{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:39:08Z","timestamp":1794004748224,"version":"4.8.0"},"reference-count":174,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ20042"],"award-info":[{"award-number":["2023JJ20042"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405131"],"award-info":[{"award-number":["82405131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104309"],"award-info":[{"award-number":["82104309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["23PTKF1019"],"award-info":[{"award-number":["23PTKF1019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.pharmthera.2025.108801","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T16:28:53Z","timestamp":1738168133000},"page":"108801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["From physiology to pathology: Emerging roles of GPER in cardiovascular disease"],"prefix":"10.1016","volume":"267","author":[{"given":"Zixuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junren","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranbo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongshuai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.pharmthera.2025.108801_bb0005","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s00018-023-04886-6","article-title":"Estradiol mitigates stress-induced cardiac injury and inflammation by downregulating ADAM17 via the GPER-1\/PI3K signaling pathway","volume":"80","author":"Adu-Amankwaah","year":"2023","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"Suppl. 2","key":"10.1016\/j.pharmthera.2025.108801_bb0010","first-page":"S1","article-title":"Guide to receptors and channels (GRAC), 3rd edition","volume":"153","author":"Alexander","year":"2008","journal-title":"British Journal of Pharmacology"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0015","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/etc.4691","article-title":"The effects of 17alpha-ethinylestradiol on the heart rate of embryonic japanese medaka (oryzias latipes)","volume":"39","author":"Anderson","year":"2020","journal-title":"Environmental Toxicology and Chemistry"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.maturitas.2014.04.002","article-title":"Vasodilatory effects of the selective GPER agonist G-1 is maximal in arteries of postmenopausal women","volume":"78","author":"Arefin","year":"2014","journal-title":"Maturitas"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10549-009-0631-7","article-title":"GPR30 and estrogen receptor expression: New insights into hormone dependence of inflammatory breast cancer","volume":"123","author":"Arias-Pulido","year":"2010","journal-title":"Breast Cancer Research and Treatment"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0030","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-pharmtox-031122-121944","article-title":"G protein-coupled estrogen receptor GPER: Molecular pharmacology and therapeutic applications","volume":"63","author":"Arterburn","year":"2023","journal-title":"Annual Review of Pharmacology and Toxicology"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108801_bb0035","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.3390\/ijms21124314","article-title":"The role of estrogen receptors in cardiovascular disease","volume":"21","author":"Aryan","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107250","article-title":"G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ER\u03b1 and ER\u03b2 in pancreatic beta cells","volume":"164","author":"Babiloni-Chust","year":"2022","journal-title":"Environment International"},{"issue":"14","key":"10.1016\/j.pharmthera.2025.108801_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411295","article-title":"Endothelin-1 in health and disease","volume":"24","author":"Banecki","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0050","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jsbmb.2017.03.021","article-title":"Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives","volume":"176","author":"Barton","year":"2018","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.tem.2015.02.003","article-title":"Emerging roles of GPER in diabetes and atherosclerosis","volume":"26","author":"Barton","year":"2015","journal-title":"Trends in Endocrinology and Metabolism"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2025.108801_bb0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jneuroim.2009.06.023","article-title":"Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis","volume":"214","author":"Blasko","year":"2009","journal-title":"Journal of Neuroimmunology"},{"issue":"8","key":"10.1016\/j.pharmthera.2025.108801_bb0065","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1161\/CIRCRESAHA.116.307509","article-title":"The importance of biological sex and estrogen in rodent models of cardiovascular health and disease","volume":"118","author":"Blenck","year":"2016","journal-title":"Circulation Research"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0070","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nchembio775","article-title":"Virtual and biomolecular screening converge on a selective agonist for GPR30","volume":"2","author":"Bologa","year":"2006","journal-title":"Nature Chemical Biology"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0075","doi-asserted-by":"crossref","first-page":"H16","DOI":"10.1152\/ajpheart.00588.2009","article-title":"A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury","volume":"298","author":"Bopassa","year":"2010","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0080","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3390\/genes1030413","article-title":"Programming pluripotent precursor cells derived from Xenopus embryos to generate specific tissues and organs","volume":"1","author":"Borchers","year":"2010","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.587221","article-title":"Sex differences in the pro-angiogenic response of human endothelial cells: Focus on PFKFB3 and FAK activation","volume":"11","author":"Boscaro","year":"2020","journal-title":"Frontiers in Pharmacology"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0090","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1677\/JOE-07-0017","article-title":"Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system","volume":"193","author":"Brailoiu","year":"2007","journal-title":"The Journal of Endocrinology"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0095","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1113\/expphysiol.2012.069377","article-title":"Bradycardic effects mediated by activation of G protein-coupled estrogen receptor in rat nucleus ambiguus","volume":"98","author":"Brailoiu","year":"2013","journal-title":"Experimental Physiology"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/CJI.0b013e31828d8e3b","article-title":"The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions","volume":"36","author":"Brunsing","year":"2013","journal-title":"Journal of Immunotherapy"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2567.2011.03471.x","article-title":"Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1","volume":"134","author":"Brunsing","year":"2011","journal-title":"Immunology"},{"issue":"430","key":"10.1016\/j.pharmthera.2025.108801_bb0110","doi-asserted-by":"crossref","first-page":"ra56","DOI":"10.1126\/scisignal.aaf0583","article-title":"Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1","volume":"9","author":"Bullen","year":"2016","journal-title":"Science Signaling"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0115","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2147\/JPR.S175312","article-title":"Update on the pathophysiology of cluster headache: Imaging and neuropeptide studies","volume":"12","author":"Buture","year":"2019","journal-title":"Journal of Pain Research"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2025.108801_bb0120","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/BF03402102","article-title":"Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein e knockout mice","volume":"9","author":"Caligiuri","year":"2003","journal-title":"Molecular Medicine"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bib862","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1590\/S0100-879X2012007500027","article-title":"Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems","volume":"45","author":"Cam Etoz","year":"2012","journal-title":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176636","article-title":"17-beta-estradiol and phytoestrogens elicit NO production and vasodilatation through PI3K, PKA and EGF receptors pathways, evidencing functional selectivity","volume":"975","author":"Catalan-Salas","year":"2024","journal-title":"European Journal of Pharmacology"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0130","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/HM9.0000000000000024","article-title":"Effects of Tongmai Yangxin pills on ventricular remodeling in myocardial ischemia-reperfusion rats","volume":"3","author":"Chen","year":"2023","journal-title":"Acupuncture and Herbal Medicine"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0135","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/13880209.2023.2184481","article-title":"Tongmai Yangxin pill alleviates myocardial no-reflow by activating GPER to regulate HIF-1\u03b1 signaling and downstream potassium channels","volume":"61","author":"Chen","year":"2023","journal-title":"Pharmaceutical Biology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0140","article-title":"Dapagliflozin alleviates myocardial ischemia\/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition","volume":"14","author":"Chen","year":"2023","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0145","article-title":"GPER and testicular germ cell cancer","volume":"11","author":"Chevalier","year":"2021","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034672","article-title":"GPR30, the non-classical membrane G protein related estrogen receptor, is overexpressed in human seminoma and promotes seminoma cell proliferation","volume":"7","author":"Chevalier","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.pharmthera.2025.108801_bb0155","article-title":"GPER mediates cardiotropic effects in spontaneously hypertensive rat hearts","volume":"8","author":"Cignarella","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.pharmthera.2025.108801_bb0160","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.3390\/ijms22084254","article-title":"Estrogen receptor functions and pathways at the vascular immune interface","volume":"22","author":"Dama","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0165","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2174\/157340641202160209094548","article-title":"Calcium homeostasis and kinetics in heart failure","volume":"12","author":"Davlouros","year":"2016","journal-title":"Medicinal Chemistry"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108801_bb0170","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1002\/jcp.25585","article-title":"Protective role of GPER agonist G-1 on cardiotoxicity induced by doxorubicin","volume":"232","author":"De Francesco","year":"2017","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116337","article-title":"The Janus face of mitophagy in myocardial ischemia\/reperfusion injury and recovery","volume":"173","author":"Deng","year":"2024","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110714","article-title":"The role of PI3K\/AKT signaling pathway in myocardial ischemia-reperfusion injury","volume":"123","author":"Deng","year":"2023","journal-title":"International Immunopharmacology"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0185","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41598-020-57819-9","article-title":"Estradiol\/GPER affects the integrity of mammary duct-like structures in vitro","volume":"10","author":"Deng","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0190","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fbioe.2019.00489","article-title":"Application of the nano-drug delivery system in treatment of cardiovascular diseases","volume":"7","author":"Deng","year":"2019","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108801_bb0195","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nchembio.168","article-title":"In vivo effects of a GPR30 antagonist","volume":"5","author":"Dennis","year":"2009","journal-title":"Nature Chemical Biology"},{"issue":"3\u20135","key":"10.1016\/j.pharmthera.2025.108801_bb0200","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jsbmb.2011.07.002","article-title":"Identification of a GPER\/GPR30 antagonist with improved estrogen receptor counterselectivity","volume":"127","author":"Dennis","year":"2011","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108801_bb0205","doi-asserted-by":"crossref","first-page":"H1806","DOI":"10.1152\/ajpheart.00283.2009","article-title":"Activation of a novel estrogen receptor, GPER, is cardioprotective in male and female rats","volume":"297","author":"Deschamps","year":"2009","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117211","article-title":"The activation of the G protein-coupled estrogen receptor (GPER) prevents and regresses cardiac hypertrophy","volume":"242","author":"Di Mattia","year":"2020","journal-title":"Life Sciences"},{"issue":"19","key":"10.1016\/j.pharmthera.2025.108801_bb0215","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1111\/bph.15521","article-title":"G protein-coupled estrogen receptor 1: A novel target to treat cardiovascular disease in a sex-specific manner?","volume":"178","author":"Dinh","year":"2021","journal-title":"British Journal of Pharmacology"},{"issue":"19","key":"10.1016\/j.pharmthera.2025.108801_bb0220","doi-asserted-by":"crossref","first-page":"e558","DOI":"10.1161\/CIR.0000000000000570","article-title":"Projected costs of informal caregiving for cardiovascular disease: 2015 to 2035: A policy statement from the american heart association","volume":"137","author":"Dunbar","year":"2018","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0225","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvy010","article-title":"Role of smooth muscle cells in vascular calcification: Implications in atherosclerosis and arterial stiffness","volume":"114","author":"Durham","year":"2018","journal-title":"Cardiovascular Research"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0230","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/ndt\/gfad194","article-title":"Heart disease and stroke statistics 2023 update from the American Heart Association-implications for nephrology","volume":"39","author":"Edwards","year":"2023","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0235","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ceb.2015.01.002","article-title":"PINK1\/Parkin-mediated mitophagy in mammalian cells","volume":"33","author":"Eiyama","year":"2015","journal-title":"Current Opinion in Cell Biology"},{"issue":"25","key":"10.1016\/j.pharmthera.2025.108801_bb0240","doi-asserted-by":"crossref","first-page":"e506","DOI":"10.1161\/CIR.0000000000000912","article-title":"Menopause transition and cardiovascular disease risk: Implications for timing of early prevention: A scientific statement from the american heart association","volume":"142","author":"El Khoudary","year":"2020","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0245","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.409","article-title":"The G protein-coupled estrogen receptor agonist, G-1, attenuates BK channel activation in cerebral arterial smooth muscle cells","volume":"6","author":"Evanson","year":"2018","journal-title":"Pharmacology Research & Perspectives"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114106","article-title":"Anti-inflammatory activity of the Tongmai Yangxin pill in the treatment of coronary heart disease is associated with estrogen receptor and NF-\u03baB signaling pathway","volume":"276","author":"Fan","year":"2021","journal-title":"Journal of Ethnopharmacology"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108801_bb0255","first-page":"2298","article-title":"Genistein improves viability, proliferation and mitochondrial function of cardiomyoblasts cultured in physiologic and peroxidative conditions","volume":"44","author":"Farruggio","year":"2019","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0260","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-pharmtox-010716-104651","article-title":"GPER (GPR30): A nongenomic receptor (GPCR) for steroid hormones with implications for cardiovascular disease and cancer","volume":"57","author":"Feldman","year":"2017","journal-title":"Annual Review of Pharmacology and Toxicology"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0265","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1006\/bbrc.1997.6161","article-title":"Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors","volume":"231","author":"Feng","year":"1997","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"23","key":"10.1016\/j.pharmthera.2025.108801_bb0270","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1111\/bph.14033","article-title":"Activation of G protein-coupled oestrogen receptor 1 at the onset of reperfusion protects the myocardium against ischemia\/reperfusion injury by reducing mitochondrial dysfunction and mitophagy","volume":"174","author":"Feng","year":"2017","journal-title":"British Journal of Pharmacology"},{"issue":"10","key":"10.1016\/j.pharmthera.2025.108801_bb0275","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1210\/mend.14.10.0532","article-title":"Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF","volume":"14","author":"Filardo","year":"2000","journal-title":"Molecular Endocrinology"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108801_bb0280","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1210\/en.2012-1061","article-title":"Minireview: G protein-coupled estrogen receptor-1, GPER-1: Its mechanism of action and role in female reproductive cancer, renal and vascular physiology","volume":"153","author":"Filardo","year":"2012","journal-title":"Endocrinology"},{"issue":"Supplement_2","key":"10.1016\/j.pharmthera.2025.108801_bb0285","doi-asserted-by":"crossref","DOI":"10.1093\/ehjci\/ehaa946.3599","article-title":"The effect of oestrogen withdrawal on cardiac Ca2+ regulation and the influence of GPER1","volume":"41","author":"Francis","year":"2020","journal-title":"European Heart Journal"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0290","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jsbmb.2017.05.006","article-title":"Role of GPER in estrogen-dependent nitric oxide formation and vasodilation","volume":"176","author":"Fredette","year":"2018","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0295","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.yjmcc.2004.11.013","article-title":"Estrogen receptor beta mediates gender differences in ischemia\/reperfusion injury","volume":"38","author":"Gabel","year":"2005","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"18","key":"10.1016\/j.pharmthera.2025.108801_bb0300","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.3390\/cells12182226","article-title":"GPER1 activation exerts anti-tumor activity in multiple myeloma","volume":"12","author":"Gallo Cantafio","year":"2023","journal-title":"Cells"},{"issue":"Pt 3","key":"10.1016\/j.pharmthera.2025.108801_bb0305","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.mce.2015.07.016","article-title":"The G-protein coupled estrogen receptor, GPER: The inside and inside-out story","volume":"418","author":"Gaudet","year":"2015","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"10","key":"10.1016\/j.pharmthera.2025.108801_bb0310","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1161\/ATVBAHA.118.310792","article-title":"Estrogen inhibits LDL (low-density lipoprotein) transcytosis by human coronary artery endothelial cells via GPER (G-protein-coupled estrogen receptor) and SR-BI (scavenger receptor class B type 1)","volume":"38","author":"Ghaffari","year":"2018","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108801_bb0315","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00395-020-00829-5","article-title":"Mouse models of atherosclerosis and their suitability for the study of myocardial infarction","volume":"115","author":"Golforoush","year":"2020","journal-title":"Basic Research in Cardiology"},{"issue":"8","key":"10.1016\/j.pharmthera.2025.108801_bb0320","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.tcm.2021.08.015","article-title":"Implications for the role of lipopolysaccharide in the development of atherosclerosis","volume":"32","author":"Gorabi","year":"2022","journal-title":"Trends in Cardiovascular Medicine"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0325","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3389\/fendo.2020.00517","article-title":"Computational approaches for the discovery of GPER targeting compounds","volume":"11","author":"Grande","year":"2020","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0330","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3389\/fendo.2019.00919","article-title":"Female heart health: Is GPER the missing link?","volume":"10","author":"Groban","year":"2020","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0335","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s11357-021-00331-3","article-title":"Alterations in the estrogen receptor profile of cardiovascular tissues during aging","volume":"43","author":"Gurrala","year":"2021","journal-title":"GeroScience"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0340","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/CIRCRESAHA.108.190892","article-title":"Regulatory role of G protein\u2013coupled estrogen receptor for vascular function and obesity","volume":"104","author":"Haas","year":"2009","journal-title":"Circulation Research"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0345","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.ctdb.2016.12.005","article-title":"Estrogen hormone biology","volume":"125","author":"Hamilton","year":"2017","journal-title":"Current Topics in Developmental Biology"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0350","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1677\/JOE-09-0066","article-title":"Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues","volume":"202","author":"Hazell","year":"2009","journal-title":"The Journal of Endocrinology"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0355","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3831\/KPI.2023.26.4.298","article-title":"Cucumber (Cucumis sativus L.) fruit and combination with losartan attenuate the elevation of blood pressure in hypertensive rats induced by angiotensin II","volume":"26","author":"Hendrayana","year":"2023","journal-title":"Journal of Pharmacopuncture"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0360","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13293-017-0152-8","article-title":"The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy","volume":"8","author":"Iorga","year":"2017","journal-title":"Biology of Sex Differences"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0365","first-page":"1","article-title":"A conversation with Elwood Jensen. Interview by David D. Moore","volume":"74","author":"Jensen","year":"2012","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0370","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jep.2017.06.052","article-title":"Liuwei Dihuang soft capsules attenuates endothelial cell apoptosis to prevent atherosclerosis through GPR30-mediated regulation in ovariectomized ApoE-deficient mice","volume":"208","author":"Jing","year":"2017","journal-title":"Journal of Ethnopharmacology"},{"issue":"9","key":"10.1016\/j.pharmthera.2025.108801_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135988","article-title":"G protein-coupled estrogen receptor 1 mediates acute estrogen-induced cardioprotection via MEK\/ERK\/GSK-3beta pathway after ischemia\/reperfusion","volume":"10","author":"Kabir","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0380","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41392-022-00955-7","article-title":"Inflammation and atherosclerosis: Signaling pathways and therapeutic intervention","volume":"7","author":"Kong","year":"2022","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0385","doi-asserted-by":"crossref","DOI":"10.3389\/fgwh.2022.979708","article-title":"The influence of inflammation on cardiovascular disease in women","volume":"3","author":"Kottilil","year":"2022","journal-title":"Frontiers in Global Women's Health"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108801_bb0390","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1073\/pnas.93.12.5925","article-title":"Cloning of a novel receptor expressed in rat prostate and ovary","volume":"93","author":"Kuiper","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0395","first-page":"66","article-title":"GPER function in breast cancer: An overview","volume":"5","author":"Lappano","year":"2014","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108801_bb0400","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jgr.2022.02.001","article-title":"The potential inhibitory effect of ginsenoside Rh2 on mitophagy in UV-irradiated human dermal fibroblasts","volume":"46","author":"Lee","year":"2022","journal-title":"Journal of Ginseng Research"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108801_bb0405","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1111\/jcmm.12430","article-title":"Both GPER and membrane oestrogen receptor-\u03b1 activation protect ventricular remodelling in 17\u03b2 oestradiol-treated ovariectomized infarcted rats","volume":"18","author":"Lee","year":"2014","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0410","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.steroids.2013.10.017","article-title":"Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling","volume":"81","author":"Lindsey","year":"2014","journal-title":"Steroids"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108801_bb0415","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41422-024-00963-y","article-title":"Structural and functional evidence that GPR30 is not a direct estrogen receptor","volume":"34","author":"Liu","year":"2024","journal-title":"Cell Research"},{"issue":"31","key":"10.1016\/j.pharmthera.2025.108801_bb0420","doi-asserted-by":"crossref","first-page":"12920","DOI":"10.1073\/pnas.1107332108","article-title":"Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission","volume":"108","author":"Liu","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109125","article-title":"YAP-mediated GPER signaling impedes proliferation and survival of prostate epithelium in benign prostatic hyperplasia","volume":"27","author":"Liu","year":"2024","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0430","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1095\/biolreprod.110.084160","article-title":"Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells","volume":"83","author":"Lucas","year":"2010","journal-title":"Biology of Reproduction"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0435","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1530\/ERC-13-0237","article-title":"GPER-mediated proliferation and estradiol production in breast cancer-associated fibroblasts","volume":"21","author":"Luo","year":"2014","journal-title":"Endocrine-Related Cancer"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0440","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.610516","article-title":"Sex hrmone regulation of proteins modulating mitochondrial metabolism, dynamics and inter-organellar cross talk in cardiovascular disease","volume":"8","author":"Lynch","year":"2021","journal-title":"Frontiers in Cell and Development Biology"},{"issue":"14","key":"10.1016\/j.pharmthera.2025.108801_bb0445","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1158\/0008-5472.CAN-10-0408","article-title":"Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts","volume":"70","author":"Madeo","year":"2010","journal-title":"Cancer Research"},{"issue":"4\u20135","key":"10.1016\/j.pharmthera.2025.108801_bb0450","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11064-006-9167-y","article-title":"NO-cGMP signaling and regenerative medicine involving stem cells","volume":"32","author":"Madhusoodanan","year":"2007","journal-title":"Neurochemical Research"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0455","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4172\/2157-7013.1000153","article-title":"Cardiomyocyte-specific estrogen receptor alpha increases angiogenesis, lymphangiogenesis and reduces fibrosis in the female mouse heart post-myocardial infarction","volume":"5","author":"Mahmoodzadeh","year":"2014","journal-title":"Journal of Cell Science Therapy"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108801_bb0460","doi-asserted-by":"crossref","first-page":"H762","DOI":"10.1152\/ajpheart.00024.2022","article-title":"GPER-dependent estrogen signaling increases cardiac GCN5L1 expression","volume":"322","author":"Manning","year":"2022","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"issue":"11","key":"10.1016\/j.pharmthera.2025.108801_bb0465","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1158\/1541-7786.MCR-14-0128-T","article-title":"G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis","volume":"12","author":"Marjon","year":"2014","journal-title":"Molecular Cancer Research"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2022.106176","article-title":"Differential effects of estrogen receptors in the rostral ventrolateral medulla in Goldblatt hypertension","volume":"224","author":"Maruyama","year":"2022","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108801_bb0475","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1124\/mi.3.5.281","article-title":"Estrogen signaling: A subtle balance between ER alpha and ER beta","volume":"3","author":"Matthews","year":"2003","journal-title":"Molecular Interventions"},{"issue":"25","key":"10.1016\/j.pharmthera.2025.108801_bb0480","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.jacc.2023.11.003","article-title":"A heart-healthy and stroke-free world: Using data to inform global action","volume":"82","author":"Mensah","year":"2023","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0485","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000315497","article-title":"Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780","volume":"86","author":"Meyer","year":"2010","journal-title":"Pharmacology"},{"issue":"13\u201314","key":"10.1016\/j.pharmthera.2025.108801_bb0490","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.lfs.2012.01.007","article-title":"GPER regulates endothelin-dependent vascular tone and intracellular calcium","volume":"91","author":"Meyer","year":"2012","journal-title":"Life Sciences"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0495","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1530\/JOE-15-0257","article-title":"G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity","volume":"227","author":"Meyer","year":"2015","journal-title":"The Journal of Endocrinology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0500","doi-asserted-by":"crossref","first-page":"7564","DOI":"10.1038\/srep07564","article-title":"G protein-coupled estrogen receptor protects from atherosclerosis","volume":"4","author":"Meyer","year":"2014","journal-title":"Scientific Reports"},{"issue":"1\u20133","key":"10.1016\/j.pharmthera.2025.108801_bb0505","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.vph.2011.06.003","article-title":"The G protein-coupled estrogen receptor GPER\/GPR30 as a regulator of cardiovascular function","volume":"55","author":"Meyer","year":"2011","journal-title":"Vascular Pharmacology"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108801_bb0510","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/ar.24612","article-title":"Estrogen receptors and their roles in the immune and respiratory systems","volume":"304","author":"Millas","year":"2021","journal-title":"The Anatomical Record (Hoboken)"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0515","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0014-5793(96)00782-X","article-title":"ER beta: Identification and characterization of a novel human estrogen receptor","volume":"392","author":"Mosselman","year":"1996","journal-title":"FEBS Letters"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108801_bb0520","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/CIRCRESAHA.110.236687","article-title":"Estrogen signaling and cardiovascular disease","volume":"109","author":"Murphy","year":"2011","journal-title":"Circulation Research"},{"issue":"5573","key":"10.1016\/j.pharmthera.2025.108801_bb0525","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1126\/science.1071550","article-title":"G protein pathways","volume":"296","author":"Neves","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0530","article-title":"G protein-coupled estrogen receptor in immune cells and its role in immune-related diseases","volume":"11","author":"Notas","year":"2020","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0535","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/geno.1998.5095","article-title":"Discovery of three novel G-protein-coupled receptor genes","volume":"47","author":"O\u2019Dowd","year":"1998","journal-title":"Genomics"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0540","doi-asserted-by":"crossref","first-page":"H336","DOI":"10.1152\/ajpheart.00238.2022","article-title":"Sex differences in vascular aging and impact of GPER deletion","volume":"323","author":"Ogola","year":"2022","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0545","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jacc.2022.04.046","article-title":"Trends and disparities in Cardiometabolic health among U.S. adults, 1999-2018","volume":"80","author":"O\u2019Hearn","year":"2022","journal-title":"Journal of the American College of Cardiology"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108801_bb0550","doi-asserted-by":"crossref","first-page":"H1499","DOI":"10.1152\/ajpheart.00194.2018","article-title":"Sex differences in the vascular function and related mechanisms: Role of 17\u03b2-estradiol","volume":"315","author":"Pabbidi","year":"2018","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0555","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1039\/C9NH00291J","article-title":"Biomimetic nanoparticle technology for cardiovascular disease detection and treatment","volume":"5","author":"Park","year":"2020","journal-title":"Nanoscale Horizons"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0560","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.biopha.2018.03.078","article-title":"Estrogen: The necessary evil for human health, and ways to tame it","volume":"102","author":"Patel","year":"2018","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0565","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.steroids.2014.06.012","article-title":"Estrogen receptors alpha (ER\u03b1) and beta (ER\u03b2): Subtype-selective ligands and clinical potential","volume":"90","author":"Paterni","year":"2014","journal-title":"Steroids"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0570","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7150\/ijbs.28304","article-title":"G protein-coupled estrogen receptor 1 inhibits angiotensin II-induced cardiomyocyte hypertrophy via the regulation of PI3K-Akt-mTOR signalling and autophagy","volume":"15","author":"Pei","year":"2019","journal-title":"International Journal of Biological Sciences"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0575","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0475-21.2022","article-title":"Differential effects of the G-protein-coupled estrogen receptor (GPER) on rat embryonic (E18) hippocampal and cortical neurons","volume":"9","author":"Pemberton","year":"2022","journal-title":"eNeuro"},{"issue":"13","key":"10.1016\/j.pharmthera.2025.108801_bb0580","first-page":"2544","article-title":"Humoral immunity in atherosclerosis and myocardial infarction: From B cells to antibodies","volume":"117","author":"Porsch","year":"2021","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0585","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jsbmb.2017.03.005","article-title":"GPER modulators: Opportunity Nox on the heels of a class Akt","volume":"176","author":"Prossnitz","year":"2018","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108801_bb0590","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrendo.2011.122","article-title":"The G-protein-coupled estrogen receptor GPER in health and disease","volume":"7","author":"Prossnitz","year":"2011","journal-title":"Nature Reviews. Endocrinology"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2025.108801_bb0595","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mce.2014.02.002","article-title":"Estrogen biology: New insights into GPER function and clinical opportunities","volume":"389","author":"Prossnitz","year":"2014","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108801_bb0600","first-page":"407","article-title":"The G protein-coupled oestrogen receptor GPER in health and disease: An update","volume":"19","author":"Prossnitz","year":"2023","journal-title":"Eric R Prossnitz"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2025.108801_bb0605","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2009.03.026","article-title":"Mechanisms of estrogen signaling and gene expression via GPR30","volume":"308","author":"Prossnitz","year":"2009","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0610","doi-asserted-by":"crossref","unstructured":"Rae, J., & Johnson, M. (2005). What does an orphan G-protein-coupled receptor have to do with estrogen? Breast Cancer Research, 7(6), 243\u2013244. doi:https:\/\/doi.org\/10.1186\/bcr1330) https:\/\/doi.org\/10.1186\/bcr1330.","DOI":"10.1186\/bcr1330"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108801_bb0615","doi-asserted-by":"crossref","first-page":"432","DOI":"10.7861\/clinmed.2023-2023-23.5.Cardio1","article-title":"Updates in heart failure","volume":"23","author":"Rees","year":"2023","journal-title":"Clinical Medicine (London, England)"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0620","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41569-022-00797-4","article-title":"Gender medicine: Effects of sex and gender on cardiovascular disease manifestation and outcomes","volume":"20","author":"Regitz-Zagrosek","year":"2023","journal-title":"Nature Reviews. Cardiology"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2025.108801_bb0625","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mce.2010.07.017","article-title":"GPR30\/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages","volume":"328","author":"Rettew","year":"2010","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"5715","key":"10.1016\/j.pharmthera.2025.108801_bb0630","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.1106943","article-title":"A transmembrane intracellular estrogen receptor mediates rapid cell signaling","volume":"307","author":"Revankar","year":"2005","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0635","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00059-019-4785-8","article-title":"Key inflammatory mechanisms underlying heart failure","volume":"44","author":"Riehle","year":"2019","journal-title":"Herz"},{"issue":"10","key":"10.1016\/j.pharmthera.2025.108801_bb0640","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007069","article-title":"G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish","volume":"13","author":"Romano","year":"2017","journal-title":"PLoS Genetics"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0645","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015","volume":"70","author":"Roth","year":"2017","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0650","article-title":"Therapeutic perspectives on the modulation of G-protein coupled estrogen receptor, GPER, function","volume":"11","author":"Rouhimoghadam","year":"2020","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0655","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jjcc.2021.11.018","article-title":"Interventional heart failure therapy: A new concept fighting against heart failure","volume":"80","author":"Saku","year":"2022","journal-title":"Journal of Cardiology"},{"issue":"11","key":"10.1016\/j.pharmthera.2025.108801_bb0660","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1210\/en.2013-1357","article-title":"GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state","volume":"154","author":"Sharma","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0665","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/978-1-4939-3127-9_38","article-title":"GPER\/GPR30 knockout mice: Effects of GPER on metabolism","volume":"1366","author":"Sharma","year":"2016","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0670","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/978-1-0716-1920-9_21","article-title":"Assessment of metabolic regulation by estrogen receptors","volume":"2418","author":"Sharma","year":"2022","journal-title":"Methods in Molecular Biology"},{"issue":"6803","key":"10.1016\/j.pharmthera.2025.108801_bb0675","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35035131","article-title":"Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase","volume":"407","author":"Simoncini","year":"2000","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0680","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0006-291X(69)90540-3","article-title":"Purification of estradiol receptor from rat uterus and blockade of its estrogen-binding function by specific antibody","volume":"34","author":"Soloff","year":"1969","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0685","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1037\/a0016393","article-title":"Reduced specificity of autobiographical memory in cluster c personality disorders and the role of depression, worry, and experiential avoidance","volume":"118","author":"Spinhoven","year":"2009","journal-title":"Journal of Abnormal Psychology"},{"issue":"11","key":"10.1016\/j.pharmthera.2025.108801_bb0690","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/jne.12071","article-title":"G-protein oestrogen receptor 1: Trials and tribulations of a membrane oestrogen receptor","volume":"25","author":"Srivastava","year":"2013","journal-title":"Journal of Neuroendocrinology"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0695","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1161\/01.HYP.0000260141.30703.0c","article-title":"Aldosterone excess, hypertension, and chromosome 7p22: Evidence continues to mount","volume":"49","author":"Stowasser","year":"2007","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0700","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0735-1097(95)00248-3","article-title":"Mechanisms of estrogen-induced vasodilation: In vivo studies in canine coronary conductance and resistance arteries","volume":"26","author":"Sudhir","year":"1995","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0705","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2019.33.1_supplement.532.5","article-title":"Equivalence of G1\/GPER monotherapy compared with dual administration of G1 and lisinopril in preventing diastolic dysfunction due to estrogen loss in SHR","volume":"33","author":"Sun","year":"2019","journal-title":"The FASEB Journal"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108801_bb0710","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1002\/ehf2.13013","article-title":"Reverse electromechanical modelling of diastolic dysfunction in spontaneous hypertensive rat after sacubitril\/valsartan therapy","volume":"7","author":"Sung","year":"2020","journal-title":"ESC Heart Failure"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0715","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bbrc.2014.07.073","article-title":"GPER mediated estradiol reduces miR-148a to promote HLA-G expression in breast cancer","volume":"451","author":"Tao","year":"2014","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0720","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4939-2914-6_2","article-title":"Purification and crystallization of a thermostabilized agonist-bound conformation of the human adenosine A(2A) receptor","volume":"1335","author":"Tate","year":"2015","journal-title":"Methods in Molecular Biology"},{"issue":"8\u20139","key":"10.1016\/j.pharmthera.2025.108801_bb0725","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.steroids.2009.11.005","article-title":"Conserved estrogen binding and signaling functions of the G protein-coupled estrogen receptor 1 (GPER) in mammals and fish","volume":"75","author":"Thomas","year":"2010","journal-title":"Steroids"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108801_bb0730","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/en.2004-1064","article-title":"Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells","volume":"146","author":"Thomas","year":"2005","journal-title":"Endocrinology"},{"issue":"18","key":"10.1016\/j.pharmthera.2025.108801_bb0735","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"72","author":"Thygesen","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0740","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.yjmcc.2006.10.007","article-title":"Pharmacological postconditioning with the phytoestrogen genistein","volume":"42","author":"Tissier","year":"2007","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0745","article-title":"Reciprocality between estrogen biology and calcium signaling in the cardiovascular system","volume":"11","author":"Tran","year":"2020","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0750","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1053\/j.jvca.2021.05.008","article-title":"Perioperative implications of the 2020 american heart association scientific statement on drug-induced arrhythmias-A focused review","volume":"36","author":"Vanneman","year":"2022","journal-title":"Journal of Cardiothoracic and Vascular Anesthesia"},{"issue":"23","key":"10.1016\/j.pharmthera.2025.108801_bb0755","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.1073\/pnas.82.23.7889","article-title":"Cloning of the human estrogen receptor cDNA","volume":"82","author":"Walter","year":"1985","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"10.1016\/j.pharmthera.2025.108801_bb0760","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1210\/en.2008-0441","article-title":"G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary","volume":"149","author":"Wang","year":"2008","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0765","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.bbrc.2019.05.045","article-title":"NLRP3 inhibition improves heart function in GPER knockout mice","volume":"514","author":"Wang","year":"2019","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0770","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.trsl.2018.04.005","article-title":"G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress","volume":"199","author":"Wang","year":"2018","journal-title":"Translational Research"},{"issue":"1\u20132","key":"10.1016\/j.pharmthera.2025.108801_bb0775","first-page":"135","article-title":"Activation of GPR30 inhibits cardiac fibroblast proliferation","volume":"405","author":"Wang","year":"2015","journal-title":"Molecular and Cellular Biochemistry"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0780","article-title":"G protein-coupled estrogen receptor 30 reduces transverse aortic constriction-induced myocardial fibrosis in aged female mice by inhibiting the ERK1\/2 -MMP-9 signaling pathway","volume":"12","author":"Wang","year":"2021","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0785","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113727","article-title":"Regulation of beta adrenoceptor-mediated myocardial contraction and calcium dynamics by the G protein-coupled estrogen receptor 1","volume":"171","author":"Whitcomb","year":"2020","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.pharmthera.2025.108801_bib861","article-title":"Association between Estradiol\/Estrogen Receptors and Cognition: A Knowledge Domain Visualization Analysis of Trends","volume":"29","author":"Wu","year":"2023","journal-title":"Medical science monitor\u202f: international medical journal of experimental and clinical research"},{"issue":"29","key":"10.1016\/j.pharmthera.2025.108801_bb0790","doi-asserted-by":"crossref","first-page":"27071","DOI":"10.1074\/jbc.M100312200","article-title":"Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i)","volume":"276","author":"Wyckoff","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0795","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5523516","article-title":"Protective effects of estrogen on cardiovascular disease mediated by oxidative stress","volume":"2021","author":"Xiang","year":"2021","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"9","key":"10.1016\/j.pharmthera.2025.108801_bb0800","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.3390\/biom13091410","article-title":"The role of G protein-coupled estrogen receptor (GPER) in vascular pathology and physiology","volume":"13","author":"Xu","year":"2023","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0805","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.neuroscience.2008.11.028","article-title":"Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus","volume":"158","author":"Xu","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0810","doi-asserted-by":"crossref","first-page":"7407","DOI":"10.12659\/MSM.912986","volume":"25","author":"Yang","year":"2019","journal-title":"Medical Science Monitor"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108801_bb0815","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.3390\/ijms24065205","article-title":"Nanoparticles in the new era of cardiovascular therapeutics: Challenges and opportunities","volume":"24","author":"Yang","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0820","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.2147\/DDDT.S409232","article-title":"Galangin attenuates myocardial ischemic reperfusion-induced ferroptosis by targeting Nrf2\/Gpx4 signaling pathway","volume":"17","author":"Yang","year":"2023","journal-title":"Drug Design, Development and Therapy"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108801_bb0825","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.3390\/ijms24031853","article-title":"Roles of estrogen, estrogen receptors, and estrogen-related receptors in skeletal muscle: Regulation of mitochondrial function","volume":"24","author":"Yoh","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108801_bb0830","doi-asserted-by":"crossref","first-page":"E398","DOI":"10.1152\/ajpendo.00534.2013","article-title":"G protein-coupled estrogen receptor 1 mediates relaxation of coronary arteries via cAMP\/PKA-dependent activation of MLCP","volume":"307","author":"Yu","year":"2014","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108801_bb0835","doi-asserted-by":"crossref","first-page":"E882","DOI":"10.1152\/ajpendo.00037.2011","article-title":"Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle","volume":"301","author":"Yu","year":"2011","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108801_bb0840","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191418","article-title":"The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries","volume":"13","author":"Yu","year":"2018","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108801_bb0845","doi-asserted-by":"crossref","first-page":"H1640","DOI":"10.1152\/ajpheart.2000.278.5.H1640","article-title":"Myocardial ischemia-reperfusion injury in estrogen receptor-alpha knockout and wild-type mice","volume":"278","author":"Zhai","year":"2000","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"issue":"11","key":"10.1016\/j.pharmthera.2025.108801_bb0850","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/ejhf.942","article-title":"Immune mechanisms in heart failure","volume":"19","author":"Zhang","year":"2017","journal-title":"European Journal of Heart Failure"},{"key":"10.1016\/j.pharmthera.2025.108801_bb0855","article-title":"Ferroptosis: Opportunities and challenges in myocardial ischemia-reperfusion injury","volume":"2021","author":"Zhao","year":"2021","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108801_bb0860","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1042\/CS20160114","article-title":"GPER\u2013novel membrane oestrogen receptor","volume":"130","author":"Zimmerman","year":"2016","journal-title":"Clinical Science (London, England)"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725825000130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725825000130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:08:17Z","timestamp":1777493297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725825000130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":174,"alternative-id":["S0163725825000130"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2025.108801","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From physiology to pathology: Emerging roles of GPER in cardiovascular disease","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2025.108801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108801"}}