{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:33:52Z","timestamp":1789878832391,"version":"4.0.1"},"reference-count":78,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":531,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.phrs.2011.12.001","type":"journal-article","created":{"date-parts":[[2011,12,12]],"date-time":"2011-12-12T05:55:57Z","timestamp":1323669357000},"page":"221-230","source":"Crossref","is-referenced-by-count":33,"title":["The anabolic\/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"65","author":[{"given":"Mariarita","family":"Galbiati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Onesto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Zito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Crippa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Rusmini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Mariotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Bentivoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Bendotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2011.12.001_bib0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuint.2010.02.004","article-title":"Time course of oxidant markers and antioxidant defenses in subgroups of amyotrophic lateral sclerosis patients","volume":"56","author":"Cova","year":"2010","journal-title":"Neurochem Int"},{"key":"10.1016\/j.phrs.2011.12.001_bib0010","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.nbd.2010.04.008","article-title":"Sod1 mrna expression in sporadic amyotrophic lateral sclerosis","volume":"39","author":"Gagliardi","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.phrs.2011.12.001_bib0015","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrn1971","article-title":"Molecular biology of amyotrophic lateral sclerosis: Insights from genetics","volume":"7","author":"Pasinelli","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.phrs.2011.12.001_bib0020","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molmed.2004.06.009","article-title":"Lessons from models of sod1-linked familial als","volume":"10","author":"Bendotti","year":"2004","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.phrs.2011.12.001_bib0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"Als: A disease of motor neurons and their nonneuronal neighbors","volume":"52","author":"Boillee","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2011.12.001_bib0030","doi-asserted-by":"crossref","DOI":"10.3109\/17482961003610853","article-title":"The sex ratio in amyotrophic lateral sclerosis: a population based study","author":"Manjaly","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1016\/j.phrs.2011.12.001_bib0035","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2004.06.024","article-title":"Ovariectomy and 17beta-estradiol modulate disease progression of a mouse model of als","volume":"1021","author":"Groeneveld","year":"2004","journal-title":"Brain Res"},{"issue":"Pt 3","key":"10.1016\/j.phrs.2011.12.001_bib0040","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/brain\/118.3.707","article-title":"Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction","volume":"118","author":"Haverkamp","year":"1995","journal-title":"Brain"},{"key":"10.1016\/j.phrs.2011.12.001_bib0045","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/jnnp.2009.183525","article-title":"Incidence of amyotrophic lateral sclerosis in europe","volume":"81","author":"Logroscino","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.phrs.2011.12.001_bib0050","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0022-510X(99)00234-8","article-title":"Estrogen replacement therapy in women with amyotrophic lateral sclerosis","volume":"169","author":"Rudnicki","year":"1999","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.phrs.2011.12.001_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2005.02.006","article-title":"Background and gender effects on survival in the tgn(sod1-g93a)1gur mouse model of als","volume":"236","author":"Heiman-Patterson","year":"2005","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.phrs.2011.12.001_bib0060","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0960-8966(03)00104-4","article-title":"Sexual differences in onset of disease and response to exercise in a transgenic model of als","volume":"13","author":"Veldink","year":"2003","journal-title":"Neuromuscul Disord"},{"key":"10.1016\/j.phrs.2011.12.001_bib0065","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.2466\/pms.104.4.1251-1254","article-title":"Football increases the risk for lou gehrig's disease, amyotrophic lateral sclerosis","volume":"104","author":"Abel","year":"2007","journal-title":"Percept Mot Skills"},{"key":"10.1016\/j.phrs.2011.12.001_bib0070","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/17482960903384283","article-title":"Amyotrophic lateral sclerosis, physical exercise, trauma and sports: Results of a population-based pilot case-control study","volume":"11","author":"Beghi","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1016\/j.phrs.2011.12.001_bib0075","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10654-004-6879-7","article-title":"Proportionate mortality of Italian soccer players: is amyotrophic lateral sclerosis an occupational disease","volume":"20","author":"Belli","year":"2005","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0080","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/brain\/awh373","article-title":"Severely increased risk of amyotrophic lateral sclerosis among italian professional football players","volume":"128","author":"Chio","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.phrs.2011.12.001_bib0085","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1185\/030079904125003296","article-title":"Soccer, neurotrauma and amyotrophic lateral sclerosis: Is there a connection","volume":"20","author":"Piazza","year":"2004","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.phrs.2011.12.001_bib0090","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.nbd.2008.12.009","article-title":"Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy","volume":"34","author":"Johansen","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.phrs.2011.12.001_bib0095","doi-asserted-by":"crossref","first-page":"18259","DOI":"10.1073\/pnas.0705501104","article-title":"Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease","volume":"104","author":"Monks","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2011.12.001_bib0100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000313682","article-title":"Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy","volume":"8","author":"Johansen","year":"2011","journal-title":"Neurodegener Dis"},{"key":"10.1016\/j.phrs.2011.12.001_bib0105","doi-asserted-by":"crossref","first-page":"19546","DOI":"10.1073\/pnas.0609411103","article-title":"Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis","volume":"103","author":"Miller","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2011.12.001_bib0110","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jns.2008.09.030","article-title":"Amyotrophic lateral sclerosis linked to a novel sod1 mutation with muscle mitochondrial dysfunction","volume":"276","author":"Corti","year":"2009","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.phrs.2011.12.001_bib0115","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cmet.2008.09.002","article-title":"Skeletal muscle is a primary target of sod1g93a-mediated toxicity","volume":"8","author":"Dobrowolny","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/j.phrs.2011.12.001_bib0120","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1093\/hmg\/ddq106","article-title":"Skeletal muscle-restricted expression of human sod1 causes motor neuron degeneration in transgenic mice","volume":"19","author":"Wong","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.phrs.2011.12.001_bib0125","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1523\/JNEUROSCI.20-07-02534.2000","article-title":"Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases","volume":"20","author":"Frey","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.phrs.2011.12.001_bib0130","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1097\/00001756-199605310-00021","article-title":"Neuromuscular function impairment is not caused by motor neurone loss in fals mice: an electromyographic study","volume":"7","author":"Kennel","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.phrs.2011.12.001_bib0135","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp Neurol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/17482960902803440","article-title":"Treatment with lithium carbonate does not improve disease progression in two different strains of sod1 mutant mice","volume":"10","author":"Pizzasegola","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1016\/j.phrs.2011.12.001_bib0145","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1471-4159.2003.02208.x","article-title":"Expression of sod1 g93a or wild-type sod1 in primary cultures of astrocytes down-regulates the glutamate transporter glt-1: lack of involvement of oxidative stress","volume":"88","author":"Tortarolo","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2011.12.001_bib0150","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/hmg\/9.1.133","article-title":"Motoneuronal cell death is not correlated with aggregate formation of androgen receptors containing an elongated polyglutamine tract","volume":"9","author":"Simeoni","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.phrs.2011.12.001_bib0155","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/nn1653","article-title":"Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by cntf","volume":"9","author":"Pun","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.phrs.2011.12.001_bib0160","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1038\/sj.emboj.7601288","article-title":"Cholesterol and lipid microdomains stabilize the postsynapse at the neuromuscular junction","volume":"25","author":"Willmann","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.phrs.2011.12.001_bib0165","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.bbadis.2008.04.001","article-title":"Presymptomatic biochemical changes in hindlimb muscle of g93a human cu\/zn superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis","volume":"1782","author":"Park","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.phrs.2011.12.001_bib0170","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1093\/hmg\/ddq257","article-title":"The small heat shock protein b8 (hspb8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (als)","volume":"19","author":"Crippa","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.phrs.2011.12.001_bib0175","doi-asserted-by":"crossref","first-page":"12100","DOI":"10.1073\/pnas.95.21.12100","article-title":"Role of calpain in skeletal\u2013muscle protein degradation","volume":"95","author":"Huang","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2011.12.001_bib0180","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.phrs.2011.12.001_bib0185","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.yexcr.2008.10.037","article-title":"Tgf-beta's delay skeletal muscle progenitor cell differentiation in an isoform-independent manner","volume":"315","author":"Schabort","year":"2009","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.phrs.2011.12.001_bib0190","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1471-4159.2011.07298.x","article-title":"Muscle cells and motoneurons differentially remove mutant sod1 causing familial amyotrophic lateral sclerosis","volume":"118","author":"Onesto","year":"2011","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2011.12.001_bib0195","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ecl.2009.11.004","article-title":"Sports-related issues and biochemistry of natural and synthetic anabolic substances","volume":"39","author":"Parr","year":"2010","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.phrs.2011.12.001_bib0200","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/ars.2007.1760","article-title":"Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications","volume":"10","author":"Cozzolino","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.phrs.2011.12.001_bib0205","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1093\/hmg\/ddm110","article-title":"Mutation of sod1 in als: a gain of a loss of function","volume":"16","author":"Sau","year":"2007","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.phrs.2011.12.001_bib0210","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1471-4159.2010.06572.x","article-title":"An examination of alpha B-crystalline as a modifier of sod1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis","volume":"113","author":"Karch","year":"2010","journal-title":"J Neurochem"},{"issue":"Pt 6","key":"10.1016\/j.phrs.2011.12.001_bib0215","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1242\/jcs.111.6.769","article-title":"Cell heterogeneity upon myogenic differentiation: down-regulation of myod and myf-5 generates \u2018reserve cells\u2019","volume":"111","author":"Yoshida","year":"1998","journal-title":"J Cell Sci"},{"key":"10.1016\/j.phrs.2011.12.001_bib0220","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physiolgenomics.00017.2007","article-title":"Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model","volume":"32","author":"Gonzalez de Aguilar","year":"2008","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.phrs.2011.12.001_bib0225","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1006\/nbdi.2000.0299","volume":"7","author":"Jaarsma","year":"2000","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.phrs.2011.12.001_bib0230","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.expneurol.2009.04.007","article-title":"Increased sensitivity of myoblasts to oxidative stress in amyotrophic lateral sclerosis peripheral tissues","volume":"218","author":"Bradley","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0235","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.251541198","article-title":"Atrogin-1, a muscle-specific f-box protein highly expressed during muscle atrophy","volume":"98","author":"Gomes","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2011.12.001_bib0240","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2004.09.027","article-title":"Ikkbeta\/nf-kappab activation causes severe muscle wasting in mice","volume":"119","author":"Cai","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2011.12.001_bib0245","doi-asserted-by":"crossref","first-page":"C806","DOI":"10.1152\/ajpcell.00129.2003","article-title":"Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific e2 and e3 proteins in skeletal muscle myotubes","volume":"285","author":"Li","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0250","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1096\/fj.04-2364com","article-title":"Tnf-alpha acts via p38 mapk to stimulate expression of the ubiquitin ligase atrogin1\/mafbx in skeletal muscle","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.phrs.2011.12.001_bib0255","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1096\/fj.05-5249fje","article-title":"Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in akt and an increase in atrogin-1","volume":"20","author":"Leger","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.phrs.2011.12.001_bib0260","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0928-4257(01)00077-8","article-title":"Tgf-beta and the regulation of neuron survival and death","volume":"96","author":"Krieglstein","year":"2002","journal-title":"J Physiol Paris"},{"key":"10.1016\/j.phrs.2011.12.001_bib0265","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0165-3806(90)90233-O","article-title":"Transforming growth factor beta 1 is a potent survival factor for rat embryo motoneurons in culture","volume":"52","author":"Martinou","year":"1990","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.phrs.2011.12.001_bib0270","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/neu.480240806","article-title":"Biological studies of a putative avian muscle-derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo","volume":"24","author":"Oppenheim","year":"1993","journal-title":"J Neurobiol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0275","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nm1536","article-title":"Angiotensin ii type 1 receptor blockade attenuates tgf-beta-induced failure of muscle regeneration in multiple myopathic states","volume":"13","author":"Cohn","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.phrs.2011.12.001_bib0280","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev.ph.53.030191.001221","article-title":"Hormones, growth factors, and myogenic differentiation","volume":"53","author":"Florini","year":"1991","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0285","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1128\/MCB.9.8.3576","article-title":"Fibroblast growth factor and transforming growth factor beta repress transcription of the myogenic regulatory gene myod1","volume":"9","author":"Vaidya","year":"1989","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0290","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1101\/gad.925901","article-title":"Tgf-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by smad3","volume":"15","author":"Liu","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.phrs.2011.12.001_bib0295","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature07034","article-title":"Imbalance between psmad3 and notch induces cdk inhibitors in old muscle stem cells","volume":"454","author":"Carlson","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2011.12.001_bib0300","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00401-007-0337-z","article-title":"Phosphorylated smad2\/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model","volume":"115","author":"Nakamura","year":"2008","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0305","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00401-006-0130-4","article-title":"Altered distributions of nucleocytoplasmic transport-related proteins in the spinal cord of a mouse model of amyotrophic lateral sclerosis","volume":"112","author":"Zhang","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0310","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.1523\/JNEUROSCI.0388-10.2010","article-title":"Disrupted transforming growth factor-{beta} signaling in spinal and bulbar muscular atrophy","volume":"30","author":"Katsuno","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.phrs.2011.12.001_bib0315","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1034\/j.1600-0404.2002.01301.x","article-title":"Increased plasma tgf-beta1 in patients with amyotrophic lateral sclerosis","volume":"106","author":"Houi","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.phrs.2011.12.001_bib0320","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddr268","article-title":"A functional variant in znf512b is associated with susceptibility to amyotrophic lateral sclerosis in Japanese","author":"Iida","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.phrs.2011.12.001_bib0325","doi-asserted-by":"crossref","first-page":"9599","DOI":"10.1523\/JNEUROSCI.2589-08.2008","article-title":"Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1","volume":"28","author":"Feng","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.phrs.2011.12.001_bib0330","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1210\/en.2008-0664","article-title":"Expression of the muscle atrophy factor muscle atrophy f-box is suppressed by testosterone","volume":"149","author":"Zhao","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2011.12.001_bib0335","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jsbmb.2008.03.024","article-title":"Testosterone protects against dexamethasone-induced muscle atrophy, protein degradation and mafbx upregulation","volume":"110","author":"Zhao","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0340","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1210\/en.2008-0858","article-title":"Regulation of myogenic differentiation by androgens: Cross talk between androgen receptor\/beta-catenin and follistatin\/transforming growth factor-beta signaling pathways","volume":"150","author":"Singh","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2011.12.001_bib0345","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1091\/mbc.E09-09-0812","article-title":"Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1\/s1p3 axis","volume":"21","author":"Cencetti","year":"2010","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.phrs.2011.12.001_bib0350","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1083\/jcb.200407021","article-title":"Muscle expression of a local igf-1 isoform protects motor neurons in an als mouse model","volume":"168","author":"Dobrowolny","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0355","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1126\/science.1086137","article-title":"Retrograde viral delivery of igf-1 prolongs survival in a mouse als model","volume":"301","author":"Kaspar","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.phrs.2011.12.001_bib0360","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ana.20451","article-title":"Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis","volume":"57","author":"Kaspar","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0365","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/ana.10597","article-title":"Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis","volume":"53","author":"Kirkinezos","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0370","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1113\/jphysiol.2009.169748","article-title":"Motoneuron survival is promoted by specific exercise in a mouse model of amyotrophic lateral sclerosis","volume":"587","author":"Deforges","year":"2009","journal-title":"J Physiol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0375","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1210\/en.2010-0802","article-title":"The role of gh and igf-i in mediating anabolic effects of testosterone on androgen-responsive muscle","volume":"152","author":"Serra","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2011.12.001_bib0380","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1152\/japplphysiol.91235.2008","article-title":"Effect of resistance exercise on muscle steroidogenesis","volume":"105","author":"Vingren","year":"2008","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.phrs.2011.12.001_bib0385","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2174\/156800907781662248","article-title":"Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase\/akt pathway in prostate cancer","volume":"7","author":"Wang","year":"2007","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.phrs.2011.12.001_bib0390","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/17482960902721634","article-title":"Als in Italian professional soccer players: the risk is still present and could be soccer-specific","volume":"10","author":"Chio","year":"2009","journal-title":"Amyotroph Lateral Scler"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661811002982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661811002982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T18:43:08Z","timestamp":1713206588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661811002982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S1043661811002982"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2011.12.001","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}