{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:37:16Z","timestamp":1788871036492,"version":"build-2803163510"},"reference-count":98,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["R33HL089076"],"award-info":[{"award-number":["R33HL089076"]}]},{"name":"NIH","award":["R42Hl065030"],"award-info":[{"award-number":["R42Hl065030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.phrs.2011.06.012","type":"journal-article","created":{"date-parts":[[2011,6,26]],"date-time":"2011-06-26T05:41:02Z","timestamp":1309066862000},"page":"580-589","source":"Crossref","is-referenced-by-count":23,"title":["Jack of all trades: Pleiotropy and the application of chemically modified tetracycline-3 in sepsis and the acute respiratory distress syndrome (ARDS)"],"prefix":"10.1016","volume":"64","author":[{"given":"Shreyas K.","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kendrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Sadowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Gatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Satalin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorne M.","family":"Golub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Nieman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2011.06.012_bib0005","unstructured":"Machiavelli N. The prince. Bantam: Bantam Classics1515. p. 166."},{"issue":"7","key":"10.1016\/j.phrs.2011.06.012_bib0010","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1001\/archsurg.2010.107","article-title":"Sepsis in general surgery: the 2005\u20132007 national surgical quality improvement program perspective","volume":"145","author":"Moore","year":"2010","journal-title":"Arch Surg"},{"issue":"6","key":"10.1016\/j.phrs.2011.06.012_bib0015","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.amjsurg.2009.05.025","article-title":"Sepsis in general surgery: a deadly complication","volume":"198","author":"Moore","year":"2009","journal-title":"Am J Surg"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0020","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.amjsurg.2004.06.008","article-title":"Benefit\/risk profile of drotrecogin alfa (activated) in surgical patients with severe sepsis","volume":"188","author":"Barie","year":"2004","journal-title":"Am J Surg"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/cc2167","article-title":"Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis","volume":"7","author":"Bernard","year":"2003","journal-title":"Crit Care"},{"issue":"18","key":"10.1016\/j.phrs.2011.06.012_bib0030","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/0885066606287045","article-title":"Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome","volume":"21","author":"Cepkova","year":"2006","journal-title":"J Intensive Care Med"},{"issue":"9","key":"10.1016\/j.phrs.2011.06.012_bib0040","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1097\/00003246-200009000-00034","article-title":"Thirty years of clinical trials in acute respiratory distress syndrome","volume":"28","author":"McIntyre","year":"2000","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0045","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ccm.2008.06.011","article-title":"Reducing mortality in severe sepsis: the surviving sepsis campaign","volume":"29","author":"Townsend","year":"2008","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.phrs.2011.06.012_bib0050","series-title":"The Principles and Practice of Medicine","author":"Osler","year":"1892"},{"issue":"16","key":"10.1016\/j.phrs.2011.06.012_bib0055","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"Martin","year":"2003","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0060","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/QCO.0b013e32818be70a","article-title":"Advances in pathogenesis and management of sepsis","volume":"20","author":"Cinel","year":"2007","journal-title":"Curr Opin Infect Dis"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0065","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/01.sla.0000251619.10648.32","article-title":"Gene expression profiles differentiate between sterile SIRS and early sepsis","volume":"245","author":"Johnson","year":"2007","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0070","doi-asserted-by":"crossref","first-page":"C779","DOI":"10.1152\/ajpcell.00398.2003","article-title":"Angiotensin II-induced MMP-2 release from endothelial cells is mediated by TNF-alpha","volume":"286","author":"Arenas","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0075","first-page":"82","article-title":"Human tumour necrosis factor-alpha (TNF-alpha) directly stimulates arachidonic acid release in human neutrophils","volume":"70","author":"Atkinson","year":"1990","journal-title":"Immunology"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0080","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1172\/JCI114265","article-title":"Neutrophil-activating peptide-1\/interleukin 8, a novel cytokine that activates neutrophils","volume":"84","author":"Baggiolini","year":"1989","journal-title":"J Clin Invest"},{"issue":"Suppl 1","key":"10.1016\/j.phrs.2011.06.012_bib0085","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/stem.5530140720","article-title":"Cytokine-induced alteration of platelet and hemostatic function","volume":"14","author":"Burstein","year":"1996","journal-title":"Stem Cells"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0090","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0167-4889(90)90140-9","article-title":"Stimulation of human chondrocyte prostaglandin E2 production by recombinant human interleukin-1 and tumour necrosis factor","volume":"1051","author":"Campbell","year":"1990","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0095","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-5793(89)80476-4","article-title":"Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes","volume":"242","author":"Castell","year":"1989","journal-title":"FEBS Lett"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0100","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1189\/jlb.0605353","article-title":"Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: novel pathways for tertiary granule release","volume":"79","author":"Chakrabarti","year":"2006","journal-title":"J Leukoc Biol"},{"issue":"4\u20135","key":"10.1016\/j.phrs.2011.06.012_bib0105","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3109\/08820139409066823","article-title":"The role of cytokines in the production of prostacyclin and thromboxane in human mononuclear cells","volume":"23","author":"Chen","year":"1994","journal-title":"Immunol Invest"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0110","first-page":"211","article-title":"Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: role of TNF-alpha and IL-1-beta","volume":"81","author":"Cunha","year":"1994","journal-title":"Immunology"},{"issue":"Pt 3","key":"10.1016\/j.phrs.2011.06.012_bib0115","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1042\/bj3290653","article-title":"Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in vascular smooth muscle","volume":"329","author":"De Keulenaer","year":"1998","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0120","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0006-291X(85)91678-X","article-title":"Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4","volume":"128","author":"Dewald","year":"1985","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0125","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/1523-1747.ep12378589","article-title":"Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells","volume":"102","author":"el-Lati","year":"1994","journal-title":"J Invest Dermatol"},{"issue":"6281","key":"10.1016\/j.phrs.2011.06.012_bib0130","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/346274a0","article-title":"Mast cells as a source of both preformed and immunologically inducible TNF-alpha\/cachectin","volume":"346","author":"Gordon","year":"1990","journal-title":"Nature"},{"issue":"Pt 1","key":"10.1016\/j.phrs.2011.06.012_bib0135","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1242\/jcs.114.1.131","article-title":"TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP","volume":"114","author":"Han","year":"2001","journal-title":"J Cell Sci"},{"issue":"6","key":"10.1016\/j.phrs.2011.06.012_bib0140","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.molimm.2009.12.005","article-title":"Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4","volume":"47","author":"Hebecker","year":"2010","journal-title":"Mol Immunol"},{"issue":"6","key":"10.1016\/j.phrs.2011.06.012_bib0145","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0952-3278(93)90176-W","article-title":"Arachidonic acid stimulates interleukin-6 release from rat peritoneal macrophages in vitro: evidence for a prostacyclin-dependent mechanism","volume":"49","author":"Holladay","year":"1993","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0150","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/eji.1830260522","article-title":"Inhibition of interleukin-6 synthesis in an animal model of septic shock by anti-C5a monoclonal antibodies","volume":"26","author":"Hopken","year":"1996","journal-title":"Eur J Immunol"},{"issue":"6","key":"10.1016\/j.phrs.2011.06.012_bib0155","doi-asserted-by":"crossref","first-page":"L11444","DOI":"10.1152\/ajplung.2001.281.6.L1444","article-title":"Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathway","volume":"281","author":"Hozumi","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"10","key":"10.1016\/j.phrs.2011.06.012_bib0160","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.4049\/jimmunol.160.10.5130","article-title":"Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation","volume":"160","author":"Johnson","year":"1998","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0165","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00003246-199805000-00032","article-title":"Increased circulating thrombomodulin in children with septic shock","volume":"26","author":"Krafte-Jacobs","year":"1998","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0170","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1582-4934.2006.tb00304.x","article-title":"Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells","volume":"10","author":"Moe","year":"2006","journal-title":"J Cell Mol Med"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0175","first-page":"115","article-title":"Leukotriene and prostaglandin production after infusion of tumour necrosis factor in man","volume":"4","author":"Moore","year":"1991","journal-title":"Eicosanoids"},{"issue":"12","key":"10.1016\/j.phrs.2011.06.012_bib0180","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1161\/01.ATV.17.12.3399","article-title":"Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity","volume":"17","author":"Neumann","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.phrs.2011.06.012_bib0185","first-page":"1","article-title":"Histamine in health and disease","volume":"17","author":"Repka-Ramirez","year":"2002","journal-title":"Clin Allergy Immunol"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0190","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4049\/jimmunol.170.1.503","article-title":"Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression","volume":"170","author":"Riedemann","year":"2003","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.phrs.2011.06.012_bib0195","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.4049\/jimmunol.157.9.4159","article-title":"TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages","volume":"157","author":"Saren","year":"1996","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0200","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-0037-1614223","article-title":"Transcriptional activation of the factor VIII gene in liver cell lines by interleukin-6","volume":"79","author":"Stirling","year":"1998","journal-title":"Thromb Haemost"},{"issue":"6","key":"10.1016\/j.phrs.2011.06.012_bib0205","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.4049\/jimmunol.166.6.3890","article-title":"IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk","volume":"166","author":"Strasly","year":"2001","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0210","first-page":"397","article-title":"Cytokine-induced neutrophil-derived interleukin-8","volume":"141","author":"Strieter","year":"1992","journal-title":"Am J Pathol"},{"issue":"11","key":"10.1016\/j.phrs.2011.06.012_bib0215","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1096\/fasebj.2.11.2840318","article-title":"Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist","volume":"2","author":"Thelen","year":"1988","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0220","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ki.1993.36","article-title":"Human peritoneal mesothelial cells synthesize interleukin-6: induction by IL-1 beta and TNF alpha","volume":"43","author":"Topley","year":"1993","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0225","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1084\/jem.179.4.1253","article-title":"Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees","volume":"179","author":"van der Poll","year":"1994","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0230","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0006-291X(02)02431-2","article-title":"IL-1beta induces MMP-9 via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells","volume":"298","author":"Yoo","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"issue":"6 Pt 1","key":"10.1016\/j.phrs.2011.06.012_bib0235","first-page":"L9900","article-title":"Reactive oxygen intermediates stimulate interleukin-6 production in human bronchial epithelial cells","volume":"276","author":"Yoshida","year":"1999","journal-title":"Am J Physiol"},{"issue":"10","key":"10.1016\/j.phrs.2011.06.012_bib0240","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1182\/blood-2002-06-1887","article-title":"The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome","volume":"101","author":"Aird","year":"2003","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0245","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1084\/jem.163.3.740","article-title":"Modulation of endothelial cell hemostatic properties by tumor necrosis factor","volume":"163","author":"Nawroth","year":"1986","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0250","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/jcp.1041440304","article-title":"Human recombinant interleukin-1 beta- and tumor necrosis factor alpha-mediated suppression of heparin-like compounds on cultured porcine aortic endothelial cells","volume":"144","author":"Kobayashi","year":"1990","journal-title":"J Cell Physiol"},{"issue":"12","key":"10.1016\/j.phrs.2011.06.012_bib0255","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1128\/MCB.8.12.5588","article-title":"Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells","volume":"8","author":"Conway","year":"1988","journal-title":"Mol Cell Biol"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0260","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1699-0463.1996.tb00710.x","article-title":"Interleukin-1 alpha, interleukin 6 and tumor necrosis factor alpha increase the synthesis and expression of the functional alternative and terminal complement pathways by human umbilical vein endothelial cells in vitro","volume":"104","author":"Berge","year":"1996","journal-title":"APMIS"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0265","first-page":"1869","article-title":"Essential role of the C5a receptor in E. coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation","volume":"100","author":"Mollnes","year":"2002","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0270","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/TA.0b013e31804d23e1","article-title":"Coagulation and complement protein differences between septic and uninfected systemic inflammatory response syndrome patients","volume":"62","author":"Lissauer","year":"2007","journal-title":"J Trauma"},{"issue":"10","key":"10.1016\/j.phrs.2011.06.012_bib0275","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1086\/374835","article-title":"Inflammation and coagulation: implications for the septic patient","volume":"36","author":"Dellinger","year":"2003","journal-title":"Clin Infect Dis"},{"issue":"7 Suppl","key":"10.1016\/j.phrs.2011.06.012_bib0280","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1097\/00003246-200107001-00025","article-title":"Clinical expert round table discussion (session 3) at the Margaux Conference on Critical Illness: the role of activated protein C in severe sepsis","volume":"29","author":"Bernard","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.phrs.2011.06.012_bib0285","article-title":"A clinically applicable porcine model of septic and ischemia\/reperfusion-induced shock and multiple organ injury","author":"Kubiak","year":"2010","journal-title":"J Surg Res"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0290","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1200\/JCO.2001.19.2.584","article-title":"Phase I clinical trial of oral COL-3, a matrix metalloproteinase inhibitor, in patients with refractory metastatic cancer","volume":"19","author":"Rudek","year":"2001","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0295","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/10454411910020030201","article-title":"Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs","volume":"2","author":"Golub","year":"1991","journal-title":"Crit Rev Oral Biol Med"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0300","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/08959374980120010501","article-title":"Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms","volume":"12","author":"Golub","year":"1998","journal-title":"Adv Dent Res"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0305","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1006\/jsre.2001.6180","article-title":"Metalloproteinase inhibition prevents acute respiratory distress syndrome","volume":"99","author":"Carney","year":"2001","journal-title":"J Surg Res"},{"key":"10.1016\/j.phrs.2011.06.012_bib0310","series-title":"Critical care medicine: principles of diagnosis and management in the adult","author":"Parrillo","year":"2008"},{"issue":"6 Pt 1","key":"10.1016\/j.phrs.2011.06.012_bib0315","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1164\/ajrccm.157.6.9709092","article-title":"Multiple system organ failure. Is mechanical ventilation a contributing factor?","volume":"157","author":"Slutsky","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0320","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/s-2006-948288","article-title":"Pathophysiology of acute lung injury and the acute respiratory distress syndrome","volume":"27","author":"Ware","year":"2006","journal-title":"Semin Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0325","doi-asserted-by":"crossref","first-page":"L5580","DOI":"10.1152\/ajplung.00270.2005","article-title":"Inhibition of matrix metalloproteinase-9 prevents neutrophilic inflammation in ventilator-induced lung injury","volume":"291","author":"Kim","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"6","key":"10.1016\/j.phrs.2011.06.012_bib0330","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1165\/ajrcmb.20.6.3482","article-title":"Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury. Evidence for alveolar macrophage as source of proteinases","volume":"20","author":"Gibbs","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"10.1016\/j.phrs.2011.06.012_bib0335","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S1053-2498(01)00250-9","article-title":"Increased matrix metalloproteinase 9 activity and mRNA expression in lung ischemia-reperfusion injury","volume":"20","author":"Yano","year":"2001","journal-title":"J Heart Lung Transplant"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0340","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/01.CIR.100.4.400","article-title":"Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass","volume":"100","author":"Carney","year":"1999","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0345","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1097\/00003246-200105000-00036","article-title":"Altered alveolar mechanics in the acutely injured lung","volume":"29","author":"Schiller","year":"2001","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0350","doi-asserted-by":"crossref","first-page":"pR104","DOI":"10.1186\/cc6122","article-title":"Alveolar instability caused by mechanical ventilation initially damages the nondependent normal lung","volume":"11","author":"Pavone","year":"2007","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0355","doi-asserted-by":"crossref","first-page":"pR64","DOI":"10.1186\/cc5940","article-title":"Injurious mechanical ventilation in the normal lung causes a progressive pathologic change in dynamic alveolar mechanics","volume":"11","author":"Pavone","year":"2007","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0360","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1164\/ajrccm.163.5.2006053","article-title":"Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal","volume":"163","author":"Ricard","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0365","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1001\/jama.282.1.54","article-title":"Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial","volume":"282","author":"Ranieri","year":"1999","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0370","doi-asserted-by":"crossref","first-page":"pR20","DOI":"10.1186\/cc5695","article-title":"Effect of positive end-expiratory pressure and tidal volume on lung injury induced by alveolar instability","volume":"11","author":"Halter","year":"2007","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0375","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/01.shk.0000140298.40440.51","article-title":"Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis","volume":"22","author":"Maitra","year":"2004","journal-title":"Shock"},{"issue":"9","key":"10.1016\/j.phrs.2011.06.012_bib0380","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.intimp.2008.05.003","article-title":"Anti-inflammatory effect of allylpyrocatechol in LPS-induced macrophages is mediated by suppression of iNOS and COX-2 via the NF-kappaB pathway","volume":"8","author":"Sarkar","year":"2008","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"10.1016\/j.phrs.2011.06.012_bib0385","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.4049\/jimmunol.163.6.3459","article-title":"A novel mechanism of action of chemically modified tetracyclines: inhibition of COX-2-mediated prostaglandin E2 production","volume":"163","author":"Patel","year":"1999","journal-title":"J Immunol"},{"issue":"2\u20133","key":"10.1016\/j.phrs.2011.06.012_bib0390","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0014-5793(97)00605-4","article-title":"Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines","volume":"410","author":"Amin","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.phrs.2011.06.012_bib0395","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1749-6632.1999.tb07691.x","article-title":"A chemically modified nonantimicrobial tetracycline (CMT-8) inhibits gingival matrix metalloproteinases, periodontal breakdown, and extra-oral bone loss in ovariectomized rats","volume":"878","author":"Golub","year":"1999","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0400","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.drup.2004.04.002","article-title":"Chemically modified tetracyclines as inhibitors of matrix metalloproteinases","volume":"7","author":"Acharya","year":"2004","journal-title":"Drug Resist Updat"},{"issue":"9","key":"10.1016\/j.phrs.2011.06.012_bib0405","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1197\/j.aem.2005.04.017","article-title":"Inhibition of matrix metalloproteinase on hepatic transforming growth factor beta1 and caspase-3 activation in hemorrhage","volume":"12","author":"Maitra","year":"2005","journal-title":"Acad Emerg Med"},{"issue":"7","key":"10.1016\/j.phrs.2011.06.012_bib0410","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1097\/01.CCM.0000169880.82060.F7","article-title":"Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats","volume":"33","author":"Maitra","year":"2005","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.phrs.2011.06.012_bib0415","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/01.shk.0000180619.06317.2c","article-title":"Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model","volume":"24","author":"Steinberg","year":"2005","journal-title":"Shock"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0420","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.athoracsur.2010.04.052","article-title":"A tetracycline analog improves acute respiratory distress syndrome survival in an ovine model","volume":"90","author":"Zhou","year":"2010","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0425","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00024382-200309000-00014","article-title":"Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis","volume":"20","author":"Maitra","year":"2003","journal-title":"Shock"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0430","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/01.shk.0000239771.10528.d3","article-title":"Collagenase 2\/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis","volume":"27","author":"Hastbacka","year":"2007","journal-title":"Shock"},{"issue":"2","key":"10.1016\/j.phrs.2011.06.012_bib0435","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/cc8938","article-title":"Matrix-metalloproteinase-2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis","volume":"14","author":"Gaddnas","year":"2010","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0440","doi-asserted-by":"crossref","first-page":"pR158","DOI":"10.1186\/cc8115","article-title":"Matrix metalloproteinase-9-10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis","volume":"13","author":"Lorente","year":"2009","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.phrs.2011.06.012_bib0445","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1200\/JCO.20.1.153","article-title":"Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study","volume":"20","author":"Cianfrocca","year":"2002","journal-title":"J Clin Oncol"},{"issue":"9","key":"10.1016\/j.phrs.2011.06.012_bib0450","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0006-2952(03)00450-7","article-title":"Chemically modified tetracyclines selectively inhibit IL-6 expression in osteoblasts by decreasing mRNA stability","volume":"66","author":"Kirkwood","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.phrs.2011.06.012_bib0455","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1749-6632.1999.tb07757.x","article-title":"Non-antimicrobial and antimicrobial tetracyclines inhibit IL-6 expression in murine osteoblasts","volume":"878","author":"Kirkwood","year":"1999","journal-title":"Ann N Y Acad Sci"},{"issue":"9\u201310","key":"10.1016\/j.phrs.2011.06.012_bib0460","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/S1567-5769(01)00100-X","article-title":"Anti-inflammatory effects of chemically modified tetracyclines by the inhibition of nitric oxide and interleukin-12 synthesis in J774 cell line","volume":"1","author":"D\u2019Agostino","year":"2001","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.phrs.2011.06.012_bib0465","unstructured":"Roy, S., Chemically modified tetracycline prevents ARDS in chronic porcine peritonitis & ischemia reperfusion model. Unpublished data, in preparation."},{"issue":"7","key":"10.1016\/j.phrs.2011.06.012_bib0470","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00011-005-1358-5","article-title":"Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C","volume":"54","author":"Sandler","year":"2005","journal-title":"Inflamm Res"},{"issue":"11","key":"10.1016\/j.phrs.2011.06.012_bib0475","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.intimp.2005.04.013","article-title":"Chemically modified tetracyclines induce apoptosis in cultured mast cells","volume":"5","author":"Sandler","year":"2005","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1016\/j.phrs.2011.06.012_bib0480","doi-asserted-by":"crossref","first-page":"C539","DOI":"10.1152\/ajpcell.00047.2010","article-title":"Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature","volume":"299","author":"Griffin","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"issue":"9","key":"10.1016\/j.phrs.2011.06.012_bib0485","first-page":"1807","article-title":"Chemically modified non-antimicrobial tetracyclines inhibit activity of phospholipases A2","volume":"25","author":"Pruzanski","year":"1998","journal-title":"J Rheumatol"},{"issue":"5","key":"10.1016\/j.phrs.2011.06.012_bib0490","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1097\/00003246-200005000-00036","article-title":"New clinically relevant sheep model of severe respiratory failure secondary to combined smoke inhalation\/cutaneous flame burn injury","volume":"28","author":"Alpard","year":"2000","journal-title":"Crit Care Med"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661811001897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661811001897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T15:53:50Z","timestamp":1686153230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661811001897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":98,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1043661811001897"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2011.06.012","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}