{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:31:52Z","timestamp":1791937912412,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007210","name":"Varian Medical Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["phiro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physics and Imaging in Radiation Oncology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.phro.2022.09.003","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T03:19:00Z","timestamp":1663039140000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Adoption of respiratory motion management in radiation therapy"],"prefix":"10.1016","volume":"24","author":[{"given":"Alex","family":"Burton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabeena","family":"Beveridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Hardcastle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Sanagou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Franich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phro.2022.09.003_b0005","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/aaf5d9","article-title":"Breathing-motion induced interplay effects for stereotactic body radiotherapy of liver tumours using flattening-filter free volumetric modulated arc therapy","volume":"64","author":"Edvardsson","year":"2019","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2022.09.003_b0010","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ijrobp.2013.03.038","article-title":"Dosimetric impact of the interplay effect during stereotactic lung radiation therapy delivery using flattening filter-free beams and volumetric modulated arc therapy","volume":"86","author":"Ong","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1361-6560\/aab957","article-title":"Motion induced interplay effects for VMAT radiotherapy","volume":"63","author":"Edvardsson","year":"2018","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2022.09.003_b0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1118\/1.3263614","article-title":"Evaluation of the interplay effect when using RapidArc to treat targets moving in the craniocaudal or right-left direction","volume":"37","author":"Court","year":"2010","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0025","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.1118\/1.4754297","article-title":"A method of dose reconstruction for moving targets compatible with dynamic treatments","volume":"39","author":"Poulsen","year":"2012","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0030","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1118\/1.2349696","article-title":"The management of respiratory motion in radiation oncology report of AAPM Task Group 76","volume":"33","author":"Keall","year":"2006","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0035","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/mp.14023","article-title":"Real-time 4DMRI-based internal target volume definition for moving lung tumors","volume":"47","author":"Rabe","year":"2020","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-018-1191-y","article-title":"Simulation of dosimetry impact of 4DCT uncertainty in 4D dose calculation for lung SBRT","volume":"14","author":"Liu","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0172810","article-title":"4D dose simulation in volumetric arc therapy: Accuracy and affecting parameters","volume":"12","author":"Sothmann","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phro.2022.09.003_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-014-0225-3","article-title":"Dynamic simulation of motion effects in IMAT lung SBRT","volume":"9","author":"Zou","year":"2014","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0055","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/acm2.13253","article-title":"Implementation of free breathing respiratory amplitude-gated treatments","volume":"22","author":"Hickling","year":"2021","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0060","doi-asserted-by":"crossref","first-page":"S2437","DOI":"10.21037\/jtd.2018.01.155","article-title":"Advances in the use of motion management and image guidance in radiation therapy treatment for lung cancer","volume":"10","author":"Molitoris","year":"2018","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.phro.2022.09.003_b0065","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ejmp.2016.11.114","article-title":"What do radiation oncologists require for future advancements in lung SBRT?","volume":"44","author":"Ricardi","year":"2017","journal-title":"Phys Med"},{"key":"10.1016\/j.phro.2022.09.003_b0070","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1118\/1.3002304","article-title":"A simplified method of four-dimensional dose accumulation using the mean patient density representation","volume":"35","author":"Glide-Hurst","year":"2008","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.radonc.2007.11.022","article-title":"Dose calculations accounting for breathing motion in stereotactic lung radiotherapy based on 4D-CT and the internal target volume","volume":"86","author":"Admiraal","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0080","doi-asserted-by":"crossref","DOI":"10.1088\/1742-6596\/1305\/1\/012049","article-title":"4D dosimetry and motion management in clinical radiotherapy","volume":"1305","author":"B\u00e4ck","year":"2019","journal-title":"J Phys Conf Ser"},{"key":"10.1016\/j.phro.2022.09.003_b0085","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1002\/mp.13579","article-title":"Comparison of planned dose on different CT image sets to four-dimensional Monte Carlo dose recalculation using the patient\u2019s actual breathing trace for lung stereotactic body radiation therapy","volume":"46","author":"Freislederer","year":"2019","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0090","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1002\/mp.13800","article-title":"A comparison of IROC and ACDS on-site audits of reference and non-reference dosimetry","volume":"46","author":"Lye","year":"2019","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0095","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejmp.2017.04.003","article-title":"The role of dosimetry audit in lung SBRT multi-centre clinical trials","volume":"44","author":"Clark","year":"2017","journal-title":"Phys Med"},{"key":"10.1016\/j.phro.2022.09.003_b0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.phro.2018.03.009","article-title":"The role of dosimetry audit in achieving high quality radiotherapy","volume":"5","author":"Clark","year":"2018","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0105","doi-asserted-by":"crossref","DOI":"10.1088\/1742-6596\/444\/1\/012014","article-title":"Dosimetry for audit and clinical trials: Challenges and requirements","volume":"444","author":"Kron","year":"2013","journal-title":"J Phys Conf Ser"},{"key":"10.1016\/j.phro.2022.09.003_b0110","doi-asserted-by":"crossref","DOI":"10.1088\/1742-6596\/573\/1\/012002","article-title":"Audits for advanced treatment dosimetry","volume":"573","author":"Ibbott","year":"2015","journal-title":"J Phys Conf Ser"},{"key":"10.1016\/j.phro.2022.09.003_b0115","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20150251","article-title":"Radiotherapy dosimetry audit: Three decades of improving standards and accuracy in UK clinical practice and trials","volume":"88","author":"Clark","year":"2015","journal-title":"Br J Radiol"},{"key":"10.1016\/j.phro.2022.09.003_b0120","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.prro.2020.04.004","article-title":"Differences in the Patterns of Failure Between IROC Lung and Spine Phantom Irradiations","volume":"10","author":"Edward","year":"2020","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0125","doi-asserted-by":"crossref","first-page":"e322","DOI":"10.1016\/j.prro.2020.11.008","article-title":"Failure Modes in IROC Photon Liver Phantom Irradiations","volume":"11","author":"Taylor","year":"2021","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.radonc.2019.06.008","article-title":"Results of a multicentre dosimetry audit using a respiratory phantom within the EORTC LungTech trial","volume":"138","author":"Lambrecht","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0135","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.radonc.2020.06.018","article-title":"Patterns of practice for adaptive and real-time radiation therapy (POP-ART RT) part I: Intra-fraction breathing motion management","volume":"153","author":"Anastasi","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0140","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014A metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.phro.2022.09.003_b0145","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.radonc.2014.03.023","article-title":"Radiation therapy quality assurance in clinical trials - Global harmonisation group","volume":"111","author":"Melidis","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0150","doi-asserted-by":"crossref","unstructured":"DeLuca P, Jones D, Gahbauer R, Whitmore G, Wambersie A. ICRU Report 83: Prescribing, Recording, and Reporting Photon-Beam Intensity-Modulated Radiation Therapy (IMRT). vol. 10. 2010. https:\/\/doi.org\/10.1093\/jicru\/ndq001.","DOI":"10.1093\/jicru\/ndq002"},{"key":"10.1016\/j.phro.2022.09.003_b0155","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.ijrobp.2007.11.042","article-title":"Comparison of Different Strategies to Use Four-Dimensional Computed Tomography in Treatment Planning for Lung Cancer Patients","volume":"70","author":"Wolthaus","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0160","doi-asserted-by":"crossref","DOI":"10.25080\/Majora-92bf1922-011","article-title":"Econometric and Statistical Modeling with Python","volume":"92\u20136","author":"Seabold","year":"2010","journal-title":"Proc 9th Python Sci Conf"},{"key":"10.1016\/j.phro.2022.09.003_b0165","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41592-019-0686-2","article-title":"SciPy 1.0: fundamental algorithms for scientific computing in Python","volume":"17","author":"Virtanen","year":"2020","journal-title":"Nat Methods"},{"key":"10.1016\/j.phro.2022.09.003_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-017-3164-1","article-title":"Stereotactic prostate adaptive radiotherapy utilising kilovoltage intrafraction monitoring: The TROG 15.01 SPARK trial","volume":"17","author":"Keall","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.phro.2022.09.003_b0175","doi-asserted-by":"crossref","DOI":"10.1118\/1.4898119","article-title":"Quality assurance for the clinical implementation of kilovoltage intrafraction monitoring for prostate cancer VMAT","volume":"41","author":"Ng","year":"2014","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0180","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.ijrobp.2012.05.006","article-title":"Accuracy and consistency of respiratory gating in abdominal cancer patients","volume":"85","author":"Ge","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0185","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1097\/JTO.0b013e3182307ec2","article-title":"Respiratory gating techniques for optimization of lung cancer radiotherapy","volume":"6","author":"Giraud","year":"2011","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-016-0699-2","article-title":"To gate or not to gate - dosimetric evaluation comparing Gated vs. ITV-based methodologies in stereotactic ablative body radiotherapy (SABR) treatment of lung cancer","volume":"11","author":"Kim","year":"2016","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0195","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.radonc.2020.10.036","article-title":"MLC tracking for lung SABR is feasible, efficient and delivers high-precision target dose and lower normal tissue dose","volume":"155","author":"Booth","year":"2021","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0200","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.radonc.2016.03.006","article-title":"A dosimetric comparison of real-time adaptive and non-adaptive radiotherapy: A multi-institutional study encompassing robotic, gimbaled, multileaf collimator and couch tracking","volume":"119","author":"Colvill","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fonc.2020.591430","article-title":"Potential Clinical Significance of Overall Targeting Accuracy and Motion Management in the Treatment of Tumors That Move With Respiration: Lessons Learnt From a Quarter Century of Stereotactic Body Radiotherapy From Dose Response Models","volume":"10","author":"Mahadevan","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0210","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2021.2939","article-title":"Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II): The Trans Tasman Radiation Oncology Group 13.01 Phase 2 Randomized Clinical Trial","author":"Siva","year":"2021","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0215","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S1470-2045(18)30896-9","article-title":"Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial","volume":"20","author":"Ball","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0220","unstructured":"NSW Cancer Institute. Non-small cell lung cancer definitive stereotactic EBRT peripheral tumours. EviQ 2021. https:\/\/www.eviq.org.au\/radiation-oncology\/respiratory\/3389-non-small-cell-lung-cancer-definitive-stereot#history (accessed November 5, 2021)."},{"key":"10.1016\/j.phro.2022.09.003_b0225","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/resp.13870","article-title":"Radiotherapy treatment for lung cancer: Current status and future directions","volume":"25","author":"Vinod","year":"2020","journal-title":"Respirology"},{"key":"10.1016\/j.phro.2022.09.003_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-020-01496-5","article-title":"ITV versus mid-ventilation for treatment planning in lung SBRT: A comparison of target coverage and PTV adequacy by using in-treatment 4D cone beam CT","volume":"15","author":"Bellec","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0235","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.ijrobp.2014.04.051","article-title":"Dose escalated liver stereotactic body radiation therapy at the mean respiratory position","volume":"89","author":"Velec","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2022.09.003_b0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-019-1300-6","article-title":"Clinical impact of removing respiratory motion during liver SABR","volume":"14","author":"Gargett","year":"2019","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2022.09.003_b0245","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s00066-018-1264-8","article-title":"Under-reported dosimetry errors due to interplay effects during VMAT dose delivery in extreme hypofractionated stereotactic radiotherapy","volume":"194","author":"Gauer","year":"2018","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.phro.2022.09.003_b0250","doi-asserted-by":"crossref","first-page":"S192","DOI":"10.1016\/j.ijrobp.2014.05.727","article-title":"Interplay Effect During Lung SBRT With VMAT Delivered by Flattening Filter-Free Beams","volume":"90","author":"Rao","year":"2014","journal-title":"Int J Radiat Oncol"}],"container-title":["Physics and Imaging in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631622000793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631622000793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:15:00Z","timestamp":1762503300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405631622000793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":50,"alternative-id":["S2405631622000793"],"URL":"https:\/\/doi.org\/10.1016\/j.phro.2022.09.003","relation":{},"ISSN":["2405-6316"],"issn-type":[{"value":"2405-6316","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adoption of respiratory motion management in radiation therapy","name":"articletitle","label":"Article Title"},{"value":"Physics and Imaging in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phro.2022.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V. on behalf of European Society of Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}]}}