{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T02:35:29Z","timestamp":1794278129363,"version":"4.9.0"},"reference-count":152,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024A03J1058"],"award-info":[{"award-number":["2024A03J1058"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301476"],"award-info":[{"award-number":["82301476"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021A1515011064"],"award-info":[{"award-number":["2021A1515011064"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.pharmthera.2025.108972","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T07:58:31Z","timestamp":1766563111000},"page":"108972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["N6-methyladenosine (m6A) RNA methylation: a potential clinical therapeutic target in cardiocerebrovascular diseases"],"prefix":"10.1016","volume":"278","author":[{"given":"Hao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoou","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0005","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41588-019-0549-x","article-title":"N(6)-methyladenosine regulates the stability of RNA:DNA hybrids in human cells","volume":"52","author":"Abakir","year":"2020","journal-title":"Nature Genetics"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12943-022-01500-4","article-title":"The role of m6A RNA methylation in cancer metabolism","volume":"21","author":"An","year":"2022","journal-title":"Molecular Cancer"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-020-0151-7","article-title":"Acute heart failure","volume":"6","author":"Arrigo","year":"2020","journal-title":"Nature Reviews. Disease Primers"},{"issue":"43","key":"10.1016\/j.pharmthera.2025.108972_bb0020","doi-asserted-by":"crossref","first-page":"33037","DOI":"10.1074\/jbc.M110.155283","article-title":"Characterization of hMTr1, a human Cap1 2\u2019-O-ribose methyltransferase","volume":"285","author":"B\u00e9langer","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104642","article-title":"Epigenetic mechanisms of neurodegenerative diseases and acute brain injury","volume":"133","author":"Bertogliat","year":"2020","journal-title":"Neurochemistry International"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0030","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ejhf.1672","article-title":"Changes in m6A RNA methylation contribute to heart failure progression by modulating translation","volume":"22","author":"Berulava","year":"2020","journal-title":"European Journal of Heart Failure"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0035","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/jnr.21473","article-title":"RNA-protein interactions and control of mRNA stability in neurons","volume":"86","author":"Bolognani","year":"2008","journal-title":"Journal of Neuroscience Research"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0040","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1038\/s41467-019-11232-7","article-title":"m(6)A modification of a 3\u2019 UTR site reduces RME1 mRNA levels to promote meiosis","volume":"10","author":"Bushkin","year":"2019","journal-title":"Nature Communications"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0045","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/14737159.2022.2049246","article-title":"Role of N6-methyladenosine modification in pathogenesis of ischemic stroke","volume":"22","author":"Chang","year":"2022","journal-title":"Expert Review of Molecular Diagnostics"},{"issue":"11","key":"10.1016\/j.pharmthera.2025.108972_bb0050","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrm2777","article-title":"Mechanisms of alternative splicing regulation: Insights from molecular and genomics approaches","volume":"10","author":"Chen","year":"2009","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0055","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.stem.2015.01.016","article-title":"m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency","volume":"16","author":"Chen","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147216","article-title":"Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53\/SLC7A11-mediated ferroptosis","volume":"1752","author":"Chen","year":"2021","journal-title":"Brain Research"},{"issue":"10","key":"10.1016\/j.pharmthera.2025.108972_bb0065","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1161\/STROKEAHA.119.026433","article-title":"Transient focal ischemia significantly alters the m(6)a Epitranscriptomic tagging of RNAs in the brain","volume":"50","author":"Chokkalla","year":"2019","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108972_bb0070","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1113\/EP089901","article-title":"Protective mechanism of demethylase fat mass and obesity-associated protein in energy metabolism disorder of hypoxia\u2013reoxygenation-induced cardiomyocytes","volume":"106","author":"Deng","year":"2021","journal-title":"Experimental Physiology"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.brainresbull.2020.03.011","article-title":"Hypothermia protects neurons against ischemia\/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K\/Akt\/GSK-3\u03b2 signaling pathway","volume":"159","author":"Diao","year":"2020","journal-title":"Brain Research Bulletin"},{"issue":"7397","key":"10.1016\/j.pharmthera.2025.108972_bb0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0085","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCULATIONAHA.118.036146","article-title":"The N6-methyladenosine mRNA methylase METTL3 controls cardiac homeostasis and hypertrophy","volume":"139","author":"Dorn","year":"2019","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0090","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/CIRCULATIONAHA.118.036146","article-title":"The N(6)-methyladenosine mRNA Methylase METTL3 controls cardiac homeostasis and hypertrophy","volume":"139","author":"Dorn","year":"2019","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108972_bb0095","doi-asserted-by":"crossref","DOI":"10.1289\/EHP3047","article-title":"Long-term exposure to ultrafine particles and incidence of cardiovascular and cerebrovascular disease in a prospective study of a Dutch cohort","volume":"126","author":"Downward","year":"2018","journal-title":"Environmental Health Perspectives"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4\u2013NOT deadenylase complex","volume":"7","author":"Du","year":"2016","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex","volume":"7","author":"Du","year":"2016","journal-title":"Nature Communications"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0110","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41419-021-03622-x","article-title":"N6-methyladenosine demethylase FTO impairs hepatic ischemia\u2013reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation","volume":"12","author":"Du","year":"2021","journal-title":"Cell Death & Disease"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0115","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.celrep.2019.06.072","article-title":"FMRP modulates neural differentiation through m(6)A-dependent mRNA nuclear export","volume":"28","author":"Edens","year":"2019","journal-title":"Cell Reports"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0120","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.celrep.2019.06.072","article-title":"FMRP modulates neural differentiation through m6A-dependent mRNA nuclear export","volume":"28","author":"Edens","year":"2019","journal-title":"Cell Reports"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0125","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.117.005795","article-title":"Impact of clopidogrel therapy on mortality and cancer in patients with cardiovascular and cerebrovascular disease: A patient-level meta-analysis","volume":"11","author":"Elmariah","year":"2018","journal-title":"Circulation. Cardiovascular Interventions"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0130","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1261\/rna.079554.122","article-title":"m6A-ELISA, a simple method for quantifying N6-methyladenosine from mRNA populations","volume":"29","author":"Ensinck","year":"2023","journal-title":"Rna"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108972_bb0135","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1161\/STROKEAHA.121.034173","article-title":"FTO (fat-mass and obesity-associated protein) participates in hemorrhage-induced thalamic pain by stabilizing toll-like receptor 4 expression in thalamic neurons","volume":"52","author":"Fu","year":"2021","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0140","first-page":"775","article-title":"Progress in epigenetic modification of mRNA and the function of m6A modification","volume":"35","author":"Gan","year":"2019","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"issue":"18","key":"10.1016\/j.pharmthera.2025.108972_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189949","article-title":"How are epigenetic modifications related to cardiovascular disease in older adults?","volume":"22","author":"Gharipour","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"Suppl. 8","key":"10.1016\/j.pharmthera.2025.108972_bb0150","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1186\/s12864-017-4193-5","article-title":"Physical activity in the prevention of human diseases: Role of epigenetic modifications","volume":"18","author":"Grazioli","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109553","article-title":"N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation","volume":"69","author":"Gu","year":"2020","journal-title":"Cellular Signalling"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106800","article-title":"IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome","volume":"86","author":"Guo","year":"2020","journal-title":"International Immunopharmacology"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0165","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12943-020-01158-w","article-title":"RNA demethylase ALKBH5 prevents pancreatic cancer progression by post-transcriptional activation of PER1 in an m6A-YTHDF2-dependent manner","volume":"19","author":"Guo","year":"2020","journal-title":"Molecular Cancer"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0170","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1038\/s41467-022-32963-0","article-title":"Autophagy induction promoted by m(6)A reader YTHDF3 through translation upregulation of FOXO3 mRNA","volume":"13","author":"Hao","year":"2022","journal-title":"Nature Communications"},{"issue":"24","key":"10.1016\/j.pharmthera.2025.108972_bb0175","doi-asserted-by":"crossref","first-page":"797","DOI":"10.21037\/atm.2019.12.65","article-title":"Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm","volume":"7","author":"He","year":"2019","journal-title":"Annals of Translational Medicine"},{"issue":"10","key":"10.1016\/j.pharmthera.2025.108972_bb0180","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1152\/japplphysiol.00374.2015","article-title":"Myocardial hypertrophy and its role in heart failure with preserved ejection fraction","volume":"119","author":"Heinzel","year":"2015","journal-title":"Journal of Applied Physiology (1985)"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0185","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrg.2016.169","article-title":"Detecting RNA modifications in the epitranscriptome: Predict and validate","volume":"18","author":"Helm","year":"2017","journal-title":"Nature Reviews Genetics"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0190","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13059-022-02819-3","article-title":"METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets","volume":"23","author":"Hsu","year":"2022","journal-title":"Genome Biology"},{"issue":"52","key":"10.1016\/j.pharmthera.2025.108972_bb0195","doi-asserted-by":"crossref","first-page":"19889","DOI":"10.1074\/jbc.AC119.010078","article-title":"The RNA-binding protein FMRP facilitates the nuclear export of N(6)-methyladenosine-containing mRNAs","volume":"294","author":"Hsu","year":"2019","journal-title":"The Journal of Biological Chemistry"},{"issue":"9","key":"10.1016\/j.pharmthera.2025.108972_bb0200","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/cr.2017.99","article-title":"Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis","volume":"27","author":"Hsu","year":"2017","journal-title":"Cell Research"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0205","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nature Cell Biology"},{"issue":"7748","key":"10.1016\/j.pharmthera.2025.108972_bb0210","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41586-019-1016-7","article-title":"Histone H3 trimethylation at lysine 36 guides m(6)A RNA modification co-transcriptionally","volume":"567","author":"Huang","year":"2019","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0215","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.gpb.2018.03.001","article-title":"Structural insights into N(6)-methyladenosine (m(6)A) modification in the transcriptome","volume":"16","author":"Huang","year":"2018","journal-title":"Genomics, Proteomics & Bioinformatics"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0220","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13045-021-01129-8","article-title":"N6-methyladenosine methyltransferases: Functions, regulation, and clinical potential","volume":"14","author":"Huang","year":"2021","journal-title":"Journal of Hematology & Oncology"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106432","article-title":"RBM4 regulates M1 macrophages polarization through targeting STAT1-mediated glycolysis","volume":"83","author":"Huangfu","year":"2020","journal-title":"International Immunopharmacology"},{"issue":"9\u201310","key":"10.1016\/j.pharmthera.2025.108972_bb0230","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1101\/gad.333369.119","article-title":"The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs","volume":"34","author":"Ignatova","year":"2020","journal-title":"Genes & Development"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108972_bb0235","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nature Chemical Biology"},{"issue":"20","key":"10.1016\/j.pharmthera.2025.108972_bb0240","doi-asserted-by":"crossref","first-page":"8939","DOI":"10.7150\/thno.45178","article-title":"METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications","volume":"10","author":"Jian","year":"2020","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0245","doi-asserted-by":"crossref","first-page":"19","DOI":"10.31083\/j.rcm.2019.01.3189","article-title":"Advances in epigenetic regulation of vascular aging","volume":"20","author":"Jin","year":"2019","journal-title":"Reviews in Cardiovascular Medicine"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0250","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.copsyc.2018.11.010","article-title":"Epigenetics and meditation","volume":"28","author":"Kaliman","year":"2019","journal-title":"Current Opinion in Psychology"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0255","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201800233","article-title":"m(6)A-mRNA methylation regulates cardiac gene expression and cellular growth","volume":"2","author":"Kmietczyk","year":"2019","journal-title":"Life Science Alliance"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0260","first-page":"322","article-title":"In vivo and in vitro cross-reactivity to fondaparinux in a stroke patient with IgG-PF4\/heparin antibody-negative delayed-onset heparin-induced thrombocytopenia","volume":"18","author":"Kre\u010dak","year":"2020","journal-title":"Blood Transfusion"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0265","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1006\/jmbi.1994.1525","article-title":"The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3\u2032-terminal loop of 18 S rRNA is essential in yeast","volume":"241","author":"Lafontaine","year":"1994","journal-title":"Journal of Molecular Biology"},{"issue":"16","key":"10.1016\/j.pharmthera.2025.108972_bb0270","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1016\/j.molcel.2021.07.024","article-title":"Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation","volume":"81","author":"Lee","year":"2021","journal-title":"Molecular Cell"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0275","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.cell.2014.08.005","article-title":"Emerging roles of RNA modification: m(6)A and U-tail","volume":"158","author":"Lee","year":"2014","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0280","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.tig.2019.12.007","article-title":"Molecular mechanisms driving mRNA degradation by m(6)a modification","volume":"36","author":"Lee","year":"2020","journal-title":"Trends in Genetics"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0285","doi-asserted-by":"crossref","first-page":"13827","DOI":"10.1038\/s41598-018-32310-8","article-title":"The m(6)A-methylase complex recruits TREX and regulates mRNA export","volume":"8","author":"Lesbirel","year":"2018","journal-title":"Scientific Reports"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0290","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/cr.2017.10","article-title":"Cytoplasmic m(6)A reader YTHDF3 promotes mRNA translation","volume":"27","author":"Li","year":"2017","journal-title":"Cell Research"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0295","article-title":"m6A methylation in cardiovascular diseases: From mechanisms to therapeutic potential","volume":"13","author":"Li","year":"2022","journal-title":"Frontiers in Genetics"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0300","article-title":"Novel insight into m6A regulator-mediated methylation modification patterns and immune characteristics in intracranial aneurysm","volume":"14","author":"Li","year":"2022","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0305","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12943-019-1038-7","article-title":"METTL3 facilitates tumor progression via an m(6)A-IGF2BP2-dependent mechanism in colorectal carcinoma","volume":"18","author":"Li","year":"2019","journal-title":"Molecular Cancer"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0310","doi-asserted-by":"crossref","DOI":"10.1096\/fj.201903169R","article-title":"Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts","volume":"35","author":"Li","year":"2021","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0315","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ymeth.2020.06.022","article-title":"Modern epigenetics methods in biological research","volume":"187","author":"Li","year":"2021","journal-title":"Methods (San Diego, Calif)"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108972_bb0320","article-title":"METTL3-mediated ANXA2 inhibition confers neuroprotection in ischemic stroke: Evidence from in vivo and in vitro studies","volume":"37","author":"Liu","year":"2023","journal-title":"FASEB Journal\u202f: Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0325","article-title":"N6-Methyladenosine RNA methylation in cardiovascular diseases","volume":"9","author":"Liu","year":"2022","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0330","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nature Chemical Biology"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0335","doi-asserted-by":"crossref","first-page":"C762","DOI":"10.1152\/ajpcell.00212.2019","article-title":"The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA","volume":"317","author":"Liu","year":"2019","journal-title":"American Journal of Physiology. Cell Physiology"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0340","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.ymthe.2024.01.037","article-title":"m6A epitranscriptomic and epigenetic crosstalk in cardiac fibrosis","volume":"32","author":"Liu","year":"2024","journal-title":"Molecular Therapy: The Journal of the American Society of Gene Therapy"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112761","article-title":"De-ubiquitination of p300 by USP12 critically enhances METTL3 expression and Ang II-induced cardiac hypertrophy","volume":"406","author":"Lu","year":"2021","journal-title":"Experimental Cell Research"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0350","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1038\/s41467-020-20040-3","article-title":"Structural modularity of the XIST ribonucleoprotein complex","volume":"11","author":"Lu","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0355","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.889141","article-title":"m6A regulator-mediated RNA methylation modification patterns and immune microenvironment infiltration characterization in patients with intracranial aneurysms","volume":"13","author":"Maimaiti","year":"2022","journal-title":"Frontiers in Neurology"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0360","first-page":"889","article-title":"Selected ALKBH dioxygenases are overexpressed in salivary gland tumours","volume":"69","author":"Marcinkowski","year":"2022","journal-title":"Acta Biochimica Polonica"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0365","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41418-022-01044-6","article-title":"Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers","volume":"30","author":"Mart\u00edn","year":"2023","journal-title":"Cell Death and Differentiation"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0370","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.118.033794","article-title":"FTO-dependent N(6)-methyladenosine regulates cardiac function during remodeling and repair","volume":"139","author":"Mathiyalagan","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0375","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3389\/fneur.2019.00517","article-title":"Integrative analysis identified IRF6 and NDST1 as potential causal genes for ischemic stroke","volume":"10","author":"Mo","year":"2019","journal-title":"Frontiers in Neurology"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0380","series-title":"Handbook of clinical neurology","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-444-64034-5.00019-5","article-title":"Hemorrhagic stroke","volume":"Vol. 176","author":"Monta\u00f1o","year":"2021"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108972_bb0385","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nature Reviews. Cardiology"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0390","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1006\/jmbi.1996.0391","article-title":"Intron-encoded, antisense small nucleolar RNAs: The characterization of nine novel species points to their direct role as guides for the 2\u2019-O-ribose methylation of rRNAs","volume":"260","author":"Nicoloso","year":"1996","journal-title":"Journal of Molecular Biology"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0395","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12943-019-1004-4","article-title":"RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3","volume":"18","author":"Niu","year":"2019","journal-title":"Molecular Cancer"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0400","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuron.2019.03.014","article-title":"Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions","volume":"102","author":"Nussbacher","year":"2019","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0405","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41440-019-0338-z","article-title":"N6-adenosine methylation (m6A): A promising new molecular target in hypertension and cardiovascular diseases","volume":"43","author":"Paramasivam","year":"2020","journal-title":"Hypertension Research"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0410","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biochi.2017.10.014","article-title":"N(6)-adenine DNA methylation demystified in eukaryotic genome: From biology to pathology","volume":"144","author":"Parashar","year":"2018","journal-title":"Biochimie"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0415","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.cell.2017.05.003","article-title":"The U6 snRNA m(6)a methyltransferase METTL16 regulates SAM synthetase intron retention","volume":"169","author":"Pendleton","year":"2017","journal-title":"Cell"},{"issue":"Suppl_1","key":"10.1016\/j.pharmthera.2025.108972_bb0420","doi-asserted-by":"crossref","first-page":"A13709","DOI":"10.1161\/circ.146.suppl_1.13709","article-title":"Cardioprotective mechanisms of FTO-regulated m6A in heart failure","volume":"146","author":"Phan","year":"2022","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0425","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Research"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108972_bb0430","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3892\/ijmm.2020.4746","article-title":"Role of m6A RNA methylation in cardiovascular disease (review)","volume":"46","author":"Qin","year":"2020","journal-title":"International Journal of Molecular Medicine"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119366","article-title":"The m(6)A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension","volume":"274","author":"Qin","year":"2021","journal-title":"Life Sciences"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0440","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13045-022-01224-4","article-title":"RNA demethylase ALKBH5 in cancer: From mechanisms to therapeutic potential","volume":"15","author":"Qu","year":"2022","journal-title":"Journal of Hematology & Oncology"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2024.105710","article-title":"Rethinking the necessity of long-term toxicity studies for biotherapeutics using weight of evidence assessment","volume":"153","author":"Rana","year":"2024","journal-title":"Regulatory Toxicology and Pharmacology"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0450","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/02813432.2018.1499588","article-title":"Awareness of hypertension and depressive symptoms: A cross-sectional study in a primary care population","volume":"36","author":"Rantanen","year":"2018","journal-title":"Scandinavian Journal of Primary Health Care"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0455","first-page":"6","article-title":"YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs","author":"Roundtree","year":"2017","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0460","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41572-018-0030-7","article-title":"Abdominal aortic aneurysms","volume":"4","author":"Sakalihasan","year":"2018","journal-title":"Nature Reviews. Disease Primers"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108972_bb0465","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.cell.2013.10.047","article-title":"High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis","volume":"155","author":"Schwartz","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0470","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s11010-021-04069-6","article-title":"FTO overexpression inhibits apoptosis of hypoxia\/reoxygenation-treated myocardial cells by regulating m6A modification of Mhrt","volume":"476","author":"Shen","year":"2021","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0475","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Research"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0480","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, when, and how: Context-dependent functions of RNA methylation writers, readers, and erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Molecular Cell"},{"issue":"10","key":"10.1016\/j.pharmthera.2025.108972_bb0485","doi-asserted-by":"crossref","DOI":"10.3390\/cells10102694","article-title":"Emerging roles of N6-Methyladenosine modification in neurodevelopment and neurodegeneration","volume":"10","author":"Shu","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0490","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fnmol.2020.00103","article-title":"Methyltransferase 3 mediated miRNA m6A methylation promotes stress granule formation in the early stage of acute ischemic stroke","volume":"13","author":"Si","year":"2020","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"9","key":"10.1016\/j.pharmthera.2025.108972_bb0495","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20202160","article-title":"Epigenetic modification and therapeutic targets of diabetes mellitus","volume":"40","author":"Singh","year":"2020","journal-title":"Bioscience Reports"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0500","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0022-2836(78)90183-3","article-title":"The absolute frequency of labeled N-6-methyladenosine in HeLa cell messenger RNA decreases with label time","volume":"124","author":"Sommer","year":"1978","journal-title":"Journal of Molecular Biology"},{"issue":"8","key":"10.1016\/j.pharmthera.2025.108972_bb0505","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1080\/15548627.2019.1586246","article-title":"METTL3 and ALKBH5 oppositely regulate m(6)A modification of TFEB mRNA, which dictates the fate of hypoxia\/reoxygenation-treated cardiomyocytes","volume":"15","author":"Song","year":"2019","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0510","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41556-021-00835-2","article-title":"METTL16 exerts an m(6)A-independent function to facilitate translation and tumorigenesis","volume":"24","author":"Su","year":"2022","journal-title":"Nature Cell Biology"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0515","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41419-022-04524-2","article-title":"RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m(6)A-dependent manner","volume":"13","author":"Sun","year":"2022","journal-title":"Cell Death & Disease"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0520","first-page":"00326","article-title":"Lifestyle diseases: Consequences, characteristics, causes and control","volume":"9","author":"Tabish","year":"2017","journal-title":"Journal of Cardiovascular Disease Research"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108972_bb0525","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/CIRCULATIONAHA.119.042336","article-title":"SNO-MLP (S-Nitrosylation of muscle LIM protein) facilitates myocardial hypertrophy through TLR3 (toll-like receptor 3)-mediated RIP3 (receptor-interacting protein kinase 3) and NLRP3 (NOD-like receptor pyrin domain containing 3) Inflammasome activation","volume":"141","author":"Tang","year":"2020","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0530","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12017-019-08580-4","article-title":"Stroke: molecular mechanisms and therapies","volume":"21","author":"Vemuganti","year":"2019","journal-title":"Neuromolecular Medicine"},{"issue":"11","key":"10.1016\/j.pharmthera.2025.108972_bb0535","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1093\/nar\/gkaa353","article-title":"Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B","volume":"48","author":"Vilardo","year":"2020","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0540","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1038\/s41467-022-34434-y","article-title":"METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury","volume":"13","author":"Wang","year":"2022","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0545","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12929-020-00655-w","article-title":"N6-methyladenosine methyltransferase METTL3 affects the phenotype of cerebral arteriovenous malformation via modulating notch signaling pathway","volume":"27","author":"Wang","year":"2020","journal-title":"Journal of Biomedical Science"},{"issue":"9","key":"10.1016\/j.pharmthera.2025.108972_bb0550","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1111\/jcmm.15101","article-title":"Wilms\u2019 tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation","volume":"24","author":"Wang","year":"2020","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"7481","key":"10.1016\/j.pharmthera.2025.108972_bb0555","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N 6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108972_bb0560","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N6-methyladenosine modulates messenger RNA translation efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108972_bb0565","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N(6)-methyladenosine modulates messenger RNA translation efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108972_bb0570","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrm4010","article-title":"Control of mammalian gene expression by selective mRNA export","volume":"16","author":"Wickramasinghe","year":"2015","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0575","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000330881","article-title":"Evaluation of the obesity genes FTO and MC4R and the type 2 diabetes mellitus gene TCF7L2 for contribution to stroke risk: The Mannheim-Heidelberg stroke study","volume":"4","author":"Winter","year":"2011","journal-title":"Obesity Facts"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0580","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.sbi.2017.05.011","article-title":"Readers, writers and erasers of N(6)-methylated adenosine modification","volume":"47","author":"Wu","year":"2017","journal-title":"Current Opinion in Structural Biology"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108972_bb0585","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jshs.2020.12.003","article-title":"The epigenetic landscape of exercise in cardiac health and disease","volume":"10","author":"Wu","year":"2021","journal-title":"Journal of Sport and Health Science"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108972_bb0590","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.2217\/epi-2019-0148","article-title":"Epitranscriptomic mechanisms of N6-methyladenosine methylation regulating mammalian hypertension development by determined spontaneously hypertensive rats pericytes","volume":"11","author":"Wu","year":"2019","journal-title":"Epigenomics"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0595","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41422-018-0113-8","article-title":"A novel m(6)A reader Prrc2a controls oligodendroglial specification and myelination","volume":"29","author":"Wu","year":"2019","journal-title":"Cell Research"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0600","article-title":"N1-Methyladenosine (m1A) regulation associated with the pathogenesis of abdominal aortic aneurysm through YTHDF3 modulating macrophage polarization","volume":"9","author":"Wu","year":"2022","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"4","key":"10.1016\/j.pharmthera.2025.108972_bb0605","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m(6)A reader YTHDC1 regulates mRNA splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Molecular Cell"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0610","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-070244","article-title":"Association of gestational diabetes mellitus with overall and type specific cardiovascular and cerebrovascular diseases: Systematic review and meta-analysis","volume":"378","author":"Xie","year":"2022","journal-title":"BMJ"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0615","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9744771","article-title":"The role of N(6)-methyladenosine in inflammatory diseases","volume":"2022","author":"Xu","year":"2022","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0620","doi-asserted-by":"crossref","DOI":"10.1177\/2040622320916024","article-title":"N(6)-methyladenosine demethylases Alkbh5\/Fto regulate cerebral ischemia-reperfusion injury","volume":"11","author":"Xu","year":"2020","journal-title":"Therapeutic Advances in Chronic Disease"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0625","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3390\/biom13050850","article-title":"Emerging role and mechanism of the FTO gene in cardiovascular diseases","volume":"13","author":"Xu","year":"2023","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108972_bb0630","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/s41422-019-0235-7","article-title":"m(6)A promotes R-loop formation to facilitate transcription termination","volume":"29","author":"Yang","year":"2019","journal-title":"Cell Research"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0635","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/cr.2017.31","article-title":"Extensive translation of circular RNAs driven by N(6)-methyladenosine","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Research"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0640","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.629895","article-title":"METTL3 regulates ossification of the posterior longitudinal ligament via the lncRNA XIST\/miR-302a-3p\/USP8 Axis","volume":"9","author":"Yuan","year":"2021","journal-title":"Frontiers in Cell and Development Biology"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0645","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41421-018-0019-0","article-title":"VIRMA mediates preferential m(6)A mRNA methylation in 3\u2019UTR and near stop codon and associates with alternative polyadenylation","volume":"4","author":"Yue","year":"2018","journal-title":"Cell Discovery"},{"issue":"10","key":"10.1016\/j.pharmthera.2025.108972_bb0650","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"Zaccara","year":"2019","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"6","key":"10.1016\/j.pharmthera.2025.108972_bb0655","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.gendis.2020.07.011","article-title":"The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases","volume":"8","author":"Zhang","year":"2021","journal-title":"Genes & Diseases"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108972_bb0660","first-page":"7015","article-title":"METTL14 regulates M6A methylation-modified primary miR-19a to promote cardiovascular endothelial cell proliferation and invasion","volume":"24","author":"Zhang","year":"2020","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108972_bb0665","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/cac2.12325","article-title":"Gene amplification-driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A-YTHDF2-dependent in lung adenocarcinoma","volume":"42","author":"Zhang","year":"2022","journal-title":"Cancer Commun (Lond)"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0670","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.955222","article-title":"Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke","volume":"16","author":"Zhang","year":"2022","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"11","key":"10.1016\/j.pharmthera.2025.108972_bb0675","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1007\/s12035-021-02539-y","article-title":"Long non-coding RNA PVT1 inhibits miR-30c-5p to upregulate Rock2 to modulate cerebral ischemia\/reperfusion injury through MAPK signaling pathway activation","volume":"58","author":"Zhang","year":"2021","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107744","article-title":"Long non-coding RNAs: Potential therapeutic targets in cardiocerebrovascular diseases","volume":"221","author":"Zhang","year":"2021","journal-title":"Pharmacology & Therapeutics"},{"issue":"2","key":"10.1016\/j.pharmthera.2025.108972_bb0685","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s12035-021-02648-8","article-title":"The long non-coding RNA SNHG12 functions as a competing endogenous RNA to modulate the progression of cerebral ischemia\/reperfusion injury","volume":"59","author":"Zhang","year":"2022","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148373","article-title":"METTL3 silenced inhibited the ferroptosis development via regulating the TFRC levels in the intracerebral hemorrhage progression","volume":"1811","author":"Zhang","year":"2023","journal-title":"Brain Research"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0695","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s12035-022-02739-0","article-title":"N6-methyladenosine and neurological diseases","volume":"59","author":"Zhang","year":"2022","journal-title":"Molecular Neurobiology"},{"issue":"7","key":"10.1016\/j.pharmthera.2025.108972_bb0700","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/CIRCRESAHA.118.312497","article-title":"Epigenetic modifications in cardiovascular aging and diseases","volume":"123","author":"Zhang","year":"2018","journal-title":"Circulation Research"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108972_bb0705","first-page":"930","article-title":"Doxorubicin affects myocardial methyltransferase like 3-dependent m 6 A RNA methylation modification in vivo and in vitro","volume":"32","author":"Zhang","year":"2018","journal-title":"Chinese Journal of Pharmacology and Toxicology"},{"issue":"11","key":"10.1016\/j.pharmthera.2025.108972_bb0710","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/s41419-020-03186-2","article-title":"YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death & Disease"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0715","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41420-021-00688-6","article-title":"METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner","volume":"7","author":"Zhao","year":"2021","journal-title":"Cell Death Discovery"},{"issue":"12","key":"10.1016\/j.pharmthera.2025.108972_bb0720","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Research"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0725","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.402","article-title":"Loss of m6A demethylase ALKBH5 promotes post-ischemic angiogenesis via post-transcriptional stabilization of WNT5A","volume":"11","author":"Zhao","year":"2021","journal-title":"Clinical and Translational Medicine"},{"issue":"5","key":"10.1016\/j.pharmthera.2025.108972_bb0730","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12033-018-00149-z","article-title":"Understanding m(6)a function through uncovering the diversity roles of YTH domain-containing proteins","volume":"61","author":"Zhao","year":"2019","journal-title":"Molecular Biotechnology"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0735","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106937","article-title":"microRNA-421-3p prevents inflammatory response in cerebral ischemia\/reperfusion injury through targeting m6A reader YTHDF1 to inhibit p65 mRNA translation","volume":"88","author":"Zheng","year":"2020","journal-title":"International Immunopharmacology"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0740","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1038\/s41598-023-32919-4","article-title":"m6A regulator-mediated RNA methylation modification patterns are involved in the regulation of the immune microenvironment in ischaemic cardiomyopathy","volume":"13","author":"Zheng","year":"2023","journal-title":"Scientific Reports"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0745","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.omtn.2020.06.005","article-title":"METTL3 induces AAA development and progression by modulating N6-methyladenosine-dependent primary miR34a processing","volume":"21","author":"Zhong","year":"2020","journal-title":"Molecular Therapy - Nucleic Acids"},{"key":"10.1016\/j.pharmthera.2025.108972_bb0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109935","article-title":"Total Panax notoginseng saponin inhibits vascular smooth muscle cell proliferation and migration and intimal hyperplasia by regulating WTAP\/p16 signals via m(6)A modulation","volume":"124","author":"Zhu","year":"2020","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"3","key":"10.1016\/j.pharmthera.2025.108972_bb0755","doi-asserted-by":"crossref","DOI":"10.3390\/biom8030080","article-title":"Research progress on the relationship between atherosclerosis and inflammation","volume":"8","author":"Zhu","year":"2018","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.pharmthera.2025.108972_bb0760","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41421-022-00395-1","article-title":"m(6)Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation","volume":"8","author":"Zhuo","year":"2022","journal-title":"Cell Discovery"}],"container-title":["Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725825001846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725825001846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:44:00Z","timestamp":1768970640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725825001846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":152,"alternative-id":["S0163725825001846"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2025.108972","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N6-methyladenosine (m6A) RNA methylation: a potential clinical therapeutic target in cardiocerebrovascular diseases","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2025.108972","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108972"}}