{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:40:27Z","timestamp":1776084027343,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004241","name":"China Primary Health Care Foundation","doi-asserted-by":"publisher","award":["chmdf2025-xrky02-19"],"award-info":[{"award-number":["chmdf2025-xrky02-19"]}],"id":[{"id":"10.13039\/501100004241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011676","name":"Elekta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011676","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","phiro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physics and Imaging in Radiation Oncology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.phro.2026.100923","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:21:00Z","timestamp":1770826860000},"page":"100923","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Potential of margin reduction for cervical cancer radiotherapy in an online adaptive image-guided workflow"],"prefix":"10.1016","volume":"37","author":[{"given":"FangHua","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShouLiang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZhanLin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JunYun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XinPing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WeiJun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"OuYang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoDan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FoPing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phro.2026.100923_b0005","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.clon.2021.10.010","article-title":"Set-up Errors, Organ Motion, Tumour Regression and its Implications on Internal Target Volume-Planning Target volume during Cervical Cancer Radiotherapy: results from a prospective Study","volume":"34","author":"Mahantshetty","year":"2022","journal-title":"Clin Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0010","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.14480","article-title":"Setup errors analysis in iterative kV CBCT: a clinical study of cervical cancer treated with Volumetric Modulated Arc Therapy","volume":"25","author":"Xiao","year":"2024","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2026.100923_b0015","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.radonc.2008.04.016","article-title":"An assessment of interfractional uterine and cervical motion: implications for radiotherapy target volume definition in gynaecological cancer","volume":"88","author":"Taylor","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.radonc.2007.12.017","article-title":"Motion and deformation of the target volumes during IMRT for cervical cancer: what margins do we need?","volume":"88","author":"Bunt","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0025","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1200\/JCO.20.02530","article-title":"Late Toxicity after Adjuvant conventional Radiation Versus Image-Guided Intensity-Modulated Radiotherapy for Cervical Cancer (PARCER): a Randomized Controlled Trial","volume":"39","author":"Chopra","year":"2021","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0030","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1200\/JCO.2017.77.4273","article-title":"Patient-Reported Toxicity during Pelvic Intensity-Modulated Radiation Therapy: NRG Oncology-RTOG 1203","volume":"36","author":"Klopp","year":"2018","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0035","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.clon.2021.06.007","article-title":"Adaptive Radiotherapy in the Management of Cervical Cancer: Review of strategies and Clinical Implementation","volume":"33","author":"Shelley","year":"2021","journal-title":"Clin Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0040","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.3390\/medicina59101735","article-title":"Recent advances and Adaptive strategies in image Guidance for Cervical Cancer Radiotherapy","volume":"59","author":"Anghel","year":"2023","journal-title":"Medicina"},{"key":"10.1016\/j.phro.2026.100923_b0045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13014-023-02394-2","article-title":"Evaluation of PTV margins with daily iterative online adaptive radiotherapy for postoperative treatment of endometrial and cervical cancer: a prospective single-arm phase 2 study","volume":"19","author":"Wang","year":"2024","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1399468","article-title":"First implementation and results of online adaptive radiotherapy for cervical cancer based on CT-Linac combination","volume":"14","author":"Jiang","year":"2024","journal-title":"Front Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0055","article-title":"Implementing cone-beam computed tomography-guided online adaptive radiotherapy in cervical cancer","volume":"40","author":"Shelley","year":"2023","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0060","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.phro.2026.100923_b0065","doi-asserted-by":"crossref","first-page":"209","DOI":"10.5603\/RPOR.a2021.0135","article-title":"A single centre evaluation of the 2019 UK SABR consortium guidelines for primary lung cancer: correlation between Prescription Dose Spillage and inverse Paddick Conformity Index","volume":"27","author":"Gray","year":"2022","journal-title":"Rep Pract Oncol Radiother"},{"key":"10.1016\/j.phro.2026.100923_b0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0360-3016(91)90173-2","article-title":"Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations","volume":"21","author":"Kutcher","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2026.100923_b0075","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0360-3016(01)02805-X","article-title":"Inclusion of geometric uncertainties in treatment plan evaluation","volume":"52","author":"van Herk","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2026.100923_b0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.semradonc.2003.10.003","article-title":"Errors and margins in radiotherapy","volume":"14","author":"van Herk","year":"2004","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0085","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ijrobp.2020.08.061","article-title":"NRG Oncology\/RTOG Consensus guidelines for Delineation of Clinical Target volume for Intensity Modulated Pelvic Radiation Therapy in Postoperative Treatment of Endometrial and Cervical Cancer: an Update","volume":"109","author":"Small","year":"2021","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2026.100923_b0090","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.radonc.2018.02.013","article-title":"An atlas to aid delineation of para-aortic lymph node region in cervical cancer: Design and validation of contouring guidelines","volume":"127","author":"Keenan","year":"2018","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0095","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.4066","article-title":"Comparison of Online-Onboard Adaptive Intensity-Modulated Radiation Therapy or Volumetric-Modulated Arc Radiotherapy with Image-Guided Radiotherapy for patients with Gynecologic Tumors in Dependence on Fractionation and the Planning Target volume Margin","volume":"6","author":"Guberina","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.phro.2026.100923_b0100","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.14596","article-title":"Modeling dosimetric benefits from daily adaptive RT for gynecological cancer patients with and without knowledge-based dose prediction","volume":"26","author":"Ghimire","year":"2025","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2026.100923_b0105","first-page":"9","article-title":"Forecasting patient-specific dosimetric benefit from daily online adaptive radiotherapy for cervical cancer. Biomed Phys Eng","author":"Ghimire","year":"2023","journal-title":"Express"},{"key":"10.1016\/j.phro.2026.100923_b0110","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1186\/s12885-023-11089-6","article-title":"Fan beam CT-guided online adaptive external radiotherapy of uterine cervical cancer: a dosimetric evaluation","volume":"23","author":"Peng","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.phro.2026.100923_b0115","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.ijrobp.2011.10.011","article-title":"Individualized nonadaptive and online-adaptive intensity-modulated radiotherapy treatment strategies for cervical cancer patients based on pretreatment acquired variable bladder filling computed tomography scans","volume":"83","author":"Bondar","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2026.100923_b0120","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.clon.2024.01.005","article-title":"Improved Dosimetry with Daily Online Adaptive Radiotherapy for Cervical Cancer: Waltzing the Pear","volume":"36","author":"Yen","year":"2024","journal-title":"Clin Oncol"},{"key":"10.1016\/j.phro.2026.100923_b0125","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ijrobp.2023.09.045","article-title":"Clinical Implementation of \u201cPlan of the Day\u201d strategy in Definitive Radiation Therapy of Cervical Cancer: Online Adaptation to Address the Challenge of Organ filling Reproducibility","volume":"118","author":"Ghosh","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2026.100923_b0130","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.4103\/jcrt.JCRT_253_19","article-title":"Implications of bladder volume on target coverage and dose to critical structures during high dose rate intracavitary brachytherapy for cervical cancer: a dosimetric study","volume":"15","author":"Patel","year":"2019","journal-title":"J Cancer Res Ther"},{"key":"10.1016\/j.phro.2026.100923_b0135","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.14097","article-title":"Evaluation of bladder filling effects on the dose distribution during radiotherapy for cervical cancer based on daily CT images","volume":"24","author":"Zhang","year":"2023","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.phro.2026.100923_b0140","unstructured":"https:\/\/www.chictr.org.cn\/."}],"container-title":["Physics and Imaging in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631626000230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631626000230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:40:23Z","timestamp":1776080423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405631626000230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"alternative-id":["S2405631626000230"],"URL":"https:\/\/doi.org\/10.1016\/j.phro.2026.100923","relation":{},"ISSN":["2405-6316"],"issn-type":[{"value":"2405-6316","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential of margin reduction for cervical cancer radiotherapy in an online adaptive image-guided workflow","name":"articletitle","label":"Article Title"},{"value":"Physics and Imaging in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phro.2026.100923","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Society of Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}],"article-number":"100923"}}