{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:25:39Z","timestamp":1792697139989,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.phrs.2008.03.011","type":"journal-article","created":{"date-parts":[[2008,4,2]],"date-time":"2008-04-02T13:31:56Z","timestamp":1207143116000},"page":"369-373","source":"Crossref","is-referenced-by-count":25,"title":["The PDLIM5 gene and lithium prophylaxis: An association and gene expression analysis in Sardinian patients with bipolar disorder"],"prefix":"10.1016","volume":"57","author":[{"given":"Alessio","family":"Squassina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Congiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Manconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Manchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Chillotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Lampus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Severino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Del","family":"Zompo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2008.03.011_bib1","series-title":"Manic-depressive illness","author":"Goodwin","year":"1990"},{"key":"10.1016\/j.phrs.2008.03.011_bib2","series-title":"Origin, prevention and treatment of affective disorders","author":"Shou","year":"1979"},{"key":"10.1016\/j.phrs.2008.03.011_bib3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1001\/archpsyc.1997.01830130020004","article-title":"Current therapeutic profile of lithium","volume":"54","author":"Gershon","year":"1997","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1056\/NEJM199409013310907","article-title":"Lithium in the treatment of mood disorders","volume":"331","author":"Price","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.phrs.2008.03.011_bib5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/mi.4.5.6","article-title":"Molecular effects of lithium","volume":"4","author":"Quiroz","year":"2004","journal-title":"Mol Interv"},{"key":"10.1016\/j.phrs.2008.03.011_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1017\/S1461145703003419","article-title":"Cellular mechanisms and second messengers: relevance to the psychopharmacology of bipolar disorders","volume":"6","author":"Brunello","year":"2003","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.phrs.2008.03.011_bib7","first-page":"37","article-title":"Neurobiology of lithium: an update","volume":"59","author":"LinksLenox","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib8","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1073\/pnas.82.4.1286","article-title":"Lithium induces corticotropin secretion and de-sensitization in cultured anterior pituitary cells","volume":"82","author":"Zatz","year":"1985","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.phrs.2008.03.011_bib9","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1471-4159.1987.tb00976.x","article-title":"Interactions between lithium, calcium, diacylglycerides and phorbol esters in the regulation of ACTH release from AtT-20 cells","volume":"49","author":"Reisine","year":"1987","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2008.03.011_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF00442810","article-title":"Lithium inhibition of protein kinase C activation-induced serotonin release","volume":"99","author":"Wang","year":"1989","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.phrs.2008.03.011_bib11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0006-3223(91)91285-Y","article-title":"Effects of chronic lithium treatment on protein kinase C and cyclic AMP-dependent protein phosphorylation","volume":"29","author":"Casebolt","year":"1991","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0006-8993(92)90598-4","article-title":"Chronic lithium administration alters a prominent PKC substrate in rat hippocampus","volume":"570","author":"Lenox","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.phrs.2008.03.011_bib13","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1111\/j.1471-4159.1993.tb07474.x","article-title":"Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the a isozyme","volume":"61","author":"Manji","year":"1993","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2008.03.011_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0924-977X(96)00396-3","article-title":"Altered protein phosphorylation in the rat brain following chronic lithium and carbamazepine treatments","volume":"7","author":"Jensen","year":"1997","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.phrs.2008.03.011_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1034\/j.1399-5618.2000.20303.x","article-title":"Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo","volume":"2","author":"Chen","year":"2000","journal-title":"Bipolar Disord"},{"key":"10.1016\/j.phrs.2008.03.011_bib16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jpsychires.2004.10.007","article-title":"Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patients","volume":"39","author":"Hahn","year":"2005","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.phrs.2008.03.011_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/361165a0","article-title":"Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission","volume":"361","author":"Swartz","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2008.03.011_bib18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nn1041","article-title":"A PKC\u025b-ENH-channel complex specifically modulates N-type Ca2+ channels","volume":"6","author":"Maeno-Hikichi","year":"2003","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.phrs.2008.03.011_bib19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cellsig.2005.04.007","article-title":"Essential role of the LIM domain in the formation of the PKCepsilon-ENH-N-type Ca2+ channel complex","volume":"18","author":"Chen","year":"2006","journal-title":"Cell Signal."},{"key":"10.1016\/j.phrs.2008.03.011_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1176\/ajp.149.1.118","article-title":"Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients","volume":"149","author":"Dubovsky","year":"1992","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib21","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1176\/ajp.154.7.976","article-title":"High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder","volume":"154","author":"Emamghoreishi","year":"1997","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1017\/S1461145703003717","article-title":"Mechanisms of altered Ca2+ signalling in transformed lymphoblastoid cells from patients with bipolar disorder","volume":"6","author":"Kato","year":"2003","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.phrs.2008.03.011_bib23","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/archpsyc.1989.01810070058010","article-title":"Increased platelet intracellular calcium concentration in patients with bipolar affective disorders","volume":"46","author":"Dubovsky","year":"1989","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib24","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0024-3205(90)90454-Y","article-title":"Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls","volume":"46","author":"Tan","year":"1990","journal-title":"Life Sci"},{"key":"10.1016\/j.phrs.2008.03.011_bib25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0006-3223(98)00308-4","article-title":"Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay","volume":"46","author":"Hough","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib26","doi-asserted-by":"crossref","first-page":"10896","DOI":"10.1016\/S0021-9258(19)70391-3","article-title":"The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain","volume":"255","author":"Hallcher","year":"1980","journal-title":"J Biol Chem"},{"key":"10.1016\/j.phrs.2008.03.011_bib27","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0893-133X(95)00243-7","article-title":"Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol","volume":"15","author":"Manji","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2008.03.011_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1034\/j.1399-5618.2002.40201.x","article-title":"Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection","volume":"4","author":"Li","year":"2002","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.phrs.2008.03.011_bib29","first-page":"259","article-title":"The polymorphic inositol polyphosphate 1-phosphatase gene as a candidate for pharmacogenetic prediction of lithium-responsive manic-depressive illness","volume":"8","author":"Steen","year":"1998","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.phrs.2008.03.011_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S1461145798001230","article-title":"Dopamine receptor D3 gene and response to lithium prophylaxis in mood disorders","volume":"1","author":"Serretti","year":"1998","journal-title":"Int J Neuropsychopharmacol"},{"key":"10.1016\/j.phrs.2008.03.011_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/sj.tpj.6500006","article-title":"Serotonin transporter gene associated with lithium prophylaxis in mood disorders","volume":"1","author":"Serretti","year":"2001","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.phrs.2008.03.011_bib32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/sj.tpj.6500252","article-title":"Further evidence for a possible association between serotonin transporter gene and lithium prophylaxis in mood disorders","volume":"4","author":"Serretti","year":"2004","journal-title":"Pharmacogenomics J"},{"issue":"1","key":"10.1016\/j.phrs.2008.03.011_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2004.11.022","article-title":"Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta-50 T\/C SNP","volume":"376","author":"Benedetti","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.phrs.2008.03.011_bib34","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.mp.4001437","article-title":"Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders","volume":"9","author":"Iwamoto","year":"2004","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10038-004-0136-5","article-title":"Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia","volume":"49","author":"Iwamoto","year":"2004","journal-title":"J Hum Genet"},{"key":"10.1016\/j.phrs.2008.03.011_bib36","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/sj.mp.4001719","article-title":"Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia","volume":"10","author":"Kato","year":"2005","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib37","doi-asserted-by":"crossref","unstructured":"Squassina A, Manchia M, Manconi F, Piccardi MP, Ardau R, Chillotti C, et al. A case\u2013control association study of the PDLIM5 gene and bipolar disorder in a Sardinian sample. Psychiatr Genet 2008, 18, doi:10.1097\/YPG.0b013e3282fb003d.","DOI":"10.1097\/YPG.0b013e3282fb003d"},{"key":"10.1016\/j.phrs.2008.03.011_bib38","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.1978.01770310043002","article-title":"A diagnostic interview: the schedule for affective disorders and schizophrenia","volume":"35","author":"Endicott","year":"1978","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib39","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1176\/ajp.145.7.844","article-title":"Graphic representation of the life course of illness in patients with affective disorder","volume":"145","author":"Post","year":"1988","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib40","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4088\/JCP.v63n1013","article-title":"Is response to prophylactic lithium a familial trait?","volume":"63","author":"Grof","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib41","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1093\/nar\/19.19.5444","article-title":"A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies","volume":"19","author":"Lahiri","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.phrs.2008.03.011_bib42","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF00279094","article-title":"A routine method for the establishment of permanent growing lymphoblastoid cell lines","volume":"73","author":"Neitzel","year":"1986","journal-title":"Hum Genet"},{"key":"10.1016\/j.phrs.2008.03.011_bib43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.phrs.2008.03.011_bib44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/gepi.10252","article-title":"Pedigree disequilibrium tests for multilocus haplotypes","volume":"25","author":"Dudbridge","year":"2003","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.phrs.2008.03.011_bib45","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/sj.mp.4000447","article-title":"Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder","volume":"3","author":"Turecki","year":"1998","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.phrs.2008.03.011_bib46","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.neulet.2006.05.001","article-title":"Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder","volume":"403","author":"Michelon","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.phrs.2008.03.011_bib47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00041444-200103000-00008","article-title":"The phospholipase C-gamma1 gene (PLCG1) and lithium-responsive bipolar disorder: re-examination of an intronic dinucleotide repeat polymorphism","volume":"11","author":"L\u00f8vlie","year":"2001","journal-title":"Psychiatr Genet"},{"key":"10.1016\/j.phrs.2008.03.011_bib48","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1034\/j.1399-0004.2002.610401.x","article-title":"Genetics of population isolates","volume":"61","author":"Arcos-Burgos","year":"2002","journal-title":"Clin Genet"},{"key":"10.1016\/j.phrs.2008.03.011_bib49","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/35042049","article-title":"Use of population isolates for mapping complex traits","volume":"1","author":"Peltonen","year":"2000","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.phrs.2008.03.011_bib50","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/35019167","article-title":"Manhattan versus Reykjavik","volume":"406","author":"Abbot","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2008.03.011_bib51","first-page":"154","article-title":"Pharmacogenetics of lithium response in bipolar disorder","volume":"24","author":"Alda","year":"1999","journal-title":"J Psychiatry Neurosci"},{"key":"10.1016\/j.phrs.2008.03.011_bib52","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.tpj.6500245","article-title":"Pharmacogenetics and bipolar disorder","volume":"4","author":"Mamdani","year":"2004","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.phrs.2008.03.011_bib53","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.biopsych.2005.07.041","article-title":"A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia","volume":"59","author":"Horiuchi","year":"2006","journal-title":"Biol Psychiatry"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661808000625?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661808000625?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T01:55:46Z","timestamp":1630979746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661808000625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S1043661808000625"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2008.03.011","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}