{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:31:06Z","timestamp":1792276266100,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.phrs.2004.09.004","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T00:42:41Z","timestamp":1103157761000},"page":"269-274","source":"Crossref","is-referenced-by-count":15,"title":["Hospital-based intensive monitoring of antibiotic-induced adverse events in a university hospital"],"prefix":"10.1016","volume":"51","author":[{"given":"Filomena","family":"Mazzeo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Capuano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Avolio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Filippelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2004.09.004_bib1","first-page":"1091","article-title":"Control charts to monitor rates of adverse drug reactions","volume":"30","author":"Schumock","year":"1995","journal-title":"Hosp Pharm"},{"key":"10.1016\/j.phrs.2004.09.004_bib2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s002280050571","article-title":"Computerized surveillance of adverse drug reactions in hospital: implementation","volume":"54","author":"Levy","year":"1999","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.phrs.2004.09.004_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2165\/00002018-200225060-00007","article-title":"Signal generation in the New Zealand Intensive Medicines Monitoring Programme: a combined clinical and statistical approach","volume":"25","author":"Coulter","year":"2002","journal-title":"Drug Saf"},{"key":"10.1016\/j.phrs.2004.09.004_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/pds.668","article-title":"A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions","volume":"11","author":"van Puijenbroek","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.phrs.2004.09.004_bib5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2165\/00002018-200225060-00011","article-title":"Signal selection and follow-up in pharmacovigilance","volume":"25","author":"Meyboom","year":"2002","journal-title":"Drug Saf"},{"key":"10.1016\/j.phrs.2004.09.004_bib6","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1136\/bmj.316.7140.1295","article-title":"Fortnightly review: adverse drug reactions","volume":"316","author":"Pirmohamed","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2004.09.004_bib7","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1136\/bmj.327.7425.1222","article-title":"Joining the DoTS: new approach to classifying adverse drug reactions","volume":"327","author":"Aronson","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2004.09.004_bib8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2125.2003.01968.x","article-title":"Application of data mining techniques in Pharmacovigilance","volume":"57","author":"Wilson","year":"2004","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.phrs.2004.09.004_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1469-0691.2001.00086.x","article-title":"Impact of registration procedures on antibiotic policies","volume":"7","author":"Schlemmer","year":"2001","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.phrs.2004.09.004_bib10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1046\/j.1469-0691.2001.00079.x","article-title":"Quality of antimicrobial drug prescription in hospital","volume":"7","author":"van der Meer","year":"2001","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.phrs.2004.09.004_bib11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1155\/1996\/685704","article-title":"A multidisciplinary hospital-based antimicrobial use program: impact on hospital pharmacy expenditures and drug use","volume":"7","author":"Salama","year":"1996","journal-title":"Can J Infect Dis"},{"key":"10.1016\/j.phrs.2004.09.004_bib12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1179\/joc.2002.14.4.332","article-title":"Antibiotic use in an Italian university hospital","volume":"14","author":"Mazzeo","year":"2002","journal-title":"J Chemother"},{"key":"10.1016\/j.phrs.2004.09.004_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s002280050727","article-title":"Antibiotic utilization at the university hospital after introducing an antibiotic policy","volume":"56","author":"Vlahovic-Palcevski","year":"2000","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.phrs.2004.09.004_bib14","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2165\/00002018-200124130-00003","article-title":"Methods and systems to detect adverse drug reactions in hospitals","volume":"24","author":"Thurmann","year":"2001","journal-title":"Drug Saf"},{"key":"10.1016\/j.phrs.2004.09.004_bib15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo","year":"1981","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.phrs.2004.09.004_bib16","unstructured":"World Health Organization (WHO), Collaborating Centers for International Drug Monitoring. Geneva: WHO 1984. Report no: DEM\/NC\/84.159 (E)."},{"key":"10.1016\/j.phrs.2004.09.004_bib17","first-page":"89","article-title":"Monitoraggio intensivo ospedaliero delle reazioni avverse da ACE-inibitory","volume":"7","author":"Mangrella","year":"1998","journal-title":"Minerva Medica"},{"key":"10.1016\/j.phrs.2004.09.004_bib18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2165\/00002018-199716060-00002","article-title":"Principles of signal detection in pharmacovigilance","volume":"16","author":"Meyboom","year":"1997","journal-title":"Drug Saf"},{"key":"10.1016\/j.phrs.2004.09.004_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2125.1998.00774.x","article-title":"Prescription-event monitoring recent progress and future horizons","volume":"46","author":"Mann","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.phrs.2004.09.004_bib20","doi-asserted-by":"crossref","first-page":"C32","DOI":"10.1016\/S0149-2918(98)80006-4","article-title":"Postmarketing drug surveillance: an epidemiologic approach","volume":"20","author":"Hennessy","year":"1998","journal-title":"Clin Ther"},{"key":"10.1016\/j.phrs.2004.09.004_bib21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1365-2125.1998.00667.x","article-title":"Frequency and cost of serious adverse drug reactions in a department of general medicine","volume":"45","author":"Moore","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.phrs.2004.09.004_bib22","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/jama.279.15.1200","article-title":"Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies","volume":"279","author":"Lazarou","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.phrs.2004.09.004_bib23","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1542\/peds.110.2.254","article-title":"Survey of adverse drug reactions on a pediatric ward: a strategy for early and detailed detection","volume":"110","author":"Weiss","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.phrs.2004.09.004_bib24","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1046\/j.1532-5415.2002.50607.x","article-title":"Adverse drug reaction as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the elderly (GIFA)","volume":"50","author":"Onder","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.phrs.2004.09.004_bib25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s002280050669","article-title":"Adverse drug reactions and polypharmacy in the elderly in general practice","volume":"55","author":"Veehof","year":"1999","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.phrs.2004.09.004_bib26","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1179\/joc.2003.15.6.568","article-title":"Modification of patients endogenous bacterial flora during hospitalization in a large teaching hospital in Naples","volume":"15","author":"Esposito","year":"2003","journal-title":"J Chemother"},{"key":"10.1016\/j.phrs.2004.09.004_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00000441-197701000-00008","article-title":"The effect of an educational program upon hospital antibiotic use","volume":"273","author":"Jones","year":"1977","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.phrs.2004.09.004_bib28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1365-2125.2000.00132.x","article-title":"Epidemiology of drug exposure and adverse drug reactions in two Swiss departments of internal medicine","volume":"49","author":"Fattinger","year":"2000","journal-title":"Br J Clin Pharmacol"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366180400221X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366180400221X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T01:54:31Z","timestamp":1548899671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366180400221X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S104366180400221X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2004.09.004","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}