{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:13:36Z","timestamp":1792268016980,"version":"4.4.0"},"reference-count":205,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020T130334"],"award-info":[{"award-number":["2020T130334"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.pharmthera.2024.108652","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T15:12:56Z","timestamp":1713798776000},"page":"108652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm"],"prefix":"10.1016","volume":"259","author":[{"given":"Wenwen","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bufan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjun","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruochen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mou","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2024.108652_bb0005","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.046979","article-title":"Latent TGF\u03b2-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation","volume":"15","author":"Abrial","year":"2022","journal-title":"Disease Models & Mechanisms"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0010","doi-asserted-by":"crossref","DOI":"10.3791\/64122","article-title":"Construction of a human aorta smooth muscle cell organ-on-A-Chip model for recapitulating biomechanical strain in the Aortic Wall","author":"Abudupataer","year":"2022","journal-title":"Jove-Journal of Visualized Experiments, 6, 185"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1146\/annurev-physiol-012110-142315","article-title":"Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease","volume":"74","author":"Alexander","year":"2012","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-neuro-111020-090812","article-title":"Challenges of organoid research","volume":"45","author":"Andrews","year":"2022","journal-title":"Annual Review of Neuroscience"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0025","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1038\/s41436-019-0444-y","article-title":"Genetic diversity and pathogenic variants as possible predictors of severity in a French sample of nonsyndromic heritable thoracic aortic aneurysms and dissections (nshTAAD)","volume":"21","author":"Arnaud","year":"2019","journal-title":"Genetics in Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0030","doi-asserted-by":"crossref","first-page":"25771","DOI":"10.1021\/acsami.1c05344","article-title":"Pentagalloyl glucose-laden poly(lactide-co-glycolide) nanoparticles for the biomechanical extracellular matrix stabilization of an in vitro abdominal aortic aneurysm model","volume":"13","author":"Arnold","year":"2021","journal-title":"ACS Applied Materials & Interfaces"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0035","doi-asserted-by":"crossref","first-page":"0145031","DOI":"10.1115\/1.4032056","article-title":"Characterizations and correlations of wall shear stress in aneurysmal flow","volume":"138","author":"Arzani","year":"2016","journal-title":"Journal of Biomechanical Engineering"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0040","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/ATVBAHA.117.310333","article-title":"IL-1 beta (Interleukin-1 beta) and TNF-alpha (tumor necrosis factor-alpha) impact abdominal aortic aneurysm formation by differential effects on macrophage polarization","volume":"38","author":"Batra","year":"2018","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0045","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41598-021-04089-8","article-title":"Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition","volume":"12","author":"Berman","year":"2022","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0050","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1055\/a-1659-3908","article-title":"Rosmarinic acid suppresses abdominal aortic aneurysm progression in apolipoprotein E-deficient mice","volume":"88","author":"Bian","year":"2022","journal-title":"Planta Medica"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0055","doi-asserted-by":"crossref","first-page":"12984","DOI":"10.18632\/oncotarget.3848","article-title":"Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease","volume":"6","author":"Biros","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0060","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: Aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nature Reviews. Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0065","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1161\/CIRCRESAHA.117.311082","article-title":"Autophagy and Mitophagy in cardiovascular disease","volume":"120","author":"Bravo-San Pedro","year":"2017","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0070","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jvssci.2021.01.002","article-title":"Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery","volume":"2","author":"Busch","year":"2021","journal-title":"JVS Vasc Sci"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0075","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jss.2021.05.001","article-title":"Artesunate attenuated the progression of abdominal aortic aneurysm in a mouse model","volume":"267","author":"Cai","year":"2021","journal-title":"The Journal of Surgical Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0080","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1271\/bbb.110194","article-title":"Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products","volume":"75","author":"Cai","year":"2011","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/781780","article-title":"Xuezhikang therapy increases miR-33 expression in patients with low HDL-C levels","volume":"2014","author":"Cao","year":"2014","journal-title":"Disease Markers"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.116034","article-title":"Chinese traditional formula Kaixin San suppressed ferroptosis of hippocampal neurons and cardiomyocytes in mice with paradoxical sleep deprivation","volume":"304","author":"Cao","year":"2023","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0095","first-page":"909","article-title":"Effect of yiqi jianpi drugs on apoptosis and relevant gene expression in cultured vascular smooth muscle cell","volume":"21","author":"Chai","year":"2001","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0100","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1021\/jf502942r","article-title":"Mulberry water extracts inhibit atherosclerosis through suppression of the integrin-beta(3)\/focal adhesion kinase complex and downregulation of nuclear factor kappaB signaling in vivo and in vitro","volume":"62","author":"Chan","year":"2014","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0105","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/biof.1601","article-title":"Gypenoside a protects ischemia\/reperfusion injuries by suppressing miR-143-3p level via the activation of AMPK\/Foxo1 pathway","volume":"46","author":"Chang","year":"2020","journal-title":"Biofactors"},{"issue":"542\u2013557","key":"10.1016\/j.pharmthera.2024.108652_bb0110","article-title":"Smooth muscle cell reprogramming in aortic aneurysms","volume":"26","author":"Chen","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0115","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.avsg.2021.06.003","article-title":"Paeonol ameliorates abdominal aortic aneurysm progression by the NF-kappaB pathway","volume":"77","author":"Chen","year":"2021","journal-title":"Annals of Vascular Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0120","doi-asserted-by":"crossref","first-page":"2836128","DOI":"10.1155\/2022\/2836128","article-title":"Chinese herbal formula Huayu-Qiangshen-Tongbi decoction attenuates rheumatoid arthritis through upregulating miR-125b to suppress NF-kappaB-induced inflammation by targeting CK2","volume":"2022","author":"Chen","year":"2022","journal-title":"Journal of Immunology Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106122","article-title":"BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection","volume":"177","author":"Chen","year":"2022","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0130","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1152\/physrev.00047.2009","article-title":"Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives","volume":"91","author":"Chiu","year":"2011","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0135","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1038\/s12276-023-01130-w","article-title":"Aortic aneurysms: Current pathogenesis and therapeutic targets","volume":"55","author":"Cho","year":"2023","journal-title":"Experimental & Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0140","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/HYPERTENSIONAHA.118.11144","article-title":"Endothelial cell tetrahydrobiopterin modulates sensitivity to Ang (angiotensin) II-induced vascular remodeling, blood pressure, and abdominal aortic aneurysm","volume":"72","author":"Chuaiphichai","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0145","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1039\/D0FO02135K","article-title":"Nelumbo nucifera leaf polyphenol extract and gallic acid inhibit TNF-alpha-induced vascular smooth muscle cell proliferation and migration involving the regulation of miR-21, miR-143 and miR-145","volume":"11","author":"Chung","year":"2020","journal-title":"Food & Function"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0150","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1161\/ATVBAHA.118.311727","article-title":"Vascular smooth muscle cell plasticity and autophagy in dissecting aortic aneurysms","volume":"39","author":"Cl\u00e9ment","year":"2019","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0155","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.freeradbiomed.2011.03.010","article-title":"Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency","volume":"50","author":"Crabtree","year":"2011","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0160","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/1479164118780799","article-title":"Diabetes mellitus and abdominal aortic aneurysms: A review of the mechanisms underlying the negative relationship","volume":"15","author":"Dattani","year":"2018","journal-title":"Diabetes & Vascular Disease Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0165","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1161\/ATVBAHA.119.312000","article-title":"Updates of recent aortic aneurysm research","volume":"39","author":"Davis","year":"2019","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0170","doi-asserted-by":"crossref","first-page":"10106","DOI":"10.1038\/s41598-023-35612-8","article-title":"Terfezia boudieri and Terfezia claveryi inhibit the LPS\/IFN-gamma-mediated inflammation in RAW 264.7 macrophages through an Nrf2-independent mechanism","volume":"13","author":"Dawood","year":"2023","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0175","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0008-6363(03)00513-3","article-title":"TIMP-2 and PAI-1 mRNA levels are lower in aneurysmal as compared to athero-occlusive abdominal aortas","volume":"60","author":"Defawe","year":"2003","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/biom12040509","article-title":"Endothelial dysfunction in the pathogenesis of abdominal aortic aneurysm","volume":"12","author":"DeRoo","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174487","article-title":"Reversal of elastase-induced abdominal aortic aneurysm following the delivery of nanoparticle-based pentagalloyl glucose (PGG) is associated with reduced inflammatory and immune markers","volume":"910","author":"Dhital","year":"2021","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227165","article-title":"Nanoparticle-based targeted delivery of pentagalloyl glucose reverses elastase-induced abdominal aortic aneurysm and restores aorta to the healthy state in mice","volume":"15","author":"Dhital","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCRESAHA.116.309321","article-title":"MicroRNA-181b controls atherosclerosis and aneurysms through regulation of TIMP-3 and elastin","volume":"120","author":"Di Gregoli","year":"2017","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0200","first-page":"659","article-title":"Effects of Salviae miltiorrhizae on H2O2-induced apoptosis of rat vascular smooth muscle cells","volume":"27","author":"Du","year":"2004","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0205","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/s-0039-3400233","article-title":"Genes associated with thoracic aortic aneurysm and dissection: 2019 update and clinical implications","volume":"7","author":"Faggion Vinholo","year":"2019","journal-title":"Aorta (Stamford)"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0210","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10753-015-0259-1","article-title":"Anti-inflammatory activity of Tanshinone IIA in LPS-stimulated RAW264.7 macrophages via miRNAs and TLR4-NF-kappaB pathway","volume":"39","author":"Fan","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0215","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1161\/CIRCULATIONAHA.113.001677","article-title":"Reestablishment of the endothelial lining by endothelial cell therapy stabilizes experimental abdominal aortic aneurysms","volume":"127","author":"Franck","year":"2013","journal-title":"Circulation"},{"issue":"46\u201354","key":"10.1016\/j.pharmthera.2024.108652_bb0220","article-title":"Metformin treatment status and abdominal aortic aneurysm disease progression","volume":"64","author":"Fujimura","year":"2016","journal-title":"Journal of Vascular Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0225","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-023-01325-7","article-title":"The mechanism and therapy of aortic aneurysms","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0230","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/HYPERTENSIONAHA.111.181644","article-title":"Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation treatment with folic acid","volume":"59","author":"Gao","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0235","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41569-018-0114-9","article-title":"Abdominal aortic aneurysm: Update on pathogenesis and medical treatments","volume":"16","author":"Golledge","year":"2019","journal-title":"Nature Reviews. Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0240","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1186\/s13063-021-05915-0","article-title":"Protocol for the metformin aneurysm trial (MAT): A placebo-controlled randomised trial testing whether metformin reduces the risk of serious complications of abdominal aortic aneurysm","volume":"22","author":"Golledge","year":"2021","journal-title":"Trials"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0245","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/eurheartj\/ehm557","article-title":"Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions","volume":"29","author":"Golledge","year":"2008","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0250","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/bph.15260","article-title":"Mouse models for abdominal aortic aneurysm","volume":"179","author":"Golledge","year":"2022","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0255","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/bjs.10587","article-title":"Association between metformin prescription and growth rates of abdominal aortic aneurysms","volume":"104","author":"Golledge","year":"2017","journal-title":"The British Journal of Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0260","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/01.ATV.0000245819.32762.cb","article-title":"Abdominal aortic aneurysm: Pathogenesis and implications for management","volume":"26","author":"Golledge","year":"2006","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0265","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1093\/eurheartj\/ehad386","article-title":"Pathogenesis and management of abdominal aortic aneurysm","volume":"44","author":"Golledge","year":"2023","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0270","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00330-008-0956-3","article-title":"Measurement and determinants of infrarenal aortic thrombus volume","volume":"18","author":"Golledge","year":"2008","journal-title":"European Radiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0275","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/cvr\/cvy007","article-title":"Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis","volume":"114","author":"Grootaert","year":"2018","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0280","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1196\/annals.1383.013","article-title":"Pathogenesis of thoracic and abdominal aortic aneurysms","volume":"1085","author":"Guo","year":"2006","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176334","article-title":"Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm","volume":"21","author":"Gurung","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0290","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1161\/ATVBAHA.118.311289","article-title":"Deficiency of FAM3D (family with sequence similarity 3, member D), a novel chemokine, attenuates neutrophil recruitment and ameliorates abdominal aortic aneurysm development","volume":"38","author":"He","year":"2018","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0295","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s13239-017-0296-z","article-title":"Mechanosensitive microRNA-181b regulates aortic valve endothelial matrix degradation by targeting TIMP3","volume":"9","author":"Heath","year":"2018","journal-title":"Cardiovascular Engineering and Technology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0300","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/2045-824X-6-21","article-title":"Previously differentiated medial vascular smooth muscle cells contribute to neointima formation following vascular injury","volume":"6","author":"Herring","year":"2014","journal-title":"Vascular Cell"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0305","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.fct.2009.09.033","article-title":"Extract from the leaf of nucifera reduced the development of atherosclerosis via inhibition of vascular smooth muscle cell proliferation and migration","volume":"48","author":"Ho","year":"2010","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23042102","article-title":"Zebrafish as a model to study vascular elastic fibers and associated pathologies","volume":"23","author":"Hoareau","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0315","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3177\/jnsv.66.75","article-title":"The seed coat extract of black soybean decreases nicotine-induced vascular Fiber degradation by suppressing matrix metalloproteinase 2 expression","volume":"66","author":"Hoshino","year":"2020","journal-title":"Journal of Nutritional Science and Vitaminology (Tokyo)"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0320","doi-asserted-by":"crossref","first-page":"7560","DOI":"10.1002\/jcp.27517","article-title":"Licochalcone a attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR-181b\/SIRT1\/HO-1 signaling","volume":"234","author":"Hou","year":"2019","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0325","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1097\/CM9.0000000000002875","article-title":"Regulatory T cells and cardiovascular diseases","volume":"136","author":"Hu","year":"2023","journal-title":"Chinese Medical Journal"},{"issue":"4","key":"10.1016\/j.pharmthera.2024.108652_bb0330","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167201","article-title":"The B-cell subsets contribute to myocardial protection by inducing neutrophil apoptosis after ischemia and reperfusion","volume":"9","author":"Huang","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0335","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jacbts.2021.08.002","article-title":"Role of oxidative stress and autophagy in thoracic aortic aneurysms","volume":"6","author":"Irace","year":"2021","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0340","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jvs.2018.06.194","article-title":"Metformin prescription status and abdominal aortic aneurysm disease progression in the U.S. veteran population","volume":"69","author":"Itoga","year":"2019","journal-title":"Journal of Vascular Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0345","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-019-0286-3","article-title":"Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm","volume":"51","author":"Jana","year":"2019","journal-title":"Experimental and Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0350","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/path.4534","article-title":"Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection","volume":"236","author":"Jia","year":"2015","journal-title":"Journal of Pathology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0355","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41421-021-00363-1","article-title":"Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm","volume":"8","author":"Jia","year":"2022","journal-title":"Cell Discov"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0360","doi-asserted-by":"crossref","first-page":"214","DOI":"10.26599\/1671-5411.2023.03.002","article-title":"Trehalose attenuates abdominal aortic aneurysm formation by inducing autophagy in smooth muscle cells","volume":"20","author":"Jiang","year":"2023","journal-title":"Journal of Geriatric Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0365","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.886860","article-title":"Prediction of herbal medicines based on immune cell infiltration and immune- and ferroptosis-related gene expression levels to treat valvular atrial fibrillation","volume":"13","author":"Jiang","year":"2022","journal-title":"Frontiers in Genetics"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0370","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200353RRR","article-title":"Dendrobium officinale polysaccharide inhibits vascular calcification via anti-inflammatory and anti-apoptotic effects in chronic kidney disease","volume":"36","author":"Jiang","year":"2022","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0375","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejvs.2016.03.012","article-title":"Editor\u2019s choice - high heritability of liability to abdominal aortic aneurysms: A population based twin study","volume":"52","author":"Joergensen","year":"2016","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0380","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jvs.2016.12.140","article-title":"Upregulated interleukins (IL-6, IL-10, and IL-13) in immunoglobulin G4-related aortic aneurysm patients","volume":"67","author":"Kasashima","year":"2018","journal-title":"Journal of Vascular Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0385","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41580-020-0259-3","article-title":"Human organoids: Model systems for human biology and medicine","volume":"21","author":"Kim","year":"2020","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0390","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1161\/CIRCULATIONAHA.120.047544","article-title":"Genetic architecture of abdominal aortic aneurysm in the million Veteran program","volume":"142","author":"Klarin","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0395","first-page":"12","article-title":"Salvia miltiorrhiza alleviates memory deficit induced by ischemic brain injury in a transient MCAO mouse model by inhibiting ferroptosis","author":"Ko","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0400","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5650\/jos.ess18200","article-title":"Sesame extract attenuates the degradation of collagen and elastin fibers in the vascular walls of nicotine-administered mice","volume":"68","author":"Kugo","year":"2019","journal-title":"Journal of Oleo Science"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0405","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1161\/CIRCRESAHA.118.312438","article-title":"Role of noncoding RNAs in the pathogenesis of abdominal aortic aneurysm","volume":"124","author":"Kumar","year":"2019","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0410","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1161\/HYPERTENSIONAHA.119.14442","article-title":"Prevention of progression of aortic aneurysm by peptide vaccine against Ang II (angiotensin II) in a rat model","volume":"76","author":"Kurashiki","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0415","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.joim.2020.01.008","article-title":"Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats","volume":"18","author":"Lan","year":"2020","journal-title":"Journal of Integrative Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0420","doi-asserted-by":"crossref","first-page":"441","DOI":"10.7326\/0003-4819-126-6-199703150-00004","article-title":"Prevalence and associations of abdominal aortic aneurysm detected through screening. Aneurysm detection and management (ADAM) veterans affairs cooperative study group","volume":"126","author":"Lederle","year":"1997","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0425","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/FJC.0000000000000785","article-title":"Apigenin prevent abdominal aortic aneurysms formation by inhibiting the NF-kappaB signaling pathway","volume":"75","author":"Li","year":"2020","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2023.147181","article-title":"MiR-125b and SATB1-AS1 might be shear stress-mediated therapeutic targets","volume":"857","author":"Li","year":"2023","journal-title":"Gene"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109538","article-title":"Danhong injection enhances angiogenesis after myocardial infarction by activating MiR-126\/ERK\/VEGF pathway","volume":"120","author":"Li","year":"2019","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0440","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/CIRCULATIONAHA.120.046528","article-title":"Single-cell transcriptome analysis reveals dynamic cell populations and differential gene expression patterns in control and aneurysmal human aortic tissue","volume":"142","author":"Li","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110197","article-title":"Taxifolin ameliorates abdominal aortic aneurysm by preventing inflammation and apoptosis and extracellular matrix degradation via inactivating TLR4\/NF-kappaB axis","volume":"119","author":"Li","year":"2023","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154743","article-title":"Anti-inflammatory effect of Danhong injection through inhibition of GSDMD-mediated pyroptosis","volume":"113","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0455","first-page":"896","article-title":"Naringenin inhibits thoracic aortic aneurysm formation in mice with Marfan syndrome","volume":"54","author":"Li","year":"2022","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0460","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020301","article-title":"EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes","volume":"6","author":"Lim","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0465","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.atherosclerosis.2009.11.037","article-title":"Obovatol from Magnolia obovata inhibits vascular smooth muscle cell proliferation and intimal hyperplasia by inducing p21Cip1","volume":"210","author":"Lim","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0470","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1161\/CIRCRESAHA.118.312439","article-title":"Pharmacologic Management of Aneurysms","volume":"124","author":"Lindeman","year":"2019","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0475","doi-asserted-by":"crossref","first-page":"11219","DOI":"10.1038\/srep11219","article-title":"Administration of Danhong Injection to diabetic db\/db mice inhibits the development of diabetic retinopathy and nephropathy","volume":"5","author":"Liu","year":"2015","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116178","article-title":"Exploring the effect of Er miao San-containing serum on macrophage polarization through miR-33\/NLRP3 pathway","volume":"307","author":"Liu","year":"2023","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0485","first-page":"1396","article-title":"Gambogic acid prevents angiotensin II-induced abdominal aortic aneurysm through inflammatory and oxidative stress dependent targeting the PI3K\/Akt\/mTOR and NF-kappaB signaling pathways","volume":"19","author":"Liu","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0490","first-page":"2365","article-title":"Embelin inhibits abdominal aortic aneurysm through decreasing IL-6-induced STAT3 and NF-kappaB inactivation","volume":"18","author":"Liu","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0495","article-title":"Single-cell sequencing of immune cells in human aortic dissection tissue provides insights into immune cell heterogeneity","volume":"9","author":"Liu","year":"2022","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"232\u2013242","key":"10.1016\/j.pharmthera.2024.108652_bb0500","article-title":"A novel chronic advanced stage abdominal aortic aneurysm murine model","volume":"66","author":"Lu","year":"2017","journal-title":"Journal of Vascular Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0505","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.023601","article-title":"Vascular smooth muscle cells in aortic aneurysm: From genetics to mechanisms","volume":"10","author":"Lu","year":"2021","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.01.057","article-title":"The effects of Radix Angelica Sinensis and Radix Hedysari ultrafiltration extract on X-irradiation-induced myocardial fibrosis in rats","volume":"112","author":"Ma","year":"2019","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0515","first-page":"680","article-title":"Grape-seed polyphenols inhibit AAA in mice via regulation of macrophage polarization","volume":"121","author":"Ma","year":"2020","journal-title":"Bratislavsk\u00e9 Lek\u00e1rske Listy"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0520","first-page":"1621","article-title":"Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF-kappa B-mediated inflammatory response","volume":"20","author":"Ma","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0525","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1161\/ATVBAHA.107.141069","article-title":"Developmental basis of vascular smooth muscle diversity","volume":"27","author":"Majesky","year":"2007","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0530","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10020359","article-title":"Cycloastragenol inhibits experimental abdominal aortic aneurysm progression","volume":"10","author":"Melin","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0535","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1161\/CIRCULATIONAHA.120.049922","article-title":"Fate and state of vascular smooth muscle cells in atherosclerosis","volume":"143","author":"Miano","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0540","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1161\/STROKEAHA.118.021757","article-title":"Modified Citrus pectin prevents blood-brain barrier disruption in mouse subarachnoid hemorrhage by inhibiting Galectin-3","volume":"49","author":"Nishikawa","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0545","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s12265-016-9709-x","article-title":"Systemic delivery of nanoparticles loaded with Pentagalloyl glucose protects elastic Lamina and prevents abdominal aortic aneurysm in rats","volume":"9","author":"Nosoudi","year":"2016","journal-title":"Journal of Cardiovascular Translational Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0550","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310777","article-title":"Effects of miR-33 deficiency on metabolic and cardiovascular diseases: Implications for therapeutic intervention","volume":"24","author":"Ortega","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020182","article-title":"The genetics of thoracic aortic aneurysms and dissection: A clinical perspective","volume":"10","author":"Ostberg","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0560","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1152\/physrev.1995.75.3.487","article-title":"Regulation of differentiation of vascular smooth muscle cells","volume":"75","author":"Owens","year":"1995","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0565","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1161\/CIRCULATIONAHA.120.048378","article-title":"Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and human","volume":"142","author":"Pan","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0570","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/413189","article-title":"Morphological and biomechanical differences in the elastase and AngII apoE(\u2212\/\u2212) rodent models of abdominal aortic aneurysms","volume":"2015","author":"Phillips","year":"2015","journal-title":"BioMed Research International"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0575","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/CIRCRESAHA.118.312436","article-title":"Genetics of thoracic and abdominal aortic diseases","volume":"124","author":"Pinard","year":"2019","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0580","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.biochi.2015.10.010","article-title":"Endothelial cells and cathepsins: Biochemical and biomechanical regulation","volume":"122","author":"Platt","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0585","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168379","article-title":"Immunity in atherosclerosis: Focusing on T and B cells","volume":"22","author":"Poznyak","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0590","doi-asserted-by":"crossref","DOI":"10.3390\/genes13010123","article-title":"Phenotyping zebrafish mutant models to assess candidate genes associated with aortic aneurysm","volume":"13","author":"Prendergast","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0595","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.871486","article-title":"Artificial intelligence uncovers natural MMP inhibitor Crocin as a potential treatment of thoracic aortic aneurysm and dissection","volume":"9","author":"Qi","year":"2022","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0600","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1248\/bpb.b21-00042","article-title":"Betanin prevents experimental abdominal aortic aneurysm progression by modulating the TLR4\/NF-kappaB and Nrf2\/HO-1 pathways","volume":"44","author":"Qiu","year":"2021","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0605","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1248\/bpb.b21-00042","article-title":"Betanin prevents experimental abdominal aortic aneurysm progression by modulating the TLR4\/NF-\u03baB and Nrf2\/HO-1 pathways","volume":"44","author":"Qiu","year":"2021","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0610","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1365-2125.2000.00277.x","article-title":"Flow-mediated dilatation","volume":"50","author":"Raitakari","year":"2000","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0615","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1111\/jcmm.16312","article-title":"GDF11 prevents the formation of thoracic aortic dissection in mice: Promotion of contractile transition of aortic SMCs","volume":"25","author":"Ren","year":"2021","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0620","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jacc.2018.04.089","article-title":"Clinical validity of genes for heritable thoracic aortic aneurysm and dissection","volume":"72","author":"Renard","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0625","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nrneph.2015.118","article-title":"Development and application of human adult stem or progenitor cell organoids","volume":"11","author":"Rookmaaker","year":"2015","journal-title":"Nature Reviews Nephrology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0630","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pcad.2013.04.002","article-title":"Pathophysiology of thoracic aortic aneurysm (TAA): Is it not one uniform aorta? Role of embryologic origin","volume":"56","author":"Ruddy","year":"2013","journal-title":"Progress in Cardiovascular Diseases"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0635","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/1471-2164-10-298","article-title":"Whole genome expression analysis within the angiotensin II-apolipoprotein E deficient mouse model of abdominal aortic aneurysm","volume":"10","author":"Rush","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0640","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41572-018-0030-7","article-title":"Abdominal aortic aneurysms","volume":"4","author":"Sakalihasan","year":"2018","journal-title":"Nature Reviews. Disease Primers"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0645","doi-asserted-by":"crossref","first-page":"H508","DOI":"10.1152\/ajpheart.00559.2019","article-title":"Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells","volume":"318","author":"Sampilvanjil","year":"2020","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0650","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-pathmechdis-012419-032611","article-title":"Human organoids: Tools for understanding biology and treating diseases","volume":"15","author":"Schutgens","year":"2020","journal-title":"Annual Review of Pathology: Mechanisms of Disease"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0655","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fcvm.2018.00033","article-title":"Chinese herbal medicine as a potential treatment of abdominal aortic aneurysm","volume":"5","author":"Seto","year":"2018","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0660","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.atherosclerosis.2020.01.014","article-title":"Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm","volume":"297","author":"Shen","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0665","first-page":"e37","article-title":"Aortic aneurysms and dissections series","volume":"40","author":"Shen","year":"2020","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0670","doi-asserted-by":"crossref","first-page":"E822","DOI":"10.21037\/jtd.2016.07.63","article-title":"Insights into ascending aortic aneurysm pathogenesis using in vivo and ex vivo imaging systems in angiotensin II-infused mice","volume":"8","author":"Sheppard","year":"2016","journal-title":"Journal of Thoracic Disease"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0675","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1103784","article-title":"Novel SMAD3 variant identified in a patient with familial aortopathy modeled using a zebrafish embryo assay","volume":"10","author":"Sheppard","year":"2023","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0680","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1080\/01480545.2020.1862859","article-title":"Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3\/miRNA-21 axis","volume":"45","author":"Sherif","year":"2022","journal-title":"Drug and Chemical Toxicology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0685","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/s41374-020-0454-z","article-title":"MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice","volume":"100","author":"Shi","year":"2020","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0690","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/01.RES.0000016501.56641.83","article-title":"Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of metalloproteinase-1 (TIMP-1) gene","volume":"90","author":"Silence","year":"2002","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0695","doi-asserted-by":"crossref","DOI":"10.3390\/md17050272","article-title":"Pyrogallol-Phloroglucinol-6,6\u2019-Bieckol from Ecklonia cava improved blood circulation in diet-induced obese and diet-induced hypertension mouse models","volume":"17","author":"Son","year":"2019","journal-title":"Marine Drugs"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0700","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22020312","article-title":"Phenolic acid profiling, antioxidant, and anti-inflammatory activities, and miRNA regulation in the polyphenols of 16 blueberry samples from China","volume":"22","author":"Su","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0705","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.intimp.2005.11.014","article-title":"Raphanus sativus and its isothiocyanates inhibit vascular smooth muscle cells proliferation and induce G(1) cell cycle arrest","volume":"6","author":"Suh","year":"2006","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0710","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jvs.2020.03.046","article-title":"Evaluating the prevalence of abdominal aortic aneurysms in the United States through a national screening database","volume":"73","author":"Summers","year":"2021","journal-title":"Journal of Vascular Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0715","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/19336918.2021.1909899","article-title":"Nicotinate-curcumin inhibits AngII-induced vascular smooth muscle cell phenotype switching by upregulating Daxx expression","volume":"15","author":"Sun","year":"2021","journal-title":"Cell Adhesion & Migration"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0720","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/jcp.30569","article-title":"Disturbed flow\u2019s impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review","volume":"237","author":"Sunderland","year":"2022","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0725","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.ijcard.2012.11.002","article-title":"Reduced number and impaired function of circulating endothelial progenitor cells in patients with abdominal aortic aneurysm","volume":"168","author":"Sung","year":"2013","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0730","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/bjs.8707","article-title":"Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms","volume":"99","author":"Sweeting","year":"2012","journal-title":"The British Journal of Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0735","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.immuni.2017.09.008","article-title":"Monocyte-macrophages and T cells in atherosclerosis","volume":"47","author":"Tabas","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0740","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jacc.2009.07.074","article-title":"Use of herbal products and potential interactions in patients with cardiovascular diseases","volume":"55","author":"Tachjian","year":"2010","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0745","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jjcc.2019.03.014","article-title":"Genetic basis of hereditary thoracic aortic aneurysms and dissections","volume":"74","author":"Takeda","year":"2019","journal-title":"Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0750","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cca.2020.12.031","article-title":"TGF-beta signaling and microRNA cross-talk regulates abdominal aortic aneurysm progression","volume":"515","author":"Tang","year":"2021","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0755","doi-asserted-by":"crossref","first-page":"335","DOI":"10.7461\/jcen.2014.16.4.335","article-title":"A comparative review of the hemodynamics and pathogenesis of cerebral and abdominal aortic aneurysms: Lessons to learn from each other","volume":"16","author":"Tanweer","year":"2014","journal-title":"J Cerebrovasc Endovasc Neurosurg"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0760","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1161\/ATVBAHA.116.307211","article-title":"Ascending aortic aneurysm in angiotensin II-infused mice: Formation, progression, and the role of focal dissections","volume":"36","author":"Trachet","year":"2016","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0765","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1161\/ATVBAHA.114.303763","article-title":"Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm","volume":"35","author":"Usui","year":"2015","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0770","first-page":"2537","article-title":"Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq","volume":"117","author":"Vallejo","year":"2021","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0775","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1093\/eurheartj\/ehac771","article-title":"The emerging role of endothelial cells in the pathogenesis of thoracic aortic aneurysm and dissection","volume":"44","author":"Verstraeten","year":"2023","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0780","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1152\/physrev.00041.2008","article-title":"Vascular Extracellular Matrix and Arterial Mechanics","volume":"89","author":"Wagenseil","year":"2009","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0785","doi-asserted-by":"crossref","first-page":"9402","DOI":"10.1038\/s41598-017-09674-4","article-title":"Grape-seed polyphenols play a protective role in elastase-induced abdominal aortic aneurysm in mice","volume":"7","author":"Wang","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0790","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3389\/fphar.2018.00496","article-title":"Astragaloside IV attenuated 3,4-Benzopyrene-induced abdominal aortic aneurysm by ameliorating macrophage-mediated inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0795","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/FJC.0000000000000837","article-title":"Resveratrol attenuates aortic dissection by increasing endothelial barrier function through the SIRT1 pathway","volume":"76","author":"Wang","year":"2020","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0800","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jep.2013.08.048","article-title":"Suppression of experimental abdominal aortic aneurysms in the mice by treatment with Ginkgo biloba extract (EGb 761)","volume":"150","author":"Wang","year":"2013","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0805","first-page":"9485398","article-title":"Quercetin downregulates Cyclooxygenase-2 expression and HIF-1alpha\/VEGF signaling-related angiogenesis in a mouse model of abdominal aortic aneurysm","volume":"2020","author":"Wang","year":"2020","journal-title":"BioMed Research International"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0810","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.joim.2020.08.006","article-title":"Fuzheng Huayu recipe, a traditional Chinese compound herbal medicine, attenuates renal interstitial fibrosis via targeting the miR-21\/PTEN\/AKT axis","volume":"18","author":"Wang","year":"2020","journal-title":"Journal of Integrative Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0815","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113712","article-title":"Targeting autophagy in atherosclerosis: Advances and therapeutic potential of natural bioactive compounds from herbal medicines and natural products","volume":"155","author":"Wang","year":"2022","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0820","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/bph.14515","article-title":"Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms","volume":"176","author":"Wang","year":"2019","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0825","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.atherosclerosis.2012.09.010","article-title":"The calcium chloride-induced rodent model of abdominal aortic aneurysm","volume":"226","author":"Wang","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112367","article-title":"Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction","volume":"145","author":"Wang","year":"2022","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0835","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13578-019-0332-9","article-title":"Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K\/AKT\/mTOR\/autophagy pathway in ApoE(\u2212\/\u2212) mice","volume":"9","author":"Wang","year":"2019","journal-title":"Cell & Bioscience"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0840","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.ejvs.2020.11.048","article-title":"The metformin for abdominal aortic aneurysm growth inhibition (MAAAGI) trial","volume":"61","author":"Wanhainen","year":"2021","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0845","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/ATVBAHA.114.304776","article-title":"Deficiency of endogenous acute-phase serum amyloid a protects apoE(\u2212\/\u2212) mice from angiotensin II-induced abdominal aortic aneurysm formation","volume":"35","author":"Webb","year":"2015","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"issue":"6","key":"10.1016\/j.pharmthera.2024.108652_bb0920","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.ymthe.2023.04.020","article-title":"Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression","volume":"31","author":"Winter","year":"2023","journal-title":"Molecular Therapy"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0850","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1161\/ATVBAHA.116.307648","article-title":"NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3)-Caspase-1 Inflammasome degrades contractile proteins: Implications for aortic biomechanical dysfunction and aneurysm and dissection formation","volume":"37","author":"Wu","year":"2017","journal-title":"Arteriosclerosis Thrombosis and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0855","doi-asserted-by":"crossref","first-page":"1095757","DOI":"10.3389\/fphar.2022.1095757","article-title":"Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level","volume":"13","author":"Wu","year":"2022","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0860","doi-asserted-by":"crossref","DOI":"10.3390\/cells11193042","article-title":"Nrf2-mediated dichotomy in the vascular system: Mechanistic and therapeutic perspective","volume":"11","author":"Wu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0865","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21070956","article-title":"Qingxuan Jiangya decoction reverses vascular remodeling by inducing vascular smooth muscle cell apoptosis in spontaneously hypertensive rats","volume":"21","author":"Xiao","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0870","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3892\/etm.2020.9351","article-title":"Daphnetin suppresses experimental abdominal aortic aneurysms in mice via inhibition of aortic mural inflammation","volume":"20","author":"Xie","year":"2020","journal-title":"Experimental and Therapeutic Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0875","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jnutbio.2011.02.011","article-title":"Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis","volume":"23","author":"Xie","year":"2012","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0880","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ijcard.2016.07.016","article-title":"Association between diabetes and prevalence and growth rate of abdominal aortic aneurysms: A meta-analysis","volume":"221","author":"Xiong","year":"2016","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0885","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jep.2014.11.013","article-title":"Shexiang Tongxin dropping pill attenuates atherosclerotic lesions in ApoE deficient mouse model","volume":"159","author":"Xiong","year":"2015","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0890","first-page":"1083","article-title":"Anti-atherosclerotic effects of bear bile powder in Shexiang Tongxin dripping pill: A mechanism study","volume":"35","author":"Xiong","year":"2015","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0895","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jvs.2012.01.038","article-title":"Accelerated aneurysmal dilation associated with apoptosis and inflammation in a newly developed calcium phosphate rodent abdominal aortic aneurysm model","volume":"56","author":"Yamanouchi","year":"2012","journal-title":"Journal of Vascular Surgery"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0900","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/ATVBAHA.120.315607","article-title":"Single-cell RNA sequencing reveals heterogeneity of vascular cells in early stage murine abdominal aortic aneurysm-brief report","volume":"41","author":"Yang","year":"2021","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0905","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1093\/eurheartj\/ehac823","article-title":"Targeting endothelial tight junctions to predict and protect thoracic aortic aneurysm and dissection","volume":"44","author":"Yang","year":"2023","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0910","first-page":"4519","article-title":"Mechanism of Danzhi Jiangtang capsules in treatment of diabetic macrovascular disease in GK rats based on correlation between microRNAs and inflammatory factors","volume":"44","author":"You","year":"2019","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0915","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.4923","article-title":"Dexmedetomidine suppresses the development of abdominal aortic aneurysm by downregulating the mircoRNA-21\/PDCD 4 axis","volume":"47","author":"Yu","year":"2021","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0925","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154336","article-title":"Shexiang Baoxin pill attenuates myocardial ischemia\/reperfusion injury by activating autophagy via modulating the ceRNA-Map3k8 pathway","volume":"104","author":"Yu","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0930","first-page":"827","article-title":"Effect of extract from Tripterygium hypoglaucum on proliferation and apoptosis of vascular smooth muscle cells","volume":"24","author":"Yu","year":"2004","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0935","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1055\/s-2008-1081290","article-title":"Astragaloside IV inhibits proliferation and promotes apoptosis in rat vascular smooth muscle cells under high glucose concentration in vitro","volume":"74","author":"Yuan","year":"2008","journal-title":"Planta Medica"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0940","doi-asserted-by":"crossref","first-page":"94","DOI":"10.31083\/j.fbl2805094","article-title":"The Cardioprotective effects and mechanisms of Astragalus-safflower herb pairs on coronary heart disease identified by network pharmacology and experimental verification","volume":"28","author":"Yuan","year":"2023","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0945","first-page":"3327","article-title":"The protective effect of puerarin on angiotensin II-induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress-triggered AP-1 signaling pathways","volume":"16","author":"Yue","year":"2018","journal-title":"Oncology Letters"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0950","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.atherosclerosis.2018.02.022","article-title":"Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice","volume":"271","author":"Zhai","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0955","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/ptr.7358","article-title":"Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-kappaB and COX-2","volume":"36","author":"Zhai","year":"2022","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0960","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1042\/CS20201057","article-title":"Vinpocetine protects against the development of experimental abdominal aortic aneurysms","volume":"134","author":"Zhang","year":"2020","journal-title":"Clinical Science (London, England)"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0965","first-page":"1733834","article-title":"Calycosin alleviates doxorubicin-induced cardiotoxicity and Pyroptosis by inhibiting NLRP3 Inflammasome activation","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0970","doi-asserted-by":"crossref","first-page":"H2004","DOI":"10.1152\/ajpheart.00208.2009","article-title":"Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: A comparison with a high-dose simvastatin therapy","volume":"297","author":"Zhang","year":"2009","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0975","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10735-020-09909-1","article-title":"Lycium barbarum polysaccharide protects against homocysteine-induced vascular smooth muscle cell proliferation and phenotypic transformation via PI3K\/Akt pathway","volume":"51","author":"Zhang","year":"2020","journal-title":"Journal of Molecular Histology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0980","doi-asserted-by":"crossref","first-page":"H552","DOI":"10.1152\/ajpheart.00936.2013","article-title":"Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-alpha","volume":"307","author":"Zhang","year":"2014","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0985","first-page":"1484","article-title":"Effect of shikonin, a phytocompound from Lithospermum erythrorhizon, on rat vascular smooth muscle cells proliferation and apoptosis in vitro","volume":"85","author":"Zhang","year":"2005","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0990","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01478885.2023.2170772","article-title":"Cell culture: In vitro model system and a promising path to in vivo applications","volume":"46","author":"Zhao","year":"2023","journal-title":"Journal of Histotechnology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb0995","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107698","article-title":"Current state and future perspective of cardiovascular medicines derived from natural products","volume":"216","author":"Zhao","year":"2020","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108652_bb1000","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1093\/cvr\/cvaa214","article-title":"Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta","volume":"117","author":"Zhao","year":"2021","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2024.108652_bb1005","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s43586-022-00174-y","article-title":"Organoids","volume":"2","author":"Zhao","year":"2022","journal-title":"Nature Reviews Methods Primers"},{"key":"10.1016\/j.pharmthera.2024.108652_bb1010","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109759","article-title":"Cordycepin suppresses vascular inflammation, apoptosis and oxidative stress of arterial smooth muscle cell in thoracic aortic aneurysm with VEGF inhibition","volume":"116","author":"Zhou","year":"2023","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb1015","article-title":"Synergistic inhibition of pro-inflammatory pathways by ginger and turmeric extracts in RAW 264.7 cells","volume":"13","author":"Zhou","year":"2022","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108652_bb1020","first-page":"680","article-title":"Experimental study of vascular smooth muscle cell apoptosis induced by Huotong capsule","volume":"18","author":"Zhou","year":"1998","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.pharmthera.2024.108652_bb1025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1186\/s13023-021-02143-2","article-title":"Novel LTBP3 mutations associated with thoracic aortic aneurysms and dissections","volume":"16","author":"Zhu","year":"2021","journal-title":"Orphanet Journal of Rare Diseases"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016372582400072X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016372582400072X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T21:29:07Z","timestamp":1717882147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016372582400072X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":205,"alternative-id":["S016372582400072X"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108652","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108652"}}