{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:47:01Z","timestamp":1774540021844,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"The Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26460724"],"award-info":[{"award-number":["26460724"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["phiro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physics and Imaging in Radiation Oncology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.phro.2018.05.005","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T08:40:00Z","timestamp":1527756000000},"page":"77-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["An uncertainty metric to evaluate deformation vector fields for dose accumulation in radiotherapy"],"prefix":"10.1016","volume":"6","author":[{"given":"Akihiro","family":"Takemura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriomi","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiya","family":"Noto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Isomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phro.2018.05.005_b0005","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13014-014-0318-z","article-title":"Impact of head and neck cancer adaptive radiotherapy to spare the parotid glands and decrease the risk of xerostomia","volume":"10","author":"Castelli","year":"2015","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2018.05.005_b0010","doi-asserted-by":"crossref","first-page":"20130532","DOI":"10.1259\/bjr.20130532","article-title":"Co-registration of cone beam CT and planning CT in head and neck IMRT dose estimation: a feasible adaptive radiotherapy strategy","volume":"87","author":"Yip","year":"2014","journal-title":"Br J Radiol"},{"key":"10.1016\/j.phro.2018.05.005_b0015","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.radonc.2012.11.005","article-title":"Volume and dosimetric changes and initial clinical experience of a two-step adaptive intensity modulated radiation therapy (IMRT) scheme for head and neck cancer","volume":"106","author":"Nishi","year":"2013","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2018.05.005_b0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijrobp.2007.05.046","article-title":"Adaptive radiotherapy for prostate cancer using kilovoltage cone-beam computed tomography: first clinical results","volume":"70","author":"Nijkamp","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0025","doi-asserted-by":"crossref","DOI":"10.1002\/mp.12156","article-title":"Cone-beam CT-based adaptive planning improves permanent prostate brachytherapy dosimetry: an analysis of 1266 patients","author":"Westendorp","year":"2017","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0030","doi-asserted-by":"crossref","first-page":"e0170901","DOI":"10.1371\/journal.pone.0170901","article-title":"Late-course adaptive adjustment based on metabolic tumor volume changes during radiotherapy may reduce radiation toxicity in patients with non-small cell lung cancer","volume":"12","author":"Xiao","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.phro.2018.05.005_b0035","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/aa5de2","article-title":"Impact of dose escalation and adaptive radiotherapy for cervical cancers on tumour shrinkage-a modelling study","volume":"62","author":"Arnesen","year":"2017","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2018.05.005_b0040","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.ijrobp.2016.01.055","article-title":"First clinical investigation of cone beam computed tomography and deformable registration for adaptive proton therapy for lung cancer","volume":"95","author":"Veiga","year":"2016","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.phro.2018.05.005_b0045","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1088\/1361-6560\/aa5200","article-title":"Generation of synthetic CT data using patient specific daily MR image data and image registration","volume":"62","author":"Kraus","year":"2017","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2018.05.005_b0050","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1080\/0284186X.2016.1185149","article-title":"Accuracy of software-assisted contour propagation from planning CT to cone beam CT in head and neck radiotherapy","volume":"55","author":"Hvid","year":"2016","journal-title":"Acta Oncol"},{"key":"10.1016\/j.phro.2018.05.005_b0055","first-page":"7","article-title":"A multi-institution evaluation of deformable image registration algorithms for automatic organ delineation in adaptive head and neck radiotherapy","author":"Hardcastle","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2018.05.005_b0060","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1088\/0031-9155\/51\/17\/015","article-title":"Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy","volume":"51","author":"Lu","year":"2006","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2018.05.005_b0065","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1118\/1.2836945","article-title":"Calibration of megavoltage cone-beam CT for radiotherapy dose calculations: correction of cupping artifacts and conversion of CT numbers to electron density","volume":"35","author":"Petit","year":"2008","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0070","doi-asserted-by":"crossref","first-page":"31703","DOI":"10.1118\/1.4864240","article-title":"Toward adaptive radiotherapy for head and neck patients: feasibility study on using CT-to-CBCT deformable registration for \u201cdose of the day\u201d calculations","volume":"41","author":"Veiga","year":"2014","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0075","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.ijrobp.2006.08.031","article-title":"Dosimetric feasibility of cone-beam CT-based treatment planning compared to CT-based treatment planning","volume":"66","author":"Yoo","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0080","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1088\/0031-9155\/52\/3\/011","article-title":"Evaluation of on-board kV cone beam CT (CBCT)-based dose calculation","volume":"52","author":"Yang","year":"2007","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2018.05.005_b0085","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ijrobp.2014.02.007","article-title":"Evaluation of on-board kV cone beam computed tomography-based dose calculation with deformable image registration using Hounsfield unit modifications","volume":"89","author":"Onozato","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0090","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.1088\/0031-9155\/54\/20\/013","article-title":"Dose calculation accuracy using cone-beam CT (CBCT) for pelvic adaptive radiotherapy","volume":"54","author":"Guan","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2018.05.005_b0095","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12194-012-0176-z","article-title":"Dose calculation with a cone beam CT image in image-guided radiation therapy","volume":"6","author":"Usui","year":"2013","journal-title":"Radiol Phys Technol"},{"key":"10.1016\/j.phro.2018.05.005_b0100","first-page":"1","article-title":"Dosimetric and geometric evaluation of the use of deformable image registration in adaptive intensity-modulated radiotherapy for head-and-neck cancer","author":"Eiland","year":"2014","journal-title":"J Radiat Res"},{"key":"10.1016\/j.phro.2018.05.005_b0105","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ijrobp.2013.06.2054","article-title":"Estimation of rectal dose using daily megavoltage cone-beam computed tomography and deformable image registration","volume":"87","author":"Akino","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0110","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1120\/jacmp.v13i3.3859","article-title":"Accumulating daily-varied dose distributions of prostate radiation therapy with soft-tissue-based kV CT guidance","volume":"13","author":"Godley","year":"2012","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0115","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/mp.12734","article-title":"An adaptive motion regularization technique to support sliding motion in deformable image registration","volume":"45","author":"Fu","year":"2018","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0120","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1118\/1.3673772","article-title":"A method to estimate the effect of deformable image registration uncertainties on daily dose mapping","volume":"39","author":"Murphy","year":"2012","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0125","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2307\/1932409","article-title":"Measures of the amount of ecologic association between species","volume":"26","author":"Dice","year":"1945","journal-title":"Ecology"},{"key":"10.1016\/j.phro.2018.05.005_b0130","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1118\/1.4905050","article-title":"Toward adaptive radiotherapy for head and neck patients: uncertainties in dose warping due to the choice of deformable registration algorithm","volume":"42","author":"Veiga","year":"2015","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0135","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1120\/jacmp.v14i1.4066","article-title":"A framework for deformable image registration validation in radiotherapy clinical applications","volume":"14","author":"Varadhan","year":"2013","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0140","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1120\/jacmp.v8i4.2432","article-title":"Quantitative evaluation of a cone-beam computed tomography-planning computed tomography deformable image registration method for adaptive radiation therapy","volume":"8","author":"Lawson","year":"2007","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0145","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ijrobp.2009.06.031","article-title":"Deformable registration accuracy consortium. Results of a multi-institution deformable registration accuracy study (MIDRAS)","volume":"76","author":"Brock","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0150","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1120\/jacmp.v14i1.3834","article-title":"Validation of three deformable image registration algorithms for the thorax","volume":"14","author":"Latifi","year":"2013","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0155","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1120\/jacmp.v15i1.4564","article-title":"Accuracy quantification of a deformable image registration tool applied in a clinical setting","volume":"15","author":"Hoffmann","year":"2014","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0160","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.ijrobp.2014.06.045","article-title":"Deformable image registration for adaptive radiation therapy of head and neck cancer: Accuracy and precision in the presence of tumor changes","volume":"90","author":"Mencarelli","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0165","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ijrobp.2016.05.012","article-title":"Multi-institutional validation study of commercially available deformable image registration software for thoracic images","volume":"96","author":"Kadoya","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1118\/1.2816107","article-title":"A simple fixed-point approach to invert a deformation field","volume":"35","author":"Chen","year":"2008","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0175","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1088\/0031-9155\/54\/18\/014","article-title":"The utilization of consistency metrics for error analysis in deformable image registration","volume":"54","author":"Bender","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2018.05.005_b0180","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1120\/jacmp.v13i5.3829","article-title":"A measure to evaluate deformable registration fields in clinical settings","volume":"13","author":"Schreibmann","year":"2012","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2018.05.005_b0185","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1088\/0031-9155\/59\/3\/733","article-title":"The distance discordance metric-a novel approach to quantifying spatial uncertainties in intra- and inter-patient deformable image registration","volume":"59","author":"Saleh","year":"2014","journal-title":"Phys Med Biol"}],"container-title":["Physics and Imaging in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631617300787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631617300787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T08:18:19Z","timestamp":1569399499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405631617300787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":37,"alternative-id":["S2405631617300787"],"URL":"https:\/\/doi.org\/10.1016\/j.phro.2018.05.005","relation":{},"ISSN":["2405-6316"],"issn-type":[{"value":"2405-6316","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An uncertainty metric to evaluate deformation vector fields for dose accumulation in radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Physics and Imaging in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phro.2018.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V. on behalf of European Society of Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}]}}