{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:23:56Z","timestamp":1790767436522,"version":"4.1.0"},"reference-count":195,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.pharmthera.2020.107713","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T21:26:59Z","timestamp":1603488419000},"page":"107713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis"],"prefix":"10.1016","volume":"220","author":[{"given":"A. Scotto","family":"Rosato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2020.107713_bb0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/MCB.06159-11","article-title":"Role of AMPK-mTOR-Ulk1\/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks","volume":"32","author":"Alers","year":"2012","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0010","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1212\/WNL.59.3.306","article-title":"The neurogenetics of mucolipidosis type IV","volume":"59","author":"Altarescu","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0015","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1542\/peds.79.6.953","article-title":"Mucolipidosis type IV: clinical spectrum and natural history","volume":"79","author":"Amir","year":"1987","journal-title":"Pediatrics"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0020","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0962-8924(00)01794-3","article-title":"Regulated secretion of conventional lysosomes","volume":"10","author":"Andrews","year":"2000","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0025","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1091\/mbc.e13-09-0523","article-title":"NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa","volume":"25","author":"Arndt","year":"2014","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0030","doi-asserted-by":"crossref","first-page":"21376","DOI":"10.1074\/jbc.M115.671248","article-title":"Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic beta Cells","volume":"290","author":"Arredouani","year":"2015","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0035","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/mgme.2001.3195","article-title":"Mucolipidosis type IV","volume":"73","author":"Bach","year":"2001","journal-title":"Molecular Genetics and Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0040","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0009-8981(98)00183-1","article-title":"Elevated lysosomal pH in Mucolipidosis type IV cells","volume":"280","author":"Bach","year":"1999","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0045","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/humu.9385","article-title":"The frequency of mucolipidosis type IV in the Ashkenazi Jewish population and the identification of 3 novel MCOLN1 mutations","volume":"26","author":"Bach","year":"2005","journal-title":"Human Mutation"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0050","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/79095","article-title":"Identification of the gene causing mucolipidosis type IV","volume":"26","author":"Bargal","year":"2000","journal-title":"Nature Genetics"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0055","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/humu.1115","article-title":"Mucolipidosis type IV: novel MCOLN1 mutations in Jewish and non-Jewish patients and the frequency of the disease in the Ashkenazi Jewish population","volume":"17","author":"Bargal","year":"2001","journal-title":"Human Mutation"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0060","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1023\/A:1005362123443","article-title":"Mucolipidosis type IV: abnormal transport of lipids to lysosomes","volume":"20","author":"Bargal","year":"1997","journal-title":"Journal of Inherited Metabolic Disease"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0065","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/S0002-9297(07)62941-3","article-title":"Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV","volume":"67","author":"Bassi","year":"2000","journal-title":"American Journal of Human Genetics"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0070","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.biochem.72.121801.161800","article-title":"Signals for sorting of transmembrane proteins to endosomes and lysosomes","volume":"72","author":"Bonifacino","year":"2003","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0075","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1083\/jcb.200904073","article-title":"Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling","volume":"186","author":"Brailoiu","year":"2009","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0080","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1074\/jbc.C109.081943","article-title":"An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles","volume":"285","author":"Brailoiu","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0085","doi-asserted-by":"crossref","first-page":"38511","DOI":"10.1074\/jbc.M110.162073","article-title":"An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals","volume":"285","author":"Brailoiu","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0090","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1093\/molbev\/msq122","article-title":"Degeneration of an intracellular ion channel in the primate lineage by relaxation of selective constraints","volume":"27","author":"Cai","year":"2010","journal-title":"Molecular Biology and Evolution"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0095","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature08030","article-title":"NAADP mobilizes calcium from acidic organelles through two-pore channels","volume":"459","author":"Calcraft","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0100","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1038\/ncomms6015","article-title":"A non-inactivating high-voltage-activated two-pore Na(+) channel that supports ultra-long action potentials and membrane bistability","volume":"5","author":"Cang","year":"2014","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0105","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nchembio.1522","article-title":"The voltage-gated sodium channel TPC1 confers endolysosomal excitability","volume":"10","author":"Cang","year":"2014","journal-title":"Nature Chemical Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0110","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.cell.2013.01.023","article-title":"mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state","volume":"152","author":"Cang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0115","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1074\/jbc.M116.772160","article-title":"The lysosomal Ca(2+) release channel TRPML1 regulates lysosome size by activating calmodulin","volume":"292","author":"Cao","year":"2017","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0120","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ceca.2012.03.001","article-title":"Mitochondrial Ca(2+) signals in autophagy","volume":"52","author":"Cardenas","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0125","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.tcb.2005.08.005","article-title":"Coincidence detection in phosphoinositide signaling","volume":"15","author":"Carlton","year":"2005","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0130","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1152\/physrev.00032.2014","article-title":"The physiology of protein S-acylation","volume":"95","author":"Chamberlain","year":"2015","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0135","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12915-019-0735-4","article-title":"A two-pore channel protein required for regulating mTORC1 activity on starvation","volume":"18","author":"Chang","year":"2020","journal-title":"BMC Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0140","first-page":"E8595","article-title":"TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms","volume":"114","author":"Chao","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0145","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1002\/j.1460-2075.1994.tb06514.x","article-title":"Retrieval of TGN proteins from the cell surface requires endosomal acidification","volume":"13","author":"Chapman","year":"1994","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0150","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1038\/ncomms5681","article-title":"A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV","volume":"5","author":"Chen","year":"2014","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0155","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.1073\/pnas.95.11.6373","article-title":"Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease","volume":"95","author":"Chen","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0160","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/nm.3611","article-title":"The intracellular Ca(2)(+) channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy","volume":"20","author":"Cheng","year":"2014","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0165","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbrc.2013.11.044","article-title":"The Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy","volume":"443","author":"Choi","year":"2014","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0170","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(02)01082-6","article-title":"NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs","volume":"111","author":"Churchill","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0175","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1124\/pr.57.4.7","article-title":"International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels","volume":"57","author":"Clapham","year":"2005","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0180","doi-asserted-by":"crossref","first-page":"38251","DOI":"10.1074\/jbc.M110.125864","article-title":"The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells","volume":"285","author":"Cosker","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0185","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1530\/REP-09-0134","article-title":"Ca2+-stores in sperm: Their identities and functions","volume":"138","author":"Costello","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0190","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00424-008-0523-4","article-title":"The varitint-waddler mouse phenotypes and the TRPML3 ion channel mutation: cause and consequence","volume":"457","author":"Cuajungco","year":"2008","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-94-007-3015-1_3","article-title":"Phosphoinositides in the mammalian endo-lysosomal network","volume":"59","author":"Cullen","year":"2012","journal-title":"Sub-Cellular Biochemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0200","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41580-018-0053-7","article-title":"To degrade or not to degrade: Mechanisms and significance of endocytic recycling","volume":"19","author":"Cullen","year":"2018","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0205","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.nbd.2010.06.010","article-title":"Macroautophagy is defective in mucolipin-1-deficient mouse neurons","volume":"40","author":"Curcio-Morelli","year":"2010","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0210","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jcp.21956","article-title":"Functional multimerization of mucolipin channel proteins","volume":"222","author":"Curcio-Morelli","year":"2010","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0215","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/j.cub.2012.10.035","article-title":"NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing","volume":"22","author":"Davis","year":"2012","journal-title":"Current Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0220","doi-asserted-by":"crossref","first-page":"e104058","DOI":"10.15252\/embj.2019104058","article-title":"NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca(2+) nanodomains, calcineurin and dynamin","author":"Davis","year":"2020","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0225","first-page":"53","article-title":"Preferential Coupling of the NAADP Pathway to Exocytosis in T-Cells","volume":"4","author":"Davis","year":"2015","journal-title":"Messenger (Los Angel)"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0230","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/tra.12303","article-title":"The Phosphoinositide-Gated Lysosomal Ca(2+) Channel, TRPML1, Is Required for Phagosome Maturation","volume":"16","author":"Dayam","year":"2015","journal-title":"Traffic"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0235","doi-asserted-by":"crossref","first-page":"49326","DOI":"10.1074\/jbc.M208587200","article-title":"The intraacrosomal calcium pool plays a direct role in acrosomal exocytosis","volume":"277","author":"De Blas","year":"2002","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0240","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbamcr.2005.04.013","article-title":"The role of the phosphoinositides at the Golgi complex","volume":"1744","author":"De Matteis","year":"2005","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0245","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ceca.2011.04.001","article-title":"A dual role for Ca(2+) in autophagy regulation","volume":"50","author":"Decuypere","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0250","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ceca.2017.06.006","article-title":"TRPML1: The Ca((2+))retaker of the lysosome","volume":"69","author":"Di Paola","year":"2018","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0255","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nature07311","article-title":"The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel","volume":"455","author":"Dong","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0260","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/ncomms1037","article-title":"PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome","volume":"1","author":"Dong","year":"2010","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0265","doi-asserted-by":"crossref","first-page":"32040","DOI":"10.1074\/jbc.M109.037184","article-title":"Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis","volume":"284","author":"Dong","year":"2009","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0270","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0275","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s10354-016-0432-7","article-title":"Endocytic pathways and endosomal trafficking: a primer","volume":"166","author":"Elkin","year":"2016","journal-title":"Wiener Medizinische Wochenschrift (1946)"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149614","article-title":"Genetic Variants of TPCN2 Associated with Type 2 Diabetes Risk in the Chinese Population","volume":"11","author":"Fan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0285","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1074\/jbc.M113.506501","article-title":"Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane","volume":"289","author":"Feng","year":"2014","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0290","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1080\/15548627.2016.1190072","article-title":"Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A","volume":"12","author":"Fernandez","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0295","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.aaw9544","article-title":"Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance","volume":"367","author":"Freeman","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0300","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0143416002001902","article-title":"Interactions between calcium release pathways: Multiple messengers and multiple stores","volume":"32","author":"Galione","year":"2002","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0305","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1042\/BST0381424","article-title":"NAADP as an intracellular messenger regulating lysosomal calcium-release channels","volume":"38","author":"Galione","year":"2010","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0310","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/978-3-642-54215-2_25","article-title":"TRPML2 and mucolipin evolution","volume":"222","author":"Garcia-Anoveros","year":"2014","journal-title":"Handbook of Experimental Pharmacology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0315","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1113\/JP271332","article-title":"Endolysosomal two-pore channels regulate autophagy in cardiomyocytes","volume":"594","author":"Garcia-Rua","year":"2016","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0320","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54712","article-title":"Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function","volume":"9","author":"Gerndt","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0325","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1093\/emboj\/19.17.4577","article-title":"Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells","volume":"19","author":"Gillooly","year":"2000","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0330","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/hmg\/ddr481","article-title":"Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP","volume":"21","author":"Gomez-Suaga","year":"2012","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0335","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1038\/ncomms5699","article-title":"High susceptibility to fatty liver disease in two-pore channel 2-deficient mice","volume":"5","author":"Grimm","year":"2014","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0340","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.chembiol.2009.12.016","article-title":"Small molecule activators of TRPML3","volume":"17","author":"Grimm","year":"2010","journal-title":"Chemistry & Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0345","doi-asserted-by":"crossref","first-page":"102212","DOI":"10.1016\/j.ceca.2020.102212","article-title":"Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?","volume":"88","author":"Grimm","year":"2020","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0350","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35096054","article-title":"The endocytic pathway: a mosaic of domains","volume":"2","author":"Gruenberg","year":"2001","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0355","doi-asserted-by":"crossref","first-page":"pe18","DOI":"10.1126\/scisignal.2002890","article-title":"Linking NAADP to ion channel activity: A unifying hypothesis","volume":"5","author":"Guse","year":"2012","journal-title":"Science Signaling"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0360","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.2337\/db17-1102","article-title":"Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca(2+) Mobilization From Acidic Stores in Pancreatic alpha-Cells","volume":"67","author":"Hamilton","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0365","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1042\/BJ20090428","article-title":"Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2)","volume":"422","author":"Hammond","year":"2009","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0370","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1530\/jrf.0.0440125","article-title":"The acrosome-lysosome relationship","volume":"44","author":"Hartree","year":"1975","journal-title":"Journal of Reproduction and Fertility"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0375","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1042\/BST0331285","article-title":"Phosphoinositide regulation of clathrin-mediated endocytosis","volume":"33","author":"Haucke","year":"2005","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0380","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/jcp.20172","article-title":"The acrosomal vesicle of mouse sperm is a calcium store","volume":"202","author":"Herrick","year":"2005","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0385","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225543","article-title":"A Double Negative Feedback Loop between mTORC1 and AMPK Kinases Guarantees Precise Autophagy Induction upon Cellular Stress","volume":"20","author":"Holczer","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0390","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/978-94-007-2888-2_14","article-title":"NAADP on target","volume":"740","author":"Hooper","year":"2012","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0395","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1038\/emboj.2011.286","article-title":"Endosome maturation","volume":"30","author":"Huotari","year":"2011","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0400","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1006\/bbrc.2000.2435","article-title":"Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels","volume":"270","author":"Ishibashi","year":"2000","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0405","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21114181","article-title":"Evolutionary Aspects of TRPMLs and TPCs","volume":"21","author":"Jaslan","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0410","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/embj.201387035","article-title":"Convergent regulation of the lysosomal two-pore channel-2 by Mg(2)(+), NAADP, PI(3,5)P(2) and multiple protein kinases","volume":"33","author":"Jha","year":"2014","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0415","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1091\/mbc.e08-11-1102","article-title":"Eps15 homology domain 1-associated tubules contain phosphatidylinositol-4-phosphate and phosphatidylinositol-(4,5)-bisphosphate and are required for efficient recycling","volume":"20","author":"Jovic","year":"2009","journal-title":"Molecular Biology of the Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0420","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/19336950.2019.1666457","article-title":"TRPML1 and RAS-driven cancers - exploring a link with great therapeutic potential","volume":"13","author":"Jung","year":"2019","journal-title":"Channels (Austin, Tex.)"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0425","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1111\/j.1600-0854.2007.00619.x","article-title":"Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs","volume":"8","author":"Karacsonyi","year":"2007","journal-title":"Traffic"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0430","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1600-0854.2009.00924.x","article-title":"The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy","volume":"10","author":"Kim","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0435","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0440","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/15548627.2018.1518671","article-title":"Palmitoylation controls trafficking of the intracellular Ca(2+) channel MCOLN3\/TRPML3 to regulate autophagy","volume":"15","author":"Kim","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0445","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4161\/chan.21723","article-title":"The intracellular Ca(2)(+) channels of membrane traffic","volume":"6","author":"Kiselyov","year":"2012","journal-title":"Channels (Austin, Tex.)"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0450","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ymgme.2006.05.016","article-title":"Lysosomal exocytosis is impaired in mucolipidosis type IV","volume":"89","author":"LaPlante","year":"2006","journal-title":"Molecular Genetics and Metabolism"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0455","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0460","doi-asserted-by":"crossref","first-page":"33693","DOI":"10.1074\/jbc.R500012200","article-title":"Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling","volume":"280","author":"Lee","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-2569-8_1","article-title":"Rab family of GTPases","volume":"1298","author":"Li","year":"2015","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0470","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19360","article-title":"Regulation of mTORC1 by lysosomal calcium and calmodulin","volume":"5","author":"Li","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0475","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1038\/bjc.2013.484","article-title":"P2Y2 receptor promotes cell invasion and metastasis in prostate cancer cells","volume":"109","author":"Li","year":"2013","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0480","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ncb3324","article-title":"A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation","volume":"18","author":"Li","year":"2016","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0485","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1074\/jbc.M114.608471","article-title":"Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling","volume":"290","author":"Lin","year":"2015","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0490","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrm2084","article-title":"Palmitoylation: Policing protein stability and traffic","volume":"8","author":"Linder","year":"2007","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0495","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1074\/jbc.M111.305813","article-title":"Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells","volume":"287","author":"Lin-Moshier","year":"2012","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0500","doi-asserted-by":"crossref","DOI":"10.4161\/cib.27595","article-title":"NAADP\/TPC2\/Ca(2+) Signaling Inhibits Autophagy","volume":"6","author":"Lu","year":"2013","journal-title":"Communicative & Integrative Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0505","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1042\/BST0351088","article-title":"The role of calcium and other ions in sorting and delivery in the late endocytic pathway","volume":"35","author":"Luzio","year":"2007","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0510","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.febslet.2004.04.080","article-title":"Overexpression of wild-type and mutant mucolipin proteins in mammalian cells: Eeffects on the late endocytic compartment organization","volume":"567","author":"Manzoni","year":"2004","journal-title":"FEBS Letters"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0515","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1042\/BST20140303","article-title":"Two-pore channels at the intersection of endolysosomal membrane traffic","volume":"43","author":"Marchant","year":"2015","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0520","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1600-0854.2009.00935.x","article-title":"The calcium channel mucolipin-3 is a novel regulator of trafficking along the endosomal pathway","volume":"10","author":"Martina","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0525","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/15216540701222872","article-title":"Acrosomal exocytosis, a special type of regulated secretion","volume":"59","author":"Mayorga","year":"2007","journal-title":"IUBMB Life"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0530","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ncb3114","article-title":"Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB","volume":"17","author":"Medina","year":"2015","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0535","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.devcel.2011.07.016","article-title":"Transcriptional activation of lysosomal exocytosis promotes cellular clearance","volume":"21","author":"Medina","year":"2011","journal-title":"Developmental Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0540","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/26.2.24069","article-title":"The pH of the hamster sperm acrosome","volume":"26","author":"Meizel","year":"1978","journal-title":"The Journal of Histochemistry and Cytochemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0545","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.cell.2015.05.009","article-title":"A TRP channel senses lysosome neutralization by pathogens to trigger their expulsion","volume":"161","author":"Miao","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0550","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tibs.2005.11.013","article-title":"Phosphatidylinositol 3,5-bisphosphate: Metabolism and cellular functions","volume":"31","author":"Michell","year":"2006","journal-title":"Trends in Biochemical Sciences"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0555","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1084\/jem.20072194","article-title":"Membrane traffic and turnover in TRP-ML1-deficient cells: A revised model for mucolipidosis type IV pathogenesis","volume":"205","author":"Miedel","year":"2008","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0560","doi-asserted-by":"crossref","first-page":"12751","DOI":"10.1074\/jbc.M511104200","article-title":"Posttranslational cleavage and adaptor protein complex-dependent trafficking of mucolipin-1","volume":"281","author":"Miedel","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0565","doi-asserted-by":"crossref","first-page":"11057","DOI":"10.1074\/jbc.M210257200","article-title":"Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6)","volume":"278","author":"Mitchell","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0570","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0304-4157(90)90008-Z","article-title":"Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity","volume":"1031","author":"Mollenhauer","year":"1990","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0575","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1042\/BJ20060759","article-title":"NAADP induces pH changes in the lumen of acidic Ca2+ stores","volume":"402","author":"Morgan","year":"2007","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0580","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/dbio.2001.0353","article-title":"Alkalinization of acrosome measured by GFP as a pH indicator and its relation to sperm capacitation","volume":"237","author":"Nakanishi","year":"2001","journal-title":"Developmental Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0585","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.216499","article-title":"The enigmatic endosome - sorting the ins and outs of endocytic trafficking","volume":"131","author":"Naslavsky","year":"2018","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0590","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao5775","article-title":"mTORC1 controls lysosomal Ca(2+) release through the two-pore channel TPC2","volume":"11","author":"Ogunbayo","year":"2018","journal-title":"Science Signaling"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0595","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1074\/jbc.M114.610493","article-title":"Organelle-specific subunit interactions of the vertebrate two-pore channel family","volume":"290","author":"Ogunbayo","year":"2015","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0600","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1042\/BJ20150219","article-title":"The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase","volume":"470","author":"Onyenwoke","year":"2015","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0605","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/hmg\/ddr306","article-title":"Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways","volume":"20","author":"Palmieri","year":"2011","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0610","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tcb.2010.02.003","article-title":"Acidic calcium stores open for business: Expanding the potential for intracellular Ca2+ signaling","volume":"20","author":"Patel","year":"2010","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0615","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.bbamcr.2018.05.004","article-title":"Two-pore channels and disease","volume":"1865","author":"Patel","year":"2018","journal-title":"Biochimica et Biophysica Acta, Molecular Cell Research"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0620","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ceca.2010.05.001","article-title":"Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals","volume":"47","author":"Patel","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0625","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ceca.2011.03.009","article-title":"Acidic Ca(2+) stores come to the fore","volume":"50","author":"Patel","year":"2011","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0630","doi-asserted-by":"crossref","first-page":"12730","DOI":"10.18632\/oncotarget.14404","article-title":"Glutamate induces autophagy via the two-pore channels in neural cells","volume":"8","author":"Pereira","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0635","doi-asserted-by":"crossref","first-page":"27875","DOI":"10.1074\/jbc.C110.216580","article-title":"Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes","volume":"286","author":"Pereira","year":"2011","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0640","doi-asserted-by":"crossref","first-page":"ra46","DOI":"10.1126\/scisignal.2004854","article-title":"Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+","volume":"7","author":"Pitt","year":"2014","journal-title":"Science Signaling"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0645","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39720","article-title":"Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells","volume":"7","author":"Plesch","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0650","doi-asserted-by":"crossref","first-page":"13929","DOI":"10.1074\/jbc.272.21.13929","article-title":"Bafilomycin A1 treatment retards transferrin receptor recycling more than bulk membrane recycling","volume":"272","author":"Presley","year":"1997","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0655","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/j.1600-0854.2006.00475.x","article-title":"Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic","volume":"7","author":"Pryor","year":"2006","journal-title":"Traffic"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0660","doi-asserted-by":"crossref","first-page":"F1245","DOI":"10.1152\/ajprenal.90522.2008","article-title":"TRPMLs: in sickness and in health","volume":"296","author":"Puertollano","year":"2009","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0665","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1096\/fj.201601290R","article-title":"NAADP-mediated Ca(2+) signaling promotes autophagy and protects against LPS-induced liver injury","volume":"31","author":"Rah","year":"2017","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0670","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ceca.2016.08.002","article-title":"Biphasic regulation of lysosomal exocytosis by oxidative stress","volume":"60","author":"Ravi","year":"2016","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0675","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1083\/jcb.137.1.93","article-title":"Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells","volume":"137","author":"Rodriguez","year":"1997","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0680","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.15252\/embj.201490009","article-title":"Expression of Ca(2)(+)-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells","volume":"34","author":"Ruas","year":"2015","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0685","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cub.2010.02.049","article-title":"Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking","volume":"20","author":"Ruas","year":"2010","journal-title":"Current Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0690","doi-asserted-by":"crossref","first-page":"20407","DOI":"10.1074\/jbc.M112.359612","article-title":"Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1","volume":"287","author":"Rybalchenko","year":"2012","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0695","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.1258758","article-title":"Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment","volume":"347","author":"Sakurai","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0700","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.devcel.2013.08.003","article-title":"A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis","volume":"26","author":"Samie","year":"2013","journal-title":"Developmental Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0705","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ydbio.2006.02.008","article-title":"Basis of lethality in C. elegans lacking CUP-5, the Mucolipidosis Type IV orthologue","volume":"293","author":"Schaheen","year":"2006","journal-title":"Developmental Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0710","doi-asserted-by":"crossref","first-page":"21219","DOI":"10.1074\/jbc.C110.143123","article-title":"Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes","volume":"285","author":"Schieder","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0715","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ccr.2013.05.008","article-title":"Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor","volume":"24","author":"Schumacher","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0720","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/bies.201000108","article-title":"Ion flux and the function of endosomes and lysosomes: pH is just the start: the flux of ions across endosomal membranes influences endosome function not only through regulation of the luminal pH","volume":"33","author":"Scott","year":"2011","journal-title":"Bioessays"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0725","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1038\/s41467-019-13572-w","article-title":"TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKbeta\/VPS34 pathway","volume":"10","author":"Scotto Rosato","year":"2019","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0730","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"Settembre","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0735","first-page":"1","article-title":"Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block","author":"Sharma","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0740","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1073\/pnas.0308061100","article-title":"The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress","volume":"101","author":"Shaw","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0745","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/ncomms1735","article-title":"Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release","volume":"3","author":"Shen","year":"2012","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0750","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1111\/jth.12361","article-title":"Protease-activated receptor-2 induces migration of pancreatic cancer cells in an extracellular ATP-dependent manner","volume":"11","author":"Shi","year":"2013","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0755","doi-asserted-by":"crossref","first-page":"8709","DOI":"10.1074\/jbc.R110.210005","article-title":"Ion channel regulation by protein palmitoylation","volume":"286","author":"Shipston","year":"2011","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0760","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1085\/jgp.201411176","article-title":"Ion channel regulation by protein S-acylation","volume":"143","author":"Shipston","year":"2014","journal-title":"The Journal of General Physiology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0765","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1086\/302549","article-title":"Mapping of the mucolipidosis type IV gene to chromosome 19p and definition of founder haplotypes","volume":"65","author":"Slaugenhaupt","year":"1999","journal-title":"American Journal of Human Genetics"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0770","doi-asserted-by":"crossref","first-page":"252","DOI":"10.2174\/156652413804810772","article-title":"The role of calcium stores in apoptosis and autophagy","volume":"13","author":"Smaili","year":"2013","journal-title":"Current Molecular Medicine"},{"issue":"Pt 2","key":"10.1016\/j.pharmthera.2020.107713_bb0775","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1242\/jcs.113.2.183","article-title":"Rab GTPases coordinate endocytosis","volume":"113","author":"Somsel Rodman","year":"2000","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0780","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.ejcb.2006.08.004","article-title":"TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytes","volume":"85","author":"Song","year":"2006","journal-title":"European Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0785","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1074\/jbc.M508211200","article-title":"TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity","volume":"281","author":"Soyombo","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0790","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3389\/fimmu.2020.00225","article-title":"TRPML Cation Channels in Inflammation and Immunity","volume":"11","author":"Spix","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0795","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.4049\/jimmunol.1500163","article-title":"Novel Role of TRPML2 in the Regulation of the Innate Immune Response","volume":"195","author":"Sun","year":"2015","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0800","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1093\/hmg\/9.17.2471","article-title":"Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel","volume":"9","author":"Sun","year":"2000","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0805","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.4161\/auto.7.11.17759","article-title":"CUP-5, the C. elegans ortholog of the mammalian lysosomal channel protein MLN1\/TRPML1, is required for proteolytic degradation in autolysosomes","volume":"7","author":"Sun","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0810","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.yexcr.2018.07.013","article-title":"TPC2 mediates autophagy progression and extracellular vesicle secretion in cancer cells","volume":"370","author":"Sun","year":"2018","journal-title":"Experimental Cell Research"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0815","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/15548627.2017.1389822","article-title":"A negative feedback regulation of MTORC1 activity by the lysosomal Ca(2+) channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism","volume":"14","author":"Sun","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0820","first-page":"275","article-title":"Molecular mechanisms of membrane fusion during acrosomal exocytosis","volume":"65","author":"Tomes","year":"2007","journal-title":"Society of Reproduction and Fertility Supplement"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0825","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/01.RES.0000256090.42690.05","article-title":"AMP-activated protein kinase in metabolic control and insulin signaling","volume":"100","author":"Towler","year":"2007","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0830","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1534\/genetics.114.162982","article-title":"Identification of a novel gene for diabetic traits in rats, mice, and humans","volume":"198","author":"Tsaih","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0835","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1523\/JNEUROSCI.3085-18.2019","article-title":"Increased Lysosomal Exocytosis Induced by Lysosomal Ca(2+) Channel Agonists Protects Human Dopaminergic Neurons from alpha-Synuclein Toxicity","volume":"39","author":"Tsunemi","year":"2019","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0840","doi-asserted-by":"crossref","first-page":"24925","DOI":"10.1074\/jbc.M110.129833","article-title":"TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle","volume":"285","author":"Tugba Durlu-Kandilci","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0845","doi-asserted-by":"crossref","first-page":"18262","DOI":"10.1074\/jbc.M109.087858","article-title":"The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction","volume":"285","author":"Vasudevan","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"issue":"25","key":"10.1016\/j.pharmthera.2020.107713_bb9955","doi-asserted-by":"crossref","first-page":"17517","DOI":"10.1074\/jbc.M600807200","article-title":"Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1","volume":"281","author":"Venkatachalam","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0850","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cell.2008.09.041","article-title":"Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells","volume":"135","author":"Venkatachalam","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0855","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4161\/auto.22260","article-title":"Feast or famine: role of TRPML in preventing cellular amino acid starvation","volume":"9","author":"Venkatachalam","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0860","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ceca.2014.10.008","article-title":"The role of TRPMLs in endolysosomal trafficking and function","volume":"58","author":"Venkatachalam","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0865","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1600-0854.2006.00387.x","article-title":"Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomes","volume":"7","author":"Vergarajauregui","year":"2006","journal-title":"Traffic"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0870","doi-asserted-by":"crossref","first-page":"832","DOI":"10.4161\/auto.6567","article-title":"Mucolipidosis type IV: The importance of functional lysosomes for efficient autophagy","volume":"4","author":"Vergarajauregui","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0875","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s11064-015-1558-5","article-title":"AMPK activation affects glutamate metabolism in astrocytes","volume":"40","author":"Voss","year":"2015","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0880","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1074\/jbc.M111.306563","article-title":"Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg","volume":"287","author":"Walseth","year":"2012","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0885","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2012.08.036","article-title":"TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes","volume":"151","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0890","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1083\/jcb.130.4.821","article-title":"Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump","volume":"130","author":"van Weert","year":"1995","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0895","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.devcel.2011.02.006","article-title":"LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis","volume":"20","author":"Weidberg","year":"2011","journal-title":"Developmental Cell"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0900","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.cub.2012.06.055","article-title":"Drosophila TRPML is required for TORC1 activation","volume":"22","author":"Wong","year":"2012","journal-title":"Current Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0905","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-physiol-021014-071649","article-title":"Lysosomal physiology","volume":"77","author":"Xu","year":"2015","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0910","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ceca.2019.02.010","article-title":"The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways","volume":"79","author":"Xu","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0915","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejcb.2019.05.001","article-title":"Lysosomal Ca(2+) release channel TRPML1 regulates lysosome size by promoting mTORC1 activity","volume":"98","author":"Yang","year":"2019","journal-title":"European Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0920","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41421-020-0141-7","article-title":"Lysosome biology in autophagy","volume":"6","author":"Yim","year":"2020","journal-title":"Cell Discovery"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0925","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/pr.57.4.13","article-title":"Overview of molecular relationships in the voltage-gated ion channel superfamily","volume":"57","author":"Yu","year":"2005","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0930","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nature09076","article-title":"Termination of autophagy and reformation of lysosomes regulated by mTOR","volume":"465","author":"Yu","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0935","doi-asserted-by":"crossref","first-page":"eaaz2736","DOI":"10.1126\/sciadv.aaz2736","article-title":"Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models","volume":"6","author":"Yu","year":"2020","journal-title":"Science Advances"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0940","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/path.2587","article-title":"A potentially dynamic lysosomal role for the endogenous TRPML proteins","volume":"219","author":"Zeevi","year":"2009","journal-title":"The Journal of Pathology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0945","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1242\/jcs.067330","article-title":"Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy","volume":"123","author":"Zeevi","year":"2010","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0950","doi-asserted-by":"crossref","first-page":"12109","DOI":"10.1038\/ncomms12109","article-title":"MCOLN1 is a ROS sensor in lysosomes that regulates autophagy","volume":"7","author":"Zhang","year":"2016","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0955","doi-asserted-by":"crossref","first-page":"11384","DOI":"10.1073\/pnas.1202194109","article-title":"Phosphoinositide isoforms determine compartment-specific ion channel activity","volume":"109","author":"Zhang","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0960","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.canlet.2010.01.010","article-title":"Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression","volume":"293","author":"Zhang","year":"2010","journal-title":"Cancer Letters"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0965","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/nsmb.3502","article-title":"Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states","volume":"24","author":"Zhou","year":"2017","journal-title":"Nature Structural & Molecular Biology"},{"key":"10.1016\/j.pharmthera.2020.107713_bb0970","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00424-009-0690-y","article-title":"The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores","volume":"458","author":"Zong","year":"2009","journal-title":"Pfl\u00fcgers Archiv"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725820302448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725820302448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:12:09Z","timestamp":1759011129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725820302448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":195,"alternative-id":["S0163725820302448"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107713","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107713"}}