{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T19:43:47Z","timestamp":1786218227626,"version":"build-2736575974"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100405"],"award-info":[{"award-number":["82100405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019330","name":"Shanghai Clinical Research Center for Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.pharmthera.2026.109093","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:09:27Z","timestamp":1785697767000},"page":"109093","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The critical role of ceramide in mental health and psychiatric diseases"],"prefix":"10.1016","volume":"286","author":[{"given":"Xinran","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuncheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.pharmthera.2026.109093_bb0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.freeradbiomed.2022.07.001","article-title":"MiR-495\u20133p regulates sphingolipid metabolic reprogramming to induce Sphk1\/ceramide mediated mitophagy and apoptosis in NSCLC","volume":"189","author":"Arora","year":"2022","journal-title":"Free Radical Biology & Medicine"},{"issue":"5","key":"10.1016\/j.pharmthera.2026.109093_bb0010","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1093\/jxb\/erad456","article-title":"Aberrant accumulation of ceramides in mitochondria triggers cell death by inducing autophagy in Arabidopsis","volume":"75","author":"Bao","year":"2024","journal-title":"Journal of Experimental Botany"},{"issue":"6","key":"10.1016\/j.pharmthera.2026.109093_bb0015","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/jnc.15759","article-title":"Contribution of ceramides metabolism in psychiatric disorders","volume":"164","author":"Bernal-Vega","year":"2023","journal-title":"Journal of Neurochemistry"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0020","first-page":"125","article-title":"Collecting language, speech acoustics, and facial expression to predict psychosis and other clinical outcomes: Strategies from the AMP\u00ae SCZ initiative","volume":"11","author":"Bilgrami","year":"2025","journal-title":"Schizophrenia (Heidelberg, Germany)"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0025","doi-asserted-by":"crossref","DOI":"10.1186\/s12944-015-0053-y","article-title":"Sphingolipids in cardiovascular diseases and metabolic disorders","volume":"14","author":"Borodzicz","year":"2015","journal-title":"Lipids in Health and Disease"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/wps.21038","article-title":"Accelerating medicines partnership\u00ae schizophrenia (AMP\u00ae SCZ): Developing tools to enable early intervention in the psychosis high risk state","volume":"22","author":"Brady","year":"2023","journal-title":"World Psychiatry"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.metabol.2019.04.002","article-title":"Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder","volume":"95","author":"Brunkhorst-Kanaan","year":"2019","journal-title":"Metabolism"},{"issue":"9","key":"10.1016\/j.pharmthera.2026.109093_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091173","article-title":"Sphingolipid and endocannabinoid profiles in adult attention deficit hyperactivity disorder","volume":"9","author":"Brunkhorst-Kanaan","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-physiol-031620-093815","article-title":"Ceramides in metabolism: Key lipotoxic players","volume":"83","author":"Chaurasia","year":"2021","journal-title":"Annual Review of Physiology"},{"issue":"6451","key":"10.1016\/j.pharmthera.2026.109093_bb0050","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.aav3722","article-title":"Targeting a ceramide double bond improves insulin resistance and hepatic steatosis","volume":"365","author":"Chaurasia","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0055","first-page":"1","article-title":"Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia","author":"Chestnykh","year":"2025","journal-title":"Molecular Psychiatry"},{"issue":"7","key":"10.1016\/j.pharmthera.2026.109093_bb0060","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1038\/s41380-025-02893-6","article-title":"Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia","volume":"30","author":"Chestnykh","year":"2025","journal-title":"Molecular Psychiatry"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49049-8","article-title":"The manganese transporter SLC39A8 links alkaline ceramidase 1 to inflammatory bowel disease","volume":"15","author":"Choi","year":"2024","journal-title":"Nature Communications"},{"issue":"2","key":"10.1016\/j.pharmthera.2026.109093_bb0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"9","year":"2022","journal-title":"The Lancet Psychiatry"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76335-4","article-title":"Ceramide analog [18F] F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer\u2019s disease transgenic mice by functioning as a metabolic probe","volume":"10","author":"Crivelli","year":"2020","journal-title":"Scientific Reports"},{"issue":"8","key":"10.1016\/j.pharmthera.2026.109093_bb0080","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1007\/s12035-018-1448-3","article-title":"The role of ceramide and sphingosine-1-phosphate in Alzheimer\u2019s disease and other neurodegenerative disorders","volume":"56","author":"Czubowicz","year":"2019","journal-title":"Molecular Neurobiology"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0085","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1021\/acschemneuro.8b00556","article-title":"Inhibition of serine palmitoyltransferase by a small organic molecule promotes neuronal survival after astrocyte amyloid beta 1-42 injury","volume":"10","author":"De Vita","year":"2019","journal-title":"ACS Chemical Neuroscience"},{"issue":"2","key":"10.1016\/j.pharmthera.2026.109093_bb0090","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s13238-017-0423-5","article-title":"Structural and functional roles of ether lipids","volume":"9","author":"Dean","year":"2018","journal-title":"Protein & Cell"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2019.00100","article-title":"Stimulation of sphingosine kinase 1 (SPHK1) is beneficial in a Huntington\u2019s disease pre-clinical model","volume":"12","author":"Di Pardo","year":"2019","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"38","key":"10.1016\/j.pharmthera.2026.109093_bb0100","doi-asserted-by":"crossref","first-page":"10242","DOI":"10.1002\/anie.201403349","article-title":"Super-resolution imaging of the Golgi in live cells with a bioorthogonal ceramide probe","volume":"53","author":"Erdmann","year":"2014","journal-title":"Angewandte Chemie International Edition"},{"issue":"5","key":"10.1016\/j.pharmthera.2026.109093_bb0105","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/schbul\/sbaa052","article-title":"Evidence for altered metabolism of sphingosine-1-phosphate in the corpus callosum of patients with schizophrenia","volume":"46","author":"Esaki","year":"2020","journal-title":"Schizophrenia Bulletin"},{"issue":"11","key":"10.1016\/j.pharmthera.2026.109093_bb0110","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1038\/ejhg.2016.28","article-title":"ASAH1 variant causing a mild SMA phenotype with no myoclonic epilepsy: A clinical, biochemical and molecular study","volume":"24","author":"Filosto","year":"2016","journal-title":"European Journal of Human Genetics"},{"issue":"5","key":"10.1016\/j.pharmthera.2026.109093_bb0115","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/ceo.14343","article-title":"Lipids from ocular meibum and tears may serve as biomarkers for depression and post-traumatic stress disorder","volume":"52","author":"Gary","year":"2024","journal-title":"Clinical & Experimental Ophthalmology"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03844-2","article-title":"Structural basis for the activation of acid ceramidase","volume":"9","author":"Gebai","year":"2018","journal-title":"Nature Communications"},{"issue":"8","key":"10.1016\/j.pharmthera.2026.109093_bb0125","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.neurobiolaging.2013.02.001","article-title":"Inhibition of serine palmitoyltransferase reduces A\u03b2 and tau hyperphosphorylation in a murine model: A safe therapeutic strategy for Alzheimer\u2019s disease","volume":"34","author":"Geekiyanage","year":"2013","journal-title":"Neurobiology of Aging"},{"issue":"2","key":"10.1016\/j.pharmthera.2026.109093_bb0130","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1176\/jnp.23.2.jnp215","article-title":"Plasma ceramides are elevated in depression","volume":"23","author":"Gracia-Garcia","year":"2011","journal-title":"The Journal of Neuropsychiatry and Clinical Neurosciences"},{"issue":"7","key":"10.1016\/j.pharmthera.2026.109093_bb0135","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.cmet.2021.06.006","article-title":"Sphingolipids in metabolic disease: The good, the bad, and the unknown","volume":"33","author":"Green","year":"2021","journal-title":"Cell Metabolism"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0140","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/hep.31628","article-title":"Neutral ceramidase mediates nonalcoholic steatohepatitis by regulating monounsaturated fatty acids and gut IgA+ B cells","volume":"73","author":"Gu","year":"2021","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.pharmthera.2026.109093_bb0145","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nm.3214","article-title":"Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs","volume":"19","author":"Gulbins","year":"2013","journal-title":"Nature Medicine"},{"issue":"11","key":"10.1016\/j.pharmthera.2026.109093_bb0150","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1161\/CIRCULATIONAHA.119.041882","article-title":"Altering sphingolipid metabolism attenuates cell death and inflammatory response after myocardial infarction","volume":"141","author":"Hadas","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.694318","article-title":"Plasma sphingolipid profile associated with subclinical atherosclerosis and clinical disease markers of systemic lupus erythematosus: Potential predictive value","volume":"12","author":"Hammad","year":"2021","journal-title":"Frontiers in Immunology"},{"issue":"8","key":"10.1016\/j.pharmthera.2026.109093_bb0160","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00018-022-04401-3","article-title":"Contribution of specific ceramides to obesity-associated metabolic diseases","volume":"79","author":"Hammerschmidt","year":"2022","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0165","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tins.2017.10.006","article-title":"The emerging neurobiology of bipolar disorder","volume":"41","author":"Harrison","year":"2018","journal-title":"Trends in Neurosciences"},{"issue":"11","key":"10.1016\/j.pharmthera.2026.109093_bb0170","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.3390\/biom13111623","article-title":"Identification of a novel acid sphingomyelinase activity associated with recombinant human acid ceramidase","volume":"13","author":"He","year":"2023","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.pharmthera.2026.109093_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113195","article-title":"Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts","volume":"42","author":"Honda","year":"2023","journal-title":"Cell Reports"},{"issue":"11","key":"10.1016\/j.pharmthera.2026.109093_bb0180","doi-asserted-by":"crossref","first-page":"G1102","DOI":"10.1152\/ajpgi.00095.2016","article-title":"Compounds of the sphingomyelin-ceramide-glycosphingolipid pathways as secondary messenger molecules: New targets for novel therapies for fatty liver disease and insulin resistance","volume":"310","author":"Ilan","year":"2016","journal-title":"American Journal of Physiology - Gastrointestinal and Liver Physiology"},{"issue":"24","key":"10.1016\/j.pharmthera.2026.109093_bb0185","doi-asserted-by":"crossref","first-page":"16351","DOI":"10.1021\/acs.joc.2c02019","article-title":"Fluorescently labeled ceramides and 1-deoxyceramides: Synthesis, characterization, and cellular distribution studies","volume":"87","author":"Izquierdo","year":"2022","journal-title":"Journal of Organic Chemistry"},{"issue":"42","key":"10.1016\/j.pharmthera.2026.109093_bb0190","doi-asserted-by":"crossref","first-page":"22253","DOI":"10.1074\/jbc.M116.752634","article-title":"Valproate induces the unfolded protein response by increasing ceramide levels","volume":"291","author":"Jadhav","year":"2016","journal-title":"Journal of Biological Chemistry"},{"issue":"12","key":"10.1016\/j.pharmthera.2026.109093_bb0195","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1074\/jbc.M117.775460","article-title":"Inositol depletion induced by acute treatment of the bipolar disorder drug valproate increases levels of phytosphingosine","volume":"292","author":"Jadhav","year":"2017","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0200","article-title":"Ceramides in Alzheimer\u2019s disease: Key mediators of neuronal apoptosis induced by oxidative stress and A\u03b2 accumulation","volume":"2015","author":"Jazvin\u0161\u0107ak Jembrek","year":"2015","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"6","key":"10.1016\/j.pharmthera.2026.109093_bb0205","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.7150\/thno.123178","article-title":"Glucosylceramide regulates depression through activating peroxisome proliferator-activated receptor gamma in dorsal striatum","volume":"16","author":"Jiang","year":"2026","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.pharmthera.2026.109093_bb0210","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3390\/ijms17040477","article-title":"Exogenous C2 ceramide suppresses matrix metalloproteinase gene expression by inhibiting ROS production and MAPK signaling pathways in PMA-stimulated human astroglioma cells","volume":"17","author":"Jung","year":"2016","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"10.1016\/j.pharmthera.2026.109093_bb0215","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70379","article-title":"Sphingolipids in emotional well-being","volume":"170","author":"Kalinichenko","year":"2026","journal-title":"Journal of Neurochemistry"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0220","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1750-3639.2011.00501.x","article-title":"Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury","volume":"22","author":"Kim","year":"2012","journal-title":"Brain Pathology"},{"issue":"2","key":"10.1016\/j.pharmthera.2026.109093_bb0225","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3390\/biom13020274","article-title":"Acid ceramidase deficiency: Bridging gaps between clinical presentation, mouse models, and future therapeutic interventions","volume":"13","author":"Kleynerman","year":"2023","journal-title":"Biomolecules"},{"issue":"21","key":"10.1016\/j.pharmthera.2026.109093_bb0230","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/acs.accounts.2c00511","article-title":"Bioconjugation strategies for revealing the roles of lipids in living cells","volume":"55","author":"Knittel","year":"2022","journal-title":"Accounts of Chemical Research"},{"issue":"9","key":"10.1016\/j.pharmthera.2026.109093_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ph14090894","article-title":"New molecular targets for antidepressant drugs","volume":"14","author":"Kornhuber","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"6","key":"10.1016\/j.pharmthera.2026.109093_bb0240","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tips.2014.04.003","article-title":"The ceramide system as a novel antidepressant target","volume":"35","author":"Kornhuber","year":"2014","journal-title":"Trends in Pharmacological Sciences"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0245","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1124\/jpet.118.253955","article-title":"Neutral sphingomyelinase inhibition alleviates LPS-induced microglia activation and neuroinflammation after experimental traumatic brain injury","volume":"368","author":"Kumar","year":"2019","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"38","key":"10.1016\/j.pharmthera.2026.109093_bb0250","first-page":"E8919","article-title":"Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants","volume":"115","author":"Kunduri","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0255","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molmed.2018.10.009","article-title":"Ceramides as novel disease biomarkers","volume":"25","author":"Kurz","year":"2019","journal-title":"Trends in Molecular Medicine"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0260","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5483\/BMBRep.2020.53.1.278","article-title":"Sphingolipids in neuroinflammation: A potential target for diagnosis and therapy","volume":"53","author":"Lee","year":"2020","journal-title":"BMB Reports"},{"issue":"12","key":"10.1016\/j.pharmthera.2026.109093_bb0265","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/acn3.51687","article-title":"The clinical spectrum of SMA-PME and in vitro normalization of its cellular ceramide profile","volume":"9","author":"Lee","year":"2022","journal-title":"Annals of Clinical and Translational Neurology"},{"issue":"4","key":"10.1016\/j.pharmthera.2026.109093_bb0270","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3390\/cells14040281","article-title":"Imipramine, an acid sphingomyelinase inhibitor, promotes newborn neuron survival in the hippocampus after seizure","volume":"14","author":"Lee","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0275","doi-asserted-by":"crossref","first-page":"17089","DOI":"10.2147\/JIR.S561184","article-title":"Cuproptosis and immune microenvironment interplay in temporal lobe epilepsy: Identification of key molecular signatures and therapeutic targets","volume":"18","author":"Li","year":"2025","journal-title":"Journal of Inflammation Research"},{"issue":"5","key":"10.1016\/j.pharmthera.2026.109093_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106744","article-title":"Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish","volume":"26","author":"Li","year":"2023","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0285","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1038\/s41467-025-57330-7","article-title":"Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXR\u03b2 signaling transduction","volume":"16","author":"Liao","year":"2025","journal-title":"Nature Communications"},{"issue":"2","key":"10.1016\/j.pharmthera.2026.109093_bb0290","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.tem.2018.11.003","article-title":"Sphingolipids in the pathogenesis of Parkinson\u2019s disease and parkinsonism","volume":"30","author":"Lin","year":"2019","journal-title":"Trends in Endocrinology and Metabolism"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0295","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4049\/jimmunol.1500702","article-title":"Acid sphingomyelinase\u2013derived ceramide regulates ICAM-1 function during T cell transmigration across brain endothelial cells","volume":"196","author":"Lopes Pinheiro","year":"2016","journal-title":"The Journal of Immunology"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0300","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/s42003-024-07231-0","article-title":"Unravelling neuronal and glial differences in ceramide composition, synthesis, and sensitivity to toxicity","volume":"7","author":"Mcinnis","year":"2024","journal-title":"Communications Biology"},{"issue":"2","key":"10.1016\/j.pharmthera.2026.109093_bb0305","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00018-012-1038-x","article-title":"Ceramide function in the brain: When a slight tilt is enough","volume":"70","author":"Mencarelli","year":"2013","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"6","key":"10.1016\/j.pharmthera.2026.109093_bb0310","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/acel.12369","article-title":"Demographic and clinical variables affecting mid-to late-life trajectories of plasma ceramide and dihydroceramide species","volume":"14","author":"Mielke","year":"2015","journal-title":"Aging Cell"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0315","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1528-1157.2003.22502.x","article-title":"Hippocampal programmed cell death after status epilepticus: Evidence for NMDA-receptor and ceramide-mediated mechanisms","volume":"44","author":"Mikati","year":"2003","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0320","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41398-019-0478-6","article-title":"Differential lipid composition and regulation along the hippocampal longitudinal axis","volume":"9","author":"Miranda","year":"2019","journal-title":"Translational Psychiatry"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0325","article-title":"Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study","volume":"16","author":"Moseholm","year":"2024","journal-title":"Alzheimer\u2019s & Dementia: Diagnosis, Assessment & Disease Monitoring"},{"issue":"6","key":"10.1016\/j.pharmthera.2026.109093_bb0330","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJMoa1508808","article-title":"Clonal immunoglobulin against lysolipids in the origin of myeloma","volume":"374","author":"Nair","year":"2016","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0335","doi-asserted-by":"crossref","DOI":"10.1038\/s41537-025-00605-1","article-title":"Pathways to prevention: The Accelerating Medicines Partnership\u00ae Schizophrenia (AMP\u00ae SCZ) Program","volume":"11","author":"Nelson","year":"2025","journal-title":"Schizophrenia"},{"issue":"17","key":"10.1016\/j.pharmthera.2026.109093_bb0340","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1158\/0008-5472.CAN-24-4042","article-title":"Ceramide-induced metabolic stress depletes fumarate and drives mitophagy to mediate tumor suppression","volume":"85","author":"Oleinik","year":"2025","journal-title":"Cancer Research"},{"issue":"11","key":"10.1016\/j.pharmthera.2026.109093_bb0345","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/glycob\/cwab046","article-title":"Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease","volume":"31","author":"Reza","year":"2021","journal-title":"Glycobiology"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0350","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36144-2","article-title":"DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation","volume":"8","author":"Rojas","year":"2018","journal-title":"Scientific Reports"},{"issue":"10","key":"10.1016\/j.pharmthera.2026.109093_bb0355","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1016\/j.ymthe.2024.08.004","article-title":"Hematopoietic stem cell transplantation leads to biochemical and functional correction in two mouse models of acid ceramidase deficiency","volume":"32","author":"Rybova","year":"2024","journal-title":"Molecular Therapy"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0360","doi-asserted-by":"crossref","DOI":"10.1186\/s13023-026-04238-0","article-title":"Zuclopenthixol inhibits residual activity of acid sphingomyelinase in Niemann pick disease type B: A case report with in vitro validation","volume":"21","author":"Schiller","year":"2026","journal-title":"Orphanet Journal of Rare Diseases"},{"issue":"6","key":"10.1016\/j.pharmthera.2026.109093_bb0365","doi-asserted-by":"crossref","DOI":"10.1093\/glycob\/cwaf022","article-title":"Region-specific quantitation of glycosphingolipids in the elderly human brain with nanoflow MEA chip Q\/ToF mass spectrometry","volume":"35","author":"Schindler","year":"2025","journal-title":"Glycobiology"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0370","article-title":"Neuroanatomy of anxiety: A brief review","volume":"10","author":"Schmidt","year":"2018","journal-title":"Cureus"},{"issue":"8","key":"10.1016\/j.pharmthera.2026.109093_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102185","article-title":"Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice","volume":"298","author":"Schumacher","year":"2022","journal-title":"Journal of Biological Chemistry"},{"issue":"10","key":"10.1016\/j.pharmthera.2026.109093_bb0380","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1021\/pr800188y","article-title":"High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides","volume":"7","author":"Schwarz","year":"2008","journal-title":"Journal of Proteome Research"},{"issue":"5","key":"10.1016\/j.pharmthera.2026.109093_bb0385","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1194\/jlr.S092874","article-title":"Advances in determining signaling mechanisms of ceramide and role in disease","volume":"60","author":"Stith","year":"2019","journal-title":"Journal of Lipid Research"},{"issue":"678","key":"10.1016\/j.pharmthera.2026.109093_bb0390","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abl7895","article-title":"Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models","volume":"15","author":"Su","year":"2023","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.667885","article-title":"The role of ceramides in diabetes and cardiovascular disease","volume":"12","author":"Summers","year":"2021","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"11","key":"10.1016\/j.pharmthera.2026.109093_bb0400","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s42255-019-0134-8","article-title":"Metabolic messengers: Ceramides","volume":"1","author":"Summers","year":"2019","journal-title":"Nature Metabolism"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0405","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-026-07881-0","article-title":"Very long chain sphingolipids govern brain myelination by regulating oligodendrocyte differentiation and membrane microdomain integrity","volume":"24","author":"Sun","year":"2026","journal-title":"Journal of Translational Medicine"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0410","doi-asserted-by":"crossref","first-page":"115586","DOI":"10.1016\/j.biopha.2023.115586","article-title":"SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors","volume":"170","author":"Sun","year":"2024","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"13","key":"10.1016\/j.pharmthera.2026.109093_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110560","article-title":"Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection","volume":"38","author":"Sun","year":"2022","journal-title":"Cell Reports"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0420","article-title":"Plasma ceramide mediates the association of peripheral T cells with Alzheimer\u2019s disease","author":"Sun","year":"2025","journal-title":"Journal of Advanced Research"},{"issue":"5","key":"10.1016\/j.pharmthera.2026.109093_bb0425","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1136\/gut.2010.216671","article-title":"Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma","volume":"60","author":"Tagaram","year":"2011","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0430","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-023-00383-9","article-title":"Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer\u2019s disease mouse model","volume":"12","author":"Tallon","year":"2023","journal-title":"Translational Neurodegeneration"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0435","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.plipres.2015.11.001","article-title":"Unraveling the role of the target of rapamycin signaling in sphingolipid metabolism","volume":"61","author":"Teixeira","year":"2016","journal-title":"Progress in Lipid Research"},{"issue":"4","key":"10.1016\/j.pharmthera.2026.109093_bb0440","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/glia.24329","article-title":"Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes","volume":"71","author":"Teo","year":"2023","journal-title":"Glia"},{"issue":"10","key":"10.1016\/j.pharmthera.2026.109093_bb0445","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.142","article-title":"Membrane lipidomics in schizophrenia patients: A correlational study with clinical and cognitive manifestations","volume":"6","author":"Tessier","year":"2016","journal-title":"Translational Psychiatry"},{"issue":"7","key":"10.1016\/j.pharmthera.2026.109093_bb0450","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1053\/j.gastro.2023.02.023","article-title":"Sphingolipids are depleted in alcohol-related liver fibrosis","volume":"164","author":"Thiele","year":"2023","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.pharmthera.2026.109093_bb0455","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1021\/acsmedchemlett.0c00120","article-title":"Brain penetrable inhibitors of ceramide galactosyltransferase for the treatment of lysosomal storage disorders","volume":"11","author":"Thurairatnam","year":"2020","journal-title":"ACS Medicinal Chemistry Letters"},{"issue":"4","key":"10.1016\/j.pharmthera.2026.109093_bb0460","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41574-020-0320-5","article-title":"The role of ceramides in metabolic disorders: When size and localization matters","volume":"16","author":"Turpin-Nolan","year":"2020","journal-title":"Nature Reviews Endocrinology"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104802","article-title":"Impaired metabolism predicts coronary artery calcification in women with systemic lupus erythematosus","volume":"96","author":"Urbain","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0470","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2025.1602149","article-title":"Fasting the mitochondria to prevent neurodegeneration: The role of ceramides","volume":"19","author":"Valenzuela-Ahumada","year":"2025","journal-title":"Frontiers in Neuroscience"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0475","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00401-012-1014-4","article-title":"Fingolimod attenuates ceramide-induced blood-brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes","volume":"124","author":"Van Doorn","year":"2012","journal-title":"Acta Neuropathologica"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0480","doi-asserted-by":"crossref","DOI":"10.1172\/JCI156624","article-title":"Sortilin drives hypertension by modulating sphingolipid\/ceramide homeostasis and by triggering oxidative stress","volume":"132","author":"Varzideh","year":"2022","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0485","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/15548627.2022.2027193","article-title":"Ceramide-induced mitophagy impairs \u00df-oxidation-linked energy production in PINK1 deficiency","volume":"18","author":"Vos","year":"2022","journal-title":"Autophagy"},{"issue":"25","key":"10.1016\/j.pharmthera.2026.109093_bb0490","doi-asserted-by":"crossref","first-page":"21384","DOI":"10.1074\/jbc.M112.340513","article-title":"Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): Potential mechanism of apoptosis induction in Alzheimer disease (AD)","volume":"287","author":"Wang","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103491","article-title":"Impaired lipid homeostasis and elevated lipid oxidation of erythrocyte membrane in adolescent depression","volume":"80","author":"Wang","year":"2025","journal-title":"Redox Biology"},{"issue":"11","key":"10.1016\/j.pharmthera.2026.109093_bb0500","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1016\/j.apsb.2024.09.010","article-title":"Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism","volume":"14","author":"Wang","year":"2024","journal-title":"Acta Pharmaceutica Sinica B"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0505","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/schbul\/sbae011","article-title":"Accelerating Medicines Partnership\u00ae Schizophrenia (AMP\u00ae SCZ): Rationale and study design of the largest global prospective cohort study of clinical high risk for psychosis","volume":"50","author":"Wannan","year":"2024","journal-title":"Schizophrenia Bulletin"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0510","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.schres.2019.08.003","article-title":"Targeted lipidomics and metabolomics evaluations of cortical neuronal stress in schizophrenia","volume":"212","author":"Wood","year":"2019","journal-title":"Schizophrenia Research"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0515","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2024.08.031","article-title":"Icariin targets p53 to protect against ceramide-induced neuronal senescence: Implication in Alzheimer\u2019s disease","volume":"224","author":"Wu","year":"2024","journal-title":"Free Radical Biology & Medicine"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0520","article-title":"Sphingolipid metabolism-related genes as diagnostic markers in pneumonia-induced sepsis: The AUG model","volume":"15","author":"Wu","year":"2025","journal-title":"Scientific Reports"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0525","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1007\/s12035-024-04477-x","article-title":"Dysregulation of serum exosomal lipid metabolism in schizophrenia: A biomarker perspective","volume":"62","author":"Xu","year":"2025","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0530","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jconrel.2018.09.011","article-title":"Novel glucosylceramide synthase inhibitor based prodrug copolymer micelles for delivery of anticancer agents","volume":"288","author":"Xu","year":"2018","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0535","first-page":"1","article-title":"Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2","author":"Xu","year":"2017","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111473","article-title":"Low-grade elevation of palmitate and lipopolysaccharide synergistically induced \u03b2-cell damage via inhibition of neutral ceramidase","volume":"539","author":"Xu","year":"2022","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"2","key":"10.1016\/j.pharmthera.2026.109093_bb0545","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-026-04734-6","article-title":"STING mediates microglial polarization to promote neuroinflammation in epilepsy-related cognitive dysfunction","volume":"51","author":"Yang","year":"2026","journal-title":"Neurochemical Research"},{"issue":"40","key":"10.1016\/j.pharmthera.2026.109093_bb0550","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202400794","article-title":"Sphingosine kinase 2 regulates aryl hydrocarbon receptor nuclear translocation and target gene activation","volume":"11","author":"Yokoyama","year":"2024","journal-title":"Advanced Science"},{"issue":"8004","key":"10.1016\/j.pharmthera.2026.109093_bb0555","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41586-024-07098-5","article-title":"IL-10 constrains sphingolipid metabolism to limit inflammation","volume":"627","author":"York","year":"2024","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.pharmthera.2026.109093_bb0560","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.jaci.2022.12.808","article-title":"ELOVL6 deficiency aggravates allergic airway inflammation through the ceramide-S1P pathway in mice","volume":"151","author":"Yoshida","year":"2023","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113511","article-title":"Stimulating the expression of sphingosine kinase 1 (SphK1) is beneficial to reduce acrylamide-induced nerve cell damage","volume":"237","author":"Yu","year":"2022","journal-title":"Ecotoxicology and Environmental Safety"},{"issue":"39","key":"10.1016\/j.pharmthera.2026.109093_bb0570","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adx2681","article-title":"Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH","volume":"11","author":"Yu","year":"2025","journal-title":"Science Advances"},{"issue":"12","key":"10.1016\/j.pharmthera.2026.109093_bb0575","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1007\/s00125-024-06280-8","article-title":"Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle","volume":"67","author":"Zemski Berry","year":"2024","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0580","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-025-01362-5","article-title":"Transcriptomics, lipidomics, and single-nucleus RNA sequencing integration: Exploring sphingolipids in MASH-HCC progression","volume":"15","author":"Zeng","year":"2025","journal-title":"Cell & Bioscience"},{"issue":"10","key":"10.1016\/j.pharmthera.2026.109093_bb0585","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/cac2.70047","article-title":"Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis","volume":"45","author":"Zhan","year":"2025","journal-title":"Cancer Communications"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107682","article-title":"Human serum lipidomics analysis revealed glyphosate may lead to lipid metabolism disorders and health risks","volume":"171","author":"Zhang","year":"2023","journal-title":"Environment International"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0595","article-title":"Red blood cell membrane lipidomics: Potential biomarkers detecting method for plasma volume overload and major adverse cardiovascular events in chronic heart failure patients","author":"Zhang","year":"2025","journal-title":"Advanced Science"},{"issue":"4","key":"10.1016\/j.pharmthera.2026.109093_bb0600","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s13402-023-00798-6","article-title":"The ceramide synthase (CERS\/LASS) family: Functions involved in cancer progression","volume":"46","author":"Zhang","year":"2023","journal-title":"Cellular Oncology"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0605","first-page":"1","article-title":"Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis","author":"Zhang","year":"2025","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.pharmthera.2026.109093_bb0610","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.4103\/NRR.NRR-D-23-01933","article-title":"Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury","volume":"20","author":"Zhang","year":"2025","journal-title":"Neural Regeneration Research"},{"issue":"12","key":"10.1016\/j.pharmthera.2026.109093_bb0615","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/s44161-023-00364-1","article-title":"Alkaline ceramidase 1\u2013mediated platelet ceramide catabolism mitigates vascular inflammation and abdominal aortic aneurysm formation","volume":"2","author":"Zhang","year":"2023","journal-title":"Nature Cardiovascular Research"},{"issue":"5","key":"10.1016\/j.pharmthera.2026.109093_bb0620","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.cmet.2019.09.016","article-title":"Adipocyte hypoxia-inducible factor 2\u03b1 suppresses atherosclerosis by promoting adipose ceramide catabolism","volume":"30","author":"Zhang","year":"2019","journal-title":"Cell Metabolism"},{"issue":"8","key":"10.1016\/j.pharmthera.2026.109093_bb0625","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.cmet.2024.07.004","article-title":"A microbial metabolite inhibits the HIF-2\u03b1-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH","volume":"36","author":"Zhang","year":"2024","journal-title":"Cell Metabolism"},{"issue":"6","key":"10.1016\/j.pharmthera.2026.109093_bb0630","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/jnc.15837","article-title":"Plasma C18: 0-ceramide is a novel potential biomarker for disease severity in myasthenia gravis","volume":"165","author":"Zhang","year":"2023","journal-title":"Journal of Neurochemistry"},{"issue":"17","key":"10.1016\/j.pharmthera.2026.109093_bb0635","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1161\/CIRCULATIONAHA.118.037487","article-title":"Elevated plasma ceramides are associated with antiretroviral therapy use and progression of carotid artery atherosclerosis in HIV infection","volume":"139","author":"Zhao","year":"2019","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0640","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s40168-023-01661-4","article-title":"Integrated multi-omics analysis reveals the positive leverage of citrus flavonoids on hindgut microbiota and host homeostasis by modulating sphingolipid metabolism in mid-lactation dairy cows consuming a high-starch diet","volume":"11","author":"Zhao","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.pharmthera.2026.109093_bb0645","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pharmthera.2018.10.011","article-title":"The sphingosine kinase-1\/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy","volume":"195","author":"Zheng","year":"2019","journal-title":"Pharmacology & Therapeutics"},{"issue":"3","key":"10.1016\/j.pharmthera.2026.109093_bb0650","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.chom.2022.01.004","article-title":"Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides","volume":"30","author":"Zheng","year":"2022","journal-title":"Cell Host & Microbe"},{"issue":"6746","key":"10.1016\/j.pharmthera.2026.109093_bb0655","doi-asserted-by":"crossref","DOI":"10.1126\/science.adp5540","article-title":"A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite\u2013CerS6\u2013ceramide axis","volume":"388","author":"Zhou","year":"2025","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0660","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41392-022-01199-1","article-title":"Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"4","key":"10.1016\/j.pharmthera.2026.109093_bb0665","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1001\/jamaophthalmol.2022.0140","article-title":"Association between depression and severity of dry eye symptoms, signs, and inflammatory markers in the DREAM study","volume":"140","author":"Zhou","year":"2022","journal-title":"JAMA Ophthalmology"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0670","doi-asserted-by":"crossref","first-page":"311","DOI":"10.7150\/ijbs.78525","article-title":"Insights into the roles and pathomechanisms of ceramide and sphigosine-1-phosphate in nonalcoholic fatty liver disease","volume":"19","author":"Zhu","year":"2023","journal-title":"International Journal of Biological Sciences"},{"issue":"7","key":"10.1016\/j.pharmthera.2026.109093_bb0675","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/s42255-024-01078-9","article-title":"PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels","volume":"6","author":"Zhu","year":"2024","journal-title":"Nature Metabolism"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0680","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/s41467-025-56891-x","article-title":"CerS6 links ceramide metabolism to innate immune responses in diabetic kidney disease","volume":"16","author":"Zhu","year":"2025","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/j.pharmthera.2026.109093_bb0685","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41398-022-01999-7","article-title":"Acid sphingomyelinase\/ceramide system in schizophrenia: Implications for therapeutic intervention as a potential novel target","volume":"12","author":"Zhuo","year":"2022","journal-title":"Translational Psychiatry"},{"issue":"10","key":"10.1016\/j.pharmthera.2026.109093_bb0690","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/ATVBAHA.122.318048","article-title":"Ceramide metabolism in cardiovascular disease: A network with high therapeutic potential","volume":"42","author":"Zietzer","year":"2022","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"6","key":"10.1016\/j.pharmthera.2026.109093_bb0695","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12847","article-title":"Ceramides affect alcohol consumption and depressive-like and anxiety-like behavior in a brain region-and ceramide species-specific way in male mice","volume":"25","author":"Zoicas","year":"2020","journal-title":"Addiction Biology"},{"issue":"6","key":"10.1016\/j.pharmthera.2026.109093_bb0700","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23063398","article-title":"Acid sphingomyelinase is a modulator of contextual fear","volume":"23","author":"Zoicas","year":"2022","journal-title":"International Journal of Molecular Sciences"}],"container-title":["Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725826001208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163725826001208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T19:25:21Z","timestamp":1786217121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163725826001208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":140,"alternative-id":["S0163725826001208"],"URL":"https:\/\/doi.org\/10.1016\/j.pharmthera.2026.109093","relation":{},"ISSN":["0163-7258"],"issn-type":[{"value":"0163-7258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The critical role of ceramide in mental health and psychiatric diseases","name":"articletitle","label":"Article Title"},{"value":"Pharmacology & Therapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.pharmthera.2026.109093","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109093"}}