{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:41:44Z","timestamp":1787168504650,"version":"build-2736575974"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["374031971 \u2013 TRR 240"],"award-info":[{"award-number":["374031971 \u2013 TRR 240"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BO3786\/3-1"],"award-info":[{"award-number":["BO3786\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.pharmthera.2022.108258","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T22:05:16Z","timestamp":1659045916000},"page":"108258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Platelet lipid metabolism in vascular thrombo-inflammation"],"prefix":"10.1016","volume":"237","author":[{"given":"Mailin-Christin","family":"Manke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ahrends","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Borst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2022.108258_bb0005","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/01.RES.86.2.131","article-title":"The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques","volume":"86","author":"Abi-Younes","year":"2000","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0010","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1161\/ATVBAHA.117.309868","article-title":"First selective 12-LOX inhibitor, ML355, impairs thrombus formation and vessel occlusion in vivo with minimal effects on hemostasis","volume":"37","author":"Adili","year":"2017","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0015","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1177\/106002809202601205","article-title":"Abnormal platelet aggregation associated with fluoxetine therapy","volume":"26","author":"Alderman","year":"1992","journal-title":"The Annals of Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/sj.bjp.0705063","article-title":"Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function","volume":"138","author":"Altmann","year":"2003","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0025","series-title":"FDA Drug Bulletin","first-page":"34","volume":"15","author":"Aspirin for heart patients","year":"1985"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0030","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/cvr\/cvab003","article-title":"The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis","volume":"117","author":"Badimon","year":"2021","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107630","article-title":"Glycoprotein VI - novel target in antiplatelet medication","volume":"217","author":"Borst","year":"2021","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0040","series-title":"Platelets, Haemostasis and inflammation","first-page":"181","article-title":"PI3K-dependent platelet signaling in vascular inflammation and atherothrombosis","author":"Borst","year":"2017"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0045","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1161\/CIRCRESAHA.112.276444","article-title":"The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase\/Akt signaling","volume":"111","author":"Borst","year":"2012","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0050","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1182\/blood-2011-06-359976","article-title":"The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes","volume":"119","author":"Borst","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0055","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nrd3248","article-title":"Fingolimod (FTY720): Discovery and development of an oral drug to treat multiple sclerosis","volume":"9","author":"Brinkmann","year":"2010","journal-title":"Nature Reviews Drug Discovery"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0060","first-page":"1871","article-title":"Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice","volume":"119","author":"Camerer","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0065","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1182\/blood.2021013097","article-title":"Platelet ACKR3\/CXCR7 favors anti-platelet lipids over an atherothrombotic lipidome and regulates thrombo-inflammation","volume":"139","author":"Cebo","year":"2022","journal-title":"Blood."},{"key":"10.1016\/j.pharmthera.2022.108258_bb0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.aca.2019.10.005","article-title":"Simultaneous targeted and untargeted UHPLC-ESI-MS\/MS method with data-independent acquisition for quantification and profiling of (oxidized) fatty acids released upon platelet activation by thrombin","volume":"1094","author":"Cebo","year":"2020","journal-title":"Analytica Chimica Acta"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0075","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1038\/s41467-021-22642-x","article-title":"Deletion of Mfsd2b impairs thrombotic functions of platelets","volume":"12","author":"Chandrakanthan","year":"2021","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0080","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/jth.14721","article-title":"Platelet lipidome: Dismantling the \u201cTrojan horse\u201d in the bloodstream","volume":"18","author":"Chatterjee","year":"2020","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0085","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1093\/eurheartj\/ehx146","article-title":"Regulation of oxidized platelet lipidome: Implications for coronary artery disease","volume":"38","author":"Chatterjee","year":"2017","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0090","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1182\/blood-2012-10-461897","article-title":"PDK1 regulates platelet activation and arterial thrombosis","volume":"121","author":"Chen","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0095","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1021\/acs.jproteome.1c00017","article-title":"Targeted phosphoinositides analysis using high-performance ion chromatography-coupled selected reaction monitoring mass spectrometry","volume":"20","author":"Cheung","year":"2021","journal-title":"Journal of Proteome Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0100","first-page":"5446","article-title":"Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate","volume":"63","author":"Clair","year":"2003","journal-title":"Cancer Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0105","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/01.RES.0000132281.78948.65","article-title":"Platelet 12-lipoxygenase activation via glycoprotein VI: Involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis","volume":"94","author":"Coffey","year":"2004","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0110","article-title":"Antidepressant use and risk of cardiovascular outcomes in people aged 20 to 64: Cohort study using primary care database","volume":"352","author":"Coupland","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40169-020-0261-6","article-title":"PI3K inhibitors in thrombosis and cardiovascular disease","volume":"9","author":"Durrant","year":"2020","journal-title":"Clinical and Translational Medicine"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0120","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF02533876","article-title":"Study of the two pathways for arachidonate oxygenation in blood platelets","volume":"14","author":"Dutilh","year":"1979","journal-title":"Lipids"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0125","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1160\/TH17-03-0219","article-title":"Protease-activated receptor PAR-4: An inducible switch between thrombosis and vascular inflammation?","volume":"117","author":"Fender","year":"2017","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0130","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI27196","article-title":"Platelets in inflammation and atherogenesis","volume":"115","author":"Gawaz","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0135","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1182\/blood-2013-05-468694","article-title":"Platelets in tissue repair: Control of apoptosis and interactions with regenerative cells","volume":"122","author":"Gawaz","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0140","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1038\/s41401-018-0036-4","article-title":"Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases","volume":"39","author":"Ge","year":"2018","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0145","doi-asserted-by":"crossref","first-page":"21407","DOI":"10.1038\/s41598-020-78522-9","article-title":"Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome","volume":"10","author":"van Geffen","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0150","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.1021\/bi952927v","volume":"35","author":"Han","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0155","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/mas.20342","article-title":"Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses","volume":"31","author":"Han","year":"2012","journal-title":"Mass Spectrometry Reviews"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0160","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: Lessons from sphingolipids","volume":"9","author":"Hannun","year":"2008","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0165","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/eurheartj\/eht462","article-title":"Depression and cardiovascular disease: A clinical review","volume":"35","author":"Hare","year":"2014","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0170","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1093\/cvr\/cvab238","article-title":"Acute coronary syndrome is associated with a substantial change in the platelet lipidome","volume":"118","author":"Harm","year":"2022","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0175","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1042\/BST0340647","article-title":"Signalling through class I PI3Ks in mammalian cells","volume":"34","author":"Hawkins","year":"2006","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/425191","article-title":"Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia\/reperfusion injury","volume":"2010","author":"Herzog","year":"2010","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0185","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/eurheartj\/ehz387","article-title":"Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients","volume":"41","author":"Hilvo","year":"2020","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0190","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/nm.2515","article-title":"Arterial thrombosis--insidious, unpredictable and deadly","volume":"17","author":"Jackson","year":"2011","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0195","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1182\/blood-2018-11-882993","article-title":"Thromboinflammation: Challenges of therapeutically targeting coagulation and other host defense mechanisms","volume":"133","author":"Jackson","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0200","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nm1232","article-title":"PI 3-kinase p110beta: A new target for antithrombotic therapy","volume":"11","author":"Jackson","year":"2005","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0205","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1056\/NEJMoa052643","article-title":"Oral fingolimod (FTY720) for relapsing multiple sclerosis","volume":"355","author":"Kappos","year":"2006","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0210","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1161\/01.CIR.98.25.2891","article-title":"Platelet-derived 12-Hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb\/IIIa activation","volume":"98","author":"Katoh","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0215","first-page":"596","article-title":"Platelet acetyl-CoA carboxylase phosphorylation: A risk stratification marker that reveals platelet-lipid interplay in coronary artery disease patients","volume":"4","author":"Kautbally","year":"2019","journal-title":"JACC: Basic to Translational Science"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0220","doi-asserted-by":"crossref","first-page":"10957","DOI":"10.1021\/acs.analchem.0c01690","article-title":"Goslin: A grammar of succinct lipid nomenclature","volume":"92","author":"Kopczynski","year":"2020","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0225","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1021\/acs.analchem.1c05430","article-title":"Goslin 2.0 implements the recent lipid shorthand nomenclature for MS-derived lipid structures","volume":"94","author":"Kopczynski","year":"2022","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0230","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1021\/jm070524a","article-title":"Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model","volume":"51","author":"Kornhuber","year":"2008","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0235","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCRESAHA.117.310795","article-title":"Circulating platelets as mediators of immunity, inflammation, and thrombosis","volume":"122","author":"Koupenova","year":"2018","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0240","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1161\/STROKEAHA.113.002880","article-title":"FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection","volume":"44","author":"Kraft","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0245","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/eurheartj\/ehw148","article-title":"Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol","volume":"37","author":"Laaksonen","year":"2016","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0250","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1021\/acs.analchem.1c01751","article-title":"Isomer selective comprehensive lipidomics analysis of phosphoinositides in biological samples by liquid chromatography with data independent acquisition tandem mass spectrometry","volume":"93","author":"Li","year":"2021","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0255","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1161\/ATVBAHA.110.207522","article-title":"Signaling during platelet adhesion and activation","volume":"30","author":"Li","year":"2010","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0260","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/bj3550189","article-title":"Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: A possible role in regulating cardiac function via sphingolipid receptors","volume":"355","author":"Liliom","year":"2001","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0265","doi-asserted-by":"crossref","first-page":"15308","DOI":"10.1038\/s41598-021-94052-4","article-title":"Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner","volume":"11","author":"Liu","year":"2021","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0270","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.1070238","article-title":"Alteration of lymphocyte trafficking by Sphingosine-1-phosphate receptor agonists","volume":"296","author":"Mandala","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0275","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/CIRCRESAHA.121.319207","article-title":"ANXA7 regulates platelet lipid metabolism and ca(2+) release in arterial thrombosis","volume":"129","author":"Manke","year":"2021","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0280","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/jth.14005","article-title":"PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway","volume":"16","author":"Manne","year":"2018","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004511","article-title":"The LUX score: A metric for lipidome homology","volume":"11","author":"Marella","year":"2015","journal-title":"PLoS Computational Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0290","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1182\/blood-2009-04-217224","article-title":"Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo","volume":"115","author":"Martin","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0295","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12950-014-0033-4","article-title":"12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition","volume":"11","author":"Maskrey","year":"2014","journal-title":"Journal of Inflammation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0300","doi-asserted-by":"crossref","first-page":"103504","DOI":"10.1016\/j.ebiom.2021.103504","article-title":"Shotgun mass spectrometry-based lipid profiling identifies and distinguishes between chronic inflammatory diseases","volume":"70","author":"Matthiesen","year":"2021","journal-title":"eBioMedicine"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0305","doi-asserted-by":"crossref","first-page":"s5","DOI":"10.1161\/ATVBAHA.107.158915","article-title":"Platelets: Inflammatory firebugs of vascular walls","volume":"28","author":"May","year":"2008","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0310","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/CIRCRESAHA.120.317447","article-title":"The emerging threat of (Micro)thrombosis in COVID-19 and its therapeutic implications","volume":"127","author":"McFadyen","year":"2020","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0315","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0140-6736(21)00244-0","article-title":"Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions","volume":"398","author":"McGinley","year":"2021","journal-title":"The Lancet"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0320","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1161\/ATVBAHA.118.311199","article-title":"Plasma Ceramides","volume":"38","author":"Meeusen","year":"2018","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0325","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1161\/ATVBAHA.111.234096","article-title":"Plasma lipidomic analysis of stable and unstable coronary artery disease","volume":"31","author":"Meikle","year":"2011","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0330","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giz061","article-title":"LION\/web: A web-based ontology enrichment tool for lipidomic data analysis","volume":"8","author":"Molenaar","year":"2019","journal-title":"Gigascience"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0335","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3390\/cells11040619","article-title":"CRACking the molecular regulatory mechanism of SOCE during platelet activation in thrombo-occlusive diseases","volume":"11","author":"M\u00fcnzer","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0340","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/ATVBAHA.112.300210","article-title":"Acid sphingomyelinase regulates platelet cell membrane scrambling, secretion, and thrombus formation","volume":"34","author":"Munzer","year":"2014","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0345","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.bbrc.2018.01.155","article-title":"Ceramidase critically affects GPVI-dependent platelet activation and thrombus formation","volume":"496","author":"M\u00fcnzer","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0350","doi-asserted-by":"crossref","first-page":"C920","DOI":"10.1152\/ajpcell.00029.2014","article-title":"Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formation","volume":"307","author":"M\u00fcnzer","year":"2014","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0355","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1161\/ATVBAHA.115.307105","article-title":"PDK1 determines collagen-dependent platelet Ca2+ signaling and is critical to development of ischemic stroke in vivo","volume":"36","author":"M\u00fcnzer","year":"2016","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0360","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1182\/blood-2017-05-784413","article-title":"CK2\u03b2 regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis","volume":"130","author":"M\u00fcnzer","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0365","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/CIRCRESAHA.120.316711","article-title":"Endothelial S1P(1) signaling counteracts infarct expansion in ischemic stroke","volume":"128","author":"Nitzsche","year":"2021","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0370","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.plipres.2007.11.001","article-title":"The multi-functional role of sphingosylphosphorylcholine","volume":"47","author":"Nixon","year":"2008","journal-title":"Progress in Lipid Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0375","doi-asserted-by":"crossref","first-page":"34480","DOI":"10.1074\/jbc.M103782200","article-title":"Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids","volume":"276","author":"Nofer","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0380","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1111\/j.1538-7836.2012.04898.x","article-title":"Human target validation of phosphoinositide 3-kinase (PI3K)\u03b2: Effects on platelets and insulin sensitivity, using AZD6482 a novel PI3K\u03b2 inhibitor","volume":"10","author":"Nylander","year":"2012","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0385","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/jth.13027","article-title":"Exploration of efficacy and bleeding with combined phosphoinositide 3-kinase \u03b2 inhibition and aspirin in man","volume":"13","author":"Nylander","year":"2015","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0390","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91634","article-title":"LipidFinder: A computational workflow for discovery of lipids identifies eicosanoid-phosphoinositides in platelets","volume":"2","author":"O\u2019Connor","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0395","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/CIRCRESAHA.114.301597","article-title":"Platelet lipidomics: Modern day perspective on lipid discovery and characterization in platelets","volume":"114","author":"O\u2019Donnell","year":"2014","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0400","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1126\/science.1139221","article-title":"Promotion of lymphocyte egress into blood and lymph by distinct sources of Sphingosine-1-phosphate","volume":"316","author":"Pappu","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0405","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1172\/JCI26891","article-title":"The biogenesis of platelets from megakaryocyte proplatelets","volume":"115","author":"Patel","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0410","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1182\/blood-2017-12-822890","article-title":"Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome","volume":"132","author":"Peng","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0415","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/s41467-020-15960-z","article-title":"LipidCreator workbench to probe the lipidomic landscape","volume":"11","author":"Peng","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0420","doi-asserted-by":"crossref","first-page":"12480","DOI":"10.1021\/acs.analchem.7b03576","article-title":"A comprehensive high-resolution targeted workflow for the deep profiling of sphingolipids","volume":"89","author":"Peng","year":"2017","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0425","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/nm1626","article-title":"Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype","volume":"13","author":"Podrez","year":"2007","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0430","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.ijcard.2013.10.050","article-title":"Aspirin inhibits release of platelet-derived sphingosine-1-phosphate in acute myocardial infarction","volume":"170","author":"Polzin","year":"2013","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0435","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/eurheartj\/eht448","article-title":"Expression of stromal cell-derived factor-1 receptors CXCR4 and CXCR7 on circulating platelets of patients with acute coronary syndrome and association with left ventricular functional recovery","volume":"35","author":"Rath","year":"2014","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0440","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/rth2.12266","article-title":"The dual role of platelet-innate immune cell interactions in thrombo-inflammation","volume":"4","author":"Rayes","year":"2020","journal-title":"Research and Practice in Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0445","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1111\/j.1537-2995.2010.02584.x","article-title":"Lipidomic analysis of platelet senescence","volume":"50","author":"Ruebsaamen","year":"2010","journal-title":"Transfusion"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0450","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1161\/CIRCULATIONAHA.115.012427","article-title":"Sphingosine-1-phosphate receptor agonist Fingolimod increases myocardial salvage and decreases adverse Postinfarction left ventricular remodeling in a porcine model of ischemia\/reperfusion","volume":"133","author":"Santos-Gallego","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0455","doi-asserted-by":"crossref","first-page":"12085","DOI":"10.1021\/acs.analchem.9b03270","article-title":"Quantitative fragmentation model for bottom-up shotgun lipidomics","volume":"91","author":"Schuhmann","year":"2019","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0460","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1160\/TH10-10-0689","article-title":"CXCL16 is a novel scavenger receptor on platelets and is associated with acute coronary syndrome","volume":"105","author":"Seizer","year":"2011","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0465","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1172\/JCI107971","article-title":"Platelet hypersensitivity induced by cholesterol incorporation","volume":"55","author":"Shattil","year":"1975","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0470","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.cmet.2016.04.001","article-title":"Mapping the human platelet Lipidome reveals cytosolic phospholipase A2 as a regulator of mitochondrial bioenergetics during activation","volume":"23","author":"Slatter","year":"2016","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0475","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/CIRCULATIONAHA.113.002500","article-title":"Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study","volume":"129","author":"Stegemann","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0480","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41582-019-0221-1","article-title":"Thrombo-inflammation in acute ischaemic stroke - implications for treatment","volume":"15","author":"Stoll","year":"2019","journal-title":"Nature Reviews. Neurology"},{"issue":"Suppl. 2","key":"10.1016\/j.pharmthera.2022.108258_bb0485","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0022-2828(88)90338-0","article-title":"Arachidonate metabolism in myocardial ischemia and reperfusion","volume":"20","author":"Tada","year":"1988","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0490","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.tips.2017.08.001","article-title":"Targeting 12-lipoxygenase as a potential novel antiplatelet therapy","volume":"38","author":"Tourdot","year":"2017","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0495","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1538-7836.2011.04194.x","article-title":"Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation","volume":"9","author":"Ulrych","year":"2011","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0500","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1161\/CIRCRESAHA.115.306901","article-title":"Sphingosine 1-phosphate produced by sphingosine kinase 2 intrinsically controls platelet aggregation in vitro and in vivo","volume":"117","author":"Urtz","year":"2015","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0505","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1161\/ATVBAHA.120.315154","article-title":"Lipid receptor GPR31 (G-protein-coupled receptor 31) regulates platelet reactivity and thrombosis without affecting hemostasis","volume":"41","author":"Van Doren","year":"2021","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0510","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1538-7836.2009.03455.x","article-title":"Calcium signaling in platelets","volume":"7","author":"Varga-Szabo","year":"2009","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0515","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/09537104.2016.1144179","article-title":"Platelet-derived sphingosine-1-phosphate and inflammation: From basic mechanisms to clinical implications","volume":"27","author":"Vito","year":"2016","journal-title":"Platelets"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0520","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature24053","article-title":"Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets","volume":"550","author":"Vu","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0525","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/jcbfm.2010.79","article-title":"Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries","volume":"31","author":"Wirrig","year":"2011","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0530","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1182\/blood.V86.1.193.bloodjournal861193","article-title":"Sphingosine-1-phosphate: A platelet-activating sphingolipid released from agonist-stimulated human platelets","volume":"86","author":"Yatomi","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0535","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1074\/jbc.272.8.5291","article-title":"Sphingosine 1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid *","volume":"272","author":"Yatomi","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0540","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1160\/TH13-01-0014","article-title":"12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity","volume":"110","author":"Yeung","year":"2013","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0545","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1182\/blood-2014-05-575878","article-title":"Platelet 12-LOX is essential for Fc\u03b3RIIa-mediated platelet activation","volume":"124","author":"Yeung","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0550","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1039\/C8AN01046C","article-title":"Lipid metabolism in inflammation-related diseases","volume":"143","author":"Zhang","year":"2018","journal-title":"Analyst"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0555","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/j.cmet.2021.08.014","article-title":"Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species","volume":"33","author":"Zhang","year":"2021","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0560","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/CIRCULATIONAHA.115.016371","article-title":"Combination of the immune modulator Fingolimod with Alteplase in acute ischemic stroke: A pilot trial","volume":"132","author":"Zhu","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2022.108258_bb0565","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.thromres.2016.06.031","article-title":"Relationship between metabolites of arachidonic acid and prognosis in patients with acute coronary syndrome","volume":"144","author":"Zu","year":"2016","journal-title":"Thrombosis Research"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822001528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822001528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:34:03Z","timestamp":1759012443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725822001528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":113,"alternative-id":["S0163725822001528"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108258","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet lipid metabolism in vascular thrombo-inflammation","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108258","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108258"}}