{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:53:38Z","timestamp":1784055218609,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007210","name":"Varian Medical Systems Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["phiro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physics and Imaging in Radiation Oncology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.phro.2024.100586","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T03:33:27Z","timestamp":1715312007000},"page":"100586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Robustness analysis of dynamic trajectory radiotherapy and volumetric modulated arc therapy plans for head and neck cancer"],"prefix":"10.1016","volume":"30","author":[{"given":"Hannes A.","family":"Loebner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Bertholet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Henry","family":"Mackeprang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Volken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olgun","family":"Elicin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvan","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian","family":"Guyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Aebersold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco F.M.","family":"Stampanoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Fix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Manser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phro.2024.100586_b0005","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/CMAR.S115761","article-title":"Head and neck cancer: Improving outcomes with a multidisciplinary approach","volume":"9","author":"Lo Nigro","year":"2017","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.phro.2024.100586_b0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00520-007-0300-5","article-title":"The influence of xerostomia after radiotherapy on quality of life: Results of a questionnaire in head and neck cancer","volume":"16","author":"Dirix","year":"2008","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.phro.2024.100586_b0015","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1002\/hed.25880","article-title":"Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy","volume":"41","author":"Baudelet","year":"2019","journal-title":"Head Neck"},{"key":"10.1016\/j.phro.2024.100586_b0020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): A phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0025","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1118\/1.2818738","article-title":"Volumetric modulated arc therapy: IMRT in a single gantry arc","volume":"35","author":"Otto","year":"2008","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2024.100586_b0030","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1259\/bjr\/22373346","article-title":"Volumetric modulated arc therapy: A review of current literature and clinical use in practice","volume":"84","author":"Teoh","year":"2011","journal-title":"Brit J Radiol"},{"key":"10.1016\/j.phro.2024.100586_b0035","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1002\/mp.13086","article-title":"Part 1: Optimization and evaluation of dynamic trajectory radiotherapy","volume":"45","author":"Fix","year":"2018","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2024.100586_b0040","article-title":"Recent developments in non-coplanar radiotherapy. Brit","volume":"92","author":"Smyth","year":"2019","journal-title":"J Radiol"},{"key":"10.1016\/j.phro.2024.100586_b0045","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13014-022-02092-5","article-title":"Organ-at-risk sparing with dynamic trajectory radiotherapy for head and neck cancer: comparison with volumetric arc therapy on a publicly available library of cases","volume":"17","author":"Bertholet","year":"2022","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0050","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0360-3016(93)90257-V","article-title":"The effect of setup uncertainties on the treatment of nasopharynx cancer","volume":"27","author":"Hunt","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2024.100586_b0055","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0167-8140(02)00140-8","article-title":"Geometrical uncertainties, radiotherapy planning margins, and the ICRU-62 report","volume":"64","author":"Stroom","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0060","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1002\/mp.15683","article-title":"Development of a Monte Carlo based robustness calculation and evaluation tool","volume":"49","author":"Loebner","year":"2022","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2024.100586_b0065","first-page":"505","article-title":"Determination of patient set-up error and optimal treatment margin for intensity modulated radiotherapy using image guidance system","volume":"2","author":"Kanakavelu","year":"2016","journal-title":"J BUON"},{"key":"10.1016\/j.phro.2024.100586_b0070","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.ijrobp.2006.08.054","article-title":"Repositioning accuracy of two different mask systems-3D revisited: Comparison using true 3D\/3D matching with cone-beam CT","volume":"66","author":"Boda-Heggemann","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2024.100586_b0075","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.phro.2022.04.006","article-title":"Precision of image-guided spinal stereotactic ablative radiotherapy and impact of positioning variables","volume":"22","author":"Billiet","year":"2022","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0080","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3857\/roj.2017.00493","article-title":"Set-up errors in head and neck cancer treated with IMRT technique assessed by cone-beam computed tomography: a feasible protocol","volume":"36","author":"Delishaj","year":"2018","journal-title":"Radiat Oncol J"},{"key":"10.1016\/j.phro.2024.100586_b0085","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1088\/0031-9155\/55\/13\/002","article-title":"Dose reconstruction for volumetric modulated arc therapy (VMAT) using cone-beam CT and dynamic log files","volume":"55","author":"Qian","year":"2010","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2024.100586_b0090","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejmp.2016.12.013","article-title":"Evaluation of MLC performance in VMAT and dynamic IMRT by log file analysis","volume":"33","author":"Olasolo-Alonso","year":"2017","journal-title":"Phys Med"},{"key":"10.1016\/j.phro.2024.100586_b0095","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.1002\/mp.16749","article-title":"Impact of the gradient in gantry-table rotation on dynamic trajectory radiotherapy plan quality","volume":"50","author":"Loebner","year":"2023","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2024.100586_b0100","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1002\/mp.16533","article-title":"Technical note: Feasibility of gating for dynamic trajectory radiotherapy \u2013 Mechanical accuracy and dosimetric performance","volume":"50","author":"Loebner","year":"2023","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2024.100586_b0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejmp.2018.03.006","article-title":"Log file-based patient dose calculations of double-arc VMAT for head-and-neck radiotherapy","volume":"48","author":"Katsuta","year":"2018","journal-title":"Phys Med"},{"key":"10.1016\/j.phro.2024.100586_b0110","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2016.02.016","article-title":"Evaluation of robustness to setup and range uncertainties for head and neck patients treated with pencil beam scanning proton therapy","volume":"95","author":"Malyapa","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2024.100586_b0115","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4103\/0973-0168.197975","article-title":"An audit of setup reproducibility in radiotherapy of head and neck cancers","volume":"7","author":"Verma","year":"2016","journal-title":"J Radiat Cancer Res"},{"key":"10.1016\/j.phro.2024.100586_b0120","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.ejmp.2015.09.002","article-title":"Set-up errors and planning margins in planar and CBCT image-guided radiotherapy using three different imaging systems: A clinical study for prostate and head-and-neck cancer","volume":"31","author":"Dzierma","year":"2015","journal-title":"Phys Med"},{"key":"10.1016\/j.phro.2024.100586_b0125","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.semradonc.2003.10.003","article-title":"Errors and Margins in Radiotherapy","volume":"14","author":"Van","year":"2004","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.semradonc.2017.11.008","article-title":"Clinical trial strategies to compare protons with photons","volume":"28","author":"Langendijk","year":"2018","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0135","doi-asserted-by":"crossref","first-page":"110237","DOI":"10.1016\/j.radonc.2024.110237","article-title":"Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer","volume":"195","author":"Bertholet","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0140","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.radonc.2013.10.035","article-title":"Recommendation for a contouring method and atlas of organs at risk in nasopharyngeal carcinoma patients receiving intensity-modulated radiotherapy","volume":"110","author":"Sun","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0145","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.radonc.2015.05.018","article-title":"Identifying patients who may benefit from adaptive radiotherapy: Does the literature on anatomic and dosimetric changes in head and neck organs at risk during radiotherapy provide information to help?","volume":"115","author":"Brouwer","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0150","doi-asserted-by":"crossref","DOI":"10.1088\/1742-6596\/74\/1\/021004","article-title":"Efficient photon treatment planning by the use of Swiss Monte Carlo Plan","volume":"74","author":"Fix","year":"2007","journal-title":"J Phys Conf Ser"},{"key":"10.1016\/j.phro.2024.100586_b0155","doi-asserted-by":"crossref","first-page":"N425","DOI":"10.1088\/0031-9155\/52\/19\/N01","article-title":"An efficient framework for photon Monte Carlo treatment planning","volume":"52","author":"Fix","year":"2007","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2024.100586_b0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.phro.2019.07.001","article-title":"The influence of a six degrees of freedom couch and an individual head support in patient positioning in radiotherapy of head and neck cancer","volume":"11","author":"Rodrigues","year":"2019","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0165","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1118\/1.598381","article-title":"Physical and dosimetric aspects of a multileaf collimation system used in the dynamic mode for implementing intensity modulated radiotherapy","volume":"25","author":"LoSasso","year":"1998","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2024.100586_b0170","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/mp.16907","article-title":"Multi-institutional investigation into the robustness of intra-cranial multi-target stereotactic radiosurgery plans to delivery errors","volume":"51","author":"May","year":"2024","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2024.100586_b0175","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ejmp.2016.04.015","article-title":"Quantification of residual dose estimation error on log file-based patient dose calculation","volume":"32","author":"Katsuta","year":"2016","journal-title":"Phys Med"},{"key":"10.1016\/j.phro.2024.100586_b0180","unstructured":"Nederslandse Vereniging voor Radiotherapie en Oncologie. Landelijk Indicatie Protocol Protonentherapie (versie 2.2) (LIPPv2.2), accessed on 25.10.2023 2019. https:\/\/docplayer.nl\/195792198-Landelijk-indicatie-protocol-protonentherapie-versie-2-2-lippv2-2.html."},{"key":"10.1016\/j.phro.2024.100586_b0185","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.radonc.2020.09.038","article-title":"What is plan quality in radiotherapy? The importance of evaluating dose metrics, complexity, and robustness of treatment plans","volume":"153","author":"Hernandez","year":"2020","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0190","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0001-2998(86)80027-7","article-title":"ALARA and an integrated approach to radiation protection","volume":"16","author":"Hendee","year":"1986","journal-title":"Semin Nucl Med"},{"key":"10.1016\/j.phro.2024.100586_b0195","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ab1459","article-title":"Impact of setup and range uncertainties on TCP and NTCP following VMAT or IMPT of oropharyngeal cancer patients","volume":"64","author":"Hamming-Vrieze","year":"2019","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2024.100586_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109488","article-title":"Inter- and intrafractional 4D dose accumulation for evaluating \u0394NTCP robustness in lung cancer","volume":"182","author":"Smolders","year":"2023","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2024.100586_b0205","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/acm2.12072","article-title":"Evaluation of the truebeam machine performance check (MPC): mechanical and collimation checks","volume":"18","author":"Barnes","year":"2017","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2024.100586_b0210","series-title":"Intensity-modulated radiation therapy: the state of the art","first-page":"593","article-title":"Tolerance limits and action levels for planning and delivery of IMRT","author":"Palta","year":"2003"},{"key":"10.1016\/j.phro.2024.100586_b0215","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1118\/1.3190392","article-title":"Task Group 142 report: quality assurance of medical accelerators","volume":"36","author":"Klein","year":"2009","journal-title":"Med Phys"},{"key":"10.1016\/j.phro.2024.100586_b0220","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/aae659","article-title":"Robust radiotherapy planning","volume":"63","author":"Unkelbach","year":"2018","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.phro.2024.100586_b0225","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1118\/1.3679340","article-title":"Robust optimization of intensity modulated proton therapy","volume":"39","author":"Liu","year":"2012","journal-title":"Med Phys"}],"container-title":["Physics and Imaging in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631624000563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631624000563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T20:21:52Z","timestamp":1730838112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405631624000563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":45,"alternative-id":["S2405631624000563"],"URL":"https:\/\/doi.org\/10.1016\/j.phro.2024.100586","relation":{},"ISSN":["2405-6316"],"issn-type":[{"value":"2405-6316","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Robustness analysis of dynamic trajectory radiotherapy and volumetric modulated arc therapy plans for head and neck cancer","name":"articletitle","label":"Article Title"},{"value":"Physics and Imaging in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phro.2024.100586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of European Society of Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100586"}}