{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:57:04Z","timestamp":1791320224501,"version":"4.3.1"},"reference-count":113,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.phrs.2011.03.003","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T09:04:37Z","timestamp":1300352677000},"page":"504-511","source":"Crossref","is-referenced-by-count":156,"title":["The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension"],"prefix":"10.1016","volume":"63","author":[{"given":"Dongmin","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.S.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Wort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2011.03.003_bib0005","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1183\/09031936.00139009","article-title":"Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"34","author":"Galie","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.phrs.2011.03.003_bib0570","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCULATIONAHA.109.911818","article-title":"Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era","volume":"122","author":"Humbert","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0015","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/79226","article-title":"Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension","volume":"26","author":"Lane","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.phrs.2011.03.003_bib0020","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1086\/303059","article-title":"Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene","volume":"67","author":"Deng","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.phrs.2011.03.003_bib0025","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/jmg.37.10.741","article-title":"Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family","volume":"37","author":"Thomson","year":"2000","journal-title":"J Med Genet"},{"key":"10.1016\/j.phrs.2011.03.003_bib0030","first-page":"194","article-title":"Familial primary pulmonary hypertension: clinical patterns","volume":"129","author":"Loyd","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.phrs.2011.03.003_bib0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1086\/316947","article-title":"BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension","volume":"68","author":"Machado","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.phrs.2011.03.003_bib0040","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1161\/01.CIR.0000012754.72951.3D","article-title":"Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor","volume":"105","author":"Atkinson","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0045","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1161\/01.CIR.0000143836.40431.F5","article-title":"Signaling molecules in overcirculation-induced pulmonary hypertension in piglets: effects of sildenafil therapy","volume":"110","author":"Rondelet","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0050","doi-asserted-by":"crossref","first-page":"L450","DOI":"10.1152\/ajplung.00206.2005","article-title":"Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension","volume":"290","author":"Takahashi","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0055","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/CIRCULATIONAHA.107.736801","article-title":"Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension","volume":"118","author":"Hong","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0575","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00018-010-0518-0","article-title":"Endothelin","volume":"68","author":"Kawanabe","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.phrs.2011.03.003_bib0065","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2165\/00129784-200808030-00004","article-title":"Endothelin receptor antagonists for pulmonary arterial hypertension: rationale and place in therapy","volume":"8","author":"Price","year":"2008","journal-title":"Am J Cardiovasc Drugs"},{"issue":"Suppl. 3","key":"10.1016\/j.phrs.2011.03.003_bib0070","first-page":"S2","article-title":"Vascular biology of endothelin","volume":"32","author":"Schiffrin","year":"1998","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0075","first-page":"831","article-title":"Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease","volume":"151","author":"Abraham","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0080","first-page":"L668","article-title":"Effects of separate and combined ETA and ETB blockade on ET-1-induced constriction in perfused rat lungs","volume":"269","author":"Sato","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0580","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1096\/fj.10-161612","article-title":"Endothelin-1 gene regulation","volume":"25","author":"Stow","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.phrs.2011.03.003_bib0090","doi-asserted-by":"crossref","first-page":"12645","DOI":"10.1074\/jbc.M011344200","article-title":"Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, and p300\/CBP","volume":"276","author":"Yamashita","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.phrs.2011.03.003_bib0095","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0014-2999(91)90641-3","article-title":"Glucocorticoids induce endothelin release from vascular smooth muscle cells but not endothelial cells","volume":"199","author":"Kanse","year":"1991","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0100","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1161\/01.RES.0000078491.79697.7F","article-title":"Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression","volume":"92","author":"Rodriguez-Pascual","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.phrs.2011.03.003_bib0105","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/0024-3205(91)90434-D","article-title":"Cytokine stimulated endothelin release from endothelial cells","volume":"48","author":"Kanse","year":"1991","journal-title":"Life Sci"},{"key":"10.1016\/j.phrs.2011.03.003_bib0110","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1073\/pnas.90.13.5999","article-title":"Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP","volume":"90","author":"Malek","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2011.03.003_bib0115","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/jmcc.1998.0873","article-title":"Endothelin-1 gene suppression by shear stress: pharmacological evaluation of the role of tyrosine kinase, intracellular calcium, cytoskeleton, and mechanosensitive channels","volume":"31","author":"Malek","year":"1999","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0120","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0006-291X(91)91806-N","article-title":"Molecular cloning of a non-isopeptide-selective human endothelin receptor","volume":"178","author":"Ogawa","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.phrs.2011.03.003_bib0125","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/348730a0","article-title":"Cloning and expression of a cDNA encoding an endothelin receptor","volume":"348","author":"Arai","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2011.03.003_bib0585","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1139\/Y10-041","article-title":"Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1","volume":"88","author":"Kelland","year":"2010","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0135","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1006\/bbrc.1994.1395","article-title":"Clearance of circulating endothelin-1 by ETB receptors in rats","volume":"199","author":"Fukuroda","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.phrs.2011.03.003_bib0140","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1056\/NEJM199306173282402","article-title":"Expression of endothelin-1 in the lungs of patients with pulmonary hypertension","volume":"328","author":"Giaid","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0145","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","article-title":"A novel potent vasoconstrictor peptide produced by vascular endothelial cells","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2011.03.003_bib0150","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1073\/pnas.86.8.2863","article-title":"The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes","volume":"86","author":"Inoue","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Suppl. 48","key":"10.1016\/j.phrs.2011.03.003_bib0155","doi-asserted-by":"crossref","first-page":"S289","DOI":"10.1042\/CS103S289S","article-title":"Effects of increased pulmonary flow on the expression of endothelial nitric oxide synthase and endothelin-1 in the rat","volume":"103","author":"Dai","year":"2002","journal-title":"Clin Sci (Lond.)"},{"key":"10.1016\/j.phrs.2011.03.003_bib0160","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1159\/000226224","article-title":"Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors","volume":"46","author":"Li","year":"2009","journal-title":"J Vasc Res"},{"key":"10.1016\/j.phrs.2011.03.003_bib0165","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/sj.bjp.0701682","article-title":"Influence of applied tension and nitric oxide on responses to endothelins in rat pulmonary resistance arteries: effect of chronic hypoxia","volume":"123","author":"MacLean","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0170","first-page":"25","article-title":"Effects of hypoxia and taurine on vasoconstriction peptides from cultured bovine pulmonary arterial endothelial cells","volume":"20","author":"Yu","year":"1997","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"10.1016\/j.phrs.2011.03.003_bib0175","doi-asserted-by":"crossref","first-page":"S410","DOI":"10.1097\/00005344-200036051-00120","article-title":"The prostacyclin-mimetic cicaprost inhibits endogenous endothelin-1 release from human pulmonary artery smooth muscle cells","volume":"36","author":"Wort","year":"2000","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0180","doi-asserted-by":"crossref","first-page":"12478","DOI":"10.1073\/pnas.93.22.12478","article-title":"Lipopolysaccharide and interleukin 1 augment the effects of hypoxia and inflammation in human pulmonary arterial tissue","volume":"93","author":"Ziesche","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2011.03.003_bib0185","first-page":"L854","article-title":"Thrombin regulation of endothelin-1 gene in isolated human pulmonary endothelial cells","volume":"274","author":"Golden","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0190","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/0006-291X(89)92270-5","article-title":"Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells","volume":"159","author":"Kurihara","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.phrs.2011.03.003_bib0195","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vph.2008.09.001","article-title":"Effects of bone morphogenic proteins and transforming growth factor-beta on in-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells","volume":"50","author":"Star","year":"2009","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0200","first-page":"A5240","article-title":"Bone morphogenetic protein (BMP)-9 increases endothelin (ET)-1 release by human pulmonary artery endothelial cells via a MAPK dependent pathway","volume":"181","author":"Park","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0205","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1160\/TH09-02-0128","article-title":"Proliferative stimulation of the vascular endothelin-1 axis in vitro and ex vivo by infection with Chlamydia pneumoniae","volume":"102","author":"Kern","year":"2009","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.phrs.2011.03.003_bib0210","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/S0002-9440(10)64807-9","article-title":"Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo","volume":"157","author":"Salani","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0215","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.cellsig.2008.08.021","article-title":"Endothelin-1 promotes migration of endothelial cells through the activation of ARF6 and the regulation of FAK activity","volume":"20","author":"Daher","year":"2008","journal-title":"Cell Signal"},{"key":"10.1016\/j.phrs.2011.03.003_bib0220","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1038\/sj.onc.1210182","article-title":"Functional implication of BMP4 expression on angiogenesis in malignant melanoma","volume":"26","author":"Rothhammer","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.phrs.2011.03.003_bib0225","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1165\/ajrcmb.25.1.4331","article-title":"Endogenously released endothelin-1 from human pulmonary artery smooth muscle promotes cellular proliferation: relevance to pathogenesis of pulmonary hypertension and vascular remodeling","volume":"25","author":"Wort","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0230","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1124\/mol.64.4.923","article-title":"Role for nuclear factor-kappaB and signal transducer and activator of transcription 1\/interferon regulatory factor-1 in cytokine-induced endothelin-1 release in human vascular smooth muscle cells","volume":"64","author":"Woods","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0235","doi-asserted-by":"crossref","first-page":"24297","DOI":"10.1074\/jbc.M109.032524","article-title":"Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites","volume":"284","author":"Wort","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.phrs.2011.03.003_bib0240","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1124\/mol.62.5.1147","article-title":"Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension","volume":"62","author":"Wort","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0245","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0008-6363(00)00221-2","article-title":"Regulation of endothelin-1 synthesis in human pulmonary arterial smooth muscle cells. Effects of transforming growth factor-beta and hypoxia","volume":"49","author":"Markewitz","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phrs.2011.03.003_bib0250","first-page":"A1183","article-title":"Regulation of endothelin-1 production by the transforming growth factor beta 1\/bone morphogenetic protein pathway in human pulmonary artery smooth muscle cells","volume":"181","author":"De Souza","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0255","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.vph.2009.09.001","article-title":"Interaction between bone morphogenetic proteins and endothelin-1 in human pulmonary artery smooth muscle","volume":"51","author":"Din","year":"2009","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0260","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1258\/0007142991902286","article-title":"The role of the endothelium in modulating vascular control in sepsis and related conditions","volume":"55","author":"Wort","year":"1999","journal-title":"Br Med Bull"},{"key":"10.1016\/j.phrs.2011.03.003_bib0265","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3181\/00379727-199-43342","article-title":"Endothelin 1: mitogenic activity on pulmonary artery smooth muscle cells and release from hypoxic endothelial cells","volume":"199","author":"Hassoun","year":"1992","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0270","first-page":"L101","article-title":"Overexpression of endothelin-1 and enhanced growth of pulmonary artery smooth muscle cells from fawn-hooded rats","volume":"270","author":"Zamora","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0275","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1172\/JCI622","article-title":"Regional variability in preprozendothelin-1 gene expression in sheep pulmonary artery and lung during the onset of air-induced chronic pulmonary hypertension. Participation of arterial smooth muscle cells","volume":"101","author":"Tchekneva","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.phrs.2011.03.003_bib0280","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1203\/01.pdr.0000233056.37254.0b","article-title":"Endothelin-1 inhibits apoptosis of pulmonary arterial smooth muscle in the neonatal rat","volume":"60","author":"Jankov","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.phrs.2011.03.003_bib0590","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1139\/Y10-059","article-title":"Endothelin-1 induces pulmonary but not aortic smooth muscle cell migration by activating ERK1\/2 MAP kinase","volume":"88","author":"Meoli","year":"2010","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0595","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/ard.2010.132464","article-title":"dsRNA activation of endothelin-1 and markers of vascular activation in endothelial cells and fibroblasts","volume":"70","author":"Farina","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.phrs.2011.03.003_bib0295","doi-asserted-by":"crossref","first-page":"H700","DOI":"10.1152\/ajpheart.00326.2005","article-title":"Endothelin-1 expression in vascular adventitial fibroblasts","volume":"290","author":"An","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0300","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cardiores.2007.02.015","article-title":"NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts","volume":"75","author":"An","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phrs.2011.03.003_bib0305","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1128\/MCB.00625-06","article-title":"Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors","volume":"26","author":"Shi-Wen","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0310","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.matbio.2007.06.003","article-title":"Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts","volume":"26","author":"Shi-Wen","year":"2007","journal-title":"Matrix Biol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0315","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/jcb.20608","article-title":"Endothelin-1 induces proliferation of human lung fibroblasts and IL-11 secretion through an ET(A) receptor-dependent activation of MAP kinases","volume":"96","author":"Gallelli","year":"2005","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.phrs.2011.03.003_bib0320","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1165\/ajrcmb\/7.5.492","article-title":"Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary artery fibroblasts","volume":"7","author":"Peacock","year":"1992","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0325","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1165\/rcmb.2008-0447OC","article-title":"Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activation","volume":"41","author":"Kulasekaran","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0330","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1096\/fj.05-4702fje","article-title":"Adventitia contribution in vascular tone: insights from adventitia-derived cells in a tissue-engineered human blood vessel","volume":"20","author":"Laflamme","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.phrs.2011.03.003_bib0335","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1152\/japplphysiol.90719.2008","article-title":"Elevated levels of activin A in clinical and experimental pulmonary hypertension","volume":"106","author":"Yndestad","year":"2009","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0340","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1152\/japplphysiol.00840.2004","article-title":"Hypoxia, leukocytes, and the pulmonary circulation","volume":"98","author":"Stenmark","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0600","doi-asserted-by":"crossref","first-page":"L363","DOI":"10.1152\/ajplung.00295.2009","article-title":"BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension","volume":"299","author":"Talati","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0350","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/cvr\/cvp026","article-title":"Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation","volume":"82","author":"Anggrahini","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phrs.2011.03.003_bib0355","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1006\/bbrc.2001.5485","article-title":"The effect of endothelin-1 on nuclear factor kappa B in macrophages","volume":"286","author":"Wilson","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.phrs.2011.03.003_bib0360","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1097\/00003246-199706000-00011","article-title":"Endothelin-1 and endothelin-4 stimulate monocyte production of cytokines","volume":"25","author":"Cunningham","year":"1997","journal-title":"Crit Care Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0365","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1203\/00006450-199601000-00016","article-title":"Endothelin-1 has a priming effect on production of superoxide anion by alveolar macrophages: its possible correlation with bronchopulmonary dysplasia","volume":"39","author":"Kojima","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1016\/j.phrs.2011.03.003_bib0370","doi-asserted-by":"crossref","unstructured":"Price LC, Montani D, Tcherakian C, Dorfmuller P, Souza R, Gambaryan N, et al. Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in rats. Eur Respir J 2010; in press.","DOI":"10.1164\/ajrccm-conference.2009.179.1_MeetingAbstracts.A2358"},{"key":"10.1016\/j.phrs.2011.03.003_bib0375","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0014-5793(93)80476-B","article-title":"Increased production of endothelin-1 in the hypertrophied rat heart due to pressure overload","volume":"332","author":"Yorikane","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/j.phrs.2011.03.003_bib0380","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.RES.73.5.887","article-title":"Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension","volume":"73","author":"Miyauchi","year":"1993","journal-title":"Circ Res"},{"key":"10.1016\/j.phrs.2011.03.003_bib0385","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1161\/CIRCULATIONAHA.104.491456","article-title":"Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension","volume":"111","author":"Ivy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0390","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1152\/jappl.1997.83.4.1209","article-title":"Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats","volume":"83","author":"Hill","year":"1997","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0395","doi-asserted-by":"crossref","first-page":"PL137","DOI":"10.1016\/S0024-3205(98)00347-6","article-title":"Endothelin converting enzyme inhibitor protects development of right ventricular overload and medial thickening of pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension","volume":"63","author":"Takahashi","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.phrs.2011.03.003_bib0400","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s004330050080","article-title":"Type V phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary hypertension","volume":"197","author":"Takahashi","year":"1998","journal-title":"Res Exp Med (Berl.)"},{"key":"10.1016\/j.phrs.2011.03.003_bib0405","first-page":"R1260","article-title":"Normobaric hypoxia stimulates endothelin-1 gene expression in the rat","volume":"263","author":"Elton","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0410","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1172\/JCI15496","article-title":"Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia","volume":"111","author":"Brusselmans","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.phrs.2011.03.003_bib0415","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1152\/jappl.1994.77.3.1451","article-title":"Enhanced endothelin-1 and endothelin receptor gene expression in chronic hypoxia","volume":"77","author":"Li","year":"1994","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0420","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1165\/ajrcmb.20.4.3356","article-title":"Localization and distribution of endothelin receptor subtypes in pulmonary vasculature of normal and hypoxia-exposed rats","volume":"20","author":"Soma","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0425","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1152\/jappl.1995.79.6.2122","article-title":"Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats","volume":"79","author":"Chen","year":"1995","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0430","first-page":"H1327","article-title":"BQ123, an ETA-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats","volume":"266","author":"Bonvallet","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0435","first-page":"L95","article-title":"Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat","volume":"268","author":"Oparil","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0440","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0735-1097(10)80214-1","article-title":"Increased plasma endothelin-1 in the early hours of acute myocardial infarction","volume":"18","author":"Stewart","year":"1991","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0445","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1056\/NEJM199312233292618","article-title":"Endothelin-1 in pulmonary hypertension","volume":"329","author":"Cacoub","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0450","doi-asserted-by":"crossref","first-page":"55A","DOI":"10.1016\/S0002-9149(99)80384-1","article-title":"Role of pharmacologic tests in the treatment of primary pulmonary hypertension","volume":"75","author":"Galie","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0455","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0008-6363(96)00189-7","article-title":"Endothelin-1 in the lungs of patients with pulmonary hypertension","volume":"33","author":"Cacoub","year":"1997","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.phrs.2011.03.003_bib0460","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/0735-1097(95)00399-1","article-title":"Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: relation to hemodynamic variables and endothelin levels","volume":"26","author":"Nootens","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0465","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1164\/ajrccm.165.3.2104059","article-title":"ET(A) and ET(B) receptors modulate the proliferation of human pulmonary artery smooth muscle cells","volume":"165","author":"Davie","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0470","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1161\/hc0902.105719","article-title":"Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension","volume":"105","author":"Bauer","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0475","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/CS19990174","article-title":"Venous endothelin receptor function in patients with chronic heart failure","volume":"98","author":"Love","year":"2000","journal-title":"Clin Sci (Lond.)"},{"key":"10.1016\/j.phrs.2011.03.003_bib0480","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1161\/01.CIR.97.8.752","article-title":"Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade","volume":"97","author":"Verhaar","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0485","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1097\/01.ASN.0000141313.84470.4B","article-title":"receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism","volume":"15","author":"Goddard","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0490","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1378\/chest.129.3.689","article-title":"Etiology-specific endothelin-1 clearance in human precapillary pulmonary hypertension","volume":"129","author":"Langleben","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.phrs.2011.03.003_bib0495","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1161\/01.CIR.101.25.2922","article-title":"Acute endothelin A receptor blockade causes selective pulmonary vasodilation in patients with chronic heart failure","volume":"101","author":"Givertz","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0500","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1161\/01.CIR.102.4.411","article-title":"Hemodynamic effects of Bosentan, an endothelin receptor antagonist, in patients with pulmonary hypertension","volume":"102","author":"Williamson","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0505","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1164\/rccm.2208008","article-title":"Therapy of pulmonary hypertension: the evolution from vasodilators to antiproliferative agents","volume":"166","author":"Rubin","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0510","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1183\/09031936.04.00028404","article-title":"Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2","volume":"24","author":"Humbert","year":"2004","journal-title":"Eur Respir J"},{"key":"10.1016\/j.phrs.2011.03.003_bib0515","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1183\/09031936.05.00054804","article-title":"Survival with first-line bosentan in patients with primary pulmonary hypertension","volume":"25","author":"McLaughlin","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.phrs.2011.03.003_bib0520","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/thx.2005.040618","article-title":"Survival in patients with class III idiopathic pulmonary arterial hypertension treated with first line oral bosentan compared with an historical cohort of patients started on intravenous epoprostenol","volume":"60","author":"Sitbon","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.phrs.2011.03.003_bib0525","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.106.630715","article-title":"Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study","volume":"114","author":"Galie","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0530","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1164\/rccm.200404-445OC","article-title":"Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension","volume":"170","author":"Sitbon","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0535","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1161\/CIRCULATIONAHA.107.742510","article-title":"Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2","volume":"117","author":"Galie","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2011.03.003_bib0540","doi-asserted-by":"crossref","first-page":"F1205","DOI":"10.1152\/ajprenal.00578.2007","article-title":"Renal medullary ETB receptors produce diuresis and natriuresis via NOS1","volume":"294","author":"Nakano","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0545","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1164\/rccm.200307-957OC","article-title":"Sitaxsentan therapy for pulmonary arterial hypertension","volume":"169","author":"Barst","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.phrs.2011.03.003_bib0550","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/j.jacc.2006.01.057","article-title":"Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan","volume":"47","author":"Barst","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0555","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1378\/chest.07-0767","article-title":"Sitaxsentan for the treatment of pulmonary arterial hypertension: a 1-year, prospective, open-label observation of outcome and survival","volume":"134","author":"Benza","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.phrs.2011.03.003_bib0560","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.jacc.2009.04.012","article-title":"Updated clinical classification of pulmonary hypertension","volume":"54","author":"Simonneau","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.phrs.2011.03.003_bib0565","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/hrt.2004.053991","article-title":"Endothelin antagonism in pulmonary hypertension, heart failure, and beyond","volume":"91","author":"Attina","year":"2005","journal-title":"Heart"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661811000673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661811000673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T09:11:52Z","timestamp":1560071512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661811000673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":113,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S1043661811000673"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2011.03.003","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}