{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T01:50:36Z","timestamp":1791769836832,"version":"4.3.4"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.pharmthera.2024.108689","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:44:59Z","timestamp":1720226699000},"page":"108689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Vitamins and fatty acids against chemotherapy-induced intestinal mucositis"],"prefix":"10.1016","volume":"261","author":[{"given":"Alexandra","family":"Alcorta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"L\u00f3pez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Abalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.pharmthera.2024.108689_bb0005","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1440-1746.2012.07098.x","article-title":"Emu oil: A novel therapeutic for disorders of the gastrointestinal tract?","volume":"27","author":"Abimosleh","year":"2012","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"12","key":"10.1016\/j.pharmthera.2024.108689_bb0010","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1023\/A:1021025726478","article-title":"Extra-virgin olive oil-enriched diets reduce indomethacin-induced gastric oxidative damage in rats","volume":"47","author":"Alarc\u00f3n de la Lastra","year":"2002","journal-title":"Digestive Diseases and Sciences"},{"issue":"4","key":"10.1016\/j.pharmthera.2024.108689_bb0015","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1515\/jcim-2016-0043","article-title":"Alleviation of 5-fluorouracil-induced intestinal mucositis in rats by vitamin E via targeting oxidative stress and inflammatory markers","volume":"13","author":"Al-Asmari","year":"2016","journal-title":"Journal of Complementary & Integrative Medicine"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0020","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.toxrep.2015.06.006","article-title":"Ascorbic acid attenuates antineoplastic drug 5-fluorouracil induced gastrointestinal toxicity in rats by modulating the expression of inflammatory mediators","volume":"2","author":"Al-Asmari","year":"2015","journal-title":"Toxicology Reports"},{"issue":"2","key":"10.1016\/j.pharmthera.2024.108689_bb0025","first-page":"293","article-title":"Foods for plant-based diets: Challenges and innovations","volume":"10","author":"Alcorta","year":"2021","journal-title":"Foods (Basel, Switzerland)"},{"issue":"7","key":"10.1016\/j.pharmthera.2024.108689_bb0030","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3390\/ijms19072024","article-title":"Olive oil nutraceuticals in the prevention and Management of Diabetes: From molecules to lifestyle","volume":"19","author":"Alkhatib","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0035","author":"American Cancer Society"},{"issue":"5","key":"10.1016\/j.pharmthera.2024.108689_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12924","article-title":"Endocrine cross-talk between the gut microbiome and glial cells in development and disease","volume":"33","author":"Anbalagan","year":"2021","journal-title":"Journal of Neuroendocrinology"},{"issue":"3\u20134","key":"10.1016\/j.pharmthera.2024.108689_bb0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2152\/jmi.54.385","article-title":"Research on the nutritional characteristics of medium-chain fatty acids","volume":"54","author":"Aoyama","year":"2007","journal-title":"The Journal of Medical Investigation: JMI"},{"issue":"9","key":"10.1016\/j.pharmthera.2024.108689_bb0050","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/nu14091801","article-title":"A nutritional approach for the Management of Chemotherapy-Induced Diarrhea in patients with colorectal cancer","volume":"14","author":"Artale","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0055","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00041433-200206000-00005","article-title":"Conjugated linoleic acid metabolism","volume":"13","author":"Banni","year":"2002","journal-title":"Current Opinion in Lipidology"},{"issue":"2","key":"10.1016\/j.pharmthera.2024.108689_bb0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1079\/NRR200488","article-title":"N-3 polyunsaturated fatty acids throughout the cancer trajectory: Influence on disease incidence, progression, response to therapy and cancer-associated cachexia","volume":"17","author":"Baracos","year":"2004","journal-title":"Nutrition Research Reviews"},{"issue":"8","key":"10.1016\/j.pharmthera.2024.108689_bb0065","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1080\/10408398.2017.1406333","article-title":"Associations between inflammatory bowel diseases and vitamin D","volume":"59","author":"Barbalho","year":"2019","journal-title":"Critical Reviews in Food Science and Nutrition"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0070","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1038\/s41467-022-33352-3","article-title":"Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity","volume":"13","author":"Barradas","year":"2022","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104604","article-title":"Free fatty acid receptors as new potential therapeutic targets in inflammatory bowel diseases","volume":"152","author":"Bartoszek","year":"2020","journal-title":"Pharmacological Research"},{"issue":"10","key":"10.1016\/j.pharmthera.2024.108689_bb0080","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1071\/EA08134","article-title":"Comparison of the antioxidant properties of emu oil with other avian oils","volume":"48","author":"Bennett","year":"2008","journal-title":"Australian Journal of Experimental Agriculture"},{"issue":"5","key":"10.1016\/j.pharmthera.2024.108689_bb0085","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1158\/2159-8290.CD-23-0344","article-title":"Achieving the goals of the cancer moonshot requires progress against all cancers","volume":"13","author":"Bertagnolli","year":"2023","journal-title":"Cancer Discovery"},{"issue":"5","key":"10.1016\/j.pharmthera.2024.108689_bb0090","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochimica et Biophysica Acta, Molecular Basis of Disease"},{"issue":"5","key":"10.1016\/j.pharmthera.2024.108689_bb0095","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.nut.2011.09.007","article-title":"Effect of vitamin supplementation on cisplatin-induced intestinal epithelial cell apoptosis in Wistar\/NIN rats","volume":"28","author":"Bodiga","year":"2012","journal-title":"Nutrition (Burbank, Los Angeles County, Calif.)"},{"issue":"5","key":"10.1016\/j.pharmthera.2024.108689_bb0100","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/cncr.20484","article-title":"Effect of vitamin B12, folate, and dietary supplements on breast carcinoma chemotherapy - Induced mucositis and neutropenia","volume":"101","author":"Branda","year":"2004","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.pharmthera.2024.108689_bb0105","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jhep.2004.07.030","article-title":"Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc\/TGF-alpha transgenic mouse model of liver cancer","volume":"41","author":"Calvisi","year":"2004","journal-title":"Journal of Hepatology"},{"issue":"5","key":"10.1016\/j.pharmthera.2024.108689_bb0110","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3390\/nu13051703","article-title":"Vitamin A update: Forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity","volume":"13","author":"Carazo","year":"2021","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.pharmthera.2024.108689_bb0115","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3390\/nu9111211","article-title":"Vitamin C and immune function","volume":"9","author":"Carr","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.662739","article-title":"Participation of short-chain fatty acids and their receptors in gut inflammation and colon cancer","volume":"12","author":"Carretta","year":"2021","journal-title":"Frontiers in Physiology"},{"issue":"6","key":"10.1016\/j.pharmthera.2024.108689_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040087","article-title":"Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine","volume":"7","author":"Chang","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0566","first-page":"E388","article-title":"Serum vitamin levels are related with risk of nasopharyngeal carcinoma and the severity of radiation induced oral mucositis and dermatitis","volume":"105","author":"Chen","year":"2019","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"2","key":"10.1016\/j.pharmthera.2024.108689_bb0130","first-page":"17","article-title":"Results of a study to evaluate the use of Propax\u2122 to reduce adverse effects of chemotherapy","volume":"3","author":"Colodny","year":"2000","journal-title":"Journal of the American Nutraceutical Association"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neures.2016.12.005","article-title":"Enteric glial reactivity to systemic LPS administration: Changes in GFAP and S100B protein","volume":"119","author":"da Cunha Franceschi","year":"2017","journal-title":"Neuroscience Research"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0140","article-title":"Review on the effect of chemotherapy on the intestinal barrier: Epithelial permeability, mucus and bacterial translocation","volume":"162","author":"Dahlgren","year":"2023","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0145","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/01635581.2016.1225100","article-title":"Effect of conjugated linoleic acid-enriched butter after 24 hours of intestinal mucositis induction","volume":"69","author":"De Barros","year":"2017","journal-title":"Nutrition and Cancer"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0150","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.biopha.2018.04.133","article-title":"Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model","volume":"103","author":"De Barros","year":"2018","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"issue":"4","key":"10.1016\/j.pharmthera.2024.108689_bb0155","doi-asserted-by":"crossref","first-page":"335","DOI":"10.21873\/cgp.20193","article-title":"Anticancer effects of nutraceuticals in the Mediterranean diet: An epigenetic diet model","volume":"17","author":"Divella","year":"2020","journal-title":"Cancer Genomics & Proteomics"},{"issue":"8","key":"10.1016\/j.pharmthera.2024.108689_bb0160","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3748\/wjg.v16.i8.921","article-title":"Folate and fiber in the prevention of colorectal cancer: Between shadows and the light","volume":"16","author":"Du","year":"2010","journal-title":"World Journal of Gastroenterology"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0165","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1258\/0007142991902646","article-title":"Folic acid deficiency and cancer: Mechanisms of DNA instability","volume":"55","author":"Duthie","year":"1999","journal-title":"British Medical Bulletin"},{"issue":"19","key":"10.1016\/j.pharmthera.2024.108689_bb0170","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1002\/cncr.33100","article-title":"MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy","volume":"126","author":"Elad","year":"2020","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0175","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/jpn.12490","article-title":"Influence of medium-chain fatty acids and short-chain organic acids on jejunal morphology and intra-epithelial immune cells in weaned piglets","volume":"101","author":"Ferrara","year":"2017","journal-title":"Journal of Animal Physiology and Animal Nutrition"},{"issue":"7","key":"10.1016\/j.pharmthera.2024.108689_bb0180","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s11745-012-3680-3","article-title":"Oral supplementation of butyrate reduces mucositis and intestinal permeability associated with 5-fluorouracil administration","volume":"47","author":"Ferreira","year":"2012","journal-title":"Lipids"},{"issue":"4","key":"10.1016\/j.pharmthera.2024.108689_bb0185","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1200\/JCO.2010.31.5317","article-title":"Vitamin D deficiency is a cofactor of chemotherapy-induced mucocutaneous toxicity and dysgeusia","volume":"29","author":"Fink","year":"2011","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"10.1016\/j.pharmthera.2024.108689_bb0190","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.clgc.2019.03.023","article-title":"Folic acid reduces mucositis in metastatic renal cell carcinoma patients: A retrospective study","volume":"17","author":"Fristrup","year":"2019","journal-title":"Clinical Genitourinary Cancer"},{"issue":"22","key":"10.1016\/j.pharmthera.2024.108689_bb0195","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.1080\/14786419.2021.2020265","article-title":"Role of nutraceuticals on neurodegenerative diseases: Neuroprotective and immunomodulant activity","volume":"36","author":"Fumia","year":"2022","journal-title":"Natural Product Research"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0200","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/bs.vh.2022.10.008","article-title":"Ascorbic acid as antioxidant","volume":"121","author":"G\u0119gotek","year":"2023","journal-title":"Vitamins and Hormones"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0205","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12944-015-0052-z","article-title":"Dietary supplementation with omega-3 fatty acid attenuates 5-fluorouracil induced mucositis in mice","volume":"14","author":"Generoso","year":"2015","journal-title":"Lipids in Health and Disease"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1158\/1940-6207.CAPR-20-0140","article-title":"Inflammation modulation by Vitamin D and calcium in the morphologically normal colorectal mucosa of patients with colorectal adenoma in a clinical trial","volume":"14","author":"Gibbs","year":"2021","journal-title":"Cancer Prevention Research (Philadelphia, Pa.)"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0215","author":"Global Cancer Observatory"},{"issue":"39","key":"10.1016\/j.pharmthera.2024.108689_bb0220","doi-asserted-by":"crossref","first-page":"63583","DOI":"10.18632\/oncotarget.11544","article-title":"The \u03c9-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of \u03b2-catenin complex, inhibiting COX-2 through repressing NF-\u03baB, and inducing 15-prostaglandin dehydrogenase","volume":"7","author":"Han","year":"2016","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0225","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/sj.bjc.6690713","article-title":"Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects","volume":"81","author":"Hardman","year":"1999","journal-title":"British Journal of Cancer"},{"issue":"12","key":"10.1016\/j.pharmthera.2024.108689_bb0230","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1177\/1535370219867262","article-title":"Current evidence for vitamin D in intestinal function and disease","volume":"244","author":"Hassanshahi","year":"2019","journal-title":"Experimental Biology and Medicine (Maywood, N.J.)"},{"issue":"23","key":"10.1016\/j.pharmthera.2024.108689_bb0235","doi-asserted-by":"crossref","first-page":"15434","DOI":"10.3390\/ijms232315434","article-title":"Experimental chemotherapy-induced mucositis: A scoping review guiding the design of suitable preclinical models","volume":"23","author":"Huang","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0240","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurological Research"},{"issue":"10","key":"10.1016\/j.pharmthera.2024.108689_bb0245","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.3390\/ijms23105332","article-title":"Decreased tissue Omega-6\/Omega-3 fatty acid ratio prevents chemotherapy-induced gastrointestinal toxicity associated with alterations of gut microbiome","volume":"23","author":"Kaliannan","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0250","doi-asserted-by":"crossref","first-page":"11276","DOI":"10.1038\/srep11276","article-title":"A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia","volume":"5","author":"Kaliannan","year":"2015","journal-title":"Scientific Reports"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0255","doi-asserted-by":"crossref","first-page":"E25","DOI":"10.1208\/ps050325","article-title":"Nutraceutical - Definition and introduction","volume":"5","author":"Kalra","year":"2003","journal-title":"AAPS PharmSci"},{"issue":"12","key":"10.1016\/j.pharmthera.2024.108689_bb0260","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.3109\/13880209.2014.902082","article-title":"Vitamin E: A potential therapy for gastric mucosal injury","volume":"52","author":"Kamisah","year":"2014","journal-title":"Pharmaceutical Biology"},{"issue":"14","key":"10.1016\/j.pharmthera.2024.108689_bb0265","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.3390\/ijms21144919","article-title":"Irinotecan-still an important player in Cancer chemotherapy: A comprehensive overview","volume":"21","author":"Kciuk","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"10","key":"10.1016\/j.pharmthera.2024.108689_bb0270","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1089\/ars.2012.4701","article-title":"How can Faecalibacterium prausnitzii employ riboflavin for extracellular electron transfer?","volume":"17","author":"Khan","year":"2012","journal-title":"Antioxidants & Redox Signaling"},{"issue":"9","key":"10.1016\/j.pharmthera.2024.108689_bb0275","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1158\/1055-9965.EPI-07-2557","article-title":"Folic acid supplementation and cancer risk: Point","volume":"17","author":"Kim","year":"2008","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0280","first-page":"171","article-title":"Free fatty acid receptors in health and disease","volume":"100","author":"Kimura","year":"2020","journal-title":"American Physiological Society. Physiological Reviews"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0285","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3390\/nu13030888","article-title":"The mechanisms of the anti-inflammatory and anti-apoptotic effects of Omega-3 polyunsaturated fatty acids during methotrexate-induced intestinal damage in cell line and in a rat model","volume":"13","author":"Koppelmann","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0290","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/S0007114512000542","article-title":"Reversal of severe methotrexate-induced intestinal damage using enteral n-3 fatty acids","volume":"109","author":"Koppelmann","year":"2013","journal-title":"The British Journal of Nutrition"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0295","doi-asserted-by":"crossref","first-page":"16530","DOI":"10.1038\/s41598-017-16561-5","article-title":"Function of capric acid in cyclophosphamide-induced intestinal inflammation, oxidative stress, and barrier function in pigs","volume":"7","author":"Lee","year":"2017","journal-title":"Scientific Reports"},{"issue":"23","key":"10.1016\/j.pharmthera.2024.108689_bb0300","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.3390\/nu14235120","article-title":"Vitamin A ameliorated irinotecan-induced diarrhea in a piglet model involving enteric glia modulation and immune cells infiltration","volume":"14","author":"Li","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137395","article-title":"Mini-review: Enteric glial cell reactions to inflammation and potential therapeutic implications for GI diseases, motility disorders, and abdominal pain","volume":"812","author":"Linan-Rico","year":"2023","journal-title":"Neuroscience Letters"},{"issue":"10","key":"10.1016\/j.pharmthera.2024.108689_bb0310","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3390\/jpm13101487","article-title":"Probiotics and probiotic-like agents against chemotherapy-induced intestinal mucositis: A narrative review","volume":"13","author":"L\u00f3pez-G\u00f3mez","year":"2023","journal-title":"Journal of Personalized Medicine"},{"issue":"10","key":"10.1016\/j.pharmthera.2024.108689_bb0315","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s40262-018-0644-7","article-title":"Individualization of irinotecan treatment: A review of pharmacokinetics, pharmacodynamics, and pharmacogenetics","volume":"57","author":"de Man","year":"2018","journal-title":"Clinical Pharmacokinetics"},{"issue":"2","key":"10.1016\/j.pharmthera.2024.108689_bb0320","first-page":"261","article-title":"Nutraceuticals against oxidative stress in autoimmune disorders","volume":"10","author":"Mannucci","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"7","key":"10.1016\/j.pharmthera.2024.108689_bb0325","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1080\/01635581.2016.1208829","article-title":"Emu oil combined with Lyprinol\u2122 reduces small intestinal damage in a rat model of chemotherapy-induced mucositis","volume":"68","author":"Mashtoub","year":"2016","journal-title":"Nutrition and Cancer"},{"issue":"11","key":"10.1016\/j.pharmthera.2024.108689_bb0330","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1177\/1535370213493718","article-title":"Emu oil expedites small intestinal repair following 5-fluorouracil-induced mucositis in rats","volume":"238","author":"Mashtoub","year":"2013","journal-title":"Experimental Biology and Medicine (Maywood, N.J.)"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0335","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.nut.2016.07.004","article-title":"Randomized study of the clinical effects of \u03c9-3 fatty acid-containing enteral nutrition support during neoadjuvant chemotherapy on chemotherapy-related toxicity in patients with esophageal cancer","volume":"33","author":"Miyata","year":"2017","journal-title":"Nutrition (Burbank, Los Angeles County, Calif.)"},{"issue":"4","key":"10.1016\/j.pharmthera.2024.108689_bb0340","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/iub.2008","article-title":"Vitamin E: Regulatory redox interactions","volume":"71","author":"Miyazawa","year":"2019","journal-title":"IUBMB Life"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0345","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.12968\/bjcn.2013.18.Sup12.S6","article-title":"Vitamin C: A wound healing perspective","author":"Moores","year":"2013","journal-title":"British Journal of Community Nursing"},{"issue":"5 Suppl 61","key":"10.1016\/j.pharmthera.2024.108689_bb0350","first-page":"S102","article-title":"Folate supplementation during methotrexate therapy for rheumatoid arthritis","volume":"28","author":"Morgan","year":"2010","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0355","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1556\/1886.2019.00016","article-title":"Immunomodulatory and antimicrobial effects of Vitamin C","volume":"9","author":"Mousavi","year":"2019","journal-title":"European Journal of Microbiology & Immunology"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0360","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/SPC.0000000000000651","article-title":"Vitamin D is a potential treatment for the management of gastrointestinal mucositis","volume":"17","author":"Munem","year":"2023","journal-title":"Current Opinion in Supportive and Palliative Care"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0365","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/j.oooo.2019.07.041","article-title":"Comparative study on the efficacy of high-dose oral ascorbic acid with\/without zinc in reducing the severity of oral mucositis during cancer chemoradiation","volume":"129","author":"Nallan","year":"2020","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0370","author":"National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE)"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0375","author":"NCT06016400"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0380","first-page":"10","article-title":"Lipid replacement therapy with a glycophospholipid-antioxidantvitamin formulation significantly reduces fatigue within one week","volume":"13","author":"Nicolson","year":"2010","journal-title":"Journal of the American Nutraceutical Association"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0385","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF02893390","article-title":"Lipid replacement\/antioxidant therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function","volume":"11","author":"Nicolson","year":"2005","journal-title":"Pathology Oncology Research: POR"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0390","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10555-010-9245-0","article-title":"Lipid replacement therapy: A nutraceutical approach for reducing cancer-associated fatigue and the adverse effects of cancer therapy while restoring mitochondrial function","volume":"29","author":"Nicolson","year":"2010","journal-title":"Cancer and Metastasis Reviews"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0395","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphar.2018.00245","article-title":"Editorial: Adverse effects of cancer chemotherapy: Anything new to improve tolerance and reduce sequelae?","volume":"9","author":"Nurgali","year":"2018","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0400","doi-asserted-by":"crossref","first-page":"1007762","DOI":"10.3389\/fphar.2022.1007762","article-title":"Editorial: Cancer therapy: The challenge of handling a double-edged sword","volume":"13","author":"Nurgali","year":"2022","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0405","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00520-018-4312-0","article-title":"A decrease in vitamin D levels is associated with methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia","volume":"27","author":"Oosterom","year":"2019","journal-title":"Supportive Care in Cancer"},{"issue":"12","key":"10.1016\/j.pharmthera.2024.108689_bb0410","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14445","article-title":"Nutraceuticals and COVID-19: A mechanistic approach toward attenuating the disease complications","volume":"46","author":"Paudel","year":"2022","journal-title":"Journal of Food Biochemistry"},{"issue":"Suppl. 5","key":"10.1016\/j.pharmthera.2024.108689_bb0415","doi-asserted-by":"crossref","first-page":"v139","DOI":"10.1093\/annonc\/mdv202","article-title":"Management of oral and gastrointestinal mucosal injury: ESMO clinical practice guidelines for diagnosis, treatment, and follow-up","volume":"26","author":"Peterson","year":"2015","journal-title":"Annals of Oncology"},{"issue":"21","key":"10.1016\/j.pharmthera.2024.108689_bb0420","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.3390\/nu14214637","article-title":"A comprehensive review on nutraceuticals: Therapy support and formulation challenges","volume":"14","author":"Puri","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0425","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/1756283X10377820","article-title":"Vitamin D and gastrointestinal diseases: Inflammatory bowel disease and colorectal cancer","volume":"4","author":"Raman","year":"2011","journal-title":"Therapeutic Advances in Gastroenterology"},{"issue":"2","key":"10.1016\/j.pharmthera.2024.108689_bb0430","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/01635589709514577","article-title":"Oral administration of short-chain fatty acids reduces the intestinal mucositis caused by treatment with Ara-C in mice fed commercial or elemental diets","volume":"28","author":"Ramos","year":"1997","journal-title":"Nutrition and Cancer"},{"issue":"9 Suppl","key":"10.1016\/j.pharmthera.2024.108689_bb0435","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1002\/cncr.20163","article-title":"Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis","volume":"100","author":"Rubenstein","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0440","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3389\/fimmu.2019.00837","article-title":"Clinical advances in Immunonutrition and atherosclerosis: A review","volume":"10","author":"Ruiz-Le\u00f3n","year":"2019","journal-title":"Frontiers in Immunology"},{"issue":"10","key":"10.1016\/j.pharmthera.2024.108689_bb0445","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2174\/1389201021666200130113441","article-title":"Current prospects of nutraceuticals: A review","volume":"21","author":"Sachdeva","year":"2020","journal-title":"Current Pharmaceutical Biotechnology"},{"issue":"8","key":"10.1016\/j.pharmthera.2024.108689_bb0450","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.3390\/nu13082716","article-title":"Activation of free fatty acid receptor 4 affects intestinal inflammation and improves colon permeability in mice","volume":"13","author":"Salaga","year":"2021","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.pharmthera.2024.108689_bb0455","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/17512433.2018.1464911","article-title":"Nutraceuticals - shedding light on the grey area between pharmaceuticals and food","volume":"11","author":"Santini","year":"2018","journal-title":"Expert Review of Clinical Pharmacology"},{"issue":"5","key":"10.1016\/j.pharmthera.2024.108689_bb0460","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1158\/2159-8290.CD-23-0208","article-title":"Opportunities for achieving the cancer moonshot goal of a 50% reduction in cancer mortality by 2047","volume":"13","author":"Shiels","year":"2023","journal-title":"Cancer Discovery"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0465","doi-asserted-by":"crossref","first-page":"22911","DOI":"10.1038\/s41598-021-02308-w","article-title":"Development of a self-limiting model of methotrexate-induced mucositis reinforces butyrate as a potential therapy","volume":"11","author":"da Silva Ferreira","year":"2021","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0470","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/biom11010034","article-title":"Prophylactic treatment with vitamins C and B2 for methotrexate-induced gastrointestinal mucositis","volume":"11","author":"da Silva Ferreira","year":"2020","journal-title":"Biomolecules"},{"issue":"7","key":"10.1016\/j.pharmthera.2024.108689_bb0475","first-page":"261","article-title":"Marine lipids: Overview \u201cnews insights and lipid composition of Lyprinol\u201d","volume":"32","author":"Sinclair","year":"2000","journal-title":"Allergie et Immunologie"},{"issue":"6","key":"10.1016\/j.pharmthera.2024.108689_bb0480","first-page":"1449","article-title":"Folic acid and colorectal cancer prevention: Molecular mechanisms and epidemiological evidence (review)","volume":"26","author":"Str\u00f6hle","year":"2005","journal-title":"International Journal of Oncology"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0485","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3945\/an.111.000893","article-title":"Omega-3 fatty acids EPA and DHA: Health benefits throughout life","volume":"3","author":"Swanson","year":"2012","journal-title":"Advances in Nutrition (Bethesda, Md.)"},{"issue":"7","key":"10.1016\/j.pharmthera.2024.108689_bb0490","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1046\/j.1440-1746.2001.02537.x","article-title":"Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids","volume":"16","author":"Tanaka","year":"2001","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"11","key":"10.1016\/j.pharmthera.2024.108689_bb0495","first-page":"3508","article-title":"The protective role of short-chain fatty acids acting as signal molecules in chemotherapy- or radiation-induced intestinal inflammation","volume":"10","author":"Tian","year":"2020","journal-title":"American Journal of Cancer Research"},{"issue":"2","key":"10.1016\/j.pharmthera.2024.108689_bb0500","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4161\/cbt.7.2.5332","article-title":"Lyprinol only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis","volume":"7","author":"Torres","year":"2008","journal-title":"Cancer Biology & Therapy"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0505","series-title":"Handbook of cancer and immunology","article-title":"Gastrointestinal side effects of anticancer therapy","author":"Uranga","year":"2023"},{"issue":"2","key":"10.1016\/j.pharmthera.2024.108689_bb0510","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/ajcn\/54.2.346","article-title":"Effect of dietary menhaden oil on normal growth and development and on ameliorating mucosal injury in rats","volume":"54","author":"Vanderhoof","year":"1991","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"4","key":"10.1016\/j.pharmthera.2024.108689_bb0515","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/bjh.13113","article-title":"Mucosal barrier injury, fever and infection in neutropenic patients with cancer: Introducing the paradigm febrile mucositis","volume":"167","author":"van der Velden","year":"2014","journal-title":"British Journal of Haematology"},{"issue":"3","key":"10.1016\/j.pharmthera.2024.108689_bb0520","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/10408690290825529","article-title":"Biological properties of olive oil phytochemicals","volume":"42","author":"Visioli","year":"2002","journal-title":"Critical Reviews in Food Science and Nutrition"},{"issue":"23","key":"10.1016\/j.pharmthera.2024.108689_bb0525","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1158\/1078-0432.CCR-07-0823","article-title":"Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor","volume":"13","author":"Xue","year":"2007","journal-title":"Clinical Cancer Research"},{"issue":"6","key":"10.1016\/j.pharmthera.2024.108689_bb0530","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3390\/molecules26061757","article-title":"Vitamin A and bone health: A review on current evidence","volume":"26","author":"Yee","year":"2021","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0535","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/CAD.0000000000001128","article-title":"Therapeutic effects of vitamin D and IL-22 on methotrexate-induced mucositis in mice","volume":"33","author":"Yilmaz","year":"2022","journal-title":"Anti-Cancer Drugs"},{"issue":"6","key":"10.1016\/j.pharmthera.2024.108689_bb0540","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s11745-003-1104-y","article-title":"Antagonism of croton oil inflammation by topical emu oil in CD-1 mice","volume":"38","author":"Yoganathan","year":"2003","journal-title":"Lipids"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0545","doi-asserted-by":"crossref","first-page":"7255497","DOI":"10.1155\/2022\/7255497","article-title":"The intestinal redox system and its significance in chemotherapy-induced intestinal mucositis","volume":"2022","author":"Yu","year":"2022","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0550","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12865-022-00495-3","article-title":"Three important short-chain fatty acids (SCFAs) attenuate the inflammatory response induced by 5-FU and maintain the integrity of intestinal mucosal tight junction","volume":"23","author":"Yue","year":"2022","journal-title":"BMC Immunology"},{"issue":"6","key":"10.1016\/j.pharmthera.2024.108689_bb0555","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/cgt.2017.16","article-title":"New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles","volume":"24","author":"Zaimy","year":"2017","journal-title":"Cancer Gene Therapy"},{"issue":"1","key":"10.1016\/j.pharmthera.2024.108689_bb0560","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1017\/S1466252311000089","article-title":"Nutritional and physiological role of medium-chain triglycerides and medium-chain fatty acids in piglets","volume":"12","author":"Zentek","year":"2011","journal-title":"Animal Health Research Reviews"},{"key":"10.1016\/j.pharmthera.2024.108689_bb0565","article-title":"Role of Interleukin-22 in ulcerative colitis","volume":"159","author":"Zhao","year":"2023","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725824001098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725824001098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T12:28:38Z","timestamp":1728476918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725824001098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":114,"alternative-id":["S0163725824001098"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108689","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamins and fatty acids against chemotherapy-induced intestinal mucositis","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108689"}}