{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T01:52:35Z","timestamp":1794448355963,"version":"4.9.1"},"reference-count":166,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson\u2019s","doi-asserted-by":"publisher","award":["ASAP-000420"],"award-info":[{"award-number":["ASAP-000420"]}],"id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.pharmthera.2022.108311","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T01:34:13Z","timestamp":1668562453000},"page":"108311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"special_numbering":"C","title":["Bile acids and neurological disease"],"prefix":"10.1016","volume":"240","author":[{"given":"Michael J.","family":"Hurley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Macnaughtan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony H.V.","family":"Schapira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2022.108311_bb0005","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1007\/s12035-014-9043-8","article-title":"Ursodeoxycholic acid ameliorates apoptotic cascade in the rotenone model of Parkinson\u2019s disease: Modulation of mitochondrial perturbations","volume":"53","author":"Abdelkader","year":"2016","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0010","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1194\/jlr.P071639","article-title":"Defective cholesterol metabolism in amyotrophic lateral sclerosis","volume":"58","author":"Abdel-Khalik","year":"2017","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0015","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2013.03.013","article-title":"Pleiotropic roles of bile acids in metabolism","volume":"17","author":"de Aguiar Vallim","year":"2013","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0020","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.neuint.2007.08.012","article-title":"Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier","volume":"52","author":"Akanuma","year":"2008","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2020.100138","article-title":"Metabolic network analysis reveals altered bile acid synthesis and metabolism in Alzheimer\u2019s disease","volume":"1","author":"Baloni","year":"2020","journal-title":"Cell Reports Medicine"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/bj1660065","article-title":"The role of tubular reabsorption in the renal excretion of bile acids","volume":"166","author":"Barnes","year":"1977","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24101992","article-title":"Chenodeoxycholic acid ameliorates AlCl3-induced Alzheimer\u2019s disease neurotoxicity and cognitive deterioration via enhanced insulin signaling in rats","volume":"24","author":"Bazzari","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0040","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1016\/j.jmb.2018.08.019","article-title":"Ursodeoxycholic acid improves mitochondrial function and redistributes Drp1 in fibroblasts from patients with either sporadic or familial Alzheimer\u2019s disease","volume":"430","author":"Bell","year":"2018","journal-title":"Journal of Molecular Biology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0045","doi-asserted-by":"crossref","first-page":"12208","DOI":"10.1073\/pnas.95.21.12208","article-title":"Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction","volume":"95","author":"Bertilsson","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0050","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2362.2007.01808.x","article-title":"Age-related changes in bile acid synthesis and hepatic nuclear receptor expression","volume":"37","author":"Bertolotti","year":"2007","journal-title":"European Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0055","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1172\/JCI129401","article-title":"Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation","volume":"130","author":"Bhargava","year":"2020","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0060","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.ATV.0000120374.59826.1b","article-title":"Brain cholesterol: Long secret life behind a barrier","volume":"24","author":"Bjorkhem","year":"2004","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0070","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1101\/gad.12.20.3195","article-title":"SXR, a novel steroid and xenobiotic-sensing nuclear receptor","volume":"12","author":"Blumberg","year":"1998","journal-title":"Genes & Development"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0075","series-title":"Bile acid receptor (version 2019.4) IUPHAR\/BPS Guide to Pharmacology Database. GtoPdb CITE [Internet]","author":"Bonner","year":"2019"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nchembio782","article-title":"Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization","volume":"2","author":"Bosco","year":"2006","journal-title":"Nature Chemical Biology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0085","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/brain\/awv384","article-title":"CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease","volume":"139","author":"Boussicault","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0090","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054673","article-title":"Brain microbial populations in HIV\/AIDS: alpha-proteobacteria predominate independent of host immune status","volume":"8","author":"Branton","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0100","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1210\/en.2002-0129","article-title":"Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice","volume":"144","author":"Cai","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0105","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.12659\/MSM.920065","article-title":"Farnesoid X receptor (FXR) aggravates amyloid-beta-triggered apoptosis by modulating the cAMP-response element-binding protein (CREB)\/brain-derived neurotrophic factor (BDNF) pathway in vitro","volume":"25","author":"Chen","year":"2019","journal-title":"Medical Science Monitor"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0110","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.psychres.2018.04.025","article-title":"Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation","volume":"264","author":"Chen","year":"2018","journal-title":"Psychiatry Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0115","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3727\/105221618X15156018385515","article-title":"Bile acid metabolism in liver pathobiology","volume":"18","author":"Chiang","year":"2018","journal-title":"Gene Expression"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-nutr-082018-124344","article-title":"Bile acids as metabolic regulators and nutrient sensors","volume":"39","author":"Chiang","year":"2019","journal-title":"Annual Review of Nutrition"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0125","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-nutr-082018-124344","article-title":"Bile acids as metabolic regulators and nutrient sensors","volume":"39","author":"Chiang","year":"2019","journal-title":"Annual Review of Nutrition"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/cld.861","article-title":"Bile acid biology, pathophysiology, and therapeutics","volume":"15","author":"Chiang","year":"2020","journal-title":"Clinical Liver Disease (Hoboken)"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0135","series-title":"Vitamin D receptor-like receptors (version 2019.4) in the IUPHAR\/BPS guide to pharmacology database. IUPHAR\/BPS guide to pharmacology database. GtoPdb CITE [internet]","author":"Christakos","year":"2019"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0140","doi-asserted-by":"crossref","first-page":"E1182","DOI":"10.1152\/ajpendo.00338.2019","article-title":"The gut microbiota is a major regulator of androgen metabolism in intestinal contents","volume":"317","author":"Collden","year":"2019","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101323","article-title":"Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing","volume":"68","author":"Conway","year":"2021","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0150","doi-asserted-by":"crossref","first-page":"7660","DOI":"10.1128\/JVI.01165-15","article-title":"Bile acids reduce prion conversion, reduce neuronal loss, and prolong male survival in models of prion disease","volume":"89","author":"Cortez","year":"2015","journal-title":"Journal of Virology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0155","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.tem.2016.03.018","article-title":"LXR regulation of brain cholesterol: From development to disease","volume":"27","author":"Courtney","year":"2016","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0160","doi-asserted-by":"crossref","first-page":"8009","DOI":"10.1007\/s12035-016-0281-9","article-title":"Reduced plasma levels of 25-hydroxycholesterol and increased cerebrospinal fluid levels of bile acid precursors in multiple sclerosis patients","volume":"54","author":"Crick","year":"2017","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0165","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/164_2019_237","article-title":"Chemistry and pharmacology of GPBAR1 and FXR selective agonists, dual agonists, and antagonists","volume":"256","author":"De Marino","year":"2019","journal-title":"Handbook of Experimental Pharmacology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0170","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Molecular Neurodegeneration"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0175","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12916-020-01607-9","article-title":"A prospective longitudinal study on the microbiota composition in amyotrophic lateral sclerosis","volume":"18","author":"Di Gioia","year":"2020","journal-title":"BMC Medicine"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0180","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1515\/BC.2009.035","article-title":"Central nervous system: Cholesterol turnover, brain development and neurodegeneration","volume":"390","author":"Dietschy","year":"2009","journal-title":"Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0185","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/s41598-020-80378-y","article-title":"Sterol auto-oxidation adversely affects human motor neuron viability and is a neuropathological feature of amyotrophic lateral sclerosis","volume":"11","author":"Dodge","year":"2021","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0190","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1210\/en.2003-0993","article-title":"Regulation of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice","volume":"145","author":"Drover","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184522","article-title":"Oxysterols in autoimmunity","volume":"20","author":"Duc","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0200","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/ene.12664","article-title":"Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis","volume":"23","author":"Elia","year":"2016","journal-title":"European Journal of Neurology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2014.02.042","article-title":"Intracellular distribution of the vitamin D receptor in the brain: Comparison with classic target tissues and redistribution with development","volume":"268","author":"Eyles","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchemneu.2004.08.006","article-title":"Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain","volume":"29","author":"Eyles","year":"2005","journal-title":"Journal of Chemical Neuroanatomy"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1988.tb42093.x","article-title":"Topographic organization of ascending dopaminergic projections","volume":"537","author":"Fallon","year":"1988","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0220","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1167\/iovs.11-7496","article-title":"Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23H rats","volume":"52","author":"Fernandez-Sanchez","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0225","article-title":"Temporal evolution of the microbiome, immune system and epigenome with disease progression in ALS mice","volume":"13","author":"Figueroa-Romero","year":"2019","journal-title":"Disease Models & Mechanisms"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0230","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/164_2019_238","article-title":"The pharmacology of bile acids and their receptors","volume":"256","author":"Fiorucci","year":"2019","journal-title":"Handbook of Experimental Pharmacology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101094","article-title":"Bile acids and their receptors in metabolic disorders","volume":"82","author":"Fiorucci","year":"2021","journal-title":"Progress in Lipid Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0240","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1479-5876-10-253","article-title":"Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: A cross-sectional study","volume":"10","author":"Flores","year":"2012","journal-title":"Journal of Translational Medicine"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/metabo8040071","article-title":"Metabolomic profiling of bile acids in an experimental model of prodromal Parkinson\u2019s disease","volume":"8","author":"Graham","year":"2018","journal-title":"Metabolites"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0250","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1021\/acs.jproteome.8b00224","article-title":"Biochemical profiling of the brain and blood metabolome in a mouse model of prodromal Parkinson\u2019s disease reveals distinct metabolic profiles","volume":"17","author":"Graham","year":"2018","journal-title":"Journal of Proteome Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0255","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.685594","article-title":"The cerebrospinal fluid profile of cholesterol metabolites in Parkinson\u2019s disease and their association with disease state and clinical features","volume":"13","author":"Griffiths","year":"2021","journal-title":"Frontiers in Aging Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0260","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1515\/revneuro-2018-0074","article-title":"Multiple sclerosis - the remarkable story of a baffling disease","volume":"30","author":"Grzegorski","year":"2019","journal-title":"Reviews in the Neurosciences"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0265","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer\u2019s disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0270","doi-asserted-by":"crossref","first-page":"17085","DOI":"10.1038\/nrdp.2017.85","article-title":"Amyotrophic lateral sclerosis","volume":"3","author":"Hardiman","year":"2017","journal-title":"Nature Reviews. Disease Primers"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0275","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.steroids.2017.07.001","article-title":"Unconjugated bile acids in rat brain: Analytical method based on LC\/ESI-MS\/MS with chemical derivatization and estimation of their origin by comparison to serum levels","volume":"125","author":"Higashi","year":"2017","journal-title":"Steroids"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0280","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1073\/pnas.1524890113","article-title":"Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis","volume":"113","author":"Ho","year":"2016","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0285","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0031-6997(25)07154-6","article-title":"Dopamine (3-hydroxytyramine) and brain function","volume":"18","author":"Hornykiewicz","year":"1966","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0290","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fnbeh.2015.00070","article-title":"Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior","volume":"9","author":"Huang","year":"2015","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0295","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00401-016-1593-6","article-title":"The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion","volume":"132","author":"Hucke","year":"2016","journal-title":"Acta Neuropathologica"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0300","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF03159935","article-title":"Pathology of Parkinson\u2019s disease. Changes other than the nigrostriatal pathway","volume":"14","author":"Jellinger","year":"1991","journal-title":"Molecular and Chemical Neuropathology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0305","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/bs.irn.2017.05.005","article-title":"Neuropathology of nonmotor symptoms of Parkinson\u2019s disease","volume":"133","author":"Jellinger","year":"2017","journal-title":"International Review of Neurobiology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0310","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1093\/brain\/awab292","article-title":"Effects of statins on dopamine loss and prognosis in Parkinson\u2019s disease","volume":"144","author":"Jeong","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0315","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","article-title":"Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis","volume":"15","author":"Jia","year":"2018","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0320","first-page":"7","article-title":"Huntington\u2019s disease: Mechanisms of pathogenesis and therapeutic strategies","author":"Jimenez-Sanchez","year":"2017","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0325","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/mend.14.1.0409","article-title":"The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution","volume":"14","author":"Jones","year":"2000","journal-title":"Molecular Endocrinology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0330","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF02736846","article-title":"Localization and ontogeny of the orphan receptor OR-1 in the rat brain","volume":"7","author":"Kainu","year":"1996","journal-title":"Journal of Molecular Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0335","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1074\/jbc.M209706200","article-title":"A G protein-coupled receptor responsive to bile acids","volume":"278","author":"Kawamata","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0340","doi-asserted-by":"crossref","first-page":"10671","DOI":"10.1073\/pnas.162362299","article-title":"Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington\u2019s disease","volume":"99","author":"Keene","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0345","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/exnr.2001.7755","article-title":"A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington\u2019s disease","volume":"171","author":"Keene","year":"2001","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0350","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/glia.21049","article-title":"The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain","volume":"58","author":"Keitel","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0355","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.bbadis.2012.03.012","article-title":"X-linked adrenoleukodystrophy: Clinical, metabolic, genetic and pathophysiological aspects","volume":"1822","author":"Kemp","year":"2012","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0360","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001763","article-title":"The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity","volume":"12","author":"Kempf","year":"2014","journal-title":"PLoS Biology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0365","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40035-022-00307-z","article-title":"Tauroursodeoxycholic acid: A potential therapeutic tool in neurodegenerative diseases","volume":"11","author":"Khalaf","year":"2022","journal-title":"Translational Neurodegeneration"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0370","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0022-3565(24)37666-9","article-title":"Efflux of taurocholic acid across the blood-brain barrier: Interaction with cyclic peptides","volume":"286","author":"Kitazawa","year":"1998","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0375","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80900-9","article-title":"An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway","volume":"92","author":"Kliewer","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2018.09.001","article-title":"Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington\u2019s disease","volume":"135","author":"Kong","year":"2020","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105199","article-title":"An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington\u2019s disease","volume":"148","author":"Kong","year":"2021","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0390","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/19336896.2018.1525254","article-title":"A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds","volume":"12","author":"Ladner-Keay","year":"2018","journal-title":"Prion"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0395","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00401-016-1655-9","article-title":"Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy","volume":"133","author":"Launay","year":"2017","journal-title":"Acta Neuropathologica"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0400","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/978-3-319-17121-0_57","article-title":"Tauroursodeoxycholic acid protects retinal function and structure in rd1 mice","volume":"854","author":"Lawson","year":"2016","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0405","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1172\/JCI3703","article-title":"The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions","volume":"102","author":"Lehmann","year":"1998","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2012.10.060","article-title":"Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier","volume":"1491","author":"Lemmen","year":"2013","journal-title":"Brain Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0415","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3233\/JPD-212819","article-title":"Parkinson\u2019s disease progression and statins: Hydrophobicity matters","volume":"12","author":"Lewis","year":"2022","journal-title":"Journal of Parkinson\u2019s Disease"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0420","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbi.2013.07.007","article-title":"Cerebrospinal fluid inflammatory markers in Parkinson\u2019s disease--associations with depression, fatigue, and cognitive impairment","volume":"33","author":"Lindqvist","year":"2013","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0425","doi-asserted-by":"crossref","DOI":"10.1177\/26331055211018709","article-title":"Is there a brain microbiome?","volume":"16","author":"Link","year":"2021","journal-title":"Neuroscience Insights"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0430","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jsbmb.2015.11.018","article-title":"RXRalpha, PXR and CAR xenobiotic receptors mediate the apoptotic and neurotoxic actions of nonylphenol in mouse hippocampal cells","volume":"156","author":"Litwa","year":"2016","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0435","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/mds.27006","article-title":"Statins may facilitate Parkinson\u2019s disease: Insight gained from a large, national claims database","volume":"32","author":"Liu","year":"2017","journal-title":"Movement Disorders"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0440","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.exer.2018.02.015","article-title":"Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin","volume":"170","author":"Lobysheva","year":"2018","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0445","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1038\/s41598-021-83008-3","article-title":"High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus","volume":"11","author":"Loera-Valencia","year":"2021","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0450","doi-asserted-by":"crossref","first-page":"37735","DOI":"10.1074\/jbc.R100035200","article-title":"Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism","volume":"276","author":"Lu","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0455","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.omtm.2021.07.002","article-title":"Gene supplementation of CYP27A1 in the liver restores bile acid metabolism in a mouse model of cerebrotendinous xanthomatosis","volume":"22","author":"Lumbreras","year":"2021","journal-title":"Molecular Therapy Methods Clinical Development"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0460","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","article-title":"Identification of a nuclear receptor for bile acids","volume":"284","author":"Makishima","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0465","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s00415-019-09377-y","article-title":"Cholic acid as a treatment for cerebrotendinous xanthomatosis in adults","volume":"266","author":"Mandia","year":"2019","journal-title":"Journal of Neurology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0470","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1194\/jlr.M300369-JLR200","article-title":"Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain","volume":"45","author":"Mano","year":"2004","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0475","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.lfs.2006.11.022","article-title":"Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits","volume":"80","author":"Marini","year":"2007","journal-title":"Life Sciences"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0480","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.839526","article-title":"A gut feeling in amyotrophic lateral sclerosis: Microbiome of mice and men","volume":"12","author":"Martin","year":"2022","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0485","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0006-291X(02)02550-0","article-title":"Identification of membrane-type receptor for bile acids (M-BAR)","volume":"298","author":"Maruyama","year":"2002","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0490","series-title":"Liver X receptor-like receptors (version 2019.4). IUPHAR\/BPS guide to pharmacology database. GtoPdb CITE [internet]","author":"McDonnell","year":"2019"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0495","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fncel.2017.00191","article-title":"Bile acid-mediated sphingosine-1-phosphate receptor 2 signaling promotes neuroinflammation during hepatic encephalopathy in mice","volume":"11","author":"McMillin","year":"2017","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0500","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ajpath.2015.10.005","article-title":"Bile acid signaling is involved in the neurological decline in a murine model of acute liver failure","volume":"186","author":"McMillin","year":"2016","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0505","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/jnc.13243","article-title":"TGR5 signaling reduces neuroinflammation during hepatic encephalopathy","volume":"135","author":"McMillin","year":"2015","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0510","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jcmgh.2018.02.008","article-title":"FXR-mediated cortical cholesterol accumulation contributes to the pathogenesis of type A hepatic encephalopathy","volume":"6","author":"McMillin","year":"2018","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0515","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10545-015-9873-1","article-title":"Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis","volume":"39","author":"Mignarri","year":"2016","journal-title":"Journal of Inherited Metabolic Disease"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0520","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mce.2004.12.005","article-title":"Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues","volume":"231","author":"Miki","year":"2005","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0525","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3346\/jkms.2012.27.2.200","article-title":"Oral solubilized ursodeoxycholic acid therapy in amyotrophic lateral sclerosis: A randomized cross-over trial","volume":"27","author":"Min","year":"2012","journal-title":"Journal of Korean Medical Science"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0530","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12017-020-08625-z","article-title":"Bile acids: A communication channel in the gut-brain axis","volume":"23","author":"Monteiro-Cardoso","year":"2021","journal-title":"Neuromolecular Medicine"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0535","first-page":"68","article-title":"The fat brain","volume":"23","author":"Montesinos","year":"2020","journal-title":"Current Opinion in Clinical Nutrition and Metabolic Care"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0540","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jalz.2018.08.012","article-title":"Altered bile acid profile in mild cognitive impairment and Alzheimer\u2019s disease: Relationship to neuroimaging and CSF biomarkers","volume":"15","author":"Nho","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0545","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13023-014-0179-4","article-title":"Cerebrotendinous xanthomatosis: A comprehensive review of pathogenesis, clinical manifestations, diagnosis, and management","volume":"9","author":"Nie","year":"2014","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0550","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2133\/dmpk.19.135","article-title":"Tissue-specific mRNA expression profiles of human nuclear receptor subfamilies","volume":"19","author":"Nishimura","year":"2004","journal-title":"Drug Metabolism and Pharmacokinetics"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0555","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1248\/yakushi.123.369","article-title":"Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR","volume":"123","author":"Nishimura","year":"2003","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0560","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00222-18","article-title":"High dose and delayed treatment with bile acids ineffective in RML prion-infected mice","volume":"62","author":"Norman","year":"2018","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0565","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s12035-012-8256-y","article-title":"TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-beta deposition in APP\/PS1 mice","volume":"45","author":"Nunes","year":"2012","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0570","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.18632\/aging.203880","article-title":"Cholesterol metabolism in aging simultaneously altered in liver and nervous system","volume":"14","author":"Nunes","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0575","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13726","article-title":"Nigral overexpression of alpha-synuclein in a rat Parkinson\u2019s disease model indicates alterations in the enteric nervous system and the gut microbiome","volume":"32","author":"O\u2019Donovan","year":"2020","journal-title":"Neurogastroenterology and Motility"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0580","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1124\/dmd.109.029454","article-title":"Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier","volume":"38","author":"Ose","year":"2010","journal-title":"Drug Metabolism and Disposition"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0585","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/mus.27091","article-title":"Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis","volume":"63","author":"Paganoni","year":"2021","journal-title":"Muscle & Nerve"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0590","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMoa1916945","article-title":"Trial of sodium phenylbutyrate-taurursodiol for amyotrophic lateral sclerosis","volume":"383","author":"Paganoni","year":"2020","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0595","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.3233\/JPD-212655","article-title":"Statins in Parkinson\u2019s disease: Influence on motor progression","volume":"11","author":"Palermo","year":"2021","journal-title":"Journal of Parkinson\u2019s Disease"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0600","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2004.06.001","article-title":"Mitochondrially-mediated toxicity of bile acids","volume":"203","author":"Palmeira","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0605","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/WNF.0b013e3181c47569","article-title":"Safety, tolerability, and cerebrospinal fluid penetration of ursodeoxycholic acid in patients with amyotrophic lateral sclerosis","volume":"33","author":"Parry","year":"2010","journal-title":"Clinical Neuropharmacology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0610","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174470","article-title":"Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease","volume":"12","author":"Paterniti","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0615","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1152\/physrev.00049.2019","article-title":"Molecular physiology of bile acid signaling in health, disease, and aging","volume":"101","author":"Perino","year":"2021","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0620","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s42255-021-00398-4","article-title":"Central anorexigenic actions of bile acids are mediated by TGR5","volume":"3","author":"Perino","year":"2021","journal-title":"Nature Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0625","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000013353","article-title":"Case report of dysregulation of primary bile acid synthesis in a family with X-linked adrenoleukodystrophy","volume":"97","author":"Platek","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0630","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.dld.2014.01.159","article-title":"Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms","volume":"46","author":"Quinn","year":"2014","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0635","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-2999(02)02690-0","article-title":"Selective interaction of bile acids with muscarinic receptors: A case of molecular mimicry","volume":"457","author":"Raufman","year":"2002","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0640","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2006682","article-title":"Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward","volume":"16","author":"Reddy","year":"2018","journal-title":"PLoS Biology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0645","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/01.ATV.0000103951.67680.B1","article-title":"Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: Effects on lipid homeostasis, inflammation, and atherosclerosis","volume":"24","author":"Ricote","year":"2004","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0650","doi-asserted-by":"crossref","first-page":"9139","DOI":"10.1007\/s12035-018-1062-4","article-title":"Tauroursodeoxycholic acid improves motor symptoms in a mouse model of Parkinson\u2019s disease","volume":"55","author":"Rosa","year":"2018","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0655","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.brainresrev.2007.04.012","article-title":"Androgen regulation of beta-amyloid protein and the risk of Alzheimer\u2019s disease","volume":"57","author":"Rosario","year":"2008","journal-title":"Brain Research Reviews"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0660","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.jhep.2020.07.013","article-title":"Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy","volume":"73","author":"Rose","year":"2020","journal-title":"Journal of Hepatology"},{"issue":"Suppl","key":"10.1016\/j.pharmthera.2022.108311_bb0665","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1194\/jlr.R800026-JLR200","article-title":"Fifty years of advances in bile acid synthesis and metabolism","volume":"50","author":"Russell","year":"2009","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0670","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.neulet.2011.11.036","article-title":"The bile steroid chenodeoxycholate is a potent antagonist at NMDA and GABA(A) receptors","volume":"506","author":"Schubring","year":"2012","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0675","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.nbd.2018.11.018","article-title":"Inactivation of sphingosine-1-phosphate receptor 2 (S1PR2) decreases demyelination and enhances remyelination in animal models of multiple sclerosis","volume":"124","author":"Seyedsadr","year":"2019","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0680","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1194\/jlr.M014548","article-title":"Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer\u2019s patients with the Swedish APP 670\/671 mutation","volume":"52","author":"Shafaati","year":"2011","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0685","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s11745-013-3836-9","article-title":"Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver","volume":"48","author":"Smiljanic","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0690","doi-asserted-by":"crossref","first-page":"10809","DOI":"10.1073\/pnas.91.23.10809","article-title":"Ubiquitous receptor: A receptor that modulates gene activation by retinoic acid and thyroid hormone receptors","volume":"91","author":"Song","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0695","doi-asserted-by":"crossref","first-page":"18270","DOI":"10.1038\/s41598-020-75229-9","article-title":"Increased intestinal permeability and gut dysbiosis in the R6\/2 mouse model of Huntington\u2019s disease","volume":"10","author":"Stan","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0700","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1499-3872(14)60307-6","article-title":"Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases","volume":"14","author":"Stanimirov","year":"2015","journal-title":"Hepatobiliary & Pancreatic Diseases International"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0705","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/hep.24681","article-title":"Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes","volume":"55","author":"Studer","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109021","article-title":"Subcutaneous delivery of tauroursodeoxycholic acid rescues the cone photoreceptors in degenerative retina: A promising therapeutic molecule for retinopathy","volume":"117","author":"Tao","year":"2019","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0715","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ymthe.2018.10.010","article-title":"A stem cell-based screening platform identifies compounds that desensitize motor neurons to endoplasmic reticulum stress","volume":"27","author":"Thams","year":"2019","journal-title":"Molecular Therapy"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0720","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2009.08.001","article-title":"TGR5-mediated bile acid sensing controls glucose homeostasis","volume":"10","author":"Thomas","year":"2009","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0725","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003615","article-title":"Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study","volume":"18","author":"Varma","year":"2021","journal-title":"PLoS Medicine"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0730","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/BJ20060537","article-title":"Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation","volume":"398","author":"Vassileva","year":"2006","journal-title":"The Biochemical Journal"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0735","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/s12035-014-8731-8","article-title":"Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration","volume":"51","author":"Vaz","year":"2015","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0740","doi-asserted-by":"crossref","first-page":"13878","DOI":"10.1073\/pnas.172510899","article-title":"Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration","volume":"99","author":"Wang","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0745","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/nmo.12148","article-title":"The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon","volume":"25","author":"Ward","year":"2013","journal-title":"Neurogastroenterology and Motility"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.107974","article-title":"Taurocholic acid inhibits features of age-related macular degeneration in vitro","volume":"193","author":"Warden","year":"2020","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0755","doi-asserted-by":"crossref","DOI":"10.3390\/biom11050626","article-title":"Glycine-conjugated bile acids protect RPE tight junctions against oxidative stress and inhibit choroidal endothelial cell angiogenesis in vitro","volume":"11","author":"Warden","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0760","doi-asserted-by":"crossref","first-page":"fcaa110","DOI":"10.1093\/braincomms\/fcaa110","article-title":"Gut dysbiosis in Huntington\u2019s disease: Associations among gut microbiota, cognitive performance and clinical outcomes","volume":"2","author":"Wasser","year":"2020","journal-title":"Brain Communications"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0765","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.jhep.2016.07.046","article-title":"Cerebrospinal fluid metabolomics highlights dysregulation of energy metabolism in overt hepatic encephalopathy","volume":"65","author":"Weiss","year":"2016","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0770","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1101\/gad.9.9.1033","article-title":"LXR, a nuclear receptor that defines a distinct retinoid response pathway","volume":"9","author":"Willy","year":"1995","journal-title":"Genes & Development"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0775","article-title":"Satiety induced by bile acids is mediated via vagal afferent pathways. JCI","volume":"5","author":"Wu","year":"2020","journal-title":"Insight"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0780","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbi.2018.06.018","article-title":"Neuroprotective effects of INT-777 against Abeta1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice","volume":"73","author":"Wu","year":"2018","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0785","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105018","article-title":"The S1P2 receptor regulates blood-brain barrier integrity and leukocyte extravasation with implications for neurodegenerative disease","volume":"146","author":"Xiang","year":"2021","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0790","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ebiom.2018.10.030","article-title":"Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure","volume":"37","author":"Xie","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104704","article-title":"Implications of gut microbiota dysbiosis and metabolic changes in prion disease","volume":"135","author":"Yang","year":"2020","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0800","doi-asserted-by":"crossref","first-page":"G549","DOI":"10.1152\/ajpgi.00152.2020","article-title":"Bile acid metabolism and circadian rhythms","volume":"319","author":"Yang","year":"2020","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0805","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0306-4522(03)00438-X","article-title":"Dehydroepiandrosterone 7-hydroxylase CYP7B: Predominant expression in primate hippocampus and reduced expression in Alzheimer\u2019s disease","volume":"121","author":"Yau","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0810","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119252","article-title":"The bile acid TUDCA and neurodegenerative disorders: An overview","volume":"272","author":"Zangerolamo","year":"2021","journal-title":"Life Sciences"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0815","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.111116","article-title":"The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer\u2019s disease mice model","volume":"521","author":"Zangerolamo","year":"2021","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0820","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/abbi.1999.1307","article-title":"Rat pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation","volume":"368","author":"Zhang","year":"1999","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0825","doi-asserted-by":"crossref","first-page":"18801","DOI":"10.1002\/jcp.28519","article-title":"Disease mechanisms and neuroprotection by tauroursodeoxycholic acid in Rpgr knockout mice","volume":"234","author":"Zhang","year":"2019","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0830","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1074\/jbc.M209505200","article-title":"Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation","volume":"278","author":"Zhang","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2022.108311_bb0835","article-title":"Neuroprotective effects of a cholecystokinin analogue in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinson\u2019s disease mouse model","volume":"16","author":"Zhang","year":"2022","journal-title":"Frontiers in Neuroscience"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822002054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725822002054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:34:24Z","timestamp":1759012464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725822002054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":166,"alternative-id":["S0163725822002054"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108311","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bile acids and neurological disease","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108311","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108311"}}