{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T16:00:24Z","timestamp":1794412824618,"version":"4.9.1"},"reference-count":173,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900644"],"award-info":[{"award-number":["31900644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971243"],"award-info":[{"award-number":["81971243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071238"],"award-info":[{"award-number":["82071238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82122068"],"award-info":[{"award-number":["82122068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20180619"],"award-info":[{"award-number":["BK20180619"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20181459"],"award-info":[{"award-number":["BK20181459"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20200026"],"award-info":[{"award-number":["BK20200026"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["JUSRP121009"],"award-info":[{"award-number":["JUSRP121009"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.pharmthera.2022.108176","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T21:02:19Z","timestamp":1648242139000},"page":"108176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":239,"special_numbering":"C","title":["Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy"],"prefix":"10.1016","volume":"238","author":[{"given":"Xiaohua","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Long","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2022.108176_bb0005","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1093\/ecco-jcc\/jjab031","article-title":"Restored macrophage function ameliorates disease pathophysiology in a mouse model for IL10 receptor-deficient very early onset inflammatory bowel disease","volume":"15","author":"Ackermann","year":"2021","journal-title":"Journal of Crohns & Colitis"},{"issue":"5","key":"10.1016\/j.pharmthera.2022.108176_bb0010","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.ajpath.2018.01.011","article-title":"Microbiota-derived indole metabolites promote human and murine intestinal homeostasis through regulation of interleukin-10 receptor","volume":"188","author":"Alexeev","year":"2018","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0015","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jff.2018.11.019","article-title":"Arginine supplementation reduces colonic injury, inflammation and oxidative stress of DSS-induced colitis in mice","volume":"52","author":"Andrade","year":"2019","journal-title":"Journal of Functional Foods"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190074","article-title":"Knockdown of myeloid cell hypoxia-inducible factor-1\u03b1 ameliorates the acute pathology in DSS-induced colitis","volume":"12","author":"B\u00e4cker","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0025","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni.2967","article-title":"Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice","volume":"15","author":"Bain","year":"2014","journal-title":"Nature Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/imr.12192","article-title":"Macrophages in intestinal homeostasis and inflammation","volume":"260","author":"Bain","year":"2014","journal-title":"Immunological Reviews"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0035","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.3389\/fimmu.2018.02733","article-title":"Origin, differentiation, and function of intestinal macrophages","volume":"9","author":"Bain","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0040","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/mi.2012.89","article-title":"Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors","volume":"6","author":"Bain","year":"2013","journal-title":"Mucosal Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0045","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1053\/j.gastro.2020.08.029","article-title":"Succinate produced by intestinal microbes promotes specification of Tuft cells to suppress ileal inflammation","volume":"159","author":"Banerjee","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0050","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf9232","article-title":"Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity","volume":"373","author":"Bang","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0055","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1172\/JCI76099","article-title":"Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage","volume":"125","author":"Barrett","year":"2015","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0060","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.clnu.2012.03.002","article-title":"Conjugated linoleic acid modulates immune responses in patients with mild to moderately active Crohn\u2019s disease","volume":"31","author":"Bassaganya-Riera","year":"2012","journal-title":"Clinical Nutrition"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0070","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1053\/j.gastro.2004.06.049","article-title":"Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease","volume":"127","author":"Bassaganya-Riera","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031238","article-title":"Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR \u03b3 to suppress colitis","volume":"7","author":"Bassaganya-Riera","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0080","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1093\/ecco-jcc\/jjab076.159","article-title":"P030 SUCNR1 mediates inflammasome activation: Relevance in ulcerative colitis","volume":"15","author":"Bauset","year":"2021","journal-title":"Journal of Crohns & Colitis"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0085","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.it.2021.07.006","article-title":"Regional specialization of macrophages along the gastrointestinal tract","volume":"42","author":"Berthold","year":"2021","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0090","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4049\/jimmunol.1700183","article-title":"The bile acid receptor GPBAR1 regulates the M1\/M2 phenotype of intestinal macrophages and activation of GPBAR1 rescues mice from murine colitis","volume":"199","author":"Biagioli","year":"2017","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0095","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/MPG.0000000000001812","article-title":"Fecal amino acid analysis can discriminate de novo treatment-na\u00efve pediatric inflammatory bowel disease from controls","volume":"66","author":"Bosch","year":"2018","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0100","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.molmed.2020.06.006","article-title":"Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease","volume":"26","author":"Bourgonje","year":"2020","journal-title":"Trends in Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0105","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s00125-017-4526-6","article-title":"Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses","volume":"61","author":"Boutens","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0110","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1038\/s41467-020-17750-z","article-title":"Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine","volume":"11","author":"Campesato","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107521","article-title":"Pharmacological targets of metabolism in disease: Opportunities from macrophages","volume":"210","author":"Castegna","year":"2020","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107857","article-title":"GM-CSF calibrates macrophage defense and wound healing programs during intestinal infection and inflammation","volume":"32","author":"Castro-Dopico","year":"2020","journal-title":"Cell Reports"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0125","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"111","author":"Chang","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/83336","article-title":"PPAR-\u03b3 dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation","volume":"7","author":"Chawla","year":"2001","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0135","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.cell.2019.03.036","article-title":"A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology","volume":"177","author":"Chen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0140","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/CIRCRESAHA.119.315833","article-title":"Mitochondrial metabolic reprogramming by CD36 signaling drives macrophage inflammatory responses","volume":"125","author":"Chen","year":"2019","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0145","doi-asserted-by":"crossref","first-page":"23820","DOI":"10.1038\/srep23820","article-title":"Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity","volume":"6","author":"Chng","year":"2016","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0150","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jnutbio.2011.06.002","article-title":"Pretreatment with alanyl-glutamine suppresses T-helper-cell-associated cytokine expression and reduces inflammatory responses in mice with acute DSS-induced colitis","volume":"23","author":"Chu","year":"2012","journal-title":"Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0155","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1097\/MIB.0000000000000790","article-title":"L-arginine availability and metabolism is altered in ulcerative colitis","volume":"22","author":"Coburn","year":"2016","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0165","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.chom.2019.07.002","article-title":"Mapping interactions of microbial metabolites with human G-protein-coupled receptors","volume":"26","author":"Colosimo","year":"2019","journal-title":"Cell Host & Microbe"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0170","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/nu11010025","article-title":"The role of succinate in the regulation of intestinal inflammation","volume":"11","author":"Connors","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0175","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/ibd\/izz213","article-title":"Tofacitinib reprograms human monocytes of IBD patients and healthy controls toward a more regulatory phenotype","volume":"26","author":"Cordes","year":"2020","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0180","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.07.048","article-title":"Self-maintaining gut macrophages are essential for intestinal homeostasis","volume":"175","author":"De Schepper","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cmet.2016.06.013","article-title":"Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis","volume":"24","author":"De Vadder","year":"2016","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0190","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/ibd\/izy364","article-title":"A JAK1 selective kinase inhibitor and tofacitinib affect macrophage activation and function","volume":"25","author":"De Vries","year":"2019","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0195","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.cgh.2020.06.050","article-title":"Safety of tofacitinib in a real-world cohort of patients with ulcerative colitis","volume":"19","author":"Deepak","year":"2021","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0200","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41590-019-0539-2","article-title":"Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation","volume":"21","author":"Di Gioia","year":"2020","journal-title":"Nature Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41575-019-0228-5","article-title":"Interrogating host immunity to predict treatment response in inflammatory bowel disease","volume":"17","author":"Digby-Bell","year":"2020","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0210","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.cmet.2019.01.006","article-title":"IGF-2 preprograms maturing macrophages to acquire oxidative phosphorylation-dependent anti-inflammatory properties","volume":"29","author":"Du","year":"2019","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0215","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.4049\/jimmunol.1601520","article-title":"Efferocytosis signaling in the regulation of macrophage inflammatory responses","volume":"198","author":"Elliott","year":"2017","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0220","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008051","article-title":"Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice","volume":"6","author":"Faith","year":"2014","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0225","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/S0140-6736(21)00666-8","article-title":"Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): A phase 2b\/3 double-blind, randomised, placebo-controlled trial","volume":"397","author":"Feagan","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0230","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.4049\/jimmunol.1800085","article-title":"The TLR4 agonist monophosphoryl lipid a drives broad resistance to infection via dynamic reprogramming of macrophage metabolism","volume":"200","author":"Fensterheim","year":"2018","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0235","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.tem.2021.06.003","article-title":"Rethinking succinate: An unexpected hormone-like metabolite in energy homeostasis","volume":"32","author":"Fern\u00e1ndez-Veledo","year":"2021","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0240","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11154-019-09513-z","article-title":"Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?","volume":"20","author":"Fern\u00e1ndez-Veledo","year":"2019","journal-title":"Reviews in Endocrine and Metabolic Disorders"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109521","article-title":"A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state","volume":"36","author":"Fremder","year":"2021","journal-title":"Cell Reports"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0250","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2019.03.017","article-title":"Cytokine networks in the pathophysiology of inflammatory bowel disease","volume":"50","author":"Friedrich","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0255","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrrheum.2017.37","article-title":"Metabolic regulation of inflammation","volume":"13","author":"Gaber","year":"2017","journal-title":"Nature Reviews Rheumatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0260","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.gtc.2017.08.011","article-title":"Vitamins and minerals in inflammatory bowel disease","volume":"46","author":"Ghishan","year":"2017","journal-title":"Gastroenterology Clinics"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0270","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-020-2025-2","article-title":"Pathway paradigms revealed from the genetics of inflammatory bowel disease","volume":"578","author":"Graham","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0275","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/gutjnl-2020-322129","article-title":"Emerging treatment options for extraintestinal manifestations in IBD","volume":"70","author":"Greuter","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0280","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acs.jproteome.9b00440","article-title":"UPLC-QTOF-MS-based plasma lipidomic profiling reveals biomarkers for inflammatory bowel disease diagnosis","volume":"19","author":"Guan","year":"2020","journal-title":"Journal of Proteome Research"},{"key":"10.1016\/j.pharmthera.2022.108176_bb3001","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3389\/fcell.2021.625423","article-title":"Roles of macrophages in the development and treatment of gut inflammation","volume":"9","author":"Han","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0285","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100702R","article-title":"Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation","volume":"35","author":"Haq","year":"2021","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0290","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/S0140-6736(21)00891-6","article-title":"Expanding targeted immune modulators in ulcerative colitis","volume":"397","author":"Holmer","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0295","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/mi.2010.75","article-title":"Immunoregulatory mechanisms of macrophage PPAR-\u03b3 in mice with experimental inflammatory bowel disease","volume":"4","author":"Hontecillas","year":"2011","journal-title":"Mucosal Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2013.05.004","article-title":"Alanyl-glutamine administration suppresses Th17 and reduces inflammatory reaction in dextran sulfate sodium-induced acute colitis","volume":"17","author":"Hou","year":"2013","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0305","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1053\/j.gastro.2018.11.033","article-title":"ATF4 deficiency promotes intestinal inflammation in mice by reducing uptake of glutamine and expression of antimicrobial peptides","volume":"156","author":"Hu","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0310","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.immuni.2021.07.004","article-title":"Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn\u2019s disease","volume":"54","author":"Huang","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0315","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1053\/j.gastro.2009.12.041","article-title":"In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice","volume":"138","author":"Hunter","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0320","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/BJ20111275","article-title":"The mitochondrial citrate carrier: A new player in inflammation","volume":"438","author":"Infantino","year":"2011","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0325","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1126\/science.aal3535","article-title":"Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages","volume":"356","author":"Ip","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0330","doi-asserted-by":"crossref","first-page":"G59","DOI":"10.1152\/ajpgi.00123.2016","article-title":"Colonic macrophage polarization in homeostasis, inflammation, and cancer","volume":"311","author":"Isidro","year":"2016","journal-title":"American Journal of Physiology Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0335","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jnutbio.2016.12.019","article-title":"Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice","volume":"42","author":"Islam","year":"2017","journal-title":"Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0340","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cell.2019.05.054","article-title":"Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner","volume":"178","author":"Jaitin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0345","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.immuni.2015.02.005","article-title":"Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization","volume":"42","author":"Jha","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0350","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.4049\/jimmunol.175.10.6900","article-title":"Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria","volume":"175","author":"Kamada","year":"2005","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0355","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41590-018-0108-0","article-title":"Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization","volume":"19","author":"Kang","year":"2018","journal-title":"Nature Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0360","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","article-title":"The four epidemiological stages in the global evolution of inflammatory bowel disease","volume":"18","author":"Kaplan","year":"2021","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0365","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.4049\/jimmunol.1400347","article-title":"Crucial role of macrophage selenoproteins in experimental colitis","volume":"193","author":"Kaushal","year":"2014","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0370","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1074\/jbc.M209706200","article-title":"A G protein-coupled receptor responsive to bile acids","volume":"278","author":"Kawamata","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0375","doi-asserted-by":"crossref","first-page":"8418","DOI":"10.1073\/pnas.1808426115","article-title":"Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles","volume":"115","author":"Kayama","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0380","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1038\/s41467-019-10015-4","article-title":"Competition for nutrients and its role in controlling immune responses","volume":"10","author":"Kedia-Mehta","year":"2019","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0385","article-title":"HIF-1\u03b1 activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice","volume":"11","author":"Kim","year":"2018","journal-title":"Disease Models & Mechanism"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0390","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41590-018-0113-3","article-title":"Regulation of macrophage immunometabolism in atherosclerosis","volume":"19","author":"Koelwyn","year":"2018","journal-title":"Nature Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0395","first-page":"321","article-title":"Faecal and serum metabolomics in paediatric inflammatory bowel disease","volume":"11","author":"Kolho","year":"2017","journal-title":"Journal of Crohns & Colitis"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0400","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.it.2020.11.004","article-title":"Succinate receptor 1: An emerging regulator of myeloid cell function in inflammation","volume":"42","author":"Krzak","year":"2021","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0405","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0410","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/ecco-jcc\/jjx137","article-title":"Determinants of reduced genetic capacity for butyrate synthesis by the gut microbiome in Crohn\u2019s disease and ulcerative colitis","volume":"12","author":"Laserna-Mendieta","year":"2018","journal-title":"Journal of Crohns & Colitis"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0415","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.immuni.2019.11.009","article-title":"Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase","volume":"51","author":"Lauterbach","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0420","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites as key actors in inflammatory bowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0430","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1073\/pnas.1720758115","article-title":"Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine","volume":"115","author":"Lei","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0435","doi-asserted-by":"crossref","first-page":"G781","DOI":"10.1152\/ajpgi.00055.2013","article-title":"Bone marrow-derived alternatively activated macrophages reduce colitis without promoting fibrosis: Participation of IL-10","volume":"304","author":"Leung","year":"2013","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0440","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.20160061","article-title":"GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis","volume":"213","author":"Littlewood-Evans","year":"2016","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0445","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ni.3796","article-title":"\u03b1-Ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","volume":"18","author":"Liu","year":"2017","journal-title":"Nature Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0450","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.freeradbiomed.2020.10.029","article-title":"Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1\u03b1 upregulation and autophagy","volume":"161","author":"Liu","year":"2020","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105613","article-title":"Didymin switches M1-like toward M2-like macrophage to ameliorate ulcerative colitis via fatty acid oxidation","volume":"169","author":"Lv","year":"2021","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0460","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41385-018-0087-3","article-title":"Succinate receptor mediates intestinal inflammation and fibrosis","volume":"12","author":"Macias-Ceja","year":"2019","journal-title":"Mucosal Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0465","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/ibd\/izaa208","article-title":"Serum serotonin differentiates between disease activity states in Crohn\u2019s patients","volume":"26","author":"Manzella","year":"2020","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0470","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: Time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0475","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cmet.2019.11.014","article-title":"The untapped opportunity and challenge of immunometabolism: A new paradigm for drug discovery","volume":"31","author":"Mazumdar","year":"2020","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0480","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1172\/JCI59150","article-title":"CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice","volume":"121","author":"Medina-Contreras","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0485","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.trecan.2019.10.007","article-title":"Metabolic regulation of macrophage polarization in cancer","volume":"5","author":"Mehla","year":"2019","journal-title":"Trends in Cancer"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0490","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.cmet.2020.09.004","article-title":"The gut microbiota at the service of immunometabolism","volume":"32","author":"Michaudel","year":"2020","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0495","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tips.2020.11.006","article-title":"Tryptophan metabolism as a pharmacological target","volume":"42","author":"Modoux","year":"2021","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0500","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0505","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/CIRCRESAHA.119.312321","article-title":"Obesity, hypertension, and cardiac dysfunction: Novel roles of Immunometabolism in macrophage activation and inflammation","volume":"126","author":"Mouton","year":"2020","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0510","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.coi.2019.11.011","article-title":"Gut macrophages: Key players in intestinal immunity and tissue physiology","volume":"62","author":"Muller","year":"2020","journal-title":"Current Opinion in Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0515","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/ni.1791","article-title":"Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis","volume":"10","author":"Murai","year":"2009","journal-title":"Nature Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0520","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: Nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0525","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.4049\/jimmunol.1600745","article-title":"GM-CSF induces inflammatory macrophages by regulating glycolysis and lipid metabolism","volume":"197","author":"Na","year":"2016","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0530","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","article-title":"Macrophages in intestinal inflammation and resolution: A potential therapeutic target in IBD","volume":"16","author":"Na","year":"2019","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0535","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0540","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1053\/j.gastro.2017.08.028","article-title":"Increased tryptophan metabolism is associated with activity of inflammatory bowel diseases","volume":"153","author":"Nikolaus","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0545","doi-asserted-by":"crossref","DOI":"10.1093\/immadv\/ltab013","article-title":"Targeting immunometabolism to treat COVID-19","volume":"1","author":"O\u2019Carroll","year":"2021","journal-title":"Immunotherapy Advances"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0550","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41385-020-00356-5","article-title":"Macrophage metabolic reprogramming during chronic lung disease","volume":"14","author":"Ogger","year":"2021","journal-title":"Mucosal Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0555","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S2468-1253(20)30005-4","article-title":"Colorectal cancer in Crohn\u2019s disease: A Scandinavian population-based cohort study","volume":"5","author":"Ol\u00e9n","year":"2020","journal-title":"The Lancet Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0560","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0565","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00011-011-0340-7","article-title":"GC\/MS-based profiling of amino acids and TCA cycle-related molecules in ulcerative colitis","volume":"60","author":"Ooi","year":"2011","journal-title":"Inflammation Research"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0570","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3390\/nu9121329","article-title":"Meta-analysis of fecal microbiota and metabolites in experimental colitic mice during the inflammatory and healing phases","volume":"9","author":"Osaka","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0575","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cmet.2015.01.017","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the Warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0580","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41422-020-0291-z","article-title":"Targeting immunometabolism as an anti-inflammatory strategy","volume":"30","author":"P\u00e5lsson-McDermott","year":"2020","journal-title":"Cell Research"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0585","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.celrep.2019.06.039","article-title":"Acute iron deprivation reprograms human macrophage metabolism and reduces inflammation in vivo","volume":"28","author":"Pereira","year":"2019","journal-title":"Cell Reports"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0590","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fimmu.2014.00532","article-title":"Metabolism via arginase or nitric oxide synthase: Two competing arginine pathways in macrophages","volume":"5","author":"Rath","year":"2014","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0595","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00726-013-1551-8","article-title":"Dietary L-glutamine supplementation increases Pasteurella multocida burden and the expression of its major virulence factors in mice","volume":"45","author":"Ren","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0600","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/advances\/nmy084","article-title":"Glutamine metabolism in macrophages: A novel target for obesity\/type 2 diabetes","volume":"10","author":"Ren","year":"2019","journal-title":"Advances in Nutrition"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0605","article-title":"Serum amino acids profile and the beneficial effects of L-arginine or L-glutamine supplementation in dextran sulfate sodium colitis","volume":"9","author":"Ren","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0610","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41577-019-0124-9","article-title":"Immunometabolism at the interface between macrophages and pathogens","volume":"19","author":"Russell","year":"2019","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0615","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev-immunol-081619-104850","article-title":"Krebs cycle reborn in macrophage immunometabolism","volume":"38","author":"Ryan","year":"2020","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0620","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1053\/j.gastro.2020.01.047","article-title":"Efficacy and safety of upadacitinib in a randomized trial of patients with Crohn\u2019s disease","volume":"158","author":"Sandborn","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0625","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1053\/j.gastro.2020.02.030","article-title":"Efficacy of upadacitinib in a randomized trial of patients with active ulcerative colitis","volume":"158","author":"Sandborn","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0630","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.cgh.2018.11.035","article-title":"Safety of tofacitinib for treatment of ulcerative colitis, based on 4.4 years of data from global clinical trials","volume":"17","author":"Sandborn","year":"2019","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0635","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa1606910","article-title":"Tofacitinib as induction and maintenance therapy for ulcerative colitis","volume":"376","author":"Sandborn","year":"2017","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0640","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1021\/pr300139q","article-title":"Quantitative metabolomic profiling of serum, plasma, and urine by 1H NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals","volume":"11","author":"Schicho","year":"2012","journal-title":"Journal of Proteome Research"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0645","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.immuni.2018.12.018","article-title":"The short chain fatty acid butyrate imprints an antimicrobial program in macrophages","volume":"50","author":"Schulthess","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0650","doi-asserted-by":"crossref","first-page":"eaao4755","DOI":"10.1126\/scitranslmed.aao4755","article-title":"Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis","volume":"10","author":"Scott","year":"2018","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0655","article-title":"Macrophage metabolism in the intestine is compartment-specific and regulated by the microbiota","author":"Scott","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0660","doi-asserted-by":"crossref","first-page":"19376","DOI":"10.1073\/pnas.2000047117","article-title":"Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor","volume":"117","author":"Scott","year":"2020","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0665","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11306-017-1311-y","article-title":"Alterations in lipid, amino acid, and energy metabolism distinguish Crohn\u2019s disease from ulcerative colitis and control subjects by serum metabolomic profiling","volume":"14","author":"Scoville","year":"2018","journal-title":"Metabolomics"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0670","doi-asserted-by":"crossref","first-page":"G657","DOI":"10.1152\/ajpgi.00381.2006","article-title":"Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis","volume":"292","author":"Shah","year":"2007","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0675","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0680","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2017.09.051","article-title":"The human knockout gene CLYBL connects itaconate to vitamin B12","volume":"171","author":"Shen","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0685","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02550-18","article-title":"Biphasic dynamics of macrophage immunometabolism during mycobacterium tuberculosis infection","volume":"10","author":"Shi","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0690","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1007\/s10620-006-9473-x","article-title":"Low intestinal glutamine level and low glutaminase activity in Crohn\u2019s disease: A rational for glutamine supplementation?","volume":"51","author":"Sido","year":"2006","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0695","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fcimb.2019.00066","article-title":"Dietary arginine regulates severity of experimental colitis and affects the colonic microbiome","volume":"9","author":"Singh","year":"2019","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0700","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1172\/JCI200519229","article-title":"Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity","volume":"115","author":"Smythies","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0705","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.immuni.2016.02.016","article-title":"Macrophages and iron metabolism","volume":"44","author":"Soares","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0710","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/ibd\/izy103","article-title":"Tryptophan metabolism through the kynurenine pathway is associated with endoscopic inflammation in ulcerative colitis","volume":"24","author":"Sofia","year":"2018","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0720","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrgastro.2010.151","article-title":"Diagnosis and management of iron deficiency anemia in patients with IBD","volume":"7","author":"Stein","year":"2010","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0725","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1016\/j.crohns.2012.04.019","article-title":"Urinary NMR metabolomic profiles discriminate inflammatory bowel disease from healthy","volume":"7","author":"Stephens","year":"2013","journal-title":"Journan of Crohns & Colitis"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0730","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.immuni.2015.07.013","article-title":"Pancreatic \u03b2-cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota","volume":"43","author":"Sun","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0735","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1161\/CIRCRESAHA.119.315939","article-title":"Intracellular and intercellular aspects of macrophage immunometabolism in atherosclerosis","volume":"126","author":"Tabas","year":"2020","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0740","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.4049\/jimmunol.1203306","article-title":"IDO1 plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice","volume":"191","author":"Takamatsu","year":"2013","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0745","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0750","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.1038\/s41467-020-20164-6","article-title":"D-mannose suppresses macrophage IL-1\u03b2 production","volume":"11","author":"Torretta","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0755","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cellimm.2012.04.012","article-title":"The role of CD98hc in mouse macrophage functions","volume":"276","author":"Tsumura","year":"2012","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0760","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0765","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.it.2017.03.001","article-title":"Macrophage immunometabolism: Where are we (going)?","volume":"38","author":"Van den Bossche","year":"2017","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0770","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nrgastro.2017.101","article-title":"Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD","volume":"14","author":"Van Welden","year":"2017","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0775","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0140-6736(16)32537-5","article-title":"Clinical remission in patients with moderate-to-severe Crohn\u2019s disease treated with filgotinib (the FITZROY study): Results from a phase 2, double-blind, randomised, placebo-controlled trial","volume":"389","author":"Vermeire","year":"2017","journal-title":"The Lancet"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0785","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1038\/s41467-019-12476-z","article-title":"Interplay between the human gut microbiome and host metabolism","volume":"10","author":"Visconti","year":"2019","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0795","first-page":"1","article-title":"A guide to interrogating immunometabolism","author":"Voss","year":"2021","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0800","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tem.2012.05.001","article-title":"PPARs at the crossroads of lipid signaling and inflammation","volume":"23","author":"Wahli","year":"2012","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0805","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/j.celrep.2017.05.065","article-title":"SIRT5 desuccinylates and activates pyruvate kinase M2 to bock macrophage IL-1\u03b2 production and to prevent DSS-induced colitis in mice","volume":"19","author":"Wang","year":"2017","journal-title":"Cell Reports"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0820","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1819155","article-title":"Gut microbial bile acid metabolite skews macrophage polarization and contributes to high-fat diet-induced colonic inflammation","volume":"12","author":"Wang","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0825","doi-asserted-by":"crossref","first-page":"9029327","DOI":"10.1155\/2017\/9029327","article-title":"HIF1\u03b1-induced glycolysis metabolism is essential to the activation of inflammatory macrophages","volume":"2017","author":"Wang","year":"2017","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0830","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb7389","article-title":"IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages","volume":"6","author":"Wang","year":"2020","journal-title":"Science Advances"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0835","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cellimm.2014.02.005","article-title":"The role of indoleamine 2,3-dioxygenase (IDO) in immune tolerance: Focus on macrophage polarization of THP-1 cells","volume":"289","author":"Wang","year":"2014","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0840","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/imr.12838","article-title":"Immunometabolism in the development of rheumatoid arthritis","volume":"294","author":"Weyand","year":"2020","journal-title":"Immunological Reviews"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0845","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1053\/j.gastro.2020.12.036","article-title":"Prognostic factors for advanced colorectal neoplasia in inflammatory bowel disease: Systematic review and meta-analysis","volume":"160","author":"Wijnands","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0850","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3389\/fimmu.2018.00141","article-title":"A role for the Krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation","volume":"9","author":"Williams","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0855","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105796","article-title":"Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization","volume":"172","author":"Wu","year":"2021","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0860","doi-asserted-by":"crossref","first-page":"8028","DOI":"10.1096\/fj.202000313RR","article-title":"Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way","volume":"34","author":"Wu","year":"2020","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0865","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s42003-020-0842-3","article-title":"Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice","volume":"3","author":"Wuggenig","year":"2020","journal-title":"Communications Biology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0870","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41419-021-04235-0","article-title":"Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt","volume":"12","author":"Xiong","year":"2021","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0875","doi-asserted-by":"crossref","first-page":"5543003","DOI":"10.1155\/2021\/5543003","article-title":"Dietary bioactive peptide alanyl-glutamine attenuates dextran sodium sulfate-induced colitis by modulating gut microbiota","volume":"2021","author":"Xu","year":"2021","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0880","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.tcb.2020.09.006","article-title":"Lipid metabolism in regulation of macrophage functions","volume":"30","author":"Yan","year":"2020","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0885","article-title":"Mannose-rich oligosaccharides-functionalized selenium nanoparticles mediates macrophage reprogramming and inflammation resolution in ulcerative colitis","volume":"131715","author":"Yang","year":"2021","journal-title":"Chemical Engineering Journal"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0890","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.jcmgh.2021.08.021","article-title":"The role of intestinal macrophages in gastrointestinal homeostasis: Heterogeneity and implications in disease","volume":"12","author":"Yip","year":"2021","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0895","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2020.01.001","article-title":"Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury","volume":"31","author":"Yurdagul","year":"2020","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0900","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1136\/annrheumdis-2017-212647","article-title":"Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation","volume":"77","author":"Zeisbrich","year":"2018","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.pharmthera.2022.108176_bb0905","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.649463","article-title":"Tiliroside ameliorates ulcerative colitis by restoring the M1\/M2 macrophage balance via the HIF-1\u03b1\/glycolysis pathway","volume":"12","author":"Zhuang","year":"2021","journal-title":"Frontiers in Immunology"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822000705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822000705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:23:26Z","timestamp":1759011806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725822000705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":173,"alternative-id":["S0163725822000705"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108176","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108176"}}