{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:47:38Z","timestamp":1784382458828,"version":"3.55.0"},"reference-count":22,"publisher":"Korea Disease Control and Prevention Agency","issue":"1","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T00:00:00Z","timestamp":1424044800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["kcdc-phrp.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osong Public Health and Research Perspectives"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.phrp.2014.10.012","type":"journal-article","created":{"date-parts":[[2014,12,20]],"date-time":"2014-12-20T04:33:25Z","timestamp":1419050005000},"page":"9-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Preparation and Evaluation of a New Lipopolysaccharide-based Conjugate as a Vaccine Candidate for Brucellosis"],"prefix":"10.24171","volume":"6","author":[{"given":"Seyed Davar","family":"Siadat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzam","family":"Vaziri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamak","family":"Eftekhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Karbasian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arfa","family":"Moshiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad R.","family":"Aghasadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi S.","family":"Ardestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghdad Abdollahpour","family":"Alitappeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Arsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Fateh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin Najar","family":"Peerayeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad R.","family":"Bahrmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31909","reference":[{"key":"10.1016\/j.phrp.2014.10.012_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3844\/ajidsp.2009.11.16","article-title":"Serological evaluation of Brucella abortus S99 lipopolysaccharide extracted by an optimized method","volume":"5","author":"Sharifat Salmani","year":"2009","journal-title":"Am J Infect Dis"},{"key":"10.1016\/j.phrp.2014.10.012_bib2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF03175612","article-title":"Outer membrane vesicle of Neisseria meningitidis serogroup B as an adjuvant to induce specific antibody response against the lipopolysaccharide of Brucella abortus S99","volume":"59","author":"Sharifat Salmani","year":"2009","journal-title":"Ann Microbiol"},{"key":"10.1016\/j.phrp.2014.10.012_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3923\/jm.2008.1.8","article-title":"Optimization of Brucella abortus fermenter cultural conditions and LPS extraction methods for antigen production","volume":"3","author":"Shapuri","year":"2008","journal-title":"Res J Microbiol"},{"key":"10.1016\/j.phrp.2014.10.012_bib4","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1128\/IAI.73.5.2790-2796.2005","article-title":"Synthesis and characterization of lipooligosaccharide-based conjugate vaccines for serotype B Moraxella catarrhalis","volume":"73","author":"Sh","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.phrp.2014.10.012_bib5","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1128\/IAI.01915-06","article-title":"Biological and immunological characteristics of lipooligosaccharide-based conjugate vaccines for serotype C Moraxella catarrhalis","volume":"75","author":"Sh","year":"2007","journal-title":"Infect Immun"},{"key":"10.1016\/j.phrp.2014.10.012_bib6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3923\/jm.2007.436.444","volume":"2","author":"Siadat","year":"2007","journal-title":"Res J Microbiol"},{"key":"10.1016\/j.phrp.2014.10.012_bib7","first-page":"129","article-title":"Past, present and future perspective of meningococcal vaccine","volume":"1","author":"Siadat","year":"2007","journal-title":"J Infect Develop Countries"},{"key":"10.1016\/j.phrp.2014.10.012_bib8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3923\/jm.2007.337.345","article-title":"Comparative studies of conjugated capsular polysaccharide of Neisseria meningitidis serogroup A with outer membrane vesicle of Neisseria meningitidis serogroup B","volume":"2","author":"Siadat","year":"2007","journal-title":"Res J Microbiol"},{"key":"10.1016\/j.phrp.2014.10.012_bib9","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/0264-410X(91)90010-4","article-title":"Induction of antibody and protective responses in mice by Brucella O-polysaccharide\u2013BSA conjugate","volume":"9","author":"Jacques","year":"1991","journal-title":"Vaccine"},{"key":"10.1016\/j.phrp.2014.10.012_bib10","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1099\/00221287-139-7-1551","article-title":"Characterization of O-polysaccharide-specific monoclonal antibodies derived from mice infected with the rough Brucella melitensis strain B115","volume":"139","author":"Cloeckaert","year":"1993","journal-title":"J\u00a0Gen Microbiol"},{"key":"10.1016\/j.phrp.2014.10.012_bib11","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0264-410X(96)00018-7","article-title":"Immunization of mice with recombinant L7\/L12 ribosomal protein confers protection against Brucella abortus infection","volume":"14","author":"Oliveira","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.phrp.2014.10.012_bib12","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1128\/IAI.71.9.5115-5120.2003","article-title":"Preparation and characterization of group A meningococcal capsular polysaccharide conjugates and evaluation of their immunogenicity in mice","volume":"71","author":"Jin","year":"2003","journal-title":"Infect Immun"},{"key":"10.1016\/j.phrp.2014.10.012_bib13","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1128\/IAI.00331-06","article-title":"Comparison of protective efficacy of subcutaneous versus intranasal immunization of mice with a Brucella melitensis lipopolysaccharide subunit vaccine","volume":"74","author":"Bhattacharjee","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.phrp.2014.10.012_bib14","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/BF03179226","article-title":"Measurement of opsonophagocytic activity of antibodies specific to Neisseria meningitidis serogroup A capsular polysaccharide-serogroup B outer membrane vesicle conjugate in animal model","volume":"59","author":"Kheirandish","year":"2009","journal-title":"Ann Microbiol"},{"key":"10.1016\/j.phrp.2014.10.012_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1469-0691.2003.00530.x","article-title":"Carbohydrate\u2013protein conjugate vaccines","volume":"9","author":"Ada","year":"2003","journal-title":"Clin Microbiol Infect"},{"issue":"Suppl. 2","key":"10.1016\/j.phrp.2014.10.012_bib16","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/j.vaccine.2005.01.131","article-title":"New method for obtaining conjugated vaccines","volume":"24","author":"Cabrera","year":"2006","journal-title":"Vaccine"},{"issue":"Suppl. 2","key":"10.1016\/j.phrp.2014.10.012_bib17","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.vaccine.2005.01.130","article-title":"Preparation and evaluation of Vibrio cholerae O1 EL Tor Ogawa lipopolysaccharide\u2013tetanus toxoid conjugates","volume":"24","author":"Cabrera","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.phrp.2014.10.012_bib18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.vaccine.2005.07.064","article-title":"Outer membrane vesicles of Neisseria lactamica as a potential mucosal adjuvant","volume":"24","author":"Sardinas","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.phrp.2014.10.012_bib19","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.3923\/pjbs.2007.3578.3584","article-title":"A flow cytometric opsonophagocytic assay for measurement of functional antibodies elicited after immunization with outer membrane vesicle of Neisseria meningitidis serogroup B","volume":"10","author":"Siadat","year":"2007","journal-title":"Pak J Bio Sci"},{"key":"10.1016\/j.phrp.2014.10.012_bib20","first-page":"29","article-title":"Biological and immunological characteristics of Brucella abortus S99 major outer membrane proteins","volume":"4","author":"Siadat","year":"2011","journal-title":"Jundishapur J Microbiol"},{"key":"10.1016\/j.phrp.2014.10.012_bib21","first-page":"576","article-title":"Optimization of Brucella abortus S99 lipopolysaccharide extraction by phenol and butanol methods","volume":"3","author":"Sharifat Salmani","year":"2008","journal-title":"Res J Bio Sci"},{"key":"10.1016\/j.phrp.2014.10.012_bib22","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1128\/IAI.56.11.2808-2817.1988","article-title":"Effectiveness of natural and synthetic complexes of porin and O-polysaccharide as vaccines against Brucella abortus in mice","volume":"56","author":"Winter","year":"1988","journal-title":"Infect Immun"}],"container-title":["Osong Public Health and Research Perspectives"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S221090991400157X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S221090991400157X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T21:32:53Z","timestamp":1628803973000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221090991400157X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S221090991400157X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrp.2014.10.012","relation":{},"ISSN":["2210-9099"],"issn-type":[{"value":"2210-9099","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation and Evaluation of a New Lipopolysaccharide-based Conjugate as a Vaccine Candidate for Brucellosis","name":"articletitle","label":"Article Title"},{"value":"Osong Public Health and Research Perspectives","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.phrp.2014.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Korea LLC.","name":"copyright","label":"Copyright"}]}}