{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:45:05Z","timestamp":1791830705777,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Academy of Finland and the Helsinki University Hospital Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.phrs.2011.06.019","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T07:37:11Z","timestamp":1317713831000},"page":"590-594","source":"Crossref","is-referenced-by-count":95,"title":["Serum MMP-8, -9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines"],"prefix":"10.1016","volume":"64","author":[{"given":"Anneli","family":"Lauhio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"H\u00e4stbacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Pettil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"Tervahartiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tero","family":"Varpula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjut","family":"Varpula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esko","family":"Ruokonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"Kolho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2011.06.019_bib0005","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00134-006-0504-z","article-title":"Incidence, treatment and outcome of severe sepsis in ICU-treated adults in Finland, the Finnsepsis study","volume":"33","author":"Karlsson","year":"2007","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.phrs.2011.06.019_bib0010","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejphar.2007.12.019","article-title":"Endothelial dependence of matrix metalloproteinase-mediated vascular hyporeactivity caused by lipopolysaccharide","volume":"582","author":"Cena","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0015","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/01.shk.0000209543.83929.bd","article-title":"Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia","volume":"25","author":"Robinson","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.phrs.2011.06.019_bib0020","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/CMR.00047-08","article-title":"Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock","volume":"22","author":"Vanlaere","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.phrs.2011.06.019_bib0025","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/07853890600800103","article-title":"Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation","volume":"38","author":"Sorsa","year":"2006","journal-title":"Ann Med"},{"key":"10.1016\/j.phrs.2011.06.019_bib0030","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.4049\/jimmunol.172.12.7791","article-title":"Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase","volume":"172","author":"Owen","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0035","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.4049\/jimmunol.175.4.2589","article-title":"Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation","volume":"175","author":"Gueders","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0040","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/sj.bjc.6604239","article-title":"Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer","volume":"98","author":"Korpi","year":"2008","journal-title":"Br J Cancer"},{"key":"10.1016\/j.phrs.2011.06.019_bib0045","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1128\/IAI.00873-08","article-title":"Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis","volume":"77","author":"Kuula","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.phrs.2011.06.019_bib0050","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1398-9995.2009.02146.x","article-title":"Matrix metalloproteinases-7, -8, -9 and TIMP-1 in the follow-up of diisocyanate-induced asthma","volume":"65","author":"Piiril\u00e4","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.phrs.2011.06.019_bib0055","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1126\/science.289.5482.1202","article-title":"Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3","volume":"289","author":"McQuibban","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.phrs.2011.06.019_bib0060","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1152\/ajpheart.00273.2009","article-title":"Inhibition of matrix metalloproteinase activity in vivo protects against vascular hyporeactivity in endotoxemia","volume":"298","author":"Cena","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0065","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1749-6632.1994.tb24774.x","article-title":"Placebo-controlled study of the effects of three-month lymecycline treatment on serum matrix metalloproteinases in reactive arthritis","volume":"732","author":"Lauhio","year":"1994","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.phrs.2011.06.019_bib0070","first-page":"163","article-title":"Gelatinase B deficiency protects against endotoxin shock","volume":"2","author":"Dubois","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0075","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00024382-200309000-00014","article-title":"Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis","volume":"20","author":"Maitra","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.phrs.2011.06.019_bib0080","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bcp.2005.04.047","article-title":"Targeting neutrophil collagenase\/matrix metalloproteinase-8 and gelatinase B\/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock","volume":"70","author":"Hu","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0085","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138620706778249758","article-title":"Inhibition of lethal endotoxin shock with an l-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library","volume":"9","author":"Hu","year":"2006","journal-title":"Comb Chem High Throughput Screen"},{"key":"10.1016\/j.phrs.2011.06.019_bib0090","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/01.shk.0000180619.06317.2c","article-title":"Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model","volume":"24","author":"Steinberg","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.phrs.2011.06.019_bib0095","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/sj.bjp.0706823","article-title":"Matrix metalloproteinases contribute to endotoxin and interleukin-1beta induced vascular dysfunction","volume":"149","author":"Lalu","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0100","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1080\/00365540600702058","article-title":"Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: prognostic value of TIMP-1 in severe sepsis","volume":"38","author":"Hoffmann","year":"2006","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.phrs.2011.06.019_bib0105","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1186\/cc8115","article-title":"Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis","volume":"13","author":"Lorente","year":"2009","journal-title":"Crit Care"},{"key":"10.1016\/j.phrs.2011.06.019_bib0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/01.shk.0000239771.10528.d3","article-title":"Collagenase 2\/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis","volume":"27","author":"H\u00e4stbacka","year":"2007","journal-title":"Shock"},{"key":"10.1016\/j.phrs.2011.06.019_bib0115","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/cc8938","article-title":"Matrix-metalloproteinase-2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis","volume":"14","author":"G\u00e4ddn\u00e4s","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.phrs.2011.06.019_bib0120","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.phrs.2011.06.019_bib0125","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/07853890802482452","article-title":"Enhanced systemic matrix metalloproteinase response in Helicobacter pylori gastritis","volume":"41","author":"Rautelin","year":"2009","journal-title":"Ann Med"},{"key":"10.1016\/j.phrs.2011.06.019_bib0130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cytogfr.2006.04.001","article-title":"Matrix metalloproteinase-8: cleavage can be decisive","volume":"17","author":"Van Lint","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.phrs.2011.06.019_bib0135","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1161\/ATVBAHA.107.154831","article-title":"Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men","volume":"27","author":"Tuomainen","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0140","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1601-0825.2009.01603.x","article-title":"Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods","volume":"16","author":"Sorsa","year":"2010","journal-title":"Oral Dis"},{"key":"10.1016\/j.phrs.2011.06.019_bib0145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.phrs.2010.10.005","article-title":"Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines","volume":"63","author":"Sorsa","year":"2011","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.phrs.2011.06.019_bib0150","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/art.1780350211","article-title":"The anticollagenolytic potential of lymecycline in the long-term treatment of reactive arthritis","volume":"35","author":"Lauhio","year":"1992","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.phrs.2011.06.019_bib0155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2249.1994.tb06601.x","article-title":"In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis","volume":"98","author":"Lauhio","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0160","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/AAC.38.2.400","article-title":"Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis","volume":"38","author":"Lauhio","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.phrs.2011.06.019_bib0165","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1902\/jop.2008.070623","article-title":"Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women","volume":"79","author":"Golub","year":"2008","journal-title":"J Periodontol"},{"key":"10.1016\/j.phrs.2011.06.019_bib0170","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/08959374980120010501","article-title":"Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms","volume":"12","author":"Golub","year":"1998","journal-title":"Adv Dent Res"},{"key":"10.1016\/j.phrs.2011.06.019_bib0175","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/art.30075","article-title":"Combination treatment in Chlamydia-triggered reactive arthritis. Comment on the article by Carter et al.","volume":"63","author":"Lauhio","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.phrs.2011.06.019_bib0180","unstructured":"Roy SK, Kendrik D, Nieman G, Gatto L, Sadowitz B, Snyder K, Jack of all trades: pleotrophy and the application of chemically modified tetracycline-3 in sepsis and acute respiratory distress syndrome. Pharmacol Res; this issue."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661811002064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661811002064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T12:51:20Z","timestamp":1543495880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661811002064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1043661811002064"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2011.06.019","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}