{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:09:17Z","timestamp":1780394957377,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.phrs.2012.07.006","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T21:18:15Z","timestamp":1344547095000},"page":"409-418","source":"Crossref","is-referenced-by-count":8,"title":["Nitrite- and nitroxyl-induced relaxation in porcine coronary (micro-) arteries: Underlying mechanisms and role as endothelium-derived hyperpolarizing factor(s)"],"prefix":"10.1016","volume":"66","author":[{"given":"Ilse P.G.","family":"Botden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy W.","family":"Batenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke G.","family":"Langendonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.G.","family":"Sijbrands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.H. Jan","family":"Danser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2012.07.006_bib0005","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1073\/pnas.0234600100","article-title":"Chemical nature of nitric oxide storage forms in rat vascular tissue","volume":"100","author":"Rodriguez","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.phrs.2012.07.006_bib0010","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1097\/HJH.0b013e32832bff54","article-title":"Light-induced vs. bradykinin-induced relaxation of coronary arteries: do S-nitrosothiols act as endothelium-derived hyperpolarizing factors?","volume":"27","author":"Batenburg","year":"2009","journal-title":"Journal of Hypertension"},{"key":"10.1016\/j.phrs.2012.07.006_bib0015","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1097\/00004872-200410000-00015","article-title":"l-S-Nitrosothiols: endothelium-derived hyperpolarizing factors in porcine coronary arteries?","volume":"22","author":"Batenburg","year":"2004","journal-title":"Journal of Hypertension"},{"key":"10.1016\/j.phrs.2012.07.006_bib0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/sj.bjp.0705747","article-title":"Bradykinin-induced relaxation of coronary microarteries: S-nitrosothiols as EDHF?","volume":"142","author":"Batenburg","year":"2004","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0025","doi-asserted-by":"crossref","first-page":"H1274","DOI":"10.1152\/ajpheart.00008.2009","article-title":"Redox variants of no (NO and HNO) vasorelaxation of resistance arteries via distinct mechanisms","volume":"296","author":"Favaloro","year":"2009","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0030","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1476-5381.2009.00150.x","article-title":"A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries","volume":"157","author":"Andrews","year":"2009","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0035","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/01.HYP.0000072010.54901.DE","article-title":"NO\u2212 activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteries","volume":"41","author":"Irvine","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2012.07.006_bib0040","doi-asserted-by":"crossref","first-page":"33554","DOI":"10.1074\/jbc.M004337200","article-title":"Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism","volume":"275","author":"Adak","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.phrs.2012.07.006_bib0045","first-page":"687","article-title":"Interactions of light and sodium nitrite in producing relaxation of rabbit aorta","volume":"248","author":"Matsunaga","year":"1989","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.phrs.2012.07.006_bib0050","doi-asserted-by":"crossref","first-page":"PL1","DOI":"10.1016\/0024-3205(94)00578-8","article-title":"Photochemical generation of nitric oxide from nitro-containing compounds: possible relation to vascular photorelaxation phenomena","volume":"54","author":"Bauer","year":"1994","journal-title":"Life Sciences"},{"key":"10.1016\/j.phrs.2012.07.006_bib0055","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1113\/jphysiol.2003.041970","article-title":"Nitric oxide and the mechanism of rat vascular smooth muscle photorelaxation","volume":"550","author":"Flitney","year":"2003","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0060","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm954","article-title":"Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation","volume":"9","author":"Cosby","year":"2003","journal-title":"Nature Medicine"},{"key":"10.1016\/j.phrs.2012.07.006_bib0065","first-page":"739","article-title":"Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates","volume":"218","author":"Ignarro","year":"1981","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.phrs.2012.07.006_bib0070","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/CIRCRESAHA.109.207019","article-title":"Whole body UVA irradiation lowers systemic blood pressure by release of nitric oxide from intracutaneous photolabile nitric oxide derivates","volume":"105","author":"Oplander","year":"2009","journal-title":"Circulation Research"},{"key":"10.1016\/j.phrs.2012.07.006_bib0075","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/0140-6736(92)91277-F","article-title":"Wine, alcohol, platelets, and the French paradox for coronary heart disease","volume":"339","author":"Renaud","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2012.07.006_bib0080","first-page":"5","article-title":"Experimental evidence for the cardioprotective effects of red wine","volume":"12","author":"Das","year":"2007","journal-title":"Experimental & Clinical Cardiology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0085","first-page":"H774","article-title":"Endothelium-dependent vasorelaxing activity of wine and other grape products","volume":"265","author":"Fitzpatrick","year":"1993","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0090","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ajh.2010.227","article-title":"Daily red wine consumption improves vascular function by a soluble guanylyl cyclase-dependent pathway","volume":"24","author":"Botden","year":"2011","journal-title":"American Journal of Hypertension"},{"key":"10.1016\/j.phrs.2012.07.006_bib0095","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbrc.2003.09.028","article-title":"Red wine polyphenols cause endothelium-dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism","volume":"310","author":"Ndiaye","year":"2003","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.phrs.2012.07.006_bib0100","first-page":"H952","article-title":"Comparison of acetylcholine-dependent relaxation in large and small arteries of rat mesenteric vascular bed","volume":"266","author":"Hwa","year":"1994","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0105","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/sj.bjp.0703555","article-title":"l-NAME-resistant bradykinin-induced relaxation in porcine coronary arteries is NO-dependent: effect of ACE inhibition","volume":"131","author":"Danser","year":"2000","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0110","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","article-title":"Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents","volume":"16","author":"Singleton","year":"1965","journal-title":"American Journal of Enology and Viticulture"},{"key":"10.1016\/j.phrs.2012.07.006_bib0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/01.RES.41.1.19","article-title":"Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats","volume":"41","author":"Mulvany","year":"1977","journal-title":"Circulation Research"},{"key":"10.1016\/j.phrs.2012.07.006_bib0120","doi-asserted-by":"crossref","first-page":"H1168","DOI":"10.1152\/ajpheart.00029.2003","article-title":"Endothelium-dependent responses in coronary arteries are changed with puberty in male pigs","volume":"285","author":"Chatrath","year":"2003","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0125","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1113\/jphysiol.1996.sp021318","article-title":"Extracellular K+-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K+ channels","volume":"492","author":"Knot","year":"1996","journal-title":"The Journal of Physiology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0130","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/01.RES.85.7.634","article-title":"cAMP-independent dilation of coronary arterioles to adenosine: role of nitric oxide, G-proteins, and KATP channels","volume":"85","author":"Hein","year":"1999","journal-title":"Circulation Research"},{"key":"10.1016\/j.phrs.2012.07.006_bib0135","doi-asserted-by":"crossref","first-page":"H175","DOI":"10.1152\/ajpheart.2000.278.1.H175","article-title":"OxLDL specifically impairs endothelium-dependent, NO-mediated dilation of coronary arterioles","volume":"278","author":"Hein","year":"2000","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0140","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.HYP.0000110945.84443.d2","article-title":"Apamin-sensitive K+ currents mediate arachidonic acid-induced relaxations of rabbit aorta","volume":"43","author":"Gauthier","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2012.07.006_bib0145","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tips.2008.08.005","article-title":"Nitroxyl (HNO): the Cinderella of the nitric oxide story","volume":"29","author":"Irvine","year":"2008","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.phrs.2012.07.006_bib0150","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.bjp.0703058","article-title":"Differential actions of l-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta","volume":"129","author":"Ellis","year":"2000","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0155","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/bbrc.1994.1668","article-title":"Bioassay discrimination between nitric oxide (NO) and nitroxyl (NO\u2212) using l-cysteine","volume":"201","author":"Pino","year":"1994","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.phrs.2012.07.006_bib0160","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCULATIONAHA.107.719591","article-title":"Hypoxic modulation of exogenous nitrite-induced vasodilation in humans","volume":"117","author":"Maher","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2012.07.006_bib0165","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1161\/HYPERTENSIONAHA.110.153536","article-title":"Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO","volume":"56","author":"Kapil","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2012.07.006_bib0170","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/CIRCULATIONAHA.107.712133","article-title":"Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation","volume":"116","author":"Dejam","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2012.07.006_bib0175","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1164\/ajrccm.158.3.9709097","article-title":"Impact of inhaled nitric oxide on platelet aggregation and fibrinolysis in rats with endotoxic lung injury. Role of cyclic guanosine 5\u2032-monophosphate","volume":"158","author":"Kermarrec","year":"1998","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.phrs.2012.07.006_bib0180","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1124\/jpet.105.083824","article-title":"Bay 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1h-pyrazolo[3,4-b]pyridine-3-yl]pyri midin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump","volume":"314","author":"Bawankule","year":"2005","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.phrs.2012.07.006_bib0185","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1124\/mol.109.059915","article-title":"Mechanisms underlying activation of soluble guanylate cyclase by the nitroxyl donor Angeli's salt","volume":"76","author":"Zeller","year":"2009","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.phrs.2012.07.006_bib0190","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cardiores.2006.11.018","article-title":"The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature","volume":"73","author":"Favaloro","year":"2007","journal-title":"Cardiovascular Research"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181200151X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181200151X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T07:29:04Z","timestamp":1687678144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366181200151X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S104366181200151X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2012.07.006","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}