{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:39:31Z","timestamp":1793104771826,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K25CA283145"],"award-info":[{"award-number":["K25CA283145"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG070988"],"award-info":[{"award-number":["R01AG070988"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG053949"],"award-info":[{"award-number":["R01AG053949"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG064027"],"award-info":[{"award-number":["R01AG064027"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","phiro.science","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physics and Imaging in Radiation Oncology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.phro.2026.101081","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:46:51Z","timestamp":1790178411000},"page":"101081","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["AI-based detection of temporal changes in MR-Linac images acquired during routine prostate radiotherapy"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0569-1651","authenticated-orcid":false,"given":"Seungbin","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7488-0672","authenticated-orcid":false,"given":"Joshua","family":"Paik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5103-3311","authenticated-orcid":false,"given":"Ryan","family":"Pennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7238-8604","authenticated-orcid":false,"given":"Francesca","family":"Khani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2381-6910","authenticated-orcid":false,"given":"Himanshu","family":"Nagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"McClure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9988-5571","authenticated-orcid":false,"given":"Emily S.","family":"Weg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7068-719X","authenticated-orcid":false,"given":"Mert R.","family":"Sabuncu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8212-707X","authenticated-orcid":false,"given":"Daniel","family":"Margolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-9755","authenticated-orcid":false,"given":"Heejong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.phro.2026.101081_b1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.eururo.2016.08.003","article-title":"EAU-ESTRO-SIOG guidelines on prostate cancer. Part 1: Screening, diagnosis, and local treatment with curative intent","volume":"71","author":"Mottet","year":"2017","journal-title":"Eur Urol"},{"issue":"1","key":"10.1016\/j.phro.2026.101081_b2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13014-020-01604-5","article-title":"Dosimetric effects of adaptive prostate cancer radiotherapy in an MR-linac workflow","volume":"15","author":"Mannerberg","year":"2020","journal-title":"Radiat Oncol"},{"issue":"14","key":"10.1016\/j.phro.2026.101081_b3","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.3390\/jcm11144044","article-title":"Towards accurate and precise image-guided radiotherapy: Clinical applications of the MR-Linac","volume":"11","author":"Randall","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.phro.2026.101081_b4","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1117874","article-title":"MRI-LINAC: A transformative technology in radiation oncology","volume":"13","author":"Ng","year":"2023","journal-title":"Front Oncol"},{"issue":"Suppl 3","key":"10.1016\/j.phro.2026.101081_b5","first-page":"65","article-title":"MRI-guided radiotherapy for prostate cancer: a new paradigm","volume":"61","author":"Murgi\u0107","year":"2022","journal-title":"Acta Clin Croat"},{"key":"10.1016\/j.phro.2026.101081_b6","article-title":"Case report: MR-Guided adaptive radiotherapy, some room to maneuver","volume":"12","author":"Li","year":"2022","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.phro.2026.101081_b7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.semradonc.2019.02.007","article-title":"Adaptive radiotherapy for anatomical changes","volume":"29","author":"Sonke","year":"2019","journal-title":"Semin Radiat Oncol"},{"issue":"6","key":"10.1016\/j.phro.2026.101081_b8","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.3390\/cancers16061206","article-title":"Adaptive radiotherapy: Next-Generation radiotherapy","volume":"16","author":"Dona Lemus","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"9","key":"10.1016\/j.phro.2026.101081_b9","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1016\/j.clon.2022.03.022","article-title":"Prostate volume changes during extreme and moderately hypofractionated magnetic resonance image-guided radiotherapy","volume":"34","author":"Alexander","year":"2022","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.phro.2026.101081_b10","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.110043","article-title":"Prostate volume variation during 1.5t MR-guided adaptive stereotactic body radiotherapy (SBRT) and correlation with treatment toxicity","volume":"190","author":"Nicosia","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.phro.2026.101081_b11","article-title":"Changes in prostate volume during prostate SBRT delivered on an MR-Linac and correlation with acute toxicity","volume":"54","author":"Gurewitz","year":"2025","journal-title":"Clin Transl Radiat Oncol"},{"issue":"18","key":"10.1016\/j.phro.2026.101081_b12","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.3390\/cancers14184475","article-title":"Longitudinal changes and predictive value of multiparametric MRI features for prostate cancer patients treated with MRI-Guided lattice extreme ablative dose (LEAD) boost radiotherapy","volume":"14","author":"Algohary","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.phro.2026.101081_b13","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24557","article-title":"Longitudinal analysis of T2 relaxation time variations following radiotherapy for prostate cancer","volume":"10","author":"Hanzlikova","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.phro.2026.101081_b14","doi-asserted-by":"crossref","DOI":"10.1016\/j.mri.2025.110431","article-title":"Longitudinal quantitative MRI in prostate cancer after radiation therapy with and without androgen deprivation therapy","volume":"122","author":"Wang","year":"2025","journal-title":"Magn Reson Imaging"},{"issue":"2","key":"10.1016\/j.phro.2026.101081_b15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2478\/raon-2023-0020","article-title":"Longitudinal monitoring of apparent diffusion coefficient (ADC) in patients with prostate cancer undergoing MR-guided radiotherapy on an MR-Linac at 1.5 T: a prospective feasibility study","volume":"57","author":"Almansour","year":"2023","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.phro.2026.101081_b16","article-title":"Repeatability and reproducibility of prostate apparent diffusion coefficient values on a 1.5 T magnetic resonance linear accelerator","volume":"30","author":"Fernando","year":"2024","journal-title":"Phys Imaging Radiat Oncol"},{"key":"10.1016\/j.phro.2026.101081_b17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.media.2017.07.005","article-title":"A survey on deep learning in medical image analysis","volume":"42","author":"Litjens","year":"2017","journal-title":"Med Image Anal"},{"issue":"8","key":"10.1016\/j.phro.2026.101081_b18","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2411492122","article-title":"Learning-based inference of longitudinal image changes: Applications in embryo development, wound healing, and aging brain","volume":"122","author":"Kim","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phro.2026.101081_b19","series-title":"Advances in neural information processing systems","first-page":"737","article-title":"Signature verification using a \u201csiamese\u201d time delay neural network","volume":"vol. 6","author":"Bromley","year":"1994"},{"key":"10.1016\/j.phro.2026.101081_b20","series-title":"2005 IEEE computer society conference on computer vision and pattern recognition","first-page":"539","article-title":"Learning a similarity metric discriminatively, with application to face verification","volume":"1","author":"Chopra","year":"2005"},{"key":"10.1016\/j.phro.2026.101081_b21","series-title":"Learning to compare longitudinal images","author":"Kim","year":"2023"},{"key":"10.1016\/j.phro.2026.101081_b22","series-title":"Proceedings of the IEEE conference on computer vision and pattern recognition","first-page":"770","article-title":"Deep residual learning for image recognition","author":"He","year":"2016"},{"key":"10.1016\/j.phro.2026.101081_b23","series-title":"Proceedings of the 26th annual international conference on machine learning","first-page":"41","article-title":"Curriculum learning","author":"Bengio","year":"2009"},{"issue":"4","key":"10.1016\/j.phro.2026.101081_b24","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ijrobp.2006.04.029","article-title":"Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference","volume":"65","author":"Roach","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.phro.2026.101081_b25","series-title":"Proceedings of the IEEE international conference on computer vision","first-page":"618","article-title":"Grad-CAM: Visual explanations from deep networks via Gradient-Based localization","author":"Selvaraju","year":"2017"},{"issue":"1","key":"10.1016\/j.phro.2026.101081_b26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13014-023-02221-8","article-title":"Clinical application of MR-Linac in tumor radiotherapy: a systematic review","volume":"18","author":"Liu","year":"2023","journal-title":"Radiat Oncol"},{"issue":"7","key":"10.1016\/j.phro.2026.101081_b27","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bulcan.2022.03.011","article-title":"Urinary toxicity in patients treated with radical EBRT for prostate cancer: Analysis of predictive factors in an historical series","volume":"109","author":"Pisani","year":"2022","journal-title":"Bull Cancer"},{"key":"10.1016\/j.phro.2026.101081_b28","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.radonc.2022.04.022","article-title":"Accumulated bladder wall dose is correlated with patient-reported acute urinary toxicity in prostate cancer patients treated with stereotactic, daily adaptive MR-guided radiotherapy","volume":"171","author":"Willigenburg","year":"2022","journal-title":"Radiother Oncol"}],"container-title":["Physics and Imaging in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631626001818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405631626001818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:28:58Z","timestamp":1793104138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405631626001818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"alternative-id":["S2405631626001818"],"URL":"https:\/\/doi.org\/10.1016\/j.phro.2026.101081","relation":{},"ISSN":["2405-6316"],"issn-type":[{"value":"2405-6316","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AI-based detection of temporal changes in MR-Linac images acquired during routine prostate radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Physics and Imaging in Radiation Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phro.2026.101081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of European Society of Radiotherapy & Oncology.","name":"copyright","label":"Copyright"}],"article-number":"101081"}}