{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:23:34Z","timestamp":1790774614383,"version":"4.1.0"},"reference-count":136,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.pharmthera.2024.108730","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T02:16:59Z","timestamp":1728699419000},"page":"108730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Metrnl as a secreted protein: Discovery and cardiovascular research"],"prefix":"10.1016","volume":"263","author":[{"given":"Zhu-Wei","family":"Miao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can-Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Li","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yu","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2024.108730_bb0005","first-page":"4471","article-title":"Subfatin, asprosin, alamandine and maresin-1 in cerebral ischemia, intracranial and subarachnoid hemorrhages","volume":"27","author":"Albayrak","year":"2023","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0010","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s11325-023-02800-9","article-title":"Is meteorin-like (Metrnl) a novel biomarker to distinguish patients with obstructive sleep apnea (OSA) and patients with OSA at vascular risk","volume":"27","author":"Altintas","year":"2023","journal-title":"Sleep & Breathing"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s42255-020-0184-y","article-title":"Meteorin-like facilitates skeletal muscle repair through a Stat3\/IGF-1 mechanism","volume":"2","author":"Baht","year":"2020","journal-title":"Nature Metabolism"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0025","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.3390\/jcm10153271","article-title":"Evidence of a muscle-brain Axis by quantification of the neurotrophic myokine METRNL (Meteorin-like protein) in human cerebrospinal fluid and serum","volume":"10","author":"Berghoff","year":"2021","journal-title":"Journal of Clinical Medicine"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0030","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1146\/annurev-biochem-062917-012749","article-title":"Protein quality control of the endoplasmic reticulum and ubiquitin-proteasome-triggered degradation of aberrant proteins: Yeast pioneers the path","volume":"87","author":"Berner","year":"2018","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0035","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/01.HYP.29.1.428","article-title":"High human renin hypertension in transgenic rats","volume":"29","author":"Bohlender","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0040","first-page":"159","article-title":"Chronic wounds: Evaluation and management","volume":"101","author":"Bowers","year":"2020","journal-title":"American Family Physician"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2019.108253","article-title":"The novel cytokine Metrnl\/IL-41 is elevated in psoriatic arthritis synovium and inducible from both entheseal and synovial fibroblasts","volume":"208","author":"Bridgewood","year":"2019","journal-title":"Clinical Immunology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0050","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3390\/medicina57101072","article-title":"Diabetic wound-healing science","volume":"57","author":"Burgess","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0055","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1093\/eurheartj\/ehac015","article-title":"Prevalence of statin intolerance: A meta-analysis","volume":"43","author":"Byty\u00e7i","year":"2022","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0060","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jcsm.12865","article-title":"Serum Meteorin-like is associated with weight loss in the elderly patients with chronic heart failure","volume":"13","author":"Cai","year":"2022","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2023.104478","article-title":"Plasma interleukin-41 serves as a potential diagnostic biomarker for Kawasaki disease","volume":"147","author":"Cai","year":"2023","journal-title":"Microvascular Research"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148171","article-title":"Protective effects of METRNL overexpression against pathological cardiac remodeling","volume":"901","author":"Cao","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0075","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/hmg\/ddab236","article-title":"Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues","volume":"31","author":"Castaneda","year":"2022","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0080","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jfo.2021.09.011","article-title":"Laboratory evidence on a direct correlation between acute central serous chorioretinopathy and tenascin C, metalloprotein 1, BAX, BCL2, subfatin and asprosin","volume":"45","author":"Celik","year":"2022","journal-title":"Journal Fran\u00e7ais d\u2019Ophtalmologie"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0085","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2147\/DMSO.S452055","article-title":"Low levels of metrnl are linked to the deterioration of diabetic kidney disease","volume":"17","author":"Chen","year":"2024","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109690","article-title":"Protective role of the novel cytokine Metrnl\/ interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg\/Th17 immune cell balance","volume":"254","author":"Chen","year":"2023","journal-title":"Clinical Immunology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0095","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s10020-023-00714-6","article-title":"Meteorin-like\/Meteorin-\u03b2 protects LPS-induced acute lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway","volume":"29","author":"Chen","year":"2023","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0100","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41419-021-03614-x","article-title":"Regulated cell death pathways in doxorubicin-induced cardiotoxicity","volume":"12","author":"Christidi","year":"2021","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204180","article-title":"Lower serum levels of Meteorin-like\/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines","volume":"13","author":"Dadmanesh","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0110","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13367","article-title":"Myokines in skeletal muscle physiology and metabolism: Recent advances and future perspectives","volume":"228","author":"Das","year":"2020","journal-title":"Acta Physiologica (Oxford, England)"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0115","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pharmthera.2016.04.011","article-title":"Targeting PCSK9 as a promising new mechanism for lowering low-density lipoprotein cholesterol","volume":"164","author":"Della Badia","year":"2016","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0120","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1210\/er.2018-00141","article-title":"Insulin resistance and atherosclerosis: Implications for insulin-sensitizing agents","volume":"40","author":"Di Pino","year":"2019","journal-title":"Endocrine Reviews"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.molmed.2010.12.003","article-title":"The cardiokine story unfolds: Ischemic stress-induced protein secretion in the heart","volume":"17","author":"Doroudgar","year":"2011","journal-title":"Trends in Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0130","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1038\/s41401-022-01049-4","article-title":"Meteorin-like protein overexpression ameliorates fulminant hepatitis in mice by inhibiting chemokine-dependent immune cell infiltration","volume":"44","author":"Du","year":"2023","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0135","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.diabres.2019.02.026","article-title":"Association of low serum Meteorin like (Metrnl) concentrations with worsening of glucose tolerance, impaired endothelial function and atherosclerosis","volume":"150","author":"El-Ashmawy","year":"2019","journal-title":"Diabetes Research and Clinical Practice"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105749","article-title":"Naturally-derived targeted therapy for wound healing: Beyond classical strategies","volume":"170","author":"El-Ashram","year":"2021","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0145","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/10520295.2023.2187462","article-title":"Carvacrol protects rat liver exposed to formaldehyde by regulating oxidative stress, and asprosin and subfatin hormones","volume":"98","author":"Emre","year":"2023","journal-title":"Biotechnic & Histochemistry"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0150","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/13813455.2018.1538248","article-title":"Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules","volume":"126","author":"Fadaei","year":"2020","journal-title":"Archives of Physiology and Biochemistry"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0155","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.rec.2023.03.015","article-title":"Meteorin-like protein is associated with a higher risk profile and predicts a worse outcome in patients with STEMI","volume":"76","author":"Ferrer-Curriu","year":"2023","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231943","article-title":"Circulating levels of Meteorin-like protein in polycystic ovary syndrome: A case-control study","volume":"15","author":"Fouani","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0165","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41423-021-00803-8","article-title":"Meteorin-\u03b2\/Meteorin like\/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma","volume":"19","author":"Gao","year":"2022","journal-title":"Cellular & Molecular Immunology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0170","first-page":"208","article-title":"Meteorin-like protein decreases in acute coronary syndrome","volume":"27","author":"Giden","year":"2023","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0175","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bcp.2019.04.027","article-title":"Treatment of giant cell arteritis","volume":"165","author":"Gonz\u00e1lez-Gay","year":"2019","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0180","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12886-023-03075-0","article-title":"Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy","volume":"23","author":"G\u00fcng\u00f6r Kobat","year":"2023","journal-title":"BMC Ophthalmology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0185","article-title":"Cutaneous wound healing: An update from physiopathology to current therapies","volume":"11, 665.","author":"Gushiken","year":"2021","journal-title":"Life (Basel)"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0190","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s41401-022-01009-y","article-title":"Metrnl regulates cognitive dysfunction and hippocampal BDNF levels in D-galactose-induced aging mice","volume":"44","author":"Hong","year":"2023","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0195","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1517\/14740338.2013.793670","article-title":"Efficacy and safety of mipomersen sodium (Kynamro)","volume":"12","author":"Hovingh","year":"2013","journal-title":"Expert Opinion on Drug Safety"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101747","article-title":"Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP\/PKA\/SIRT1 pathway","volume":"37","author":"Hu","year":"2020","journal-title":"Redox Biology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108314","article-title":"A natural products solution to diabetic nephropathy therapy","volume":"241","author":"Hu","year":"2023","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0210","article-title":"Meteorin-like ameliorates \u03b2 cell function by inhibiting \u03b2 cell apoptosis of and promoting \u03b2 cell proliferation via activating the WNT\/\u03b2-catenin pathway","volume":"12","author":"Hu","year":"2021","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108480","article-title":"Targeting PCSK9 to tackle cardiovascular disease","volume":"249","author":"Hummelgaard","year":"2023","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0230","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41580-021-00390-6","article-title":"The aetiology and molecular landscape of insulin resistance","volume":"22","author":"James","year":"2021","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0235","author":"JAPAN, P"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0245","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.expneurol.2011.09.027","article-title":"Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo","volume":"233","author":"J\u00f8rgensen","year":"2012","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0250","first-page":"1","article-title":"METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPAR\u03b4-dependent pathways in skeletal muscle of mice","volume":"50","author":"Jung","year":"2018","journal-title":"Experimental & Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0255","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s12192-023-01376-3","article-title":"N-acetylcysteine may exert hepatoprotective effect by regulating Meteorin-like levels in Adriamycin-induced liver injury","volume":"28","author":"Kaya","year":"2023","journal-title":"Cell Stress & Chaperones"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0265","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.1038\/s41467-022-35390-3","article-title":"Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro\/adipogenic progenitor signaling","volume":"13","author":"Lee","year":"2022","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0270","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1111\/febs.15301","article-title":"The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPK\u03b12","volume":"287","author":"Lee","year":"2020","journal-title":"The FEBS Journal"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0275","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jacc.2019.04.068","article-title":"From ACE inhibitors\/ARBs to ARNIs in coronary artery disease and heart failure (part 2\/5)","volume":"74","author":"Leong","year":"2019","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167113","article-title":"Meteorin-like (METRNL) attenuates hypertensive induced cardiac hypertrophy by inhibiting autophagy via activating BRCA2","volume":"1870","author":"Li","year":"2024","journal-title":"Biochimica et Biophysica Acta - Molecular Basis of Disease"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0285","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2147\/DMSO.S450695","article-title":"Autophagy, pyroptosis and ferroptosis are rising stars in the pathogenesis of diabetic nephropathy","volume":"17","author":"Li","year":"2024","journal-title":"Diabetes, Metabolic Syndrome and Obesity"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0290","doi-asserted-by":"crossref","first-page":"1098570","DOI":"10.3389\/fimmu.2023.1098570","article-title":"Meteorin-like\/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies","volume":"14","author":"Li","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0295","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/aps.2016.70","article-title":"Intestinal Metrnl released into the gut lumen acts as a local regulator for gut antimicrobial peptides","volume":"37","author":"Li","year":"2016","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0300","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.2337\/db15-0274","article-title":"Adipocyte Metrnl antagonizes insulin resistance through PPAR\u03b3 signaling","volume":"64","author":"Li","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0305","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/cns.12219","article-title":"Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression","volume":"20","author":"Li","year":"2014","journal-title":"CNS Neuroscience & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0310","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nature Reviews. Disease Primers"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108541","article-title":"Signaling pathways in brain ischemia: Mechanisms and therapeutic implications","volume":"251","author":"Lin","year":"2023","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0320","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41401-021-00684-7","article-title":"Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage","volume":"42","author":"Ling","year":"2021","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114118","article-title":"Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K\/Akt\/NF-\u03baB and NLRP3\/caspase-1\/GSDMD signaling","volume":"158","author":"Liu","year":"2023","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0330","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/s41401-024-01247-2","article-title":"Macrod1 suppresses diabetic cardiomyopathy via regulating PARP1-NAD(+)-SIRT3 pathway","volume":"45","author":"Liu","year":"2024","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0335","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/jcmm.13915","article-title":"Serum Metrnl is associated with the presence and severity of coronary artery disease","volume":"23","author":"Liu","year":"2019","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0340","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jare.2022.10.014","article-title":"Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS\/STING signaling dependent on LKB1\/AMPK\/ULK1-mediated autophagy","volume":"51","author":"Lu","year":"2023","journal-title":"Journal of Advanced Research"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0345","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cmet.2019.01.018","article-title":"Caloric restriction mimetics against age-associated disease: Targets, mechanisms, and therapeutic potential","volume":"29","author":"Madeo","year":"2019","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0350","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: A scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0355","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1476-5381.2011.01404.x","article-title":"The role of perivascular adipose tissue in vascular smooth muscle cell growth","volume":"165","author":"Miao","year":"2012","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0360","unstructured":"Miao, C. Y., Li, Z. Y., & Miao, Z. W. (2016). Application of Metrnl protein or gene in treating sepsis. China patent ZL201610143110.2. 2016 Mar 14."},{"key":"10.1016\/j.pharmthera.2024.108730_bb0365","unstructured":"Miao, C. Y., Li, Z. Y., & Wang, P. (2013a). Application of Metrnl in preparing hypoglycemic medicine. China patent ZL201310525184.9. 2013 Oct 29."},{"key":"10.1016\/j.pharmthera.2024.108730_bb0370","unstructured":"Miao, C. Y., Li, Z. Y., & Wang, P. (2013b). Application of Metrnl in preparing hypolipidemic medicine. China patent ZL201310525181.5. 2013 Oct 29."},{"key":"10.1016\/j.pharmthera.2024.108730_bb0375","unstructured":"Miao, C. Y., Li, Z. Y., & Wang, P. (2016). Methods of reducing blood glucose or triglyceride levels by administration of Metrnl. US patent US10342852B2. 2016 Apr 25."},{"key":"10.1016\/j.pharmthera.2024.108730_bb0380","unstructured":"Miao, C. Y., Song, J., Li, Z. Y., & Guan, Y. F. (2016). Application of Metrnl protein or gene in treatment of endothelial dysfunction. China patent ZL201610089072.7. 2016 Feb 17."},{"key":"10.1016\/j.pharmthera.2024.108730_bb0385","first-page":"713","article-title":"Candesartan inhibits sinoaortic denervation-induced cardiovascular hypertrophy in rats","volume":"23","author":"Miao","year":"2002","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0390","first-page":"812","article-title":"Angiotensin II and AT1 receptor in hypertrophied ventricles and aortas of sinoaortic-denervated rats","volume":"24","author":"Miao","year":"2003","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0395","unstructured":"Miao, C. Y., Zhang, S. L., Li, Z. Y., & Miao, Z. W. (2016). Application of Metrnl in treatment of ulcerative colitis. China patent ZL201611128539.0. 2016 Dec 9."},{"key":"10.1016\/j.pharmthera.2024.108730_bb0400","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/s41401-020-00529-9","article-title":"Involvement of the secreted protein Metrnl in human diseases","volume":"41","author":"Miao","year":"2020","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0405","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41401-023-01204-5","article-title":"Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients","volume":"45","author":"Miao","year":"2024","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0410","series-title":"Anti-stroke biologics: From recombinant proteins to stem cells and organoids","author":"Miao","year":"2024"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0415","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.gheart.2012.10.004","article-title":"Assessing the global burden of ischemic heart disease: Part 1: Methods for a systematic review of the global epidemiology of ischemic heart disease in 1990 and 2010","volume":"7","author":"Moran","year":"2012","journal-title":"Global Heart"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0420","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/344541a0","article-title":"Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene","volume":"344","author":"Mullins","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0425","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3390\/ijms18071419","article-title":"Diabetes and Wound Angiogenesis","volume":"18","author":"Okonkwo","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0430","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/300611a0","article-title":"Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes","volume":"300","author":"Palmiter","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108418","article-title":"The tissue-specific transcriptional landscape underlines the involvement of endothelial cells in health and disease","volume":"246","author":"Parab","year":"2023","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0440","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41419-020-2276-8","article-title":"Erythropoietin and its derivatives: From tissue protection to immune regulation","volume":"11","author":"Peng","year":"2020","journal-title":"Cell Death & Disease"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0445","first-page":"S358","article-title":"Relationship of receptors of adipokines with hypertension and obesity. Murine model","volume":"55","author":"P\u00e9rez-Capistran","year":"2017","journal-title":"Revista M\u00e9dica del Instituto Mexicano del Seguro Social"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0450","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1038\/s41401-020-0368-8","article-title":"Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride","volume":"41","author":"Qi","year":"2020","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0455","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1111\/bph.15972","article-title":"Small interfering RNA: Discovery, pharmacology and clinical development-an introductory review","volume":"180","author":"Ranasinghe","year":"2023","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0460","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.cell.2014.03.065","article-title":"Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis","volume":"157","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108507","article-title":"Beyond statins: New pharmacological targets to decrease LDL-cholesterol and cardiovascular events","volume":"250","author":"Raschi","year":"2023","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111708","article-title":"Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management","volume":"139","author":"Rawat","year":"2021","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0475","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1126\/science.abn3027","article-title":"Meteorin-like promotes heart repair through endothelial KIT receptor tyrosine kinase","volume":"376","author":"Reboll","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0480","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201206","article-title":"Meteorin-like\/Meteorin-\u03b2 protects heart against cardiac dysfunction","volume":"218","author":"Rup\u00e9rez","year":"2021","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0485","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1212\/WNL.0000000000012781","article-title":"Global epidemiology of stroke and access to acute ischemic stroke interventions","volume":"97","author":"Saini","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0490","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0140-6736(08)61077-6","article-title":"Polymyalgia rheumatica and giant-cell arteritis","volume":"372","author":"Salvarani","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0495","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1007\/s11033-022-07374-5","article-title":"Effects of meteorin-like hormone on endocrine function of hypothalamo-hypophysial system and peripheral uncoupling proteins in rats","volume":"49","author":"\u015eekerci","year":"2022","journal-title":"Molecular Biology Reports"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0500","doi-asserted-by":"crossref","first-page":"4522","DOI":"10.1080\/07391102.2023.2220804","article-title":"De novo structure prediction of meteorin and meteorin-like protein for identification of domains, functional receptor binding regions, and their high-risk missense variants","volume":"42","author":"Shankar","year":"2023","journal-title":"Journal of Biomolecular Structure & Dynamics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0505","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJM199809243391307","article-title":"Doxorubicin-induced cardiomyopathy","volume":"339","author":"Singal","year":"1998","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0510","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2018.02.002","article-title":"Evolving targets for the treatment of atherosclerosis","volume":"187","author":"Solanki","year":"2018","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0515","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.bbalip.2013.05.006","article-title":"Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNF\u03b1 action in obesity","volume":"1831","author":"Song","year":"2013","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0520","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.2337\/db23-0173","article-title":"Accelerating wound closure with Metrnl in normal and diabetic mouse skin","volume":"72","author":"Song","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0525","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000528271","article-title":"Skin wound healing: Of players, patterns, and processes","volume":"64","author":"Sorg","year":"2023","journal-title":"European Surgical Research"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0530","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1177\/0004563219854115","article-title":"Correlation of serum meteorin-like concentration with the presence and severity of obstructive sleep apnoea syndrome","volume":"56","author":"Sun","year":"2019","journal-title":"Annals of Clinical Biochemistry"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0535","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"72","author":"Thygesen","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0540","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.4049\/jimmunol.1800435","article-title":"Meteorin-like\/meteorin-\u03b2 is a novel immunoregulatory cytokine associated with inflammation","volume":"201","author":"Ushach","year":"2018","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0545","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.clim.2014.11.006","article-title":"Meteorin-like is a cytokine associated with barrier tissues and alternatively activated macrophages","volume":"156","author":"Ushach","year":"2015","journal-title":"Clinical Immunology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0550","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/CIRCRESAHA.116.306531","article-title":"Thirty years of saying NO: Sources, fate, actions, and misfortunes of the endothelium-derived vasodilator mediator","volume":"119","author":"Vanhoutte","year":"2016","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0555","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.addr.2018.09.010","article-title":"Therapeutic strategies for enhancing angiogenesis in wound healing","volume":"146","author":"Veith","year":"2019","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0560","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart disease and stroke statistics-2020 update: A report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0565","doi-asserted-by":"crossref","first-page":"keae073","DOI":"10.1093\/rheumatology\/keae073","article-title":"Associations between plasma metabolism associated proteins and future development of giant cell arteritis: Results from a prospective study","author":"Wadstr\u00f6m","year":"2024","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0570","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.atherosclerosis.2018.08.039","article-title":"Treatment of atherosclerosis by traditional Chinese medicine: Questions and quandaries","volume":"277","author":"Wang","year":"2018","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0575","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4161\/auto.8.1.18274","article-title":"Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia","volume":"8","author":"Wang","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0580","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.tips.2015.08.012","article-title":"NAMPT as a therapeutic target against stroke","volume":"36","author":"Wang","year":"2015","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0585","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/cvr\/cvn288","article-title":"Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: Role of nicotinamide mononucleotide","volume":"81","author":"Wang","year":"2009","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0590","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.22236","article-title":"Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway","volume":"69","author":"Wang","year":"2011","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0595","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2119\/molmed.2010.000134","article-title":"Involvement of leptin receptor long isoform (LepRb)-STAT3 signaling pathway in brain fat mass- and obesity-associated (FTO) downregulation during energy restriction","volume":"17","author":"Wang","year":"2011","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2020.108443","article-title":"Correlation of serum meteorin-like concentrations with diabetic nephropathy","volume":"169","author":"Wang","year":"2020","journal-title":"Diabetes Research and Clinical Practice"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0605","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.gene.2016.06.058","article-title":"Comparative analysis of gene expression profiles of hip articular cartilage between non-traumatic necrosis and osteoarthritis","volume":"591","author":"Wang","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0610","first-page":"198","article-title":"Construction and validation of a mouse model with systemic overexpression of human METRNL gene","volume":"42","author":"Wang","year":"2024","journal-title":"Journal of Pharmaceutical Practice and Service"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0615","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1111\/bph.13979","article-title":"NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia","volume":"174","author":"Wei","year":"2017","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0620","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1021\/acs.analchem.6b04600","article-title":"Determination of the disulfide structure of murine Meteorin, a neurotrophic factor, by LC-MS and Electron transfer dissociation-high-energy collisional dissociation analysis of proteolytic fragments","volume":"89","author":"Wen","year":"2017","journal-title":"Analytical Chemistry"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0625","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10557-005-5734-8","article-title":"Effects of long-term treatment with candesartan on hemodynamics and organ damage in spontaneously hypertensive rats","volume":"19","author":"Xie","year":"2005","journal-title":"Cardiovascular Drugs and Therapy"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0630","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00005344-200302000-00023","article-title":"Effects of long-term treatment with candesartan on organ damages in sinoaortic denervated rats","volume":"41","author":"Xie","year":"2003","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0635","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.924564","article-title":"Meteorin-like (METRNL) attenuates myocardial ischemia\/reperfusion injury-induced cardiomyocytes apoptosis by alleviating endoplasmic reticulum stress via activation of AMPK-PAK2 signaling in H9C2 cells","volume":"26","author":"Xu","year":"2020","journal-title":"Medical Science Monitor"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0640","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.pharmthera.2016.04.006","article-title":"The critical role of the central nervous system (pro)renin receptor in regulating systemic blood pressure","volume":"164","author":"Xu","year":"2016","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0645","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/s41401-023-01090-x","article-title":"Metrnl deficiency retards skin wound healing in mice by inhibiting AKT\/eNOS signaling and angiogenesis","volume":"44","author":"Xu","year":"2023","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0650","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1007\/s12011-023-03656-6","article-title":"N-acetylcysteine may regulate altered meteorin-like levels in testicular tissue due to aluminum exposure","volume":"201","author":"Yal\u00e7\u0131n","year":"2023","journal-title":"Biological Trace Element Research"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0655","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1507\/endocrj.EJ20-0351","article-title":"Administration of metrnl delays the onset of diabetes in non-obese diabetic mice","volume":"68","author":"Yao","year":"2021","journal-title":"Endocrine Journal"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0660","article-title":"Meteorin-like protein levels decrease in patients with acute Ischaemic stroke","volume":"14","author":"Yasak","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0665","doi-asserted-by":"crossref","DOI":"10.11613\/BM.2022.020704","article-title":"Subfatin concentration decreases in acute coronary syndrome","volume":"32","author":"Yilmaz","year":"2022","journal-title":"Biochem Med (Zagreb)"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0675","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41401-019-0343-4","article-title":"Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells","volume":"41","author":"Zhang","year":"2020","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0680","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.apsb.2022.12.008","article-title":"Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis","volume":"13","author":"Zheng","year":"2023","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0685","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/aps.2016.9","article-title":"Metrnl: A secreted protein with new emerging functions","volume":"37","author":"Zheng","year":"2016","journal-title":"Acta Pharmacologica Sinica"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0690","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1248\/cpb.c17-00846","article-title":"Evaluation of two commercial enzyme-linked immunosorbent assay kits for the detection of human circulating Metrnl","volume":"66","author":"Zheng","year":"2018","journal-title":"Chemical & Pharmaceutical Bulletin (Tokyo)"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0695","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2174\/1389201023666220518113219","article-title":"Distribution of nicotinamide mononucleotide after intravenous injection in normal and ischemic stroke mice","volume":"24","author":"Zheng","year":"2023","journal-title":"Current Pharmaceutical Biotechnology"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0700","doi-asserted-by":"crossref","first-page":"611","DOI":"10.2337\/db22-0680","article-title":"Metrnl alleviates lipid accumulation by modulating mitochondrial homeostasis in diabetic nephropathy","volume":"72","author":"Zhou","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0705","article-title":"Adipokines and obesity. Potential link to metabolic disorders and chronic complications","volume":"21, 3570.","author":"Zorena","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2024.108730_bb0710","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/ecco-jcc\/jjz001","article-title":"The adipokine Metrnl ameliorates chronic colitis in Il-10\u2212\/\u2212 mice by attenuating mesenteric adipose tissue lesions during spontaneous colitis","volume":"13","author":"Zuo","year":"2019","journal-title":"Journal of Crohn\u2019s & Colitis"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725824001505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725824001505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T01:43:43Z","timestamp":1730511823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725824001505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":136,"alternative-id":["S0163725824001505"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108730","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metrnl as a secreted protein: Discovery and cardiovascular research","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108730"}}