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adenocarcinoma therapeutic targets revealed by tumor-stroma cross-talk analyses in patient-derived xenografts","volume":"21","author":"Nicolle","year":"2017","journal-title":"Cell Reports"},{"key":"10.1016\/j.pharmthera.2025.108946_bb0625","doi-asserted-by":"crossref","unstructured":"Panigrahi, G., Candia, J., Dorsey, T. H., Tang, W., Ohara, Y., Byun, J. S., Minas, T. Z., Zhang, A., Ajao, A., Cellini, A., Yfantis, H. G., Flis, A. L., Mann, D., Ioffe, O., Wang, X. W., Liu, H., Loffredo, C. A., Napoles, A. M., & Ambs, S. (n.d.). Diabetes-associated breast cancer is molecularly distinct and shows a DNA damage repair deficiency. 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