{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:54:01Z","timestamp":1791276841919,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.phrs.2013.04.004","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T18:11:44Z","timestamp":1366654304000},"page":"1-7","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients"],"prefix":"10.1016","volume":"73","author":[{"given":"Alessio","family":"Squassina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Congiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Manchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Angius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Deiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Ardau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Chillotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Severino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Calza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Del Zompo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2013.04.004_bib0005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/070674370404900208","article-title":"Prevalence and incidence studies of mood disorders: a systematic review of the literature","volume":"49","author":"Waraich","year":"2004","journal-title":"Canadian Journal of Psychiatry"},{"key":"10.1016\/j.phrs.2013.04.004_bib0010","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.phrs.2013.04.004_bib0015","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1001\/archpsyc.64.5.543","article-title":"Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication","volume":"64","author":"Merikangas","year":"2007","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.phrs.2013.04.004_bib0020","doi-asserted-by":"crossref","first-page":"e8508","DOI":"10.1136\/bmj.e8508","article-title":"Bipolar disorder","volume":"345","author":"Anderson","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2013.04.004_bib0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/archpsyc.57.2.187","article-title":"Does lithium treatment still work? Evidence of stable responses over three decades","volume":"57","author":"Baldessarini","year":"2000","journal-title":"Archives of General Psychiatry"},{"issue":"Suppl. 2","key":"10.1016\/j.phrs.2013.04.004_bib0030","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1111\/j.1399-5618.2009.00712.x","article-title":"Maintenance treatment in bipolar disorder: a reassessment of lithium as the first choice","volume":"11","author":"Coryell","year":"2009","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.phrs.2013.04.004_bib0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jad.2007.03.003","article-title":"Prophylactic treatment response in bipolar disorder: results of a naturalistic observation study","volume":"104","author":"Garnham","year":"2007","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.phrs.2013.04.004_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/npp.2010.192","article-title":"Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials","author":"Yildiz","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0045","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1755-5949.2011.00260.x","article-title":"Lithium: still a major option in the management of bipolar disorder","volume":"18","author":"Licht","year":"2012","journal-title":"CNS Neuroscience and Therapeutics"},{"key":"10.1016\/j.phrs.2013.04.004_bib0050","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1600-0447.2009.01454.x","article-title":"Lithium response across generations","volume":"120","author":"Grof","year":"2009","journal-title":"Acta Psychiatrica Scandinavica"},{"key":"10.1016\/j.phrs.2013.04.004_bib0055","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4088\/JCP.v63n1013","article-title":"Is response to prophylactic lithium a familial trait?","volume":"63","author":"Grof","year":"2002","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.phrs.2013.04.004_bib0060","doi-asserted-by":"crossref","DOI":"10.1007\/s40263-013-0040-7","article-title":"Genetic influences on response to mood stabilizers in bipolar disorder: current status of knowledge","author":"Rybakowski","year":"2013","journal-title":"CNS Drugs"},{"key":"10.1016\/j.phrs.2013.04.004_bib0065","first-page":"449","article-title":"BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder","volume":"33","author":"Tseng","year":"2008","journal-title":"Journal of Psychiatry and Neuroscience"},{"key":"10.1016\/j.phrs.2013.04.004_bib0070","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1017\/S1461145710000714","article-title":"Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses","volume":"13","author":"Lopez de Lara","year":"2010","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0075","doi-asserted-by":"crossref","first-page":"e32680","DOI":"10.1371\/journal.pone.0032680","article-title":"Synapsin II, is involved in the molecular pathway of lithium treatment in bipolar disorder","volume":"7","author":"Cruceanu","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2013.04.004_bib0080","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2045-5380-2-15","article-title":"Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation","volume":"2","author":"Lowthert","year":"2012","journal-title":"Biology of Mood and Anxiety Disorders"},{"key":"10.1016\/j.phrs.2013.04.004_bib0085","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1399-5618.2007.00572.x","article-title":"Age at onset in Sardinian bipolar I patients: evidence for three subgroups","volume":"10","author":"Manchia","year":"2008","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.phrs.2013.04.004_bib0090","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/archpsyc.1978.01770300115013","article-title":"Research Diagnostic Criteria: rationale and reliability","volume":"35","author":"Spitzer","year":"1978","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.phrs.2013.04.004_bib0095","series-title":"Diagnostic and statistical manual of mental disorders (4th ed., text rev.)","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.phrs.2013.04.004_bib0100","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.1978.01770310043002","article-title":"A diagnostic interview: the schedule for affective disorders and schizophrenia","volume":"35","author":"Endicott","year":"1978","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.phrs.2013.04.004_bib0105","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000314708","article-title":"The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment","volume":"1","author":"Schulze","year":"2010","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0110","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.2217\/pgs.11.102","article-title":"Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder","volume":"11","author":"Squassina","year":"2011","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.phrs.2013.04.004_bib0115","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF00279094","article-title":"A routine method for the establishment of permanent growing lymphoblastoid cell lines","volume":"73","author":"Neitzel","year":"1986","journal-title":"Human Genetics"},{"key":"10.1016\/j.phrs.2013.04.004_bib0120","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"10.1016\/j.phrs.2013.04.004_bib0125","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","volume":"64","author":"Storey","year":"2002","journal-title":"Journal of the Royal Statistical Society: Series B (Statistical Methodology)"},{"key":"10.1016\/j.phrs.2013.04.004_bib0130","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics R","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0135","series-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2000"},{"key":"10.1016\/j.phrs.2013.04.004_bib0140","doi-asserted-by":"crossref","first-page":"Article 3","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical Bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Statistical Applications in Genetics and Molecular Biology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0145","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ghir.2007.01.006","article-title":"Emerging roles of insulin-like growth factor-I in the adult brain","volume":"17","author":"Fernandez","year":"2007","journal-title":"Growth Hormone and IGF Research"},{"key":"10.1016\/j.phrs.2013.04.004_bib0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrn3209","article-title":"The many faces of insulin-like peptide signalling in the brain","volume":"13","author":"Fernandez","year":"2012","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.phrs.2013.04.004_bib0155","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0169-328X(91)90054-2","article-title":"Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain","volume":"10","author":"Bach","year":"1991","journal-title":"Brain Research: Molecular Brain Research"},{"key":"10.1016\/j.phrs.2013.04.004_bib0160","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1212\/WNL.0b013e3182752eef","article-title":"Insulin-like growth factors in the brain and their potential clinical implications","volume":"79","author":"Benarroch","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0165","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1124\/mi.4.5.6","article-title":"Molecular effects of lithium","volume":"5","author":"Quiroz","year":"2004","journal-title":"Molecular Interventions"},{"key":"10.1016\/j.phrs.2013.04.004_bib0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/ajmg.1320600203","article-title":"Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1","volume":"60","author":"Dawson","year":"1995","journal-title":"American Journal of Medical Genetics"},{"key":"10.1016\/j.phrs.2013.04.004_bib0175","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00041444-199800830-00002","article-title":"Significant linkage between bipolar affective disorder and chromosome 12q24","volume":"8","author":"Ewald","year":"1998","journal-title":"Psychiatric Genetics"},{"key":"10.1016\/j.phrs.2013.04.004_bib0180","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/(SICI)1096-8628(19991015)88:5<567::AID-AJMG24>3.0.CO;2-8","article-title":"Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24","volume":"88","author":"Morissette","year":"1999","journal-title":"American Journal of Medical Genetics"},{"key":"10.1016\/j.phrs.2013.04.004_bib0185","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/sj.mp.4001074","article-title":"A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3","volume":"7","author":"Ewald","year":"2002","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.phrs.2013.04.004_bib0190","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/01.ypg.0000056684.89558.d2","article-title":"Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q","volume":"13","author":"Curtis","year":"2003","journal-title":"Psychiatric Genetics"},{"key":"10.1016\/j.phrs.2013.04.004_bib0195","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ajmg.b.31153","article-title":"Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder","volume":"156","author":"Pereira","year":"2011","journal-title":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"},{"key":"10.1016\/j.phrs.2013.04.004_bib0200","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.expneurol.2011.06.014","article-title":"IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy","volume":"231","author":"Miltiadous","year":"2011","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0205","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2174\/1871527311201070818","article-title":"Insulin growth factor-I promotes functional recovery after a focal lesion in the dentate gyrus","volume":"11","author":"Liquitaya-Montiel","year":"2012","journal-title":"CNS and Neurological Disorders Drug Targets"},{"key":"10.1016\/j.phrs.2013.04.004_bib0210","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.275.5300.661","article-title":"Regulation of neuronal survival by the serine-threonine protein kinase Akt","volume":"275","author":"Dudek","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.phrs.2013.04.004_bib0215","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.brainres.2005.01.007","article-title":"Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects","volume":"1037","author":"Hoshaw","year":"2005","journal-title":"Brain Research"},{"key":"10.1016\/j.phrs.2013.04.004_bib0220","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1038\/sj.npp.1301358","article-title":"Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects","volume":"32","author":"Malberg","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0225","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.mcn.2007.10.016","article-title":"The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis","volume":"37","author":"Trejo","year":"2008","journal-title":"Molecular and Cellular Neurosciences"},{"key":"10.1016\/j.phrs.2013.04.004_bib0230","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0306-4522(01)00378-5","article-title":"Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis","volume":"107","author":"Lichtenwalner","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2013.04.004_bib0235","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1399-5618.2012.01013.x","article-title":"Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment","volume":"14","author":"Hajek","year":"2012","journal-title":"Bipolar Disorders"},{"key":"10.1016\/j.phrs.2013.04.004_bib0240","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1503\/jpn.110143","article-title":"Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis","volume":"37","author":"Hajek","year":"2012","journal-title":"Journal of Psychiatry and Neuroscience"},{"key":"10.1016\/j.phrs.2013.04.004_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399404008385","article-title":"Lithium neuroprotection: molecular mechanisms and clinical implications","volume":"6","author":"Rowe","year":"2004","journal-title":"Expert Reviews in Molecular Medicine"},{"key":"10.1016\/j.phrs.2013.04.004_bib0250","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrn2870","article-title":"GSK3 signalling in neural development","volume":"8","author":"Hur","year":"2010","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.phrs.2013.04.004_bib0255","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1038\/npp.2010.105","article-title":"Is glycogen synthase kinase-3 a central modulator in mood regulation","volume":"35","author":"Li","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0260","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.toxlet.2012.08.022","article-title":"In vitro mechanisms involved in the regulation of cell survival by lithium chloride and IGF-1 in human hormone-dependent breast cancer cells (MCF-7)","volume":"2","author":"Suganthi","year":"2012","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.phrs.2013.04.004_bib0265","doi-asserted-by":"crossref","first-page":"13028","DOI":"10.1073\/pnas.0605652103","article-title":"Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins","volume":"103","author":"Sitar","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.phrs.2013.04.004_bib0270","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.2174\/138161209789649475","article-title":"Use of cell lines in the investigation of pharmacogenetic loci","volume":"15","author":"Zhang","year":"2009","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.phrs.2013.04.004_bib0275","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/scbi.2001.0409","article-title":"EBNA2 and Notch signalling in Epstein\u2013Barr virus mediated immortalization of B lymphocytes","volume":"11","author":"Zimber-Strobl","year":"2001","journal-title":"Seminars in Cancer Biology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0280","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1099\/vir.0.2008\/003970-0","article-title":"Epstein\u2013Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes","volume":"89","author":"Morris","year":"2008","journal-title":"Journal of General Virology"},{"key":"10.1016\/j.phrs.2013.04.004_bib0285","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/ajmg.b.31062","article-title":"Analysis of whole genome biomarker expression in blood and brain","volume":"153B","author":"Rollins","year":"2010","journal-title":"American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661813000728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661813000728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T10:58:12Z","timestamp":1715252292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661813000728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":57,"alternative-id":["S1043661813000728"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2013.04.004","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]}}}