{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T14:08:33Z","timestamp":1794578913783,"version":"4.9.1"},"reference-count":240,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P-32397"],"award-info":[{"award-number":["P-32397"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["721484"],"award-info":[{"award-number":["721484"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","award":["P-32397"],"award-info":[{"award-number":["P-32397"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","award":["721484"],"award-info":[{"award-number":["721484"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["P-32397"],"award-info":[{"award-number":["P-32397"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["721484"],"award-info":[{"award-number":["721484"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["P-32397"],"award-info":[{"award-number":["P-32397"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["721484"],"award-info":[{"award-number":["721484"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.pharmthera.2021.107970","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T10:54:25Z","timestamp":1629888865000},"page":"107970","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Lipopolysaccharide lipid A: A promising molecule for new immunity-based therapies and antibiotics"],"prefix":"10.1016","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7124-1790","authenticated-orcid":false,"given":"Pilar","family":"Garcia-Vello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4821-0114","authenticated-orcid":false,"given":"Flaviana","family":"Di Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5677-1344","authenticated-orcid":false,"given":"Daniele","family":"Zucchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-3522","authenticated-orcid":false,"given":"Alla","family":"Zamyatina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5147-1756","authenticated-orcid":false,"given":"Cristina","family":"De Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3456-7369","authenticated-orcid":false,"given":"Antonio","family":"Molinaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2021.107970_bb0005","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1021\/jm500946r","article-title":"Development of aGlcN(1\u21941)aMan-based lipid A mimetics as a novel class of potent toll-like receptor 4 agonists","volume":"57","author":"Adanitsch","year":"2014","journal-title":"Journal of Medicinal Chemistry"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0008-6215(96)00019-5","article-title":"Analysis of the polysaccharide components of the lipopolysaccharide fraction of Pseudomonas caryophylli","volume":"284","author":"Adinolfi","year":"1996","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0020","doi-asserted-by":"crossref","first-page":"6759","DOI":"10.1016\/j.bmc.2006.05.051","article-title":"Synthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activities","volume":"14","author":"Akamatsu","year":"2006","journal-title":"Bioorganic & Medicinal Chemistry"},{"issue":"3","key":"10.1016\/j.pharmthera.2021.107970_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms7030068","article-title":"Microbial population changes and their relationship with human health and disease","volume":"7","author":"\u00c1lvarez-Mercado","year":"2019","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/nyas.14244","article-title":"Structure and function of lipid A\u2013modifying enzymes","volume":"1459","author":"Anandan","year":"2020","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"3","key":"10.1016\/j.pharmthera.2021.107970_bb0035","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1021\/acschembio.7b00822","article-title":"A Peptidomimetic antibiotic interacts with the periplasmic domain of LptD from Pseudomonas aeruginosa","volume":"13","author":"Andolina","year":"2018","journal-title":"ACS Chemical Biology"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041144","article-title":"Glucopyranosyl lipid adjuvant (GLA), a synthetic tlr4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with hivgp140","volume":"7","author":"Arias","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0045","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/ajad.12867","article-title":"Preclinical efficacy of an anti-methamphetamine vaccine using E6020 adjuvant","volume":"28","author":"Arora","year":"2019","journal-title":"American Journal on Addictions"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0050","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1021\/cb4003199","article-title":"Conformationally constrained lipid A mimetics for exploration of structural basis of TLR4\/MD-2 activation by lipopolysaccharide","volume":"8","author":"Artner","year":"2013","journal-title":"ACS Chemical Biology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0055","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-319-31248-4_4","article-title":"The oral microbiota","volume":"902","author":"Arweiler","year":"2016","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"12","key":"10.1016\/j.pharmthera.2021.107970_bb0060","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1021\/bi6025165","article-title":"Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli","volume":"46","author":"Barb","year":"2007","journal-title":"Biochemistry"},{"issue":"10","key":"10.1016\/j.pharmthera.2021.107970_bb0065","first-page":"1726","article-title":"Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA","volume":"197","author":"Barker","year":"2013","journal-title":"Bioorganic and Medicinal Chemistry Letters"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0070","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1517\/17425255.2011.558190","article-title":"Eritoran tetrasodium (E5564) treatment for sepsis: Review of preclinical and clinical studies","volume":"7","author":"Barochia","year":"2011","journal-title":"Expert Opinion on Drug Metabolism & Toxicology"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0075","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00066-19","article-title":"2-hydroxylation of acinetobacter baumannii lipid a contributes to virulence","volume":"87","author":"Bartholomew","year":"2019","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jconrel.2018.02.006","article-title":"Immune response to antigen adsorbed to aluminum hydroxide particles: Effects of co-adsorption of ALF or ALFQ adjuvant to the aluminum-antigen complex","volume":"275","author":"Beck","year":"2018","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0085","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jinorgbio.2015.08.007","article-title":"The adsorption of allergoids and 3-O-desacyl-4\u2032-monophosphoryl lipid A (MPL) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy","volume":"152","author":"Bell","year":"2015","journal-title":"Journal of Inorganic Biochemistry"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0090","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.str.2019.11.020","article-title":"Structure and ligand-binding properties of the O antigen ABC transporter carbohydrate-binding domain","volume":"28","author":"Bi","year":"2020","journal-title":"Structure"},{"issue":"7749","key":"10.1016\/j.pharmthera.2021.107970_bb0095","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/d41586-019-00802-w","article-title":"Ratcheting up lipopolysaccharide transport","volume":"567","author":"Bishop","year":"2019","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.pharmthera.2021.107970_bb0100","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1093\/emboj\/19.19.5071","article-title":"Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria","volume":"19","author":"Bishop","year":"2000","journal-title":"EMBO Journal"},{"issue":"8","key":"10.1016\/j.pharmthera.2021.107970_bb0105","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Canadian Journal of Biochemistry and Physiology"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1158\/1940-6207.CAPR-17-0349","article-title":"Pharmacological TLR4 antagonism using topical resatorvid blocks solar UV-induced skin tumorigenesis in SKH-1 mice","volume":"11","author":"Blohm-Mangone","year":"2018","journal-title":"Cancer Prevention Research"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0115","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/cmdc.201800505","article-title":"Disaccharide-based anionic amphiphiles as potent inhibitors of lipopolysaccharide-induced inflammation","volume":"13","author":"Borio","year":"2018","journal-title":"ChemMedChem"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad bugs, no drugs: No ESKAPE! An update from the Infectious Diseases Society of America","volume":"48","author":"Boucher","year":"2009","journal-title":"Clinical Infectious Diseases"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0125","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.neuroscience.2008.10.004","article-title":"The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain","volume":"158","author":"Cao","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0130","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aas9930","article-title":"The adjuvant GLA-AF enhances human intradermal vaccine responses","volume":"4","author":"Carter","year":"2018","journal-title":"Science Advances"},{"issue":"12","key":"10.1016\/j.pharmthera.2021.107970_bb0135","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1007\/s13361-017-1805-x","article-title":"New features in the lipid A structure of Brucella suis and Brucella abortus lipopolysaccharide","volume":"28","author":"Casabuono","year":"2017","journal-title":"Journal of the American Society for Mass Spectrometry"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0140","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1473-3099(18)30605-4","article-title":"Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European economic area in 2015: A population-level modelling analysis","volume":"19","author":"Cassini","year":"2019","journal-title":"The Lancet Infectious Diseases"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0145","doi-asserted-by":"crossref","first-page":"246","DOI":"10.4103\/2319-4170.130922","article-title":"Mammalian gut immunity","volume":"37","author":"Chassaing","year":"2014","journal-title":"Biomedical Journal"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0150","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.imbio.2017.10.016","article-title":"TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, \u22126, \u22127 and \u22129 via either STAT3 and ERK1\/2 in AGS cells","volume":"223","author":"Chavarr\u00eda-Vel\u00e1zquez","year":"2018","journal-title":"Immunobiology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0155","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.molimm.2015.07.037","article-title":"Species and mediator specific TLR4 antagonism in primary human and murine immune cells by bGlcN(1-1)aGlcN based lipid A mimetics","volume":"67","author":"Chebrolu","year":"2015","journal-title":"Molecular Immunology"},{"issue":"9","key":"10.1016\/j.pharmthera.2021.107970_bb0160","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1128\/IAI.01150-12","article-title":"Adjuvant activity of naturally occurring monophosphoryl lipopolysaccharide preparations from mucosa-associated bacteria","volume":"81","author":"Chilton","year":"2013","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0165","doi-asserted-by":"crossref","first-page":"36112","DOI":"10.1038\/srep36112","article-title":"Novel toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth","volume":"6","author":"Chin","year":"2016","journal-title":"Scientific Reports"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0170","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: At the interface of health and disease","volume":"13","author":"Cho","year":"2012","journal-title":"Nature Reviews Genetics"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4014\/jmb.1804.03051","article-title":"Antimicrobial agents that inhibit the outer membrane assembly machines of gram-negative bacteria","volume":"29","author":"Choi","year":"2019","journal-title":"Journal of Microbiology and Biotechnology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0180","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1472-6882-14-89","article-title":"Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4\/MD-2 receptor","volume":"14","author":"Chu","year":"2014","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"6","key":"10.1016\/j.pharmthera.2021.107970_bb0185","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1128\/AAC.46.6.1793-1799.2002","article-title":"Antibacterial activities and characterization of novel inhibitors of LpxC","volume":"46","author":"Clements","year":"2002","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"25","key":"10.1016\/j.pharmthera.2021.107970_bb0190","article-title":"Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFN\u03b3 response promoting vaccine immunogenicity","volume":"2","author":"Coccia","year":"2017","journal-title":"Npj Vaccines"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016333","article-title":"Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant","volume":"6","author":"Coler","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0205","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nri2056","article-title":"Siglecs and their roles in the immune system","volume":"7","author":"Crocker","year":"2007","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0210","series-title":"Gas chromatography - mass spectrometry for glycosciences","author":"De Castro","year":"2014"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0215","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0076-6879(10)80005-9","article-title":"Microbe-associated molecular patterns in innate immunity. Extraction and chemical analysis of gram-negative bacterial lipopolysaccharides","volume":"480","author":"De Castro","year":"2010","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0220","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.molimm.2011.08.003","article-title":"From agonist to antagonist: Structure and dynamics of innate immune glycoprotein MD-2 upon recognition of variably acylated bacterial endotoxins","volume":"49","author":"DeMarco","year":"2011","journal-title":"Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0225","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1021\/ja029316s","article-title":"Synthesis and biological evaluation of Rhizobium sin-1 lipid A derivatives","volume":"125","author":"Demchenko","year":"2003","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0230","doi-asserted-by":"crossref","first-page":"15049","DOI":"10.1038\/srep15049","article-title":"Induction of Mincle by helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy","volume":"5","author":"Devi","year":"2015","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0235","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00046-17","article-title":"Total lipopolysaccharide from the human gut microbiome silences toll-like receptor Signalling","volume":"2","author":"d\u2019Hennezel","year":"2017","journal-title":"MSystems"},{"issue":"11","key":"10.1016\/j.pharmthera.2021.107970_bb0240","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s10482-017-0865-z","article-title":"The lipopolysaccharide lipid A structure from the marine sponge-associated bacterium Pseudoalteromonas sp. 2A","volume":"110","author":"Di Lorenzo","year":"2017","journal-title":"Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0245","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/femsre\/fuz002","article-title":"Lipopolysaccharide structures of gram-negative populations in the gut microbiota and effects on host interactions","volume":"43","author":"Di Lorenzo","year":"2019","journal-title":"FEMS Microbiology Reviews"},{"issue":"35","key":"10.1016\/j.pharmthera.2021.107970_bb0250","doi-asserted-by":"crossref","first-page":"21305","DOI":"10.1074\/jbc.M115.649087","article-title":"Activation of human toll-like receptor 4 (TLR4)\u00b7myeloid differentiation factor 2 (MD-2) by hypoacylated lipopolysaccharide from a clinical isolate of Burkholderia cenocepacia","volume":"290","author":"Di Lorenzo","year":"2015","journal-title":"Journal of Biological Chemistry"},{"issue":"15","key":"10.1016\/j.pharmthera.2021.107970_bb0255","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1002\/chem.201604379","article-title":"The lipid A from Rhodopseudomonas palustris strain BisA53 LPS possesses a unique structure and low Immunostimulant properties","volume":"23","author":"Di Lorenzo","year":"2017","journal-title":"Chemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0260","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.carres.2016.03.026","article-title":"The structure of the lipooligosaccharide from Xanthomonas oryzae pv. Oryzae: The causal agent of the bacterial leaf blight in rice","volume":"427","author":"Di Lorenzo","year":"2016","journal-title":"Carbohydrate Research"},{"issue":"9","key":"10.1016\/j.pharmthera.2021.107970_bb0265","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1021\/acscentsci.0c00791","article-title":"Pairing bacteroides vulgatus LPS structure with its immunomodulatory effects on human cellular models","volume":"6","author":"Di Lorenzo","year":"2020","journal-title":"ACS Central Science"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0270","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.molimm.2014.04.004","article-title":"Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity","volume":"63","author":"Di Lorenzo","year":"2015","journal-title":"Molecular Immunology"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0275","first-page":"1920","article-title":"Enhancement of adaptive immunity by the human vaccine adjuvant AS01 depends on activated dendritic cells","volume":"193","author":"Didierlaurent","year":"2014","journal-title":"Journal of Immunology (Baltimore, Md.\u202f: 1950)"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0280","doi-asserted-by":"crossref","DOI":"10.1080\/14760584.2016.1213632","article-title":"Adjuvant system AS01: Helping to overcome the challenges of modern vaccines","volume":"16","author":"Didierlaurent","year":"2017","journal-title":"Expert Review of Vaccines"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0285","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF01049915","article-title":"A systematic nomenclature for carbohydrate fragmentations in FAB-MS\/MS spectra of glycoconjugates","volume":"5","author":"Domon","year":"1988","journal-title":"Glycoconjugate Journal"},{"issue":"11","key":"10.1016\/j.pharmthera.2021.107970_bb0290","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.bbalip.2017.08.003","article-title":"Structural insight into lipopolysaccharide transport from the gram-negative bacterial inner membrane to the outer membrane","volume":"1862","author":"Dong","year":"2017","journal-title":"Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0295","series-title":"Advances in experimental medicine and biology","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-024-0890-4_7","article-title":"Pathology and pathogenesis of Yersinia pestis","author":"Du","year":"2016"},{"issue":"49\u201350","key":"10.1016\/j.pharmthera.2021.107970_bb0300","doi-asserted-by":"crossref","first-page":"7167","DOI":"10.1016\/j.vaccine.2006.06.053","article-title":"A controlled clinical trial comparing the safety and immunogenicity of a new adjuvanted hepatitis B vaccine with a standard hepatitis B vaccine","volume":"24","author":"Dupont","year":"2006","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0305","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1080\/21645515.2020.1834807","article-title":"Safety and immunogenicity of an adjuvanted Escherichia coli adhesin vaccine in healthy women with and without histories of recurrent urinary tract infections: Results from a first-in-human phase 1 study","volume":"17","author":"Eldridge","year":"2021","journal-title":"Human Vaccines & Immunotherapeutics"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0315","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1177\/09680519030090060201","article-title":"Pseudomonas aeruginosa lipid A diversity and its recognition by toll-like receptor 4","volume":"9","author":"Ernst","year":"2003","journal-title":"Journal of Endotoxin Research"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0320","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000191413","article-title":"The roles of toll-like receptors in atherosclerosis","volume":"1","author":"Erridge","year":"2009","journal-title":"Journal of Innate Immunity"},{"issue":"8","key":"10.1016\/j.pharmthera.2021.107970_bb0325","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1286-4579(02)01604-0","article-title":"Structure and function of lipopolysaccharides","volume":"4","author":"Erridge","year":"2002","journal-title":"Microbes and Infection"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb0330","doi-asserted-by":"crossref","first-page":"a025304","DOI":"10.1101\/cshperspect.a025304","article-title":"Antibacterial drug discovery targeting the lipopolysaccharide biosynthetic enzyme LpxC","volume":"6","author":"Erwin","year":"2016","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0335","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10571-016-0356-1","article-title":"Neuroprotective effects of resatorvid against traumatic brain injury in rat: Involvement of neuronal autophagy and TLR4 signalling pathway","volume":"37","author":"Feng","year":"2017","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0340","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1039\/c3mb25477a","article-title":"Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses","volume":"9","author":"Fujimoto","year":"2013","journal-title":"Molecular BioSystems"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0345","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.carres.2012.03.013","article-title":"Synthesis and immunomodulatory activities of helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A","volume":"356","author":"Fujimoto","year":"2012","journal-title":"Carbohydrate Research"},{"issue":"11","key":"10.1016\/j.pharmthera.2021.107970_bb0350","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1046\/j.1432-1327.2000.01335.x","article-title":"Structure of the sialic acid-containing O-specific polysaccharide from Salmonella enterica serovar Toucra O48 lipopolysaccharide","volume":"267","author":"Gamian","year":"2000","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0355","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/prot.24223","article-title":"Lipid A from lipopolysaccharide recognition: Structure, dynamics and cooperativity by molecular dynamics simulations","volume":"81","author":"Garate","year":"2013","journal-title":"Proteins: Structure, Function, and Bioinformatics"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0360","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1177\/1753425914550426","article-title":"Anti-endotoxic activity and structural basis for human MD-2\u00b7TLR4 antagonism of tetraacylated lipid A mimetics based on bGlcN(1<\u2212>1)aGlcN scaffold","volume":"21","author":"Garate","year":"2015","journal-title":"Innate Immunity"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0365","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81003-X","article-title":"Mg2+ as an extracellular signal: Environmental regulation of Salmonella virulence","volume":"84","author":"Garc\u00eda V\u00e9scovi","year":"1996","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb0370","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/cbic.202000751","article-title":"Structure of the O-antigen and the lipid A from the lipopolysaccharide of Fusobacterium nucleatum ATCC 51191","volume":"22","author":"Garcia-Vello","year":"2020","journal-title":"Chembiochem"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0375","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ddtec.2020.09.005","article-title":"Carbohydrate-based adjuvants","volume":"35-36","author":"Garcia-Vello","year":"2020","journal-title":"Drug Discov Today Technol."},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0380","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1586\/14760584.6.5.723","article-title":"GlaxoSmithKline adjuvant systems in vaccines: Concepts, achievements and perspectives","volume":"6","author":"Gar\u00e7on","year":"2007","journal-title":"Expert Review of Vaccines"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0385","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/21645515.2016.1225635","article-title":"From discovery to licensure, the adjuvant system story","volume":"13","author":"Gar\u00e7on","year":"2017","journal-title":"Human Vaccines & Immunotherapeutics"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0390","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1586\/erv.11.29","article-title":"Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems","volume":"10","author":"Gar\u00e7on","year":"2011","journal-title":"Expert Review of Vaccines"},{"issue":"26","key":"10.1016\/j.pharmthera.2021.107970_bb0395","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1021\/bi060823m","article-title":"Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase","volume":"45","author":"Gennadios","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0400","series-title":"Sialic acids and sialoglycoconjugates in the biology of life, health and disease","first-page":"1","article-title":"Sialic acid and biology of life: An introduction","author":"Ghosh","year":"2020"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0405","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.carres.2012.02.027","article-title":"Synthesis of lipopolysaccharide O-antigens by ABC transporter-dependent pathways","volume":"356","author":"Greenfield","year":"2012","journal-title":"Carbohydrate Research"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0410","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nrmicro2537","article-title":"The skin microbiome","volume":"9","author":"Grice","year":"2011","journal-title":"Nature Reviews Microbiology"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0415","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejcb.2009.10.002","article-title":"Glycosyltransferases involved in the biosynthesis of the inner core region of different lipopolysaccharides","volume":"89","author":"Gronow","year":"2010","journal-title":"European Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0420","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.3389\/fmicb.2017.01162","article-title":"Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity","volume":"8","author":"Gupta","year":"2017","journal-title":"Frontiers in Microbiology"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb0425","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1073\/pnas.1415955112","article-title":"Inhibition of the \u03b2-barrel assembly machine by a peptide that binds BamD","volume":"112","author":"Hagan","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0430","first-page":"1129","article-title":"Structural investigation on the lipopolysaccharide of Escherichia coli rough mutant F653 representing the R3 core type","volume":"207","author":"Haishima","year":"1992","journal-title":"European Journal of Biochemistry"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0435","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/j.1365-2958.2012.08154.x","article-title":"Aminoarabinose is essential for lipopolysaccharide export and intrinsic antimicrobial peptide resistance in Burkholderia cenocepacia","volume":"85","author":"Hamad","year":"2012","journal-title":"Molecular Microbiology"},{"issue":"9","key":"10.1016\/j.pharmthera.2021.107970_bb0440","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1021\/jacs.9b13530","article-title":"Two distinct mechanisms of inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis","volume":"142","author":"Han","year":"2020","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.pharmthera.2021.107970_bb3002","first-page":"35","article-title":"Microbiome in inflammatory arthritis and human rheumatic diseases","volume":"68","author":"Han","year":"2013","journal-title":"Arthritis Rheumatol"},{"issue":"43","key":"10.1016\/j.pharmthera.2021.107970_bb0445","doi-asserted-by":"crossref","first-page":"21748","DOI":"10.1073\/pnas.1912345116","article-title":"A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier","volume":"116","author":"Hart","year":"2019","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb0450","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1128\/IAI.01273-09","article-title":"Characterization of the specific interaction between sialoadhesin and sialylated campylobacter jejuni lipooligosaccharides","volume":"78","author":"Heikema","year":"2010","journal-title":"Infection and Immunity"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0455","first-page":"12","article-title":"Tailored modulation of cellular pro-inflammatory responses with disaccharide Lipid A mimetics","author":"Heine","year":"2021","journal-title":"Frontiers in Immunology"},{"issue":"9","key":"10.1016\/j.pharmthera.2021.107970_bb0460","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092680","article-title":"Structural basis for the lipopolysaccharide export activity of the bacterial lipopolysaccharide transport system","volume":"19","author":"Hicks","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"issue":"7704","key":"10.1016\/j.pharmthera.2021.107970_bb0465","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41586-018-0083-5","article-title":"Structural basis for dual-mode inhibition of the ABC transporter MsbA","volume":"557","author":"Ho","year":"2018","journal-title":"Nature"},{"issue":"76","key":"10.1016\/j.pharmthera.2021.107970_bb0470","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4052\/tigg.14.87","article-title":"Chemical structure of the core region of lipopolysaccharides - an update","volume":"14","author":"Holst","year":"2002","journal-title":"Trends in Glycoscience and Glycotechnology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0475","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/B978-0-12-374546-0.00003-1","article-title":"Core region and lipid A components of lipopolysaccharides","author":"Holst","year":"2010","journal-title":"Microbial Glycobiology"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0480","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1432-1033.1994.tb18856.x","article-title":"Preparation and structural analysis of oligosaccharide monophosphates obtained from the lipopolysaccharide of recombinant strains of Salmonella Minnesota and Escherichia coli expressing the genus-specific epitope of Chlamydia lipopolysaccharide","volume":"222","author":"Holst","year":"1994","journal-title":"European Journal of Biochemistry"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0485","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00154-17","article-title":"Progress in our understanding of Wzx flippase for translocation of bacterial membrane lipid-linked oligosaccharide","volume":"200","author":"Hong","year":"2018","journal-title":"Journal of Bacteriology"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0490","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.immuni.2008.05.016","article-title":"Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms","volume":"29","author":"Hou","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0495","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/s41565-018-0271-3","article-title":"A malaria vaccine adjuvant based on recombinant antigen binding to liposomes","volume":"13","author":"Huang","year":"2018","journal-title":"Nature Nanotechnology"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0500","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.atherosclerosis.2015.08.010","article-title":"A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development","volume":"242","author":"Huggins","year":"2015","journal-title":"Atherosclerosis"},{"issue":"7402","key":"10.1016\/j.pharmthera.2021.107970_bb0505","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Human Microbiome Project Consortium","year":"2012","journal-title":"Nature"},{"issue":"33","key":"10.1016\/j.pharmthera.2021.107970_bb0510","doi-asserted-by":"crossref","first-page":"11187","DOI":"10.1523\/JNEUROSCI.0684-12.2012","article-title":"Opioid activation of toll-like receptor 4 contributes to drug reinforcement","volume":"32","author":"Hutchinson","year":"2012","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0515","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-019-1791-1","article-title":"A new antibiotic selectively kills gram-negative pathogens","volume":"576","author":"Imai","year":"2019","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0520","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1586\/14760584.6.5.773","article-title":"E6020: A synthetic toll-like receptor 4 agonist as a vaccine adjuvant","volume":"6","author":"Ishizaka","year":"2007","journal-title":"Expert Review of Vaccines"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0525","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/S0960-894X(02)00362-1","article-title":"Lipid A structures containing novel lipid moieties: Synthesis and adjuvant properties","volume":"12","author":"Jiang","year":"2002","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0530","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/0968051907079121","article-title":"Investigation of the chemical structure and biological activity of oligosaccharides isolated from rough-type Xanthomonas campestris pv. Campestris B100 lipopolysaccharide","volume":"13","author":"Kaczy\u0144ski","year":"2007","journal-title":"Journal of Endotoxin Research"},{"issue":"15","key":"10.1016\/j.pharmthera.2021.107970_bb0535","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1128\/JB.180.15.3891-3899.1998","article-title":"Chemical structure of lipid A isolated from Flavobacterium meningosepticum lipopolysaccharide","volume":"180","author":"Kato","year":"1998","journal-title":"Journal of Bacteriology"},{"issue":"6","key":"10.1016\/j.pharmthera.2021.107970_bb0540","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/09680519040100061001","article-title":"Deacylation and palmitoylation of lipid A by salmonellae outer membrane enzymes modulate host signalling through toll-like receptor 4","volume":"10","author":"Kawasaki","year":"2004","journal-title":"Journal of Endotoxin Research"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0545","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/sj.bjp.0702596","article-title":"E5531, a synthetic non-toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide","volume":"127","author":"Kawata","year":"1999","journal-title":"British Journal of Pharmacology"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0550","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00430-014-0356-z","article-title":"Influence of Brucella abortus lipopolysaccharide as an adjuvant on the immunogenicity of HPV-16 L1VLP vaccine in mice","volume":"204","author":"Kianmehr","year":"2015","journal-title":"Medical Microbiology and Immunology"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0555","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cell.2007.08.002","article-title":"Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran","volume":"130","author":"Kim","year":"2007","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0560","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2174\/1570159X15666170915141036","article-title":"The microbiota-gut-brain axis in neuropsychiatric disorders: Pathophysiological mechanisms and novel treatments","volume":"16","author":"Kim","year":"2018","journal-title":"Current Neuropharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2021.107970_bb0565","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chembiol.2017.12.011","article-title":"Lipoprotein signal peptidase inhibitors with antibiotic properties identified through design of a robust in vitro HT platform","volume":"25","author":"Kitamura","year":"2018","journal-title":"Cell Chemical Biology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0570","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s12272-017-0985-z","article-title":"Comparison of the adjuvanticity of two adjuvant formulations containing de-O-acylated lipooligosaccharide on Japanese encephalitis vaccine in mice","volume":"41","author":"Ko","year":"2018","journal-title":"Archives of Pharmacal Research"},{"issue":"10","key":"10.1016\/j.pharmthera.2021.107970_bb0575","first-page":"1200","article-title":"Structure of an acidic O-specific polysaccharide of the marine bacterium Pseudoalteromonas agarivorans KMM 232 (R-form)","volume":"63","author":"Komandrova","year":"2010","journal-title":"Biochemistry (Moscow)"},{"issue":"9","key":"10.1016\/j.pharmthera.2021.107970_bb0580","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1128\/IAI.00123-12","article-title":"Phosphate groups of lipid a are essential for Salmonella enterica serovar typhimurium virulence and affect innate and adaptive immunity","volume":"80","author":"Kong","year":"2012","journal-title":"Infection and Immunity"},{"issue":"28","key":"10.1016\/j.pharmthera.2021.107970_bb0585","first-page":"e6614","article-title":"Inhibitor of intramembrane protease RseP blocks the \u03c3E response causing lethal accumulation of unfolded outer membrane proteins","volume":"115","author":"Konovalova","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0590","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ni.f.203","article-title":"Protein-glycan interactions in the control of innate and adaptive immune responses","volume":"9","author":"van Kooyk","year":"2008","journal-title":"Nature Immunology"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0595","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/vaccines5040034","article-title":"TLR4 signalling pathway modulators as potential therapeutics in inflammation and sepsis","volume":"5","author":"Kuzmich","year":"2017","journal-title":"Vaccines"},{"issue":"15","key":"10.1016\/j.pharmthera.2021.107970_bb0600","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1128\/JB.01536-07","article-title":"Modulation of hexa-acyl pyrophosphate lipid A population under Escherichia coli phosphate (pho) regulon activation","volume":"190","author":"Lamarche","year":"2008","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0605","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mimet.2015.12.004","article-title":"Direct detection of lipid A on intact gram-negative bacteria by MALDI-TOF mass spectrometry","volume":"120","author":"Larrouy-Maumus","year":"2016","journal-title":"Journal of Microbiological Methods"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0610","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jnutbio.2009.11.011","article-title":"Emulsified lipids increase endotoxemia: Possible role in early postprandial low-grade inflammation","volume":"22","author":"Laugerette","year":"2011","journal-title":"Journal of Nutritional Biochemistry"},{"issue":"9","key":"10.1016\/j.pharmthera.2021.107970_bb0615","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11095-018-2453-y","article-title":"Development of a virosomal RSV vaccine containing 3D-PHAD\u00ae adjuvant: Formulation, composition, and long-term stability","volume":"35","author":"Lederhofer","year":"2018","journal-title":"Pharmaceutical Research"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0620","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.chembiol.2010.11.011","article-title":"Species-specific and inhibitor-dependent conformations of LpxC: Implications for antibiotic design","volume":"18","author":"Lee","year":"2011","journal-title":"Chemistry and Biology"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0625","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.imlet.2009.05.006","article-title":"Partial role of TLR4 as a receptor responding to damage-associated molecular pattern","volume":"125","author":"Lee","year":"2009","journal-title":"Immunology Letters"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0630","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3390\/antibiotics8040163","article-title":"Countering gram-negative antibiotic resistance: Recent progress in disrupting the outer membrane with novel therapeutics","volume":"8","author":"Lehman","year":"2019","journal-title":"Antibiotics"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0635","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.3389\/fimmu.2018.01888","article-title":"Bradyrhizobium lipid A: Immunological properties and molecular basis of its binding to the myeloid differentiation protein-2\/toll-like receptor 4 complex","volume":"9","author":"Lembo-Fazio","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0640","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1574-6976.2002.tb00597.x","article-title":"O-antigen structural variation: Mechanisms and possible roles in animal\/plant-microbe interactions","volume":"26","author":"Lerouge","year":"2002","journal-title":"FEMS Microbiology Reviews"},{"issue":"39","key":"10.1016\/j.pharmthera.2021.107970_bb0645","doi-asserted-by":"crossref","first-page":"66656","DOI":"10.18632\/oncotarget.19105","article-title":"The role of toll-like receptor 4 in tumor microenvironment","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0650","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jconrel.2020.04.031","article-title":"Bacterial outer membrane vesicles as a platform for biomedical applications: An update","volume":"323","author":"Li","year":"2020","journal-title":"Journal of Controlled Release"},{"issue":"7674","key":"10.1016\/j.pharmthera.2021.107970_bb0660","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature23889","article-title":"Strains, functions and dynamics in the expanded human microbiome project","volume":"550","author":"Lloyd-Price","year":"2017","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.pharmthera.2021.107970_bb0665","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1002\/cbic.201900087","article-title":"Human macrophage galactose-type lectin (MGL) recognizes the outer core of Escherichia coli Lipooligosaccharide","volume":"20","author":"Maalej","year":"2019","journal-title":"ChemBioChem"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0670","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/rcm.760","article-title":"New results on matrix-assisted laser desorption\/ionization mass spectrometry of widely polydisperse hydrosoluble polymers","volume":"16","author":"Malvagna","year":"2002","journal-title":"Rapid Communications in Mass Spectrometry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0675","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrmicro.2017.14","article-title":"The microbiota of the respiratory tract: Gatekeeper to respiratory health","volume":"15","author":"Man","year":"2017","journal-title":"Nature Reviews Microbiology"},{"issue":"3","key":"10.1016\/j.pharmthera.2021.107970_bb0680","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1089\/mdr.2014.0035","article-title":"Deciphering the metabolism of undecaprenyl-phosphate: The bacterial cell-wall unit carrier at the membrane frontier","volume":"20","author":"Manat","year":"2014","journal-title":"Microbial Drug Resistance"},{"issue":"22","key":"10.1016\/j.pharmthera.2021.107970_bb0685","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.1021\/jacs.8b02283","article-title":"Novobiocin enhances Polymyxin activity by stimulating lipopolysaccharide transport","volume":"140","author":"Mandler","year":"2018","journal-title":"Journal of the American Chemical Society"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0690","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/MAJ.0b013e31823ea228","article-title":"The microbiota of the vagina and its influence on women\u2019s health and disease","volume":"343","author":"Martin","year":"2012","journal-title":"American Journal of the Medical Sciences"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0695","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3390\/ijms21020379","article-title":"Recent advances in lipopolysaccharide recognition systems","volume":"21","author":"Mazgaeen","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0700","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1021\/acs.biochem.9b01086","article-title":"The fellowship of the rings: Macrocyclic antibiotic peptides reveal an anti-gram-negative target","volume":"59","author":"McLaughlin","year":"2020","journal-title":"Biochemistry"},{"issue":"6","key":"10.1016\/j.pharmthera.2021.107970_bb0705","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1128\/JB.02352-14","article-title":"Small-molecule inhibitors of gram-negative lipoprotein trafficking discovered by phenotypic screening","volume":"197","author":"McLeod","year":"2015","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0710","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.4049\/jimmunol.1101397","article-title":"Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions","volume":"187","author":"Meng","year":"2011","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0715","doi-asserted-by":"crossref","first-page":"8695","DOI":"10.1074\/jbc.M109.075127","article-title":"MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation","volume":"285","author":"Meng","year":"2009","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0720","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1038\/ncomms4125","article-title":"TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins","volume":"5","author":"Meseguer","year":"2014","journal-title":"Nature Communications"},{"issue":"7671","key":"10.1016\/j.pharmthera.2021.107970_bb0725","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature23649","article-title":"Structural basis of MsbA-mediated lipopolysaccharide transport","volume":"549","author":"Mi","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.pharmthera.2021.107970_bb0730","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1110\/ps.073324108","article-title":"Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor","volume":"17","author":"Mochalkin","year":"2008","journal-title":"Protein Science"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0735","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.1016\/S0040-4020(00)00684-0","article-title":"Lipid A-type pyrancarboxylic acid derivatives, their synthesis and their biological activities","volume":"56","author":"Mochizuki","year":"2000","journal-title":"Tetrahedron"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0740","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0008-6215(99)00326-2","article-title":"Synthesis and biological activities of lipid A-type pyrancarboxylic acid derivatives","volume":"324","author":"Mochizuki","year":"2000","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0745","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-030-16373-0_5","article-title":"Mechanisms of Polymyxin resistance","volume":"1145","author":"Moffatt","year":"2019","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0750","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/chem.201403923","article-title":"Chemistry of lipid a: At the heart of innate immunity","volume":"21","author":"Molinaro","year":"2015","journal-title":"Chemistry - A European Journal"},{"issue":"3","key":"10.1016\/j.pharmthera.2021.107970_bb0755","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/annrheumdis-2019-216487","article-title":"Efficacy and safety of NI-0101, an anti-toll-like receptor 4 monoclonal antibody, in patients with rheumatoid arthritis after inadequate response to methotrexate: A phase II study","volume":"79","author":"Monnet","year":"2019","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0760","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1432-1033.1991.tb16036.x","article-title":"Structural analysis of the lipid A component of campylobacter jejuni CCUG 10936 (serotype O:2) lipopolysaccharide: Description of a lipid A containing a hybrid backbone of 2-amino-2-deoxy-D-glucose and 2,3-diamino-2,3-dideoxy-D-glucose","volume":"198","author":"Moran","year":"1991","journal-title":"European Journal of Biochemistry"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0765","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0008-6215(00)00280-9","article-title":"Structure of an acidic polysaccharide from a marine bacterium Pseudoalteromonas distincta KMM 638 containing 5-acetamido-3,5,7,9-tetradeoxy-7-formamido-L-glycero-L-manno-nonulosonic acid","volume":"330","author":"Muldoon","year":"2001","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0770","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1124\/jpet.102.044487","article-title":"Inhibition of endotoxin response by E5564, a novel toll-like receptor 4-directed endotoxin antagonist","volume":"304","author":"Mullarkey","year":"2003","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb0775","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.3390\/ijms22073303","article-title":"Granulibacter bethesdensis, a pathogen from patients with chronic granulomatous disease, produces a Penta-Acylated Hypostimulatory Glycero-D-talo-oct-2-ulosonic acid\u2013lipid A glycolipid (Ko-lipid A)","volume":"22","author":"Muszy\u0144ski","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0780","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01680-17","article-title":"Lipopolysaccharide from crypt-specific core microbiota modulates the colonic epithelial proliferation-to-differentiation balance","volume":"8","author":"Naito","year":"2017","journal-title":"MBio"},{"issue":"10","key":"10.1016\/j.pharmthera.2021.107970_bb0785","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1128\/JB.02552-14","article-title":"Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay","volume":"197","author":"Nayar","year":"2015","journal-title":"Journal of Bacteriology"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0790","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02151-17","article-title":"A novel inhibitor of the LolCDE ABC transporter essential for lipoprotein trafficking in gram-negative Bacteria","volume":"62","author":"Nickerson","year":"2018","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0795","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12806","article-title":"Activation of lpxR gene through enterohaemorrhagic Escherichia coli virulence regulators mediates lipid A modification to attenuate innate immune response","volume":"20","author":"Ogawa","year":"2018","journal-title":"Cellular Microbiology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0800","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.1139111","article-title":"Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa","volume":"316","author":"Ohto","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0805","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1073\/pnas.1201193109","article-title":"Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4\/MD-2","volume":"109","author":"Ohto","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"10.1016\/j.pharmthera.2021.107970_bb0810","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1001\/jama.2013.2194","article-title":"Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: The ACCESS randomized trial","volume":"309","author":"Opal","year":"2013","journal-title":"JAMA\u202f: The Journal of the American Medical Association"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0815","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.ijbiomac.2018.08.035","article-title":"Structure and inflammatory activity of the LPS isolated from Acetobacter pasteurianus CIP10310","volume":"119","author":"Pallach","year":"2018","journal-title":"International Journal of Biological Macromolecules"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb0820","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/1753425918798904","article-title":"The synthetic glycolipid-based TLR4 antagonist FP7 negatively regulates in vitro and in vivo haematopoietic and non-haematopoietic vascular TLR4 signalling","volume":"24","author":"Palmer","year":"2018","journal-title":"Innate Immunity"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb0825","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1080\/07391102.2019.1624296","article-title":"Homology modeling, docking and structure-based virtual screening for new inhibitor identification of Klebsiella pneumoniae heptosyltransferase-III","volume":"38","author":"Panda","year":"2019","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0830","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/nature07830","article-title":"The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex","volume":"458","author":"Park","year":"2009","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.pharmthera.2021.107970_bb0835","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2013.97","article-title":"Recognition of lipopolysaccharide pattern by TLR4 complexes","volume":"45","author":"Park","year":"2013","journal-title":"Experimental and Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0840","doi-asserted-by":"crossref","first-page":"861","DOI":"10.3389\/fimmu.2017.00861","article-title":"Macrophage inducible C-type lectin as a multifunctional player in immunity","volume":"8","author":"Patin","year":"2017","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb0845","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10719-020-09954-8","article-title":"A chronic strain of the cystic fibrosis pathogen Pandoraea pulmonicola expresses a heterogenous hypo-acylated lipid A","volume":"38","author":"Pither","year":"2021","journal-title":"Glycoconjugate Journal"},{"issue":"15","key":"10.1016\/j.pharmthera.2021.107970_bb0850","doi-asserted-by":"crossref","first-page":"11222","DOI":"10.1074\/jbc.275.15.11222","article-title":"Characterization of a novel lipid A containing D-galacturonic acid that replaces phosphate residues. The structure of the lipid A of the lipopolysaccharide from the hyperthermophilic bacterium Aquifex pyrophilus","volume":"275","author":"Pl\u00f6tz","year":"2000","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0855","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/mmi.13872","article-title":"Expanding the paradigm for the outer membrane: Acinetobacter baumannii in the absence of endotoxin","volume":"107","author":"Powers","year":"2018","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0860","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.immuni.2018.07.016","article-title":"A map of toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns","volume":"49","author":"Price","year":"2018","journal-title":"Immunity"},{"issue":"19","key":"10.1016\/j.pharmthera.2021.107970_bb0865","doi-asserted-by":"crossref","first-page":"11808","DOI":"10.1016\/S0021-9258(18)33836-5","article-title":"Purification and structural determination of nontoxic lipid A obtained from the lipopolysaccharide of Salmonella typhimurium","volume":"257","author":"Qureshi","year":"1982","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0870","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.biochem.71.110601.135414","article-title":"Lipopolysaccharide Endotoxins","volume":"71","author":"Raetz","year":"2002","journal-title":"Annual Review of Biochemistry"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0875","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/09680519010070010201","article-title":"Regulated covalent modifications of lipid A","volume":"7","author":"Raetz","year":"2001","journal-title":"Journal of Endotoxin Research"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0880","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.biochem.76.010307.145803","article-title":"Lipid A modification systems in gram-negative bacteria","volume":"76","author":"Raetz","year":"2007","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0885","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1016\/S0021-9258(17)42924-3","article-title":"The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli","volume":"259","author":"Ray","year":"1984","journal-title":"Journal of Biological Chemistry"},{"issue":"8","key":"10.1016\/j.pharmthera.2021.107970_bb0890","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/CCM.0b013e3181e7c5c9","article-title":"A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis","volume":"38","author":"Rice","year":"2010","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0895","first-page":"7","article-title":"Folded synthetic peptides and other molecules targeting outer membrane protein complexes in gram-negative bacteria","author":"Robinson","year":"2019","journal-title":"Frontiers in Chemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0900","doi-asserted-by":"crossref","first-page":"26050","DOI":"10.3402\/mehd.v26.26050","article-title":"The composition of the gut microbiota throughout life, with an emphasis on early life","volume":"26","author":"Rodr\u00edguez","year":"2015","journal-title":"Microbial Ecology in Health and Disease"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb0905","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1073\/pnas.0808146106","article-title":"Protection from lethal gram-negative bacterial sepsis by targeting toll-like receptor 4","volume":"106","author":"Roger","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0910","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6215(00)82666-X","article-title":"Identification of a 2,3-diamino-2,3-dideoxyhexose in the lipid a component of lipopolysaccharides of Rhodopseudomonas viridis and Rhodopseudomonas palustris","volume":"40","author":"Roppel","year":"1975","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0915","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nature Reviews Immunology"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb0920","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/mmi.14085","article-title":"Escherichia coli and Pseudomonas aeruginosa lipopolysaccharide O-antigen ligases share similar membrane topology and biochemical properties","volume":"110","author":"Ruan","year":"2018","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0925","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cell.2009.07.024","article-title":"Learning tolerance while fighting ignorance","volume":"138","author":"Sansonetti","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0930","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1002\/chem.200400376","article-title":"Synthesis and biological evaluation of a lipid A derivative that contains an aminogluconate moiety","author":"Santhanam","year":"2004","journal-title":"Chemistry - A European Journal"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0935","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.vaccine.2015.10.027","article-title":"Schistosomiasis vaccine candidate Sm14\/GLA-SE: Phase 1 safety and immunogenicity clinical trial in healthy, male adults","volume":"34","author":"Santini-Oliveira","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0940","doi-asserted-by":"crossref","first-page":"L329","DOI":"10.1152\/ajplung.00014.2005","article-title":"Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide","volume":"289","author":"Savov","year":"2005","journal-title":"American Journal of Physiology - Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0945","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3389\/fimmu.2013.00387","article-title":"Targeting toll-like receptors: Promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases","volume":"4","author":"Savva","year":"2013","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0950","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2249.2007.03346.x","article-title":"Toll-like receptor 4-dependent recognition of structurally different forms of chemically synthesized lipid As of Porphyromonas gingivalis","volume":"148","author":"Sawada","year":"2007","journal-title":"Clinical and Experimental Immunology"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb0955","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3390\/pharmaceutics13040501","article-title":"Rational vaccine design in times of emerging diseases: The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation","volume":"13","author":"Schijns","year":"2021","journal-title":"Pharmaceutics"},{"issue":"30","key":"10.1016\/j.pharmthera.2021.107970_bb0960","doi-asserted-by":"crossref","first-page":"27502","DOI":"10.1074\/jbc.M303012200","article-title":"The obligate predatory Bdellovibrio bacteriovorus possesses a neutral lipid a containing \u03b1-D-mannoses that replace phosphate residues. Similarities and differences between the lipid As and the lipopolysaccharides of the wild type strain B. bacteriovorus H","volume":"278","author":"Schwudke","year":"2003","journal-title":"Journal of Biological Chemistry"},{"issue":"10","key":"10.1016\/j.pharmthera.2021.107970_bb0965","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1046\/j.1432-1033.2000.01326.x","article-title":"Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity","volume":"267","author":"Seydel","year":"2000","journal-title":"European Journal of Biochemistry"},{"issue":"16","key":"10.1016\/j.pharmthera.2021.107970_bb0970","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1016\/j.bmc.2013.04.020","article-title":"Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli","volume":"21","author":"Sherman","year":"2013","journal-title":"Bioorganic and Medicinal Chemistry"},{"issue":"7521","key":"10.1016\/j.pharmthera.2021.107970_bb0975","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0980","doi-asserted-by":"crossref","first-page":"14464","DOI":"10.1002\/chem.201003581","article-title":"Chemical synthesis of helicobacter pylori lipopolysaccharide partial structures and their selective proinflammatory responses","volume":"17","author":"Shimoyama","year":"2011","journal-title":"Chemistry - A European Journal"},{"key":"10.1016\/j.pharmthera.2021.107970_bb0985","doi-asserted-by":"crossref","first-page":"5101","DOI":"10.1016\/j.tet.2005.03.034","article-title":"Synthesis of lipid A analogues containing glucose instead of glucosamine and their LPS-antagonistic activities","volume":"61","author":"Shiozaki","year":"2005","journal-title":"Tetrahedron"},{"issue":"7450","key":"10.1016\/j.pharmthera.2021.107970_bb0990","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12118","article-title":"The TLR4 antagonist Eritoran protects mice from lethal influenza infection","volume":"497","author":"Shirey","year":"2013","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb0995","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000414","article-title":"The bacterial cell envelope","volume":"2","author":"Silhavy","year":"2010","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1000","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.carbpol.2014.08.037","article-title":"Structural and conformational study of the O-polysaccharide produced by the metabolically versatile photosynthetic bacterium Rhodopseudomonas palustris strain BisA53","volume":"114","author":"Silipo","year":"2014","journal-title":"Carbohydrate Polymers"},{"issue":"12","key":"10.1016\/j.pharmthera.2021.107970_bb1005","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1194\/jlr.D200021-JLR200","article-title":"Ammonium hydroxide hydrolysis: A valuable support in the MALDI-TOF mass spectrometry analysis of lipid A fatty acid distribution","volume":"43","author":"Silipo","year":"2002","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-90-481-9078-2_4","article-title":"The diversity of the core oligosaccharide in lipopolysaccharides","volume":"53","author":"Silipo","year":"2010","journal-title":"Sub-Cellular Biochemistry"},{"issue":"7722","key":"10.1016\/j.pharmthera.2021.107970_bb1020","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41586-018-0483-6","article-title":"Optimized arylomycins are a new class of gram-negative antibiotics","volume":"561","author":"Smith","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1025","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/rcm.1350","article-title":"New fragmentation mechanisms in matrix-assisted laser desorption\/ionization time-of-flight\/time-of-flight tandem mass spectrometry of carbohydrates","volume":"18","author":"Spina","year":"2004","journal-title":"Rapid Communications in Mass Spectrometry"},{"issue":"6675","key":"10.1016\/j.pharmthera.2021.107970_bb1030","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/33046","article-title":"Meningitis bacterium is viable without endotoxin","volume":"392","author":"Steeghs","year":"1998","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.pharmthera.2021.107970_bb1035","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.ymthe.2019.07.007","article-title":"Weak agonistic LPS restores intestinal immune homeostasis","volume":"27","author":"Steimle","year":"2019","journal-title":"Molecular Therapy\u202f: the Journal of the American Society of Gene Therapy"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb1040","doi-asserted-by":"crossref","first-page":"e00517","DOI":"10.1128\/JB.00517-18","article-title":"The Escherichia coli -barrel assembly machinery is sensitized to perturbations under high membrane fluidity","volume":"201","author":"Storek","year":"2019","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1045","doi-asserted-by":"crossref","first-page":"25400","DOI":"10.1074\/jbc.M400596200","article-title":"Oxidation and transamination of the 3\u2033-position of UDP-N-acetylglucosamine by enzymes from Acidithiobacillus ferrooxidans: Role in the formation of lipid a molecules with four amide-linked acyl chains","volume":"279","author":"Sweet","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1050","doi-asserted-by":"crossref","first-page":"25411","DOI":"10.1074\/jbc.M400597200","article-title":"Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains: LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3\u2033-hydroxyl group","volume":"279","author":"Sweet","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb1055","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/j.1476-5381.2009.00297.x","article-title":"Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model","volume":"157","author":"Takashima","year":"2009","journal-title":"British Journal of Pharmacology"},{"issue":"12","key":"10.1016\/j.pharmthera.2021.107970_bb3001","doi-asserted-by":"crossref","first-page":"7379","DOI":"10.1016\/S0021-9258(18)32190-2","article-title":"Fatty acyl derivatives of glucosamine 1-phosphate in Escherichia coli and their relation to lipid A. Complete structure of A diacyl GlcN-1-P found in a phosphatidylglycerol-deficient mutant","volume":"258","author":"Takayama","year":"1983","journal-title":"J Biol Chem."},{"key":"10.1016\/j.pharmthera.2021.107970_bb1060","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/apm.12927","article-title":"Immunogenicity of HPV and HBV vaccines: Adjuvanticity of synthetic analogs of monophosphoryl lipid A combined with aluminum hydroxide","volume":"127","author":"Taleghani","year":"2019","journal-title":"APMIS"},{"key":"10.1016\/j.pharmthera.2021.107970_bb3003","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2018.00783","article-title":"Outer membrane vesicles: Current status and future direction of these novel vaccine adjuvants","author":"Tan","year":"2018"},{"issue":"11","key":"10.1016\/j.pharmthera.2021.107970_bb1065","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1070","doi-asserted-by":"crossref","first-page":"43122","DOI":"10.1074\/jbc.M106961200","article-title":"An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: Induction in polymyxin-resistant mutants and role of a novel lipid-linked donor","volume":"276","author":"Trent","year":"2001","journal-title":"Journal of Biological Chemistry"},{"issue":"10","key":"10.1016\/j.pharmthera.2021.107970_bb1075","doi-asserted-by":"crossref","first-page":"a025288","DOI":"10.1101\/cshperspect.a025288","article-title":"Polymyxin: Alternative mechanisms of action and resistance","volume":"6","author":"Trimble","year":"2016","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"issue":"7","key":"10.1016\/j.pharmthera.2021.107970_bb1080","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/glycob\/8.7.675","article-title":"Newly found 2-N-acetyl-2,6-dideoxy-\u03b2-glucopyranose containing methyl glucose polysaccharides in M. bovis BCG: Revised structure of the mycobacterial methyl glucose lipopolysaccharides","volume":"8","author":"Tuffal","year":"1998","journal-title":"Glycobiology"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb1085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149610","article-title":"A novel synthetic TLR-4 agonist adjuvant increases the protective response to a clinical-stage West Nile virus vaccine antigen in multiple formulations","volume":"11","author":"Van Hoeven","year":"2016","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.pharmthera.2021.107970_bb1090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000625","article-title":"Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses","volume":"5","author":"Van Vliet","year":"2009","journal-title":"PLoS Pathogens"},{"issue":"5","key":"10.1016\/j.pharmthera.2021.107970_bb1095","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.cell.2016.04.015","article-title":"Bacterial outer membrane vesicles mediate cytosolic localization of LPS and Caspase-11 activation","volume":"165","author":"Vanaja","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1100","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fimmu.2014.00316","article-title":"A comparative review of toll-like receptor 4 expression and functionality in different animal species","volume":"5","author":"Vaure","year":"2014","journal-title":"Frontiers in Immunology"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2021.107970_bb1105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0008-6215(97)10029-5","article-title":"Structural studies on the lipopolysaccharide from a rough strain of Ochrobactrum anthropi containing a 2,3-diamino-2,3-dideoxy-D-glucose disaccharide lipid A backbone","volume":"306","author":"Velasco","year":"1998","journal-title":"Carbohydrate Research"},{"issue":"11","key":"10.1016\/j.pharmthera.2021.107970_bb1110","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau2634","article-title":"Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli","volume":"4","author":"Vetterli","year":"2018","journal-title":"Science Advances"},{"issue":"3","key":"10.1016\/j.pharmthera.2021.107970_bb1115","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.bbrc.2009.09.007","article-title":"Identification and characterization of novel TRPV4 modulators","volume":"389","author":"Vincent","year":"2009","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb1120","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0008-6215(00)00312-8","article-title":"The structure of the carbohydrate backbone of the core-lipid A region of the lipopolysaccharide from Proteus penneri strain 40: New Proteus strains containing open-chain acetal-linked N-acetylgalactosamine in the core part of the LPS","volume":"330","author":"Vinogradov","year":"2001","journal-title":"Carbohydrate Research"},{"issue":"1","key":"10.1016\/j.pharmthera.2021.107970_bb1125","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1432-1033.1997.00082.x","article-title":"Structural investigation of the lipopolysaccharide from Acinetobacter haemolyticus strain NCTC 10305 (ATCC 17906, DNA group 4)","volume":"247","author":"Vinogradov","year":"1997","journal-title":"European Journal of Biochemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1749-6632.1995.tb44448.x","article-title":"Immunologic adjuvants for modern vaccine formulations","volume":"754","author":"Vogel","year":"1995","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"20","key":"10.1016\/j.pharmthera.2021.107970_bb1135","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1021\/acs.orglett.0c02961","article-title":"Synthesis of l-glycero- and d-glycero-d-manno-Heptose building blocks for stereoselective assembly of the lipopolysaccharide Core Trisaccharide of Vibrio parahemolyticus O2","volume":"22","author":"Wang","year":"2020","journal-title":"Organic Letters"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1140","first-page":"E884","article-title":"TLR4\/MD-2 activation by a synthetic agonist with no similarity to LPS","volume":"113","author":"Wang","year":"2016","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1145","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1096-9888(199602)31:2<138::AID-JMS263>3.0.CO;2-Y","article-title":"Acid and base hydrolysis of lipid A from Enterobacter agglomerans as monitored by electrospray ionization mass spectrometry: Pertinence to detoxification mechanisms","volume":"31","author":"Wang","year":"1996","journal-title":"Journal of Mass Spectrometry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1150","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0008-6215(02)00357-9","article-title":"Synthesis of lipid A type carboxymethyl derivatives with ether chains instead of ester chains and their LPS-antagonistic activities","volume":"338","author":"Watanabe","year":"2003","journal-title":"Carbohydrate Research"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1155","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-biochem-060713-035600","article-title":"Biosynthesis and export of bacterial lipopolysaccharides","volume":"83","author":"Whitfield","year":"2014","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1160","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.REV120.009402","article-title":"Lipopolysaccharide O-antigens - bacterial glycans made to measure","author":"Whitfield","year":"2020","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.pharmthera.2021.107970_bb1165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tim.2012.10.001","article-title":"Synthase-dependent exopolysaccharide secretion in gram-negative bacteria","volume":"21","author":"Whitney","year":"2013","journal-title":"Trends in Microbiology"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1170","series-title":"Global priority list of antibiotic-resistant batceria to guide research, discovery, and development of new antibiotics","author":"WHO","year":"2017"},{"key":"10.1016\/j.pharmthera.2021.107970_bb6001","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11596-019-2044-0","article-title":"Lipopolysaccharide Inhibits FI-RSV Vaccine-enhanced Inflammation Through Regulating Th Responses","volume":"39","author":"Yin","year":"2019","journal-title":"Current Medical Science"},{"issue":"4","key":"10.1016\/j.pharmthera.2021.107970_bb1175","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ijantimicag.2018.11.016","article-title":"Identification of an anti-gram-negative bacteria agent disrupting the interaction between lipopolysaccharide transporters LptA and LptC","volume":"53","author":"Zhang","year":"2019","journal-title":"International Journal of Antimicrobial Agents"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1180","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/chem.200701165","article-title":"Innate immune responses of synthetic lipid A derivatives of Neisseria meningitidis","volume":"14","author":"Zhang","year":"2008","journal-title":"Chemistry - A European Journal"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1185","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1039\/b809090d","article-title":"Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4","volume":"6","author":"Zhang","year":"2008","journal-title":"Organic & Biomolecular Chemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1190","doi-asserted-by":"crossref","first-page":"526965","DOI":"10.3389\/fimmu.2020.526965","article-title":"Respiratory syncytial virus F subunit vaccine with AS02 adjuvant elicits balanced, robust humoral and cellular immunity in BALB\/c mice","volume":"11","author":"Zheng","year":"2020","journal-title":"Frontiers in Immunology"},{"issue":"46","key":"10.1016\/j.pharmthera.2021.107970_bb1195","doi-asserted-by":"crossref","first-page":"43111","DOI":"10.1074\/jbc.M106960200","article-title":"Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PmrA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation","volume":"276","author":"Zhou","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1200","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1038\/s41467-020-17992-x","article-title":"Chemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus","volume":"11","author":"Zhu","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2021.107970_bb1205","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0008-6215(89)84063-7","article-title":"Lipopolysaccharides of Proteus penneri species novum","volume":"188","author":"Zych","year":"1989","journal-title":"Carbohydrate Research"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725821001728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725821001728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:19:49Z","timestamp":1759011589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725821001728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":240,"alternative-id":["S0163725821001728"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2021.107970","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipopolysaccharide lipid A: A promising molecule for new immunity-based therapies and antibiotics","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2021.107970","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107970"}}