{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:01:31Z","timestamp":1785290491600,"version":"3.55.0"},"reference-count":182,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.pharmthera.2023.108353","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T13:06:46Z","timestamp":1675343206000},"page":"108353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Immune cells and their derived microRNA-enriched extracellular vesicles in nonalcoholic fatty liver diseases: Novel therapeutic targets"],"prefix":"10.1016","volume":"243","author":[{"given":"Liu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Boeckmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robim M.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2023.108353_bb0005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jhep.2022.04.003","article-title":"Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial","volume":"77","author":"Alkhouri","year":"2022","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0010","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1478-3231.2011.02639.x","article-title":"Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease","volume":"32","author":"Alkhouri","year":"2012","journal-title":"Liver International"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0015","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fimmu.2018.00272","article-title":"Extracellular vesicles released from mycobacterium tuberculosis-infected neutrophils promote macrophage autophagy and decrease intracellular mycobacterial survival","volume":"9","author":"Alvarez-Jimenez","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0020","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/JLB.3AB0520-339RR","article-title":"Neutrophil-derived extracellular vesicles modulate the phenotype of naive human neutrophils","volume":"110","author":"Amjadi","year":"2021","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cct.2019.105922","article-title":"Cenicriviroc for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis: AURORA Phase 3 study design","volume":"89","author":"Anstee","year":"2020","journal-title":"Contemporary Clinical Trials"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0030","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/hep.31046","article-title":"An open-label, dose-escalation study to assess the safety and efficacy of IL-22 agonist F-652 in patients with alcohol-associated hepatitis","volume":"72","author":"Arab","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0035","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/hep.31755","article-title":"Microbiota-driven activation of intrahepatic B cells aggravates NASH through innate and adaptive signaling","volume":"74","author":"Barrow","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0040","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jhep.2016.05.037","article-title":"Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions","volume":"65","author":"Beattie","year":"2016","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0045","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1038\/s41467-020-16596-9","article-title":"Durable and controlled depletion of neutrophils in mice","volume":"11","author":"Boivin","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0050","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1152\/physrev.00049.2017","article-title":"Pharmacology of adenosine receptors: the state of the art","volume":"98","author":"Borea","year":"2018","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0055","doi-asserted-by":"crossref","first-page":"G211","DOI":"10.1152\/ajpgi.00040.2019","article-title":"CD8(+) T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease","volume":"318","author":"Breuer","year":"2020","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0060","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"issue":"406\u2013421","key":"10.1016\/j.pharmthera.2023.108353_bb0065","article-title":"Macrophage MerTK promotes liver fibrosis in nonalcoholic steatohepatitis","volume":"31","author":"Cai","year":"2020","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0070","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.tem.2018.08.003","article-title":"Role of innate immune signaling in non-alcoholic fatty liver disease","volume":"29","author":"Cai","year":"2018","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0075","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI122258","article-title":"Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223","volume":"129","author":"Calvente","year":"2019","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0080","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/17474124.2021.1887730","article-title":"Hepatocyte and immune cell crosstalk in non-alcoholic fatty liver disease","volume":"15","author":"Carranza-Trejo","year":"2021","journal-title":"Expert Review of Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0085","article-title":"Circulating TREM2 as a non-invasive diagnostic biomarker for NASH in patients with elevated liver stiffness","author":"Chandran","year":"2022","journal-title":"Hepatology, 77, 558-572."},{"key":"10.1016\/j.pharmthera.2023.108353_bb0090","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/hep.28526","article-title":"Platelets: No longer bystanders in liver disease","volume":"64","author":"Chauhan","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0095","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.3389\/fimmu.2020.01500","article-title":"Roles of hepatic innate and innate-like lymphocytes in nonalcoholic steatohepatitis","volume":"11","author":"Chen","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41423-020-00561-z","article-title":"Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0105","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-022-00410-w","article-title":"Therapeutically harnessing extracellular vesicles","volume":"21","author":"Cheng","year":"2022","journal-title":"Nature Reviews. Drug Discovery"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108626","article-title":"Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH","volume":"34","author":"Daemen","year":"2021","journal-title":"Cell Reports"},{"issue":"1610\u20131620","key":"10.1016\/j.pharmthera.2023.108353_bb0115","article-title":"Hepatocytes delete regulatory T cells by enclysis, a CD4(+) T cell engulfment process","volume":"29","author":"Davies","year":"2019","journal-title":"Cell Reports"},{"issue":"2089\u20132100","key":"10.1016\/j.pharmthera.2023.108353_bb0120","article-title":"Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming","volume":"54","author":"De Simone","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.18","article-title":"Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells","volume":"6","author":"Dransfield","year":"2015","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0130","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41586-021-03233-8","article-title":"Auto-aggressive CXCR6(+) CD8 T cells cause liver immune pathology in NASH","volume":"592","author":"Dudek","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0135","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nri.2017.86","article-title":"Innate lymphoid cells: major players in inflammatory diseases","volume":"17","author":"Ebbo","year":"2017","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0140","doi-asserted-by":"crossref","first-page":"aaa6566","DOI":"10.1126\/science.aaa6566","article-title":"Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology","volume":"348","author":"Eberl","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0145","first-page":"2256","article-title":"The A3 adenosine receptor agonist, namodenoson, ameliorates nonalcoholic steatohepatitis in mice","volume":"44","author":"Fishman","year":"2019","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0150","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/hep.29477","article-title":"A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis","volume":"67","author":"Friedman","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0155","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: An organ with predominant innate immunity","volume":"47","author":"Gao","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0160","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cmet.2022.05.008","article-title":"MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH","volume":"34","author":"Gao","year":"2022","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0165","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2021.05.022","article-title":"Burden of non-alcoholic fatty liver disease in Asia, the Middle East and North Africa: data from Global Burden of Disease 2009-2019","volume":"75","author":"Golabi","year":"2021","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0170","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ccell.2016.05.020","article-title":"Metabolic inflammation-associated IL-17A causes non-alcoholic steatohepatitis and hepatocellular carcinoma","volume":"30","author":"Gomes","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0175","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jhep.2021.12.012","article-title":"Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease","volume":"76","author":"Govaere","year":"2022","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0180","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.4049\/jimmunol.1103551","article-title":"Neutrophil-mediated inhibition of proinflammatory cytokine responses","volume":"189","author":"Gresnigt","year":"2012","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0185","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/thoraxjnl-2019-214077","article-title":"Macrophage-derived exosomes attenuate fibrosis in airway epithelial cells through delivery of antifibrotic miR-142-3p","volume":"75","author":"Guiot","year":"2020","journal-title":"Thorax"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0190","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s42255-019-0076-1","article-title":"Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution","volume":"1","author":"Haas","year":"2019","journal-title":"Nature Metabolism"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.648754","article-title":"Group 3 innate lymphoid cells protect steatohepatitis from high-fat diet induced toxicity","volume":"12","author":"Hamaguchi","year":"2021","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0200","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1172\/JCI124219","article-title":"A maresin 1\/RORalpha\/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis","volume":"129","author":"Han","year":"2019","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0205","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1002\/hep.26746","article-title":"IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice","volume":"59","author":"Harley","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117010","article-title":"Amlexanox reversed non-alcoholic fatty liver disease through IKKepsilon inhibition of hepatic stellate cell","volume":"239","author":"He","year":"2019","journal-title":"Life Sciences"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0215","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03688-21","article-title":"Interleukin-17 weakens the NAFLD\/NASH process by facilitating intestinal barrier restoration depending on the gut microbiota","volume":"13","author":"He","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0220","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.30645","article-title":"MicroRNA-223 ameliorates nonalcoholic steatohepatitis and cancer by targeting multiple inflammatory and oncogenic genes in hepatocytes","volume":"70","author":"He","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0225","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141513","article-title":"Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis","volume":"131","author":"He","year":"2021","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0230","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jhep.2022.06.004","article-title":"Soluble TREM2 levels reflect the recruitment and expansion of TREM2(+) macrophages that localize to fibrotic areas and limit NASH","volume":"77","author":"Hendrikx","year":"2022","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.580968","article-title":"CD4(+) T cells mediate the development of liver fibrosis in high fat diet-induced NAFLD in humanized mice","volume":"11","author":"Her","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0240","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/hep.27793","article-title":"Liver inflammation abrogates immunological tolerance induced by Kupffer cells","volume":"62","author":"Heymann","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0245","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.it.2019.04.013","article-title":"The neutrophil life cycle","volume":"40","author":"Hidalgo","year":"2019","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0250","first-page":"E5096","article-title":"Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue","volume":"115","author":"Hill","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0255","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/hep.28814","article-title":"Extracellular vesicles in liver pathobiology: Small particles with big impact","volume":"64","author":"Hirsova","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0260","doi-asserted-by":"crossref","DOI":"10.4110\/in.2018.18.e43","article-title":"Extracellular vesicles of neutrophils","volume":"18","author":"Hong","year":"2018","journal-title":"Immune Network"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0265","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13030","article-title":"Features and roles of T helper 22 cells in immunological diseases and malignancies","volume":"93","author":"Hossein-Khannazer","year":"2021","journal-title":"Scandinavian Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0270","doi-asserted-by":"crossref","DOI":"10.1172\/JCI135197","article-title":"TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis","volume":"131","author":"Hou","year":"2021","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0275","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.31658","article-title":"Myeloid-cell-specific IL-6 signaling promotes MicroRNA-223-enriched exosome production to attenuate NAFLD-associated fibrosis","volume":"74","author":"Hou","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0280","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41565-020-00836-6","article-title":"Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis","volume":"16","author":"Hu","year":"2021","journal-title":"Nature Nanotechnology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0285","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1194\/jlr.M003004","article-title":"Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease","volume":"51","author":"Hua","year":"2010","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcmgh.2022.03.006","article-title":"Macrophage SCAP contributes to metaflammation and lean NAFLD by activating STING-NF-kappaB signaling pathway","volume":"14","author":"Huang","year":"2022","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0295","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/hep.31031","article-title":"Interleukin-22 ameliorates neutrophil-driven nonalcoholic steatohepatitis through multiple targets","volume":"72","author":"Hwang","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0300","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/hep.31390","article-title":"Protective and detrimental roles of p38alpha mitogen-activated protein kinase in different stages of nonalcoholic fatty liver disease","volume":"72","author":"Hwang","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0305","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.751802","article-title":"Role of neutrophils in the pathogenesis of nonalcoholic steatohepatitis","volume":"12","author":"Hwang","year":"2021","journal-title":"Frontiers in Endocrinology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0310","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/hep.21549","article-title":"Neutrophil depletion protects against murine acetaminophen hepatotoxicity: another perspective","volume":"45","author":"Jaeschke","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0315","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/hep.23253","article-title":"Major histocompatibility complex class I-related chains A and B (MIC A\/B): a novel role in nonalcoholic steatohepatitis","volume":"51","author":"Kahraman","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0320","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0325","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/hep.32428","article-title":"Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease","volume":"76","author":"Karl","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0330","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/hep.23837","article-title":"Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3","volume":"52","author":"Ki","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0335","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s12951-021-01120-y","article-title":"Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis","volume":"19","author":"Kim","year":"2021","journal-title":"Journal of Nanobiotechnology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0340","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1038\/s41467-021-24734-0","article-title":"CD8(+) tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells","volume":"12","author":"Koda","year":"2021","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122718","article-title":"The functional heterogeneity of neutrophil-derived extracellular vesicles reflects the status of the parent cell","volume":"9","author":"Kolonics","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0350","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.25744","article-title":"Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0355","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/hep4.1566","article-title":"Therapeutic targeting of myeloperoxidase attenuates NASH in mice","volume":"4","author":"Koop","year":"2020","journal-title":"Hepatology Communications"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0360","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-0039-1687851","article-title":"Macrophages as key players during adipose tissue-liver crosstalk in nonalcoholic fatty liver disease","volume":"39","author":"Korf","year":"2019","journal-title":"Seminars in Liver Disease"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0365","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCRESAHA.117.310795","article-title":"Circulating platelets as mediators of immunity, inflammation, and thrombosis","volume":"122","author":"Koupenova","year":"2018","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0370","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113888","article-title":"Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis","volume":"176","author":"Kumar","year":"2021","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0380","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.it.2006.05.003","article-title":"CD4+CD25+ Tregs and NKT cells: regulators regulating regulators","volume":"27","author":"La Cava","year":"2006","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0385","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/cmi.2010.5","article-title":"Th17 cells and their associated cytokines in liver diseases","volume":"7","author":"Lafdil","year":"2010","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0390","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.cell.2014.11.018","article-title":"Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment","volume":"159","author":"Lavin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0395","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1136\/gutjnl-2021-326259","article-title":"CXCR2 inhibition enables NASH-HCC immunotherapy","volume":"71","author":"Leslie","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0400","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1038\/ncomms13839","article-title":"The microbiota maintain homeostasis of liver-resident gammadeltaT-17 cells in a lipid antigen\/CD1d-dependent manner","volume":"7","author":"Li","year":"2017","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0405","article-title":"Vascular adhesion protein-1 (VAP-1)\/semicarbazide-sensitive amine oxidase (SSAO): a potential therapeutic target for atherosclerotic cardiovascular diseases","volume":"12","author":"Li","year":"2021","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0410","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/hep4.1404","article-title":"Characterization of cellular sources and circulating levels of extracellular vesicles in a dietary murine model of nonalcoholic steatohepatitis","volume":"3","author":"Li","year":"2019","journal-title":"Hepatology Communications"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0415","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/s-0041-1730926","article-title":"Interleukin-17 in liver disease pathogenesis","volume":"41","author":"Li","year":"2021","journal-title":"Seminars in Liver Disease"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0420","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00395-020-0781-7","article-title":"M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment","volume":"115","author":"Liu","year":"2020","journal-title":"Basic Research in Cardiology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0425","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0430","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0435","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/hep.31622","article-title":"Combination therapies including cilofexor and firsocostat for bridging fibrosis and cirrhosis attributable to NASH","volume":"73","author":"Loomba","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0440","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jcmgh.2021.08.004","article-title":"SYK-3BP2 pathway activity in parenchymal and myeloid cells is a key pathogenic factor in metabolic steatohepatitis","volume":"13","author":"Luci","year":"2022","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0445","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3389\/fimmu.2019.01192","article-title":"Natural killer cells and Type 1 innate lymphoid cells are new actors in non-alcoholic fatty liver disease","volume":"10","author":"Luci","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0450","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature16969","article-title":"NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis","volume":"531","author":"Ma","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0455","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41591-019-0379-5","article-title":"Platelet GPIbalpha is a mediator and potential interventional target for NASH and subsequent liver cancer","volume":"25","author":"Malehmir","year":"2019","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0460","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.640869","article-title":"Revisiting the role of natural killer cells in non-alcoholic fatty liver disease","volume":"12","author":"Martinez-Chantar","year":"2021","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0465","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.immuni.2008.03.001","article-title":"Th17 cell differentiation: the long and winding road","volume":"28","author":"McGeachy","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0470","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/hep.30401","article-title":"Dietary lipids differentially shape nonalcoholic steatohepatitis progression and the transcriptome of Kupffer cells and infiltrating macrophages","volume":"70","author":"McGettigan","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103847","article-title":"NAFLD indirectly impairs antigen-specific CD8(+) T cell immunity against liver cancer in mice","volume":"25","author":"McVey","year":"2022","journal-title":"iScience"},{"issue":"765\u2013776","key":"10.1016\/j.pharmthera.2023.108353_bb0480","article-title":"Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice","volume":"143","author":"Meng","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0485","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/s41590-018-0251-7","article-title":"Metabolic reprogramming of natural killer cells in obesity limits antitumor responses","volume":"19","author":"Michelet","year":"2018","journal-title":"Nature Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0490","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.trsl.2020.11.003","article-title":"Nonalcoholic fatty liver disease (NAFLD) severity is associated to a nonhemostatic contribution and proinflammatory phenotype of platelets","volume":"231","author":"Miele","year":"2021","journal-title":"Translational Research"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0495","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s10020-019-0084-3","article-title":"Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes","volume":"25","author":"Mirea","year":"2019","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0500","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00535-010-0272-y","article-title":"Absence of invariant natural killer T cells deteriorates liver inflammation and fibrosis in mice fed high-fat diet","volume":"45","author":"Miyagi","year":"2010","journal-title":"Journal of Gastroenterology"},{"issue":"1187\u20131204","key":"10.1016\/j.pharmthera.2023.108353_bb0505","article-title":"PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease","volume":"33","author":"Moreno-Fernandez","year":"2021","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0510","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4049\/jimmunol.1402709","article-title":"S100A8 production in CXCR2-expressing CD11b+Gr-1high cells aggravates hepatitis in mice fed a high-fat and high-cholesterol diet","volume":"196","author":"Mukai","year":"2016","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0515","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00281-021-00881-w","article-title":"Functional heterogeneity of CD4(+) T cells in liver inflammation","volume":"43","author":"Muscate","year":"2021","journal-title":"Seminars in Immunopathology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0520","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12020-017-1323-4","article-title":"Neutrophil depletion improves diet-induced non-alcoholic fatty liver disease in mice","volume":"57","author":"Ou","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0525","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0530","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3389\/fimmu.2016.00490","article-title":"Immune imbalances in non-alcoholic fatty liver disease: from general biomarkers and neutrophils to Interleukin-17 axis activation and new therapeutic targets","volume":"7","author":"Paquissi","year":"2016","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0535","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/cmi.2015.96","article-title":"Liver natural killer cells: subsets and roles in liver immunity","volume":"13","author":"Peng","year":"2016","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0540","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/B978-0-12-405211-6.00006-1","article-title":"Toll-like receptors in liver disease","volume":"59","author":"Petrasek","year":"2013","journal-title":"Advances in Clinical Chemistry"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0545","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41586-021-03362-0","article-title":"NASH limits anti-tumour surveillance in immunotherapy-treated HCC","volume":"592","author":"Pfister","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0550","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/TP.0000000000002480","article-title":"Nonalcoholic fatty liver disease: basic pathogenetic mechanisms in the progression from NAFLD to NASH","volume":"103","author":"Pierantonelli","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126696","article-title":"Combined therapy with a CCR2\/CCR5 antagonist and FGF21 analogue synergizes in ameliorating steatohepatitis and fibrosis","volume":"23","author":"Puengel","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0560","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1089\/ars.2014.6108","article-title":"Myeloperoxidase-hepatocyte-stellate cell cross talk promotes hepatocyte injury and fibrosis in experimental nonalcoholic steatohepatitis","volume":"23","author":"Pulli","year":"2015","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0565","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jhep.2020.05.047","article-title":"Blocking integrin alpha4beta7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis","volume":"73","author":"Rai","year":"2020","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0570","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/hep.31108","article-title":"Cenicriviroc treatment for adults with nonalcoholic steatohepatitis and fibrosis: final analysis of the phase 2b CENTAUR Study","volume":"72","author":"Ratziu","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0575","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4049\/jimmunol.1501175","article-title":"Progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis is marked by a higher frequency of Th17 cells in the liver and an increased Th17\/resting regulatory T cell ratio in peripheral blood and in the liver","volume":"196","author":"Rau","year":"2016","journal-title":"Journal of Immunology"},{"issue":"641\u2013657","key":"10.1016\/j.pharmthera.2023.108353_bb0580","article-title":"Osteopontin expression identifies a subset of recruited macrophages distinct from kupffer cells in the fatty liver","volume":"53","author":"Remmerie","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0585","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S2468-1253(22)00165-0","article-title":"The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis","volume":"7","author":"Riazi","year":"2022","journal-title":"The Lancet Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0590","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jhep.2007.04.019","article-title":"Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis","volume":"47","author":"Rivera","year":"2007","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0595","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/cmi.2016.3","article-title":"Liver immunology and its role in inflammation and homeostasis","volume":"13","author":"Robinson","year":"2016","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0600","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jcmgh.2021.08.002","article-title":"E-selectin-dependent inflammation and lipolysis in adipose tissue exacerbate steatosis-to-NASH progression via S100A8\/9","volume":"13","author":"Rodrigues","year":"2022","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0605","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/CS20150405","article-title":"The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice","volume":"130","author":"Rolla","year":"2016","journal-title":"Clinical Science (London, England)"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0610","doi-asserted-by":"crossref","first-page":"13464","DOI":"10.1038\/ncomms13464","article-title":"Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response","volume":"7","author":"Rossaint","year":"2016","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102429","article-title":"Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies","volume":"19","author":"Ruiz de Morales","year":"2020","journal-title":"Autoimmunity Reviews"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0620","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/apt.16664","article-title":"Randomised clinical trial: A phase 2 double-blind study of namodenoson in non-alcoholic fatty liver disease and steatohepatitis","volume":"54","author":"Safadi","year":"2021","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0625","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/hep4.1178","article-title":"Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model","volume":"2","author":"Saijou","year":"2018","journal-title":"Hepatology Communications"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0630","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nm.3547","article-title":"Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines","volume":"20","author":"Schauer","year":"2014","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0635","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1042\/CS20170218","article-title":"miR-223 represents a biomarker in acute and chronic liver injury","volume":"131","author":"Schueller","year":"2017","journal-title":"Clinical Science (London, England)"},{"issue":"1057\u20131074","key":"10.1016\/j.pharmthera.2023.108353_bb0640","article-title":"Niche-specific reprogramming of epigenetic landscapes drives myeloid cell diversity in nonalcoholic steatohepatitis","volume":"52","author":"Seidman","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0645","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.it.2019.04.012","article-title":"Neutrophil diversity in health and disease","volume":"40","author":"Silvestre-Roig","year":"2019","journal-title":"Trends in Immunology"},{"issue":"2776\u20132784","key":"10.1016\/j.pharmthera.2023.108353_bb0650","article-title":"Daily aspirin use associated with reduced risk for fibrosis progression in patients with nonalcoholic fatty liver disease","volume":"17","author":"Simon","year":"2019","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0655","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/hep.30990","article-title":"Yes-associated protein in kupffer cells enhances the production of proinflammatory cytokines and promotes the development of nonalcoholic steatohepatitis","volume":"72","author":"Song","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0660","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.tcb.2020.06.003","article-title":"The roles of CD8(+) T cell subsets in antitumor immunity","volume":"30","author":"St Paul","year":"2020","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0665","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.3389\/fimmu.2019.03130","article-title":"Mouse models and tools for the in vivo study of neutrophils","volume":"10","author":"Stackowicz","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0670","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3389\/fimmu.2019.01255","article-title":"Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease","volume":"10","author":"Stiglund","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0675","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2017.05.002","article-title":"Myeloperoxidase: A new player in autoimmunity","volume":"317","author":"Strzepa","year":"2017","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0680","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41575-019-0210-2","article-title":"Adaptive immunity: an emerging player in the progression of NAFLD","volume":"17","author":"Sutti","year":"2020","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0685","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/gutjnl-2011-301857","article-title":"NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease","volume":"61","author":"Syn","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0690","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.23599","article-title":"Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease","volume":"51","author":"Syn","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0695","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/13543784.2018.1442436","article-title":"Cenicriviroc for the treatment of non-alcoholic steatohepatitis and liver fibrosis","volume":"27","author":"Tacke","year":"2018","journal-title":"Expert Opinion on Investigational Drugs"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0700","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2885","article-title":"Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase","volume":"18","author":"Talukdar","year":"2012","journal-title":"Nature Medicine"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0705","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41423-022-00872-3","article-title":"Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver","volume":"19","author":"Tang","year":"2022","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0710","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrgastro.2016.104","article-title":"Obesity: Metabolically healthy obesity and NAFLD","volume":"13","author":"Targher","year":"2016","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"issue":"171\u2013184","key":"10.1016\/j.pharmthera.2023.108353_bb0715","article-title":"IL-6\/Stat3-dependent induction of a distinct, obesity-associated NK cell subpopulation deteriorates energy and glucose homeostasis","volume":"26","author":"Theurich","year":"2017","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0720","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature21365","article-title":"Adipose-derived circulating miRNAs regulate gene expression in other tissues","volume":"542","author":"Thomou","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0725","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/s42255-021-00501-9","article-title":"Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity","volume":"3","author":"Tilg","year":"2021","journal-title":"Nature Metabolism"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0730","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/hep.30952","article-title":"gammadelta T cells promote steatohepatitis by orchestrating innate and adaptive immune programming","volume":"71","author":"Torres-Hernandez","year":"2020","journal-title":"Hepatology"},{"issue":"627\u2013640","key":"10.1016\/j.pharmthera.2023.108353_bb0735","article-title":"Impaired kupffer cell self-renewal alters the liver response to lipid overload during non-alcoholic steatohepatitis","volume":"53","author":"Tran","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0740","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/gutjnl-2021-324305","article-title":"Novel therapeutic targets for cholestatic and fatty liver disease","volume":"71","author":"Trauner","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0745","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fimmu.2019.00082","article-title":"The differential roles of t cells in non-alcoholic fatty liver disease and obesity","volume":"10","author":"Van Herck","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0750","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.molmed.2019.02.003","article-title":"Immune cell-derived extracellular vesicles - functions and therapeutic applications","volume":"25","author":"Veerman","year":"2019","journal-title":"Trends in Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0755","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800274","article-title":"Proteomic profiling of LPS-induced macrophage-derived exosomes indicates their involvement in acute liver injury","volume":"19","author":"Wang","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0760","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41423-020-00579-3","article-title":"Immunological mechanisms and therapeutic targets of fatty liver diseases","volume":"18","author":"Wang","year":"2021","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0765","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jhep.2021.07.032","article-title":"Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis","volume":"75","author":"Wang","year":"2021","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0770","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jhep.2022.02.031","article-title":"Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis","volume":"77","author":"Wang","year":"2022","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0775","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.3389\/fimmu.2018.01298","article-title":"S100A8\/A9 in Inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0780","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1136\/gutjnl-2020-322526","article-title":"MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases","volume":"70","author":"Wang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0785","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.7150\/ijbs.58365","article-title":"MicroRNA-223 restricts liver fibrosis by inhibiting the TAZ-IHH-GLI2 and PDGF signaling pathways via the crosstalk of multiple liver cell types","volume":"17","author":"Wang","year":"2021","journal-title":"International Journal of Biological Sciences"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0790","doi-asserted-by":"crossref","first-page":"433","DOI":"10.21037\/hbsn.2016.09.10","article-title":"Immune surveillance of liver cancer in non-alcoholic fatty liver disease: excess lipids cause CD4 T-cells loss and promote hepatocellular carcinoma development","volume":"5","author":"Weiskirchen","year":"2016","journal-title":"Hepatobiliary Surgery and Nutrition"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0795","doi-asserted-by":"crossref","first-page":"1400370","DOI":"10.1080\/20013078.2017.1400370","article-title":"Biological roles and potential applications of immune cell-derived extracellular vesicles","volume":"6","author":"Wen","year":"2017","journal-title":"Journal of Extracellular Vesicles"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0800","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0805","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1172\/JCI73722","article-title":"Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis","volume":"125","author":"Weston","year":"2015","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0810","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nri2487","article-title":"Epigenetic control of T-helper-cell differentiation","volume":"9","author":"Wilson","year":"2009","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0815","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/hep.29914","article-title":"Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis","volume":"68","author":"van der Windt","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0820","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ccell.2014.09.003","article-title":"Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes","volume":"26","author":"Wolf","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0825","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3350\/cmh.2019.0004","article-title":"Underlying liver disease and advanced stage liver cancer are associated with elevated neutrophil-lymphocyte ratio","volume":"25","author":"Wong","year":"2019","journal-title":"Clinical and Molecular Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0830","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jhep.2019.11.013","article-title":"Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice","volume":"72","author":"Xiang","year":"2020","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0835","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101634","article-title":"Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH","volume":"36","author":"Xu","year":"2020","journal-title":"Redox Biology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0840","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3350\/cmh.2020.0261","article-title":"Serum lipocalin-2 is a potential biomarker for the clinical diagnosis of nonalcoholic steatohepatitis","volume":"27","author":"Xu","year":"2021","journal-title":"Clinical and Molecular Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0845","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jhep.2010.03.004","article-title":"Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22","volume":"53","author":"Yang","year":"2010","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0850","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.jhep.2016.05.041","article-title":"Lipocalin-2 mediates non-alcoholic steatohepatitis by promoting neutrophil-macrophage crosstalk via the induction of CXCR2","volume":"65","author":"Ye","year":"2016","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0855","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0153-7","article-title":"Role of miR-223 in the pathophysiology of liver diseases","volume":"50","author":"Ye","year":"2018","journal-title":"Experimental & Molecular Medicine"},{"issue":"781\u2013790","key":"10.1016\/j.pharmthera.2023.108353_bb0860","article-title":"MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice","volume":"33","author":"Ying","year":"2021","journal-title":"Cell Metabolism"},{"issue":"372\u2013384","key":"10.1016\/j.pharmthera.2023.108353_bb0865","article-title":"Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity","volume":"171","author":"Ying","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0870","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.7150\/thno.51756","article-title":"Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles","volume":"11","author":"Youn","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0875","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease - A global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0880","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1172\/JCI121842","article-title":"STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis","volume":"129","author":"Yu","year":"2019","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0885","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12030","article-title":"Extracellular vesicles: Natural liver-accumulating drug delivery vehicles for the treatment of liver diseases","volume":"10","author":"Zhang","year":"2020","journal-title":"Journal of Extracellular Vesicles"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0890","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jhep.2019.03.014","article-title":"Macrophage p38alpha promotes nutritional steatohepatitis through M1 polarization","volume":"71","author":"Zhang","year":"2019","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0895","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41419-020-2582-1","article-title":"Neutrophils undergo switch of apoptosis to NETosis during murine fatty liver injury via S1P receptor 2 signaling","volume":"11","author":"Zhao","year":"2020","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0900","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1530\/JOE-19-0198","article-title":"Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH","volume":"243","author":"Zhou","year":"2019","journal-title":"The Journal of Endocrinology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0905","article-title":"Pathogenic and potential therapeutic roles of exosomes derived from immune cells in liver diseases","volume":"13","author":"Zhou","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2023.108353_bb0910","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152579","article-title":"Dual TBK1\/IKKepsilon inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro","volume":"444","author":"Zhou","year":"2020","journal-title":"Toxicology"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725823000177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725823000177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T22:27:25Z","timestamp":1759012045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725823000177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":182,"alternative-id":["S0163725823000177"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2023.108353","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune cells and their derived microRNA-enriched extracellular vesicles in nonalcoholic fatty liver diseases: Novel therapeutic targets","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2023.108353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108353"}}