{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:09:07Z","timestamp":1790352547629,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24 K18769"],"award-info":[{"award-number":["24 K18769"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["phiro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physics and Imaging in Radiation Oncology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.phro.2024.100583","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:48:51Z","timestamp":1714265331000},"page":"100583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Comparing different boost concepts and beam configurations for proton therapy of pancreatic cancer"],"prefix":"10.1016","volume":"30","author":[{"given":"Taiki","family":"Takaoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsei","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Shibamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanari","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Torii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiya","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuo","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Hiwatashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phro.2024.100583_b0005","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2739\/kurumemedj.MS674002","article-title":"Clinical outcomes of intraoperative radiotherapy, postoperative radiotherapy, and definitive radiotherapy for non-metastatic pancreatic cancer","volume":"67","author":"Yanagi","year":"2023","journal-title":"Kurume Med J"},{"key":"10.1016\/j.phro.2024.100583_b0010","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.radonc.2008.02.007","article-title":"Efficacy of novel hypoxic cell sensitiser doranidazole in the treatment of locally advanced pancreatic cancer: long-term results of a placebo-controlled randomised study","volume":"87","author":"Karasawa","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0015","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1001\/jama.2016.4324","article-title":"Effect of chemoradiotherapy vs chemotherapy on survival in patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine with or without erlotinib: the LAP07 randomized clinical trial","volume":"315","author":"Hammel","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.phro.2024.100583_b0020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13014-022-02001-w","article-title":"Factors associated with long-term survival in gemcitabine-concurrent proton radiotherapy for non-metastatic locally advanced pancreatic cancer: a single-center retrospective study","volume":"17","author":"Ogura","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0025","first-page":"19","article-title":"Influence of dose-averaged linear energy transfer on tumour control after carbon-ion radiation therapy for pancreatic cancer","volume":"21","author":"Hagiwara","year":"2019","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0030","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ijrobp.2015.12.362","article-title":"Carbon ion radiation therapy with concurrent gemcitabine for patients with locally advanced pancreatic cancer","volume":"95","author":"Shinoto","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2024.100583_b0035","first-page":"35","article-title":"Relative biological effectiveness in proton beam therapy \u2013 Current knowledge and future challenges","volume":"9","author":"L\u00fchr","year":"2018","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0040","doi-asserted-by":"crossref","unstructured":"Ding X, Dionisi F, Tang S, Ingram M, Hung CY, Prionas E, et al. A comprehensive dosimetric study of pancreatic cancer treatment using three-dimensional conformal radiation therapy (3DCRT), intensity-modulated radiation therapy (IMRT), volumetric-modulated radiation therapy (VMAT), and passive-scattering and modulated-scanning proton therapy (PT). Med Dosim 2014;39:139\u201345. https:\/\/doi.10.1016\/j.meddos.2013.11.005.","DOI":"10.1016\/j.meddos.2013.11.005"},{"key":"10.1016\/j.phro.2024.100583_b0045","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.ijrobp.2008.10.055","article-title":"Impact of intrafractional bowel gas movement on carbon ion beam dose distribution in pancreatic radiotherapy","volume":"73","author":"Kumagai","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2024.100583_b0050","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.radonc.2016.03.004","article-title":"The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients","volume":"119","author":"Houweling","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0055","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.3390\/cancers15092550","article-title":"Patient breathing motion and delivery specifics influencing the robustness of a proton pancreas irradiation","volume":"15","author":"Kn\u00e4usl","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.phro.2024.100583_b0060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.radonc.2019.03.037","article-title":"Comprehensive 4D robustness evaluation for pencil beam scanned proton plans","volume":"136","author":"Ribeiro","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0065","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13014-017-0832-x","article-title":"Planning strategies for inter-fractional robustness in pancreatic patients treated with scanned carbon therapy","volume":"12","author":"Batista","year":"2017","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0070","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13014-015-0538-x","article-title":"Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer","volume":"10","author":"Dreher","year":"2015","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0075","doi-asserted-by":"crossref","first-page":"20190101","DOI":"10.1259\/bjr.20190101","article-title":"Beam direction arrangement using a superconducting rotating gantry in carbon ion treatment for pancreatic cancer","volume":"92","author":"Koom","year":"2019","journal-title":"Br J Radiol"},{"key":"10.1016\/j.phro.2024.100583_b0080","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13014-018-1165-0","article-title":"Comparison of different treatment planning approaches for intensity-modulated proton therapy with simultaneous integrated boost for pancreatic cancer","volume":"13","author":"Stefanowicz","year":"2018","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0085","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1002\/mp.14345","article-title":"Investigation of inter-fraction target motion variations in the context of pencil beam scanned proton therapy in non-small cell lung cancer patients","volume":"47","author":"den Otter","year":"2020","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2024.100583_b0090","article-title":"Comparison of 3D and 4D robustly optimized proton treatment plans for non-small cell lung cancer patients with tumour motion amplitudes larger than 5 mm","volume":"27","author":"Spautz","year":"2023","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0095","doi-asserted-by":"crossref","unstructured":"Hijal T, Fournier-Bidoz N, Castro-Pena P, Kirova YM, Zefkili S, Bollet MA, et al. Simultaneous integrated boost in breast conserving treatment of breast cancer: A dosimetric comparison of helical tomotherapy and three-dimensional conformal radiotherapy. Radiother Oncol 2010;94:300\u20136. https:\/\/doi.10.1016\/j.radonc.2009.12.043.","DOI":"10.1016\/j.radonc.2009.12.043"},{"key":"10.1016\/j.phro.2024.100583_b0100","first-page":"163","article-title":"Breast-conserving radiotherapy with simultaneous integrated boost; field-in-field three-dimensional conformal radiotherapy versus inverse intensity-modulated radiotherapy \u2013 a dosimetric comparison: do we need intensity-modulated radiotherapy? South Asian","volume":"7","author":"Joseph","year":"2018","journal-title":"J Cancer"},{"key":"10.1016\/j.phro.2024.100583_b0105","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/acm2.12225","article-title":"Commissioning of the world's first compact pencil-beam scanning proton therapy system","volume":"19","author":"Pidikiti","year":"2018","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2024.100583_b0110","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820985866","article-title":"Dosimetric comparison of helical tomotherapy, volumetric-modulated arc therapy, and intensity-modulated proton therapy for angiosarcoma of the scalp","volume":"20","author":"Mizuno","year":"2021","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.phro.2024.100583_b0115","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/jjco\/hyad005","article-title":"Acute genitourinary toxicity of pencil beam scanning proton therapy for localized prostate cancer: utility of the transition zone index and average urinary flow rate in predicting acute urinary retention","volume":"53","author":"Takaoka","year":"2023","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0120","doi-asserted-by":"crossref","first-page":"1149961","DOI":"10.3389\/fonc.2023.1149961","article-title":"Optimizing patient selection for stereotactic ablative radiotherapy in patients with locally advanced pancreatic cancer after initial chemotherapy - a single center prospective cohort","volume":"13","author":"Doppenberg","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0125","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2024.100583_b0130","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1634\/theoncologist.2018-0266","article-title":"Pancreas cancer-associated weight loss","volume":"24","author":"Hendifar","year":"2019","journal-title":"Oncologist"},{"key":"10.1016\/j.phro.2024.100583_b0135","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/jjco\/hyaa247","article-title":"The impact of body composition on short-term outcomes of neoadjuvant chemotherapy with gemcitabine plus S-1 in patients with resectable pancreatic cancer","volume":"51","author":"Takeda","year":"2021","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0140","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/acm2.12199","article-title":"Dosimetric effects of anatomical changes during fractionated photon radiation therapy in pancreatic cancer patients","volume":"18","author":"van der Horst","year":"2017","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2024.100583_b0145","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/acm2.13429","article-title":"Dosimetric impact of simulated changes in large bowel content during proton therapy with simultaneous integrated boost for locally advanced pancreatic cancer","volume":"22","author":"Narita","year":"2021","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2024.100583_b0150","article-title":"Evaluation of short-term gastrointestinal motion and its impact on dosimetric parameters in stereotactic body radiation therapy for pancreatic cancer","volume":"39","author":"Uchinami","year":"2023","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0155","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1007\/s00535-013-0857-3","article-title":"Upper gastrointestinal complications associated with gemcitabine-concurrent proton radiotherapy for inoperable pancreatic cancer","volume":"49","author":"Takatori","year":"2014","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.phro.2024.100583_b0160","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.3390\/cancers14112789","article-title":"Proton therapy in the management of pancreatic cancer","volume":"14","author":"Kobeissi","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.phro.2024.100583_b0165","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13014-020-01592-6","article-title":"Radiobiological model-based approach to determine the potential of dose-escalated robust intensity-modulated proton radiotherapy in reducing gastrointestinal toxicity in the treatment of locally advanced unresectable pancreatic cancer of the head","volume":"15","author":"Raturi","year":"2020","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.517061","article-title":"Dose\u2013volume and radiobiological model-based comparative evaluation of the gastrointestinal toxicity risk of photon and proton irradiation plans in localized pancreatic cancer without distant metastasis","volume":"10","author":"Raturi","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0175","article-title":"A survey of practice patterns for adaptive particle therapy for interfractional changes","volume":"26","author":"Trnkova","year":"2023","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0180","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.phro.2022.01.005","article-title":"An adaptive planning strategy in carbon ion therapy of pancreatic cancer involving beam angle selection","volume":"21","author":"Kawashima","year":"2022","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0185","article-title":"Clinical evaluation of synthetic computed tomography methods in adaptive proton therapy of lung cancer patients","volume":"27","author":"Taasti","year":"2023","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0190","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.ijrobp.2004.04.039","article-title":"Recovery from sublethal damage during intermittent exposures in cultured tumor cells: implications for dose modification in radiosurgery and IMRT","volume":"59","author":"Shibamoto","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2024.100583_b0195","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.radonc.2007.08.007","article-title":"Biological effect of intermittent radiation exposure in vivo: recovery from sublethal damage versus reoxygenation","volume":"86","author":"Tomita","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0200","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00066-017-1223-9","article-title":"Recovery from sublethal damage and potentially lethal damage : Proton beam irradiation vs","volume":"194","author":"Hashimoto","year":"2018","journal-title":"X-ray irradiation Strahlenther Onkol"},{"key":"10.1016\/j.phro.2024.100583_b0205","first-page":"24","article-title":"Dose-escalated simultaneously integrated boost photon or proton therapy in pancreatic cancer in an in-silico study: Gastrointestinal organs remain critical","volume":"27","author":"Stefanowicz","year":"2020","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0210","doi-asserted-by":"crossref","first-page":"20160790","DOI":"10.1259\/bjr.20160790","article-title":"Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four-dimensional computed tomography","volume":"90","author":"Kawashiro","year":"2017","journal-title":"Br J Radiol"},{"key":"10.1016\/j.phro.2024.100583_b0215","article-title":"A survey of practice patterns for real-time intrafractional motion-management in particle therapy","volume":"26","author":"Zhang","year":"2023","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100583_b0220","article-title":"Parameter based 4D dose calculations for proton therapy","volume":"27","author":"Lebbink","year":"2023","journal-title":"Phys Imaging Radiat Oncol"}],"container-title":["Physics and Imaging in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631624000538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631624000538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T20:21:52Z","timestamp":1730838112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405631624000538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":44,"alternative-id":["S2405631624000538"],"URL":"https:\/\/doi.org\/10.1016\/j.phro.2024.100583","relation":{},"ISSN":["2405-6316"],"issn-type":[{"value":"2405-6316","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparing different boost concepts and beam configurations for proton therapy of pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Physics and Imaging in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phro.2024.100583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of European Society of Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100583"}}