{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:24:11Z","timestamp":1793247851139,"version":"4.5.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG056689"],"award-info":[{"award-number":["AG056689"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG055707"],"award-info":[{"award-number":["AG055707"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.pharmthera.2022.108178","type":"journal-article","created":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T19:56:02Z","timestamp":1648324562000},"page":"108178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["The contribution of altered neuronal autophagy to neurodegeneration"],"prefix":"10.1016","volume":"238","author":[{"given":"Alessia","family":"Filippone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Mannino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Lyssenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Pratic\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2022.108178_bb0005","doi-asserted-by":"crossref","first-page":"105069","DOI":"10.1016\/j.phrs.2020.105069","article-title":"Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals","author":"Abbaszadeh","year":"2020","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0010","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1089\/neu.2004.21.1355","article-title":"A global perspective on spinal cord injury epidemiology","volume":"21","author":"Ackery","year":"2004","journal-title":"Journal of Neurotrauma"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0015","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s12974-020-02005-x","article-title":"Cellular infiltration in traumatic brain injury","volume":"17","author":"Alam","year":"2020","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.expneurol.2012.09.009","article-title":"Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer\u2019s disease","volume":"239","author":"Beauquis","year":"2013","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0025","first-page":"35","article-title":"The vicious cycle between \u03b1-synuclein aggregation and autophagic-lysosomal dysfunction","volume":"1","author":"Bellomo","year":"2020","journal-title":"Movement Disorders"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0030","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1242\/jcs.123075","article-title":"The role of membrane-trafficking small GTPases in the regulation of autophagy","volume":"126","author":"Bento","year":"2013","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0035","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201947954","article-title":"AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons","volume":"21","author":"Bera","year":"2020","journal-title":"EMBO Reports"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0040","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.cub.2021.02.061","article-title":"Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes","author":"Boecker","year":"2021","journal-title":"Current Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0045","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41573-019-0036-1","article-title":"Lysosomes as a therapeutic target","volume":"18","author":"Bonam","year":"2019","journal-title":"Nature Reviews. Drug Discovery"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0050","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007747","article-title":"Lysosomal sorting of amyloid-\u03b2 by the SORLA receptor is impaired by a familial Alzheimer\u2019s disease mutation","volume":"6","author":"Caglayan","year":"2014","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0055","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1007\/s12035-020-02033-x","article-title":"Role of ABT888, a novel poly(ADP-ribose) polymerase (PARP) inhibitor in countering autophagy and apoptotic processes associated to spinal cord injury","volume":"57","author":"Casili","year":"2020","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0060","first-page":"15","article-title":"Promoting tau secretion and propagation by hyperactive p300\/CBP via autophagy-lysosomal pathway in tauopathy. Mol","volume":"2","author":"Chen","year":"2020","journal-title":"Neurodegeneration"},{"issue":"4","key":"10.1016\/j.pharmthera.2022.108178_bb0065","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/14728222.2020.1733970","article-title":"Glucocerebrosidase as a therapeutic target for Parkinson\u2019s disease","volume":"24","author":"Chen","year":"2020","journal-title":"Expert Opinion on Therapeutic Targets"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0070","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biopsych.2016.05.023","article-title":"12\/15-lipoxygenase inhibition reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice","volume":"81","author":"Di Meco","year":"2017","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0075","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tcb.2015.06.002","article-title":"Regulation of mTORC1 by PI3K signaling","volume":"25","author":"Dibble","year":"2015","journal-title":"Trends in Cell Biology"},{"issue":"8","key":"10.1016\/j.pharmthera.2022.108178_bb0080","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1016\/j.jmb.2019.12.035","article-title":"Autophagy induction as a therapeutic strategy for neurodegenerative diseases","volume":"432","author":"Djajadikerta","year":"2020","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0085","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease","volume":"p22","author":"Fang","year":"2019","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3233\/JAD-2011-110662","article-title":"Extra virgin olive oil improves learning and memory in SAMP8 mice","volume":"28","author":"Farr","year":"2012","journal-title":"The Journal of Alzheimer\u2019s Disease"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0095","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Research"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0100","doi-asserted-by":"crossref","first-page":"107977","DOI":"10.1016\/j.neuropharm.2020.107977","article-title":"Protective effect of sodium propionate in A\u03b21-42 -induced neurotoxicity and spinal cord trauma","volume":"166","author":"Filippone","year":"2020","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2022.108178_bb0105","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3233\/JAD-210701","article-title":"VPS35 downregulation alters degradation pathways in neuronal cells","volume":"84","author":"Filippone","year":"2021","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"14","key":"10.1016\/j.pharmthera.2022.108178_bb0110","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.2147\/JIR.S342096","article-title":"Dysregulation of the retromer complex in brain endothelial cells results in accumulation of phosphorylated tau","volume":"29","author":"Filippone","year":"2021","journal-title":"Journal of Inflammation Research"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0115","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.15252\/embj.201796697","article-title":"Molecular definitions of autophagy and related processes","volume":"36","author":"Galluzzi","year":"2017","journal-title":"The EMBO Journal"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biocel.2015.03.006","article-title":"Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1\/S6K1 signaling","volume":"64","author":"Gao","year":"2015","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"1","key":"10.1016\/j.pharmthera.2022.108178_bb0125","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jss.2016.07.014","article-title":"Tetrahydrocurcumin provides neuroprotection in rats after traumatic brain injury: Autophagy and the PI3K\/AKT pathways as a potential mechanism","volume":"206","author":"Gao","year":"2016","journal-title":"The Journal of Surgical Research"},{"issue":"24","key":"10.1016\/j.pharmthera.2022.108178_bb0130","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1021\/acschemneuro.0c00517","article-title":"Autophagy activation represses Pyroptosis through the IL-13 and JAK1\/STAT1 pathways in a mouse model of moderate traumatic brain injury","volume":"11","author":"Gao","year":"2020","journal-title":"ACS Chemical Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0135","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fncel.2018.00185","article-title":"Autophagic degradation deficit involved in sevoflurane-induced amyloid pathology and spatial learning impairment in APP\/PS1 transgenic mice","volume":"12","author":"Geng","year":"2018","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0140","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pneurobio.2013.10.004","article-title":"Autophagy and apoptosis dysfunction in neurodegenerative disorders","volume":"112","author":"Ghavami","year":"2014","journal-title":"Progress in Neurobiology"},{"issue":"1","key":"10.1016\/j.pharmthera.2022.108178_bb0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bpa.12545","article-title":"Autophagy in neurodegenerative diseases: Pathogenesis and therapy","volume":"28","author":"Guo","year":"2018","journal-title":"Brain Pathology"},{"issue":"5","key":"10.1016\/j.pharmthera.2022.108178_bb0150","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cels.2017.09.013","article-title":"The interplay between feedback and buffering in cellular homeostasis","volume":"5","author":"Hancock","year":"2017","journal-title":"Cell Systems"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0155","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1523\/JNEUROSCI.3430-11.2012","article-title":"The energetics of CNS white matter","volume":"32","author":"Harris","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0160","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jad.2019.02.041","article-title":"Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells","volume":"249","author":"Hongxia","year":"2019","journal-title":"Journal of Affective Disorders"},{"issue":"11","key":"10.1016\/j.pharmthera.2022.108178_bb0165","doi-asserted-by":"crossref","first-page":"109259","DOI":"10.1016\/j.celrep.2021.109259","article-title":"SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network","volume":"35","author":"Hung","year":"2021","journal-title":"Cell Reports"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0170","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S1474-4422(18)30287-4","article-title":"Neuromodulation in the restoration of function after spinal cord injury","volume":"17","author":"James","year":"2018","journal-title":"Lancet Neurology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0175","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.yexcr.2013.11.017","article-title":"Genetic ablation and short-duration inhibition of lipoxygenase results in increased autophagy","volume":"321","author":"Jang","year":"2014","journal-title":"Experimental Cell Research"},{"issue":"12","key":"10.1016\/j.pharmthera.2022.108178_bb0180","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.bbamcr.2008.06.020","article-title":"Accessory subunit Ac45 controls the V-ATPase in the regulated secretory pathway","volume":"1783","author":"Jansen","year":"2022","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0185","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimer\u2019s disease risk genes and mechanisms of disease pathogenesis","volume":"77","author":"Karch","year":"2015","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0190","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0195","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuron.2020.10.005","article-title":"Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum","volume":"109","author":"Kuijpers","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.conb.2018.02.008","article-title":"Neuronal autophagy and intercellular regulation of homeostasis in the brain","volume":"51","author":"Kulkarni","year":"2018","journal-title":"Current Opinion in Neurobiology"},{"issue":"6","key":"10.1016\/j.pharmthera.2022.108178_bb0205","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm6393","article-title":"Mutant glucocerebrosidase impairs \u03b1-synuclein degradation by blockade of chaperone-mediated autophagy","volume":"8","author":"Kuo","year":"2022","journal-title":"Science Advances"},{"issue":"8","key":"10.1016\/j.pharmthera.2022.108178_bb0210","doi-asserted-by":"crossref","first-page":"p564","DOI":"10.1002\/acn3.431","article-title":"Extra virgin olive oil ameliorates cognition and neuropathology if the 3xTg mice: Role of autophagy","volume":"4","author":"Lauretti","year":"2017","journal-title":"Annals of Clinical Translational Neurology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0215","series-title":"Olives and Olive Oil in health and disease prevention","first-page":"415","article-title":"Extra-virgin olive oil, cognition and brain health","author":"Lauretti","year":"2022"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0220","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0225","doi-asserted-by":"crossref","first-page":"109126","DOI":"10.1016\/j.cbi.2020.109126","article-title":"Graphene oxide enhances \u03b2-amyloid clearance by inducing autophagy of microglia and neurons","volume":"325","author":"Li","year":"2020","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0230","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10571-016-0386-8","article-title":"Autophagy and Alzheimer\u2019s disease","volume":"p37","author":"Li","year":"2017","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0235","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuint.2018.04.002","article-title":"12\/15 lipoxygenase: A crucial enzyme in diverse types of cell death","volume":"118","author":"Li","year":"2018","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0240","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/15548627.2018.1509818","article-title":"Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations","volume":"15","author":"Li","year":"2019","journal-title":"Autophagy"},{"issue":"736","key":"10.1016\/j.pharmthera.2022.108178_bb0245","doi-asserted-by":"crossref","first-page":"135263","DOI":"10.1016\/j.neulet.2020.135263","article-title":"Zinc promotes autophagy and inhibits apoptosis through AMPK\/mTOR signaling pathway after spinal cord injury","volume":"25","author":"Lin","year":"2020","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0255","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41419-018-0469-1","article-title":"Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis","volume":"9","author":"Liu","year":"2018","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0260","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.201106120","article-title":"Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons","volume":"196","author":"Maday","year":"2012","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0265","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-019-1405-y","article-title":"Intestinal infection triggers Parkinson's disease-like symptoms in Pink1\u2212\/\u2212 mice","volume":"571","author":"Matheoud","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0270","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.arr.2016.06.003","article-title":"Cystatin C in aging and in Alzheimer\u2019s disease","volume":"32","author":"Mathews","year":"2016","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0275","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jad.2014.11.033","article-title":"GPR39 Zn(2+)-sensing receptor: A new target in antidepressant development?","volume":"174","author":"Mlyniec","year":"2015","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0280","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.2741\/2941","article-title":"Involvement of cystatin C in pathophysiology of CNS diseases","volume":"13","author":"Nagai","year":"2008","journal-title":"Frontiers in Bioscience"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0285","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1007\/s11064-020-03126-8","article-title":"\u03b1-Synuclein overexpression induces lysosomal dysfunction and autophagy impairment in human neuroblastoma SH-SY5Y","volume":"45","author":"Nascimento","year":"2020","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0290","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1242\/jcs.019265","article-title":"Autophagy, amyloidogenesis and Alzheimer disease","volume":"120","author":"Nixon","year":"2007","journal-title":"Journal of Cell Science"},{"issue":"2","key":"10.1016\/j.pharmthera.2022.108178_bb0295","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/15548627.2015.1082023","article-title":"AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects","volume":"12","author":"Papp","year":"2016","journal-title":"Autophagy."},{"key":"10.1016\/j.pharmthera.2022.108178_bb0305","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: Morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxidants & Redox Signaling"},{"issue":"51","key":"10.1016\/j.pharmthera.2022.108178_bb0310","doi-asserted-by":"crossref","first-page":"21071","DOI":"10.1074\/jbc.M117.811448","article-title":"A mechanistic model to predict effects of cathepsin B and cystatin C on \u03b2-amyloid aggregation and degradation","volume":"292","author":"Perlenfein","year":"2017","journal-title":"The Journal of Biological Chemistry"},{"issue":"6","key":"10.1016\/j.pharmthera.2022.108178_bb0315","first-page":"2190","article-title":"The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice","volume":"118","author":"Pickford","year":"2008","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2018.12.005","article-title":"Therapeutic activation of autophagy by combined treatment with rapamycin and trehalose in a mouse MPTP-induced model of Parkinson\u2019s disease","volume":"177","author":"Pupyshev","year":"2018","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0325","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jnutbio.2015.07.022","article-title":"Extra virgin olive oil attenuates amyloid0b and tau pathology in the brains of TgSwDI mice","volume":"26","author":"Qosa","year":"2015","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0330","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neuroscience.2021.02.007","article-title":"Reduction of autophagosome overload attenuates neuronal cell death after traumatic brain injury","volume":"460","author":"Quan","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0335","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/ana.24066","article-title":"Lewy body extracts from Parkinson disease brains trigger alpha-synuclein pathology and neurodegeneration in mice and monkeys","volume":"75","author":"Recasens","year":"2014","journal-title":"Annals of Neurology"},{"issue":"2","key":"10.1016\/j.pharmthera.2022.108178_bb0340","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4103\/1673-5374.152367","article-title":"Autophagy in degenerating axons following spinal cord injury: Evidence for autophagosome biogenesis in retraction bulbs","volume":"10","author":"Ribas","year":"2015","journal-title":"Neural Regeneration Research"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0345","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nchembio.1681","article-title":"A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy","volume":"10","author":"Ronan","year":"2014","journal-title":"Nature Chemical Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0350","doi-asserted-by":"crossref","first-page":"10147","DOI":"10.1038\/s41598-019-46657-z","article-title":"LC3-positive structures are prominent in autophagy-deficient cells","volume":"9","author":"Runwal","year":"2019","journal-title":"Scientific Reports"},{"issue":"8","key":"10.1016\/j.pharmthera.2022.108178_bb0420","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.tcb.2019.05.003","article-title":"Lysosome fission: Planning for an exit","volume":"29","author":"Saffi","year":"2019","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0355","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1039\/b804606a","article-title":"Small molecule enhancers of autophagy for neurodegenerative diseases","volume":"4","author":"Sarkar","year":"2008","journal-title":"Molecular BioSystems"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0360","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.1073\/pnas.1100844108","article-title":"Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK","volume":"108","author":"Shang","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0365","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/s41380-019-0396-2","article-title":"Sequential formation of different layers of dystrophic neurites in Alzheimer\u2019s brains","volume":"24","author":"Sharoar","year":"2019","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0370","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13024-021-00464-1","article-title":"Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer\u2019s disease brains","volume":"16","author":"Sharoar","year":"2021","journal-title":"Molecular Neurodegeneration"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0375","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40035-020-00196-0","article-title":"The emerging roles of vacuolar-type ATPase-dependent lysosomal acidification in neurodegenerative diseases","volume":"9","author":"Song","year":"2020","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0380","doi-asserted-by":"crossref","first-page":"13578","DOI":"10.1523\/JNEUROSCI.4390-09.2009","article-title":"Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson\u2019s and Lewy body diseases","volume":"29","author":"Spencer","year":"2009","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0385","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tcb.2013.07.008","article-title":"The beginning of the end: How scaffolds nucleate autophagosome biogenesis","volume":"24","author":"Stanley","year":"2014","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0390","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev-cellbio-100818-125242","article-title":"Autophagy in neurons","volume":"35","author":"Stavoe","year":"2019","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0395","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3892\/ol.2016.4644","article-title":"Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance","volume":"12","author":"Sun","year":"2016","journal-title":"Oncology Letters"},{"issue":"8","key":"10.1016\/j.pharmthera.2022.108178_bb0400","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1016\/j.jmb.2020.02.023","article-title":"Pharmacological tools to modulate autophagy in neurodegenerative diseases","volume":"432","author":"Suresh","year":"2020","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0410","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"Tanida","year":"2008","journal-title":"Methods in Molecular Biology"},{"issue":"4","key":"10.1016\/j.pharmthera.2022.108178_bb0415","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3390\/ijms20040901","article-title":"Autophagy activator drugs: A new opportunity in neuroprotection from misfolded protein toxicity","volume":"20","author":"Thellung","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0425","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3389\/fcell.2021.658741","article-title":"Navigating the controversies of retromer-mediated endosomal protein sorting","volume":"9","author":"Tu","year":"2021","journal-title":"Frontiers in Cell and Development Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0430","series-title":"Profile of people within the traumatic brain injury model systems","author":"United States National database","year":"2017"},{"issue":"6","key":"10.1016\/j.pharmthera.2022.108178_bb0435","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/s41380-018-0221-3","article-title":"Endosomal sorting and trafficking, the retromer complex and neurodegeneration","volume":"24","author":"Vagnozzi","year":"2019","journal-title":"Molecular Psychiatry"},{"issue":"6","key":"10.1016\/j.pharmthera.2022.108178_bb0440","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3390\/biomedicines9060593","article-title":"Involvement of mTOR pathways in recovery from spinal cord injury by modulation of autophagy and immune response","volume":"9","author":"Vargova","year":"2021","journal-title":"Biomedicines."},{"key":"10.1016\/j.pharmthera.2022.108178_bb0445","article-title":"Transformative network Modeling of multi-omics data reveals detailed circuits, key regulators, and potential therapeutics for Alzheimer\u2019s disease","author":"Wang","year":"2020","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.pharmthera.2022.108178_bb0450","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3390\/cells9092022","article-title":"Autophagy and neurodegenerative diseases","volume":"9","author":"Watanabe","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0455","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.jmb.2016.02.021","article-title":"An overview of macroautophagy in yeast","volume":"428","author":"Wen","year":"2016","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nm.4269","article-title":"Alpha-synuclein toxicity in neurodegeneration: Mechanism and therapeutic strategies","volume":"23","author":"Wong","year":"2017","journal-title":"Nature Medicine"},{"issue":"7","key":"10.1016\/j.pharmthera.2022.108178_bb0465","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3390\/cells8070693","article-title":"Autophagy in neurotrauma: good, bad, or dysregulated","volume":"8","author":"Wu","year":"2019","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.pharmthera.2022.108178_bb0470","article-title":"Cellular and molecular basis of neurodegeneration in Parkinson disease","volume":"17","author":"Xian-Si","year":"2018","journal-title":"Frontiers in Aging Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0475","first-page":"18","article-title":"A molecular approach to mitophagy and mitochondrial dynamics","volume":"41","author":"Yoo","year":"2018","journal-title":"Molecules and Cells"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0480","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0485","doi-asserted-by":"crossref","first-page":"19023","DOI":"10.1073\/pnas.0709695104","article-title":"Small molecule regulators of autophagy identified by an image-based high-throughput screen","volume":"104","author":"Zhang","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0490","article-title":"Hydrogen sulfide offers neuroprotection on traumatic brain injury in parallel with reduced apoptosis and autophagy in mice","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.pharmthera.2022.108178_bb0495","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/aps.2017.49","article-title":"Reassessment of subacute MPTP-treated mice as animal model of Parkinson\u2019s disease","volume":"38","author":"Zhang","year":"2017","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2022.108178_bb0500","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2017.02.027","article-title":"Resveratrol protects against spinal cord injury by activating autophagy and inhibiting apoptosis mediated by the SIRT1\/AMPK signaling pathway","author":"Zhao","year":"2017","journal-title":"Neuroscience."},{"issue":"3","key":"10.1016\/j.pharmthera.2022.108178_bb0505","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/jnc.14892","article-title":"Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury","volume":"154","author":"Zheng","year":"2019","journal-title":"Journal of Neurochemistry (JNC)."},{"issue":"20","key":"10.1016\/j.pharmthera.2022.108178_bb0510","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.7150\/thno.46566","article-title":"TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"issue":"2021","key":"10.1016\/j.pharmthera.2022.108178_bb0515","article-title":"Downregulation of ATP6V1A involved in Alzheimer\u2019s disease via synaptic vesicle cycle, phagosome, and oxidative phosphorylation","volume":"19","author":"Zhou","year":"2021","journal-title":"Oxidative Medicine and Cellular Longevity"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822000729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822000729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:21:31Z","timestamp":1759011691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725822000729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":100,"alternative-id":["S0163725822000729"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108178","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The contribution of altered neuronal autophagy to neurodegeneration","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108178"}}