{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:55:21Z","timestamp":1792670121794,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.pharmthera.2022.108252","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T20:48:36Z","timestamp":1659386916000},"page":"108252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Vitamin D as a chemopreventive agent in colorectal neoplasms. A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"237","author":[{"given":"Georgia","family":"Emmanouilidou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Kalopitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra Rafailia","family":"Bakaloudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Karanika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Theocharidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Germanidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Chourdakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.pharmthera.2022.108252_bb0005","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2174\/18735592MTEx9NTk2y","article-title":"Colorectal cancer epidemiology: Recent trends and impact on outcomes","volume":"22","author":"Baidoun","year":"2021","journal-title":"Current Drug Targets"},{"issue":"16","key":"10.1016\/j.pharmthera.2022.108252_bb0010","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1056\/NEJMoa1500409","article-title":"A trial of calcium and vitamin D for the prevention of colorectal adenomas","volume":"373","author":"Baron","year":"2015","journal-title":"The New England Journal of Medicine"},{"issue":"12","key":"10.1016\/j.pharmthera.2022.108252_bb0015","doi-asserted-by":"crossref","first-page":"836","DOI":"10.7326\/M16-0577","article-title":"Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U.S. preventive services task force recommendation statement","volume":"164","author":"Bibbins-Domingo","year":"2016","journal-title":"Annals of Internal Medicine"},{"issue":"7","key":"10.1016\/j.pharmthera.2022.108252_bb0020","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3945\/jn.117.250191","article-title":"Vitamin D supplementation trials aimed at reducing mortality have much higher power when focusing on people with low serum 25-Hydroxyvitamin D concentrations","volume":"147","author":"Brenner","year":"2017","journal-title":"The Journal of Nutrition"},{"key":"10.1016\/j.pharmthera.2022.108252_bb0025","article-title":"Effect of screening sigmoidoscopy and screening colonoscopy on colorectal cancer incidence and mortality: Systematic review and meta-analysis of randomised controlled trials and observational studies","volume":"348","author":"Brenner","year":"2014","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"9","key":"10.1016\/j.pharmthera.2022.108252_bb0030","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1210\/clinem\/dgab153","article-title":"Vitamin D supplementation for prevention of cancer: The D2d cancer outcomes (D2dCA) ancillary study","volume":"106","author":"Chatterjee","year":"2021","journal-title":"The Journal of Clinical Endocrinology and Metabolism"},{"issue":"4","key":"10.1016\/j.pharmthera.2022.108252_bb0035","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3892\/ijo.2013.2041","article-title":"Precancerous colorectal lesions (review)","volume":"43","author":"Conteduca","year":"2013","journal-title":"International Journal of Oncology"},{"issue":"3","key":"10.1016\/j.pharmthera.2022.108252_bb0040","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/gutjnl-2017-315242","article-title":"Calcium and vitamin D supplementation and increased risk of serrated polyps: Results from a randomised clinical trial","volume":"68","author":"Crockett","year":"2019","journal-title":"Gut"},{"issue":"10207","key":"10.1016\/j.pharmthera.2022.108252_bb0045","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","article-title":"Colorectal cancer","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet (London, England)"},{"issue":"5","key":"10.1016\/j.pharmthera.2022.108252_bb0050","doi-asserted-by":"crossref","first-page":"365","DOI":"10.7326\/0003-4819-146-5-200703060-00009","article-title":"The use of aspirin for primary prevention of colorectal cancer: A systematic review prepared for the U.S. Preventive Services Task Force","volume":"146","author":"Dub\u00e9","year":"2007","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.pharmthera.2022.108252_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsbmb.2018.07.002","article-title":"Mechanisms of action of vitamin D in colon cancer","volume":"185","author":"Ferrer-Mayorga","year":"2019","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"1","key":"10.1016\/j.pharmthera.2022.108252_bib166","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/BJ20110744","article-title":"Vitamin D and cancer: a review of molecular mechanisms.","volume":"441","author":"Fleet","year":"2012","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2022.108252_bb0060","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-3-030-46227-7_4","article-title":"Vitamin d receptor polymorphisms and cancer","volume":"1268","author":"Gnagnarella","year":"2020","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"5","key":"10.1016\/j.pharmthera.2022.108252_bb0065","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2215\/CJN.01160308","article-title":"Vitamin D in health and disease","volume":"3","author":"Heaney","year":"2008","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"8","key":"10.1016\/j.pharmthera.2022.108252_bb0070","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.clnu.2019.11.012","article-title":"Additively protective effects of vitamin D and calcium against colorectal adenoma incidence, malignant transformation and progression: A systematic review and meta-analysis","volume":"39","author":"Huang","year":"2020","journal-title":"Clinical Nutrition (Edinburgh, Scotland)"},{"key":"10.1016\/j.pharmthera.2022.108252_bb0075","series-title":"IARC working group reports","author":"IARC, H. P. V","year":"2008"},{"issue":"12","key":"10.1016\/j.pharmthera.2022.108252_bb0080","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41575-019-0189-8","article-title":"Global burden of colorectal cancer: Emerging trends, risk factors and prevention strategies","volume":"16","author":"Keum","year":"2019","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"issue":"4","key":"10.1016\/j.pharmthera.2022.108252_bb0085","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/j.gastro.2021.07.002","article-title":"Total vitamin D intake and risks of early-onset colorectal cancer and precursors","volume":"161","author":"Kim","year":"2021","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.pharmthera.2022.108252_bb0090","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1001\/jama.2017.2115","article-title":"Effect of vitamin D and calcium supplementation on cancer incidence in older women: A randomized clinical trial","volume":"317","author":"Lappe","year":"2017","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.pharmthera.2022.108252_bb0095","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/ajcn\/85.6.1586","article-title":"Vitamin D and calcium supplementation reduces cancer risk: Results of a randomized trial","volume":"85","author":"Lappe","year":"2007","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"1","key":"10.1016\/j.pharmthera.2022.108252_bb0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1809944","article-title":"Vitamin D supplements and prevention of cancer and cardiovascular disease","volume":"380","author":"Manson","year":"2019","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"10.1016\/j.pharmthera.2022.108252_bb0105","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/jnci\/djy087","article-title":"Circulating vitamin D and colorectal cancer risk: An international pooling project of 17 cohorts","volume":"111","author":"McCullough","year":"2019","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/j.pharmthera.2022.108252_bb0110","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"1","key":"10.1016\/j.pharmthera.2022.108252_bb0115","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1053\/j.gastro.2015.09.010","article-title":"Aspirin, Calcitriol, and calcium do not prevent adenoma recurrence in a randomized controlled trial","volume":"150","author":"Pommergaard","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2022.108252_bb0120","author":"Review Manager Web (RevMan Web) (1.22.0)"},{"issue":"5","key":"10.1016\/j.pharmthera.2022.108252_bb0125","doi-asserted-by":"crossref","first-page":"376","DOI":"10.7326\/0003-4819-146-5-200703060-00010","article-title":"Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: A systematic review prepared for the U.S. preventive services task force","volume":"146","author":"Rostom","year":"2007","journal-title":"Annals of Internal Medicine"},{"issue":"3","key":"10.1016\/j.pharmthera.2022.108252_bb0130","doi-asserted-by":"crossref","first-page":"458","DOI":"10.14309\/ajg.0000000000001122","article-title":"ACG clinical guidelines: colorectal cancer screening 2021","volume":"116","author":"Shaukat","year":"2021","journal-title":"The American Journal of Gastroenterology"},{"issue":"1","key":"10.1016\/j.pharmthera.2022.108252_bb0135","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA: a Cancer Journal for Clinicians"},{"issue":"1","key":"10.1016\/j.pharmthera.2022.108252_bb0140","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cgh.2020.02.013","article-title":"No association between vitamin D supplementation and risk of colorectal adenomas or serrated polyps in a randomized trial","volume":"19","author":"Song","year":"2021","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108252_bb0145","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"The BMJ"},{"issue":"1","key":"10.1016\/j.pharmthera.2022.108252_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/nu11010164","article-title":"Colorectal Cancer and nutrition","volume":"11","author":"Thanikachalam","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.pharmthera.2022.108252_bb0155","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12916-021-02044-y","article-title":"Oral vitamin D supplementation induces transcriptomic changes in rectal mucosa that are linked to anti-tumour effects","volume":"19","author":"Vaughan-Shaw","year":"2021","journal-title":"BMC Medicine"},{"issue":"7","key":"10.1016\/j.pharmthera.2022.108252_bb0160","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1056\/NEJMoa055222","article-title":"Calcium plus vitamin D supplementation and the risk of colorectal cancer","volume":"354","author":"Wactawski-Wende","year":"2006","journal-title":"The New England Journal of Medicine"},{"issue":"7","key":"10.1016\/j.pharmthera.2022.108252_bb0165","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00384-021-03879-w","article-title":"The effect of vitamin D on the occurrence and development of colorectal cancer: A systematic review and meta-analysis","volume":"36","author":"Xu","year":"2021","journal-title":"International Journal of Colorectal Disease"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822001462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822001462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:35:48Z","timestamp":1759012548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725822001462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":34,"alternative-id":["S0163725822001462"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108252","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D as a chemopreventive agent in colorectal neoplasms. A systematic review and meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108252"}}