polyglutamylase enzymes are members of the TTL domain protein family","volume":"308","author":"Janke","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0400","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-020-0214-3","article-title":"The tubulin code and its role in controlling microtubule properties and functions","author":"Janke","year":"2020","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0405","first-page":"302","article-title":"Familial dysgenesis of the vermis: A syndrome of hyperventilation, abnormal eye movements and retardation","author":"Joubert","year":"1968","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0410","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cub.2009.12.052","article-title":"Mixed microtubules steer dynein-driven cargo transport into dendrites","volume":"20","author":"Kapitein","year":"2010","journal-title":"Current Biology"},{"issue":"25","key":"10.1016\/j.pharmthera.2020.107681_bb0415","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1523\/JNEUROSCI.1382-04.2004","article-title":"Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules","volume":"24","author":"Karabay","year":"2004","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"issue":"12","key":"10.1016\/j.pharmthera.2020.107681_bb0420","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/j.bpj.2014.05.008","article-title":"Effects of alpha-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system","volume":"106","author":"Kaul","year":"2014","journal-title":"Biophysical Journal"},{"issue":"6394","key":"10.1016\/j.pharmthera.2020.107681_bb0425","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1126\/science.aat1780","article-title":"Near-atomic model of microtubule-tau interactions","volume":"360","author":"Kellogg","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0430","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1038\/ncomms9526","article-title":"Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle","volume":"6","author":"Kerr","year":"2015","journal-title":"Nature Communications"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0435","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nn.2314","article-title":"Tubulin tyrosination navigates the kinesin-1 motor domain to axons","volume":"12","author":"Konishi","year":"2009","journal-title":"Nature Neuroscience"},{"issue":"32","key":"10.1016\/j.pharmthera.2020.107681_bb0440","doi-asserted-by":"crossref","first-page":"24374","DOI":"10.1016\/S0021-9258(20)80536-5","article-title":"Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease","volume":"268","author":"K\u00f6pke","year":"1993","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0445","series-title":"Handbook of clinical neurology","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/B978-0-12-802395-2.00025-0","article-title":"Tauopathies","volume":"145","author":"Kovacs","year":"2018"},{"issue":"2","key":"10.1016\/j.pharmthera.2020.107681_bb4002","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1124\/jpet.115.231175","article-title":"Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies","volume":"357","author":"Kovalevich","year":"2016","journal-title":"J Pharmacol Exp Ther."},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0450","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1083\/jcb.131.6.1517","article-title":"The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane","volume":"131","author":"Kozminski","year":"1995","journal-title":"The Journal of Cell Biology"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0455","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1083\/jcb.102.3.1007","article-title":"Direct observation of steady-state microtubule dynamics","volume":"102","author":"Kristofferson","year":"1986","journal-title":"The Journal of Cell Biology"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0460","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbadis.2003.09.001","article-title":"Akt\/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro","volume":"1639","author":"Ksiezak-Reding","year":"2003","journal-title":"Biochimica et Biophysica Acta"},{"issue":"524","key":"10.1016\/j.pharmthera.2020.107681_bb0465","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau5732","article-title":"Prospective longitudinal atrophy in Alzheimer\u2019s disease correlates with the intensity and topography of baseline tau-PET","volume":"12","author":"La Joie","year":"2020","journal-title":"Science Translational Medicine"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0480","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.201001024","article-title":"Tubulin polyglutamylation stimulates spastin-mediated microtubule severing","volume":"189","author":"Lacroix","year":"2010","journal-title":"The Journal of Cell Biology"},{"issue":"36","key":"10.1016\/j.pharmthera.2020.107681_bb0485","doi-asserted-by":"crossref","first-page":"22117","DOI":"10.1074\/jbc.271.36.22117","article-title":"Interaction of kinesin motor domains with alpha- and beta-tubulin subunits at a tau-independent binding site. Regulation by polyglutamylation","volume":"271","author":"Larcher","year":"1996","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0490","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1074\/jbc.M110.144089","article-title":"The C terminus of tubulin, a versatile partner for cationic molecules: Binding of tau, polyamines, and calcium","volume":"286","author":"Lef\u00e8vre","year":"2011","journal-title":"The Journal of Biological Chemistry"},{"issue":"16","key":"10.1016\/j.pharmthera.2020.107681_bb0495","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1074\/jbc.RA118.005765","article-title":"Polyglutamylation of tubulin\u2019s C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A","volume":"294","author":"Lessard","year":"2019","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0500","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-018-0342-8","article-title":"Tau PET imaging in neurodegenerative tauopathies-still a challenge","author":"Leuzy","year":"2019","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0505","article-title":"Cryo-EM structure of VASH1-SVBP bound to microtubules","volume":"9","author":"Li","year":"2020","journal-title":"ELife"},{"issue":"8","key":"10.1016\/j.pharmthera.2020.107681_bb0510","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1016\/S0021-9258(17)42989-9","article-title":"Phosphorylation affects the ability of tau protein to promote microtubule assembly","volume":"259","author":"Lindwall","year":"1984","journal-title":"The Journal of Biological Chemistry"},{"issue":"15","key":"10.1016\/j.pharmthera.2020.107681_bb0515","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1016\/j.bmcl.2013.05.069","article-title":"Phosphinic acid-based inhibitors of tubulin polyglutamylases","volume":"23","author":"Liu","year":"2013","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"18","key":"10.1016\/j.pharmthera.2020.107681_bb0520","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1242\/jcs.015883","article-title":"The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line","volume":"120","author":"Luke-Glaser","year":"2007","journal-title":"Journal of Cell Science"},{"issue":"23","key":"10.1016\/j.pharmthera.2020.107681_bb0525","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100440","article-title":"Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport","volume":"37","author":"Magiera","year":"2018","journal-title":"The EMBO Journal"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0530","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.cell.2018.05.032","article-title":"SnapShot: Functions of tubulin posttranslational modifications","volume":"173","author":"Magiera","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0535","article-title":"Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes","author":"Mahalingan","year":"2020","journal-title":"Nature Structural & Molecular Biology"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0540","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s40478-016-0378-4","article-title":"Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy","volume":"4","author":"Makani","year":"2016","journal-title":"Acta Neuropathologica Communications"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0545","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0955-0674(95)80047-6","article-title":"Microtubules and microtubule-associated proteins","volume":"7","author":"Mandelkow","year":"1995","journal-title":"Current Opinion in Cell Biology"},{"issue":"20","key":"10.1016\/j.pharmthera.2020.107681_bb0550","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1073\/pnas.86.20.8152","article-title":"Hypothesis: Microtubules, a key to Alzheimer disease","volume":"86","author":"Matsuyama","year":"1989","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041160","article-title":"An overview on the clinical development of tau-based therapeutics","volume":"19","author":"Medina","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"issue":"13","key":"10.1016\/j.pharmthera.2020.107681_bb0560","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1038\/sj.emboj.7600240","article-title":"Dynein and kinesin share an overlapping microtubule-binding site","volume":"23","author":"Mizuno","year":"2004","journal-title":"The EMBO Journal"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0565","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.devcel.2020.01.029","article-title":"A combinatorial MAP code dictates polarized microtubule transport","volume":"53","author":"Monroy","year":"2020","journal-title":"Developmental Cell"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0570","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1073\/pnas.73.1.208","article-title":"Purkinje cell degeneration, a new neurological mutation in the mouse","volume":"73","author":"Mullen","year":"1976","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0575","series-title":"A Safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy study of TPI-287 in Alzheimer\u2019s disease. NCT01966666","author":"NCT01966666","year":"2019"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0580","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: A review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"issue":"6369","key":"10.1016\/j.pharmthera.2020.107681_bb0585","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1126\/science.aao5676","article-title":"Vasohibins encode tubulin detyrosinating activity","volume":"358","author":"Nieuwenhuis","year":"2017","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0590","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF02736834","article-title":"Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration","volume":"8","author":"Nunez","year":"1997","journal-title":"Journal of Molecular Neuroscience: MN"},{"issue":"20","key":"10.1016\/j.pharmthera.2020.107681_bb0595","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1093\/hmg\/ddz186","article-title":"Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice","volume":"28","author":"Pagnamenta","year":"2019","journal-title":"Human Molecular Genetics"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0600","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.144.3.473","article-title":"The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assembly","volume":"144","author":"Pazour","year":"1999","journal-title":"The Journal of Cell Biology"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0605","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1083\/jcb.200512058","article-title":"Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends","volume":"174","author":"Peris","year":"2006","journal-title":"The Journal of Cell Biology"},{"issue":"7","key":"10.1016\/j.pharmthera.2020.107681_bb0610","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1083\/jcb.200902142","article-title":"Motor-dependent microtubule disassembly driven by tubulin tyrosination","volume":"185","author":"Peris","year":"2009","journal-title":"The Journal of Cell Biology"},{"issue":"10","key":"10.1016\/j.pharmthera.2020.107681_bb0615","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1083\/jcb.201701045","article-title":"Stabilization of dynamic microtubules by mDia1 drives tau-dependent Abeta1-42 synaptotoxicity","volume":"216","author":"Qu","year":"2017","journal-title":"The Journal of Cell Biology"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0620","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"The New England Journal of Medicine"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0625","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41563-019-0546-6","article-title":"Taxanes convert regions of perturbed microtubule growth into rescue sites","volume":"19","author":"Rai","year":"2020","journal-title":"Nature Materials"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0630","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1074\/jbc.M408324200","article-title":"Mutations of tubulin glycylation sites reveal cross-talk between the C termini of alpha- and beta-tubulin and affect the ciliary matrix in Tetrahymena","volume":"280","author":"Redeker","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0635","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/cm.970120408","article-title":"Differential localisation of tyrosinated, detyrosinated, and acetylated\u202f?-tubulins in neurites and growth cones of dorsal root ganglion neurons","volume":"12","author":"Robson","year":"1989","journal-title":"Cell Motility and the Cytoskeleton"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0640","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.cell.2009.05.020","article-title":"Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation","volume":"137","author":"Rogowski","year":"2009","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0645","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2010.10.014","article-title":"A family of protein-deglutamylating enzymes associated with neurodegeneration","volume":"143","author":"Rogowski","year":"2010","journal-title":"Cell"},{"issue":"7176","key":"10.1016\/j.pharmthera.2020.107681_bb0650","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature06482","article-title":"Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin","volume":"451","author":"Roll-Mecak","year":"2008","journal-title":"Nature"},{"issue":"6232","key":"10.1016\/j.pharmthera.2020.107681_bb0655","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.aaa2958","article-title":"Systemic administration of epothilone B promotes axon regeneration after spinal cord injury","volume":"348","author":"Ruschel","year":"2015","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.pharmthera.2020.107681_bb0660","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/bioinformatics\/btv761","article-title":"Vasohibins: New transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad","volume":"32","author":"Sanchez-Pulido","year":"2016","journal-title":"Bioinformatics"},{"issue":"5733","key":"10.1016\/j.pharmthera.2020.107681_bb0665","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.1113694","article-title":"Tau suppression in a neurodegenerative mouse model improves memory function","volume":"309","author":"Santacruz","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0670","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1023\/A:1007587315630","article-title":"Differential association of tau with subsets of microtubules containing posttranslationally-modified tubulin variants in neuroblastoma cells","volume":"25","author":"Saragoni","year":"2000","journal-title":"Neurochemical Research"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0675","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain","volume":"89","author":"Scholl","year":"2016","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0680","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1083\/jcb.100.1.276","article-title":"Purification of brain tubulin-tyrosine ligase by biochemical and immunological methods","volume":"100","author":"Schroder","year":"1985","journal-title":"The Journal of Cell Biology"},{"issue":"2","key":"10.1016\/j.pharmthera.2020.107681_bb0685","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/abbi.1998.0813","article-title":"Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules","volume":"357","author":"Sengupta","year":"1998","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"20","key":"10.1016\/j.pharmthera.2020.107681_bb0690","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1021\/bi00315a024","article-title":"Controlled proteolysis of tubulin by subtilisin: Localization of the site for MAP2 interaction","volume":"23","author":"Serrano","year":"1984","journal-title":"Biochemistry"},{"issue":"7618","key":"10.1016\/j.pharmthera.2020.107681_bb0695","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces Abeta plaques in Alzheimer\u2019s disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0700","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1083\/jcb.200704021","article-title":"Katanin regulates dynamics of microtubules and biogenesis of motile cilia","volume":"178","author":"Sharma","year":"2007","journal-title":"Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0705","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15252\/embj.2018100540","article-title":"Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration","volume":"37","author":"Shashi","year":"2018","journal-title":"The EMBO Journal"},{"issue":"11","key":"10.1016\/j.pharmthera.2020.107681_bb0710","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1021\/bi061920i","article-title":"NMR investigation of the interaction between the neuronal protein tau and the microtubules","volume":"46","author":"Sillen","year":"2007","journal-title":"Biochemistry"},{"issue":"22","key":"10.1016\/j.pharmthera.2020.107681_bb0715","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1016\/j.bmcl.2017.10.002","article-title":"A comparative study of warheads for design of cysteine protease inhibitors","volume":"27","author":"Silva","year":"2017","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"1","key":"10.1016\/j.pharmthera.2020.107681_bb0720","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/biom6010006","article-title":"Tau protein hyperphosphorylation and aggregation in Alzheimer\u2019s disease and other tauopathies, and possible neuroprotective strategies","volume":"6","author":"\u0160imi\u0107","year":"2016","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0725","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ncb2920","article-title":"Regulation of microtubule motors by tubulin isotypes and post-translational modifications","volume":"16","author":"Sirajuddin","year":"2014","journal-title":"Nature Cell Biology"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0730","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/sj.emboj.7600118","article-title":"Modulation of kinesin binding by the C-termini of tubulin","volume":"23","author":"Skiniotis","year":"2004","journal-title":"The EMBO Journal"},{"issue":"5966","key":"10.1016\/j.pharmthera.2020.107681_bb0735","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1126\/science.1182179","article-title":"Axon extension occurs independently of centrosomal microtubule nucleation","volume":"327","author":"Stiess","year":"2010","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0740","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/dneu.20849","article-title":"Neuronal polarization: The cytoskeleton leads the way","volume":"71","author":"Stiess","year":"2011","journal-title":"Developmental Neurobiology"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0745","doi-asserted-by":"crossref","DOI":"10.1038\/s41374-019-0197-x","article-title":"MAPT mutations, tauopathy, and mechanisms of neurodegeneration","author":"Strang","year":"2019","journal-title":"Laboratory Investigation"},{"issue":"2","key":"10.1016\/j.pharmthera.2020.107681_bb0750","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0092-8674(95)90158-2","article-title":"Making the connection: Cytoskeletal rearrangements during growth cone guidance","volume":"83","author":"Tanaka","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0755","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pneurobio.2018.12.005","article-title":"It\u2019s all about tau","volume":"175","author":"Tapia-Rojas","year":"2019","journal-title":"Progress in Neurobiology"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0760","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.neuron.2017.11.018","article-title":"Differentiation between oppositely oriented microtubules controls polarized neuronal transport","volume":"96","author":"Tas","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0765","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.conb.2018.04.027","article-title":"Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease","volume":"51","author":"Tracy","year":"2018","journal-title":"Current Opinion in Neurobiology"},{"issue":"5","key":"10.1016\/j.pharmthera.2020.107681_bb0770","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.cell.2016.01.019","article-title":"Graded control of microtubule severing by tubulin glutamylation","volume":"164","author":"Valenstein","year":"2016","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0210","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.molcel.2007.04.012","article-title":"A targeted multienzyme mechanism for selective microtubule polyglutamylation","volume":"26","author":"van Dijk","year":"2007","journal-title":"Molecular Cell"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0215","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2019.2050","article-title":"Effect of AZD0530 on cerebral metabolic decline in Alzheimer disease: A randomized clinical trial","author":"van Dyck","year":"2019","journal-title":"JAMA Neurology"},{"issue":"11","key":"10.1016\/j.pharmthera.2020.107681_bb0470","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.4103\/1673-5374.259611","article-title":"Tubulin glutamylation: A skeleton key for neurodegenerative diseases","volume":"14","author":"van der Laan","year":"2019","journal-title":"Neural Regeneration Research"},{"issue":"12","key":"10.1016\/j.pharmthera.2020.107681_bb0475","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1016\/j.celrep.2019.11.074","article-title":"Evolutionary divergence of enzymatic mechanisms for tubulin detyrosination","volume":"29","author":"van der Laan","year":"2019","journal-title":"Cell Reports"},{"issue":"17","key":"10.1016\/j.pharmthera.2020.107681_bb0775","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.4161\/cc.6.17.4633","article-title":"The tubulin code","volume":"6","author":"Verhey","year":"2007","journal-title":"Cell Cycle"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0780","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2174\/156802606776287081","article-title":"Inhibitors of cysteine proteases","volume":"6","author":"Vicik","year":"2006","journal-title":"Current Topics in Medicinal Chemistry"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0785","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1177\/0300985810363485","article-title":"Tubulin tyrosine ligase\u2013like 1 deficiency results in chronic rhinosinusitis and abnormal development of spermatid flagella in mice","volume":"47","author":"Vogel","year":"2010","journal-title":"Veterinary Pathology"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0790","doi-asserted-by":"crossref","DOI":"10.1038\/srep40205","article-title":"Increase in \u03b1-tubulin modifications in the neuronal processes of hippocampal neurons in both kainic acid-induced epileptic seizure and Alzheimer\u2019s disease","volume":"7","author":"Vu","year":"2017","journal-title":"Scientific Reports"},{"issue":"8","key":"10.1016\/j.pharmthera.2020.107681_bb0795","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2174\/13816128113199990068","article-title":"Inhibition of amyloid-\u03b2 aggregation in Alzheimer\u2019s disease","volume":"20","author":"Wang","year":"2014","journal-title":"Current Pharmaceutical Design"},{"issue":"2","key":"10.1016\/j.pharmthera.2020.107681_bb0800","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1083\/jcb.121.2.257","article-title":"A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau","volume":"121","author":"Wang","year":"1993","journal-title":"The Journal of Cell Biology"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0805","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/S0006-3495(00)76743-9","article-title":"The C-terminus of tubulin increases cytoplasmic dynein and kinesin processivity","volume":"78","author":"Wang","year":"2000","journal-title":"Biophysical Journal"},{"issue":"7","key":"10.1016\/j.pharmthera.2020.107681_bb0810","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1172\/JCI200421152","article-title":"Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis","volume":"114","author":"Watanabe","year":"2004","journal-title":"The Journal of Clinical Investigation"},{"issue":"18","key":"10.1016\/j.pharmthera.2020.107681_bb0815","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1091\/mbc.e14-04-0916","article-title":"How Taxol\/paclitaxel kills cancer cells","volume":"25","author":"Weaver","year":"2014","journal-title":"Molecular Biology of the Cell"},{"issue":"10","key":"10.1016\/j.pharmthera.2020.107681_bb0820","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nsmb1291","article-title":"Structure-function relationship of CAP-Gly domains","volume":"14","author":"Weisbrich","year":"2007","journal-title":"Nature Structural & Molecular Biology"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0825","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40478-016-0275-x","article-title":"Epidemiological pathology of tau in the ageing brain: Application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study","volume":"4","author":"Wharton","year":"2016","journal-title":"Acta Neuropathologica Communications"},{"issue":"3","key":"10.1016\/j.pharmthera.2020.107681_bb0830","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.200707042","article-title":"Microtubule stabilization specifies initial neuronal polarization","volume":"180","author":"Witte","year":"2008","journal-title":"The Journal of Cell Biology"},{"issue":"6","key":"10.1016\/j.pharmthera.2020.107681_bb0835","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.devcel.2009.04.008","article-title":"TTLL3 is a tubulin glycine ligase that regulates the assembly of cilia","volume":"16","author":"Wloga","year":"2009","journal-title":"Developmental Cell"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0840","author":"World Health Organisation"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0845","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1523\/JNEUROSCI.2430-15.2016","article-title":"Dendrites in vitro and in vivo contain microtubules of opposite polarity and axon formation correlates with uniform plus-end-out microtubule orientation","volume":"36","author":"Yau","year":"2016","journal-title":"Journal of Neuroscience"},{"issue":"29","key":"10.1016\/j.pharmthera.2020.107681_bb0850","doi-asserted-by":"crossref","first-page":"12192","DOI":"10.1074\/jbc.M117.784702","article-title":"Axodendritic sorting and pathological missorting of tau are isoform-specific and determined by axon initial segment architecture","volume":"292","author":"Zempel","year":"2017","journal-title":"The Journal of Biological Chemistry"},{"issue":"11","key":"10.1016\/j.pharmthera.2020.107681_bb0855","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1523\/JNEUROSCI.4922-11.2012","article-title":"The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice","volume":"32","author":"Zhang","year":"2012","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/j.pharmthera.2020.107681_bb0860","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1021\/acs.chemrev.7b00305","article-title":"Electrostatic interactions in protein structure, folding, binding, and condensation","volume":"118","author":"Zhou","year":"2018","journal-title":"Chemical Reviews"},{"key":"10.1016\/j.pharmthera.2020.107681_bb0865","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bav108","article-title":"MAPanalyzer: A novel online tool for analyzing microtubule-associated proteins","volume":"2015","author":"Zhou","year":"2015","journal-title":"Database: The Journal of Biological Databases and Curation"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725820302114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725820302114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:10:47Z","timestamp":1759011047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725820302114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":176,"alternative-id":["S0163725820302114"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107681","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tubulin modifying enzymes as target for the treatment of tau-related diseases","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107681","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107681"}}