{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:43:21Z","timestamp":1780321401882,"version":"3.54.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.phrs.2014.05.009","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T21:01:05Z","timestamp":1401138065000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Roles of fatty acid ethanolamides (FAE) in traumatic and ischemic brain injury"],"prefix":"10.1016","volume":"86","author":[{"given":"Emanuela","family":"Esposito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Cordaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2014.05.009_bib0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1871527311312010010","article-title":"Palmitoylethanolamide in homeostatic and traumatic central nervous system injuries","volume":"12","author":"Esposito","year":"2013","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.phrs.2014.05.009_bib0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nbd.2008.09.015","article-title":"The endocannabinoid system is modulated in response to spinal cord injury in rats","volume":"33","author":"Garcia-Ovejero","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.phrs.2014.05.009_bib0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-2999(01)01182-7","article-title":"Receptor-dependent formation of endogenous cannabinoids in cortical neurons","volume":"425","author":"Stella","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.phrs.2014.05.009_bib0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuropharm.2007.05.015","article-title":"Microglia produce and hydrolyze palmitoylethanolamide","volume":"54","author":"Muccioli","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2014.05.009_bib0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/neu.2009.1120","article-title":"In situ detection of inflammatory mediators in post mortem human brain tissue after traumatic injury","volume":"27","author":"Frugier","year":"2010","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.phrs.2014.05.009_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1525-1373.2000.22501.x","article-title":"The cannabinoid system and cytokine network","volume":"225","author":"Klein","year":"2000","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.phrs.2014.05.009_bib0035","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0022-2275(20)32456-1","article-title":"Accumulation of N-acyl-ethanolamine phospholipids in rat brains during post-decapitative ischemia: a 31p NMR study","volume":"40","author":"Moesgaard","year":"1999","journal-title":"J Lipid Res"},{"key":"10.1016\/j.phrs.2014.05.009_bib0040","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1046\/j.1471-4159.2001.00542.x","article-title":"Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration","volume":"78","author":"Hansen","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0045","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1111\/j.1471-4159.2007.04892.x","article-title":"Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice","volume":"103","author":"Degn","year":"2007","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1471-4159.2001.00006.x","article-title":"Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death","volume":"76","author":"Hansen","year":"2001","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0055","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1046\/j.1471-4159.2003.02244.x","article-title":"Massive accumulation of N-acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?","volume":"88","author":"Berger","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0060","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0163-7258(02)00251-6","article-title":"Putative neuroprotective actions of N-acyl-ethanolamines","volume":"95","author":"Hansen","year":"2002","journal-title":"Pharmacol Therapeut"},{"key":"10.1016\/j.phrs.2014.05.009_bib0065","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1073\/pnas.93.9.3984","article-title":"The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons","volume":"93","author":"Skaper","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2014.05.009_bib0070","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1523\/JNEUROSCI.19-08-02987.1999","article-title":"Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures","volume":"19","author":"Nagayama","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.phrs.2014.05.009_bib0075","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1194\/jlr.M300170-JLR200","article-title":"Binding of anandamide to bovine serum albumin","volume":"44","author":"Bojesen","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.phrs.2014.05.009_bib0080","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1194\/jlr.M500411-JLR200","article-title":"Effect of an unstirred layer on the membrane permeability of anandamide","volume":"47","author":"Bojesen","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.phrs.2014.05.009_bib0085","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.1073\/pnas.0901515106","article-title":"Identification of intracellular carriers for the endocannabinoid anandamide","volume":"106","author":"Kaczocha","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2014.05.009_bib0090","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.chembiol.2009.05.004","article-title":"Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins","volume":"16","author":"Oddi","year":"2009","journal-title":"Chem Biol"},{"key":"10.1016\/j.phrs.2014.05.009_bib0095","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1097-0134(20000701)40:1<39::AID-PROT60>3.0.CO;2-N","article-title":"Steady-state and time resolved fluorescence of albumins interacting with N-oleylethanolamine, a component of the endogenous N-acylethanolamines","volume":"40","author":"Zolese","year":"2000","journal-title":"Proteins"},{"key":"10.1016\/j.phrs.2014.05.009_bib0100","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1742-2094-10-91","article-title":"A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury","volume":"10","author":"Paterniti","year":"2013","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.phrs.2014.05.009_bib0105","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1124\/jpet.107.123265","article-title":"Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice","volume":"322","author":"D\u2019Agostino","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.phrs.2014.05.009_bib0110","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1152\/ajpregu.00126.2008","article-title":"Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats","volume":"295","author":"Fu","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.phrs.2014.05.009_bib0115","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pharmthera.2005.09.009","article-title":"Receptor-independent actions of cannabinoids on cell membranes: focus on endocannabinoids","volume":"111","author":"Oz","year":"2006","journal-title":"Pharmacol Therapeut"},{"key":"10.1016\/j.phrs.2014.05.009_bib0120","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1046\/j.1471-4159.2000.0750861.x","article-title":"Determination of the phospholipid precursor of anandamide and other N-acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons","volume":"75","author":"Hansen","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0014-5793(95)01194-J","article-title":"Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain","volume":"375","author":"Schmid","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/j.phrs.2014.05.009_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0163-7827(90)90004-5","article-title":"N-acylated glycerophospholipids and their derivatives","volume":"29","author":"Schmid","year":"1990","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.phrs.2014.05.009_bib0135","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0005-2760(95)00134-X","article-title":"Glutamate stimulates the formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cortical neurons in culture","volume":"1258","author":"Hansen","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.phrs.2014.05.009_bib0140","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1471-4159.1997.69020631.x","article-title":"Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion","volume":"69","author":"Hillard","year":"1997","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0145","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/abbi.1998.0688","article-title":"Accumulation of various N-acylethanolamines including N-arachidonoylethanolamine (anandamide) in cadmium chloride-administered rat testis","volume":"354","author":"Kondo","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.phrs.2014.05.009_bib0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0009-3084(00)00195-X","article-title":"Cannabinoid receptors and the regulation of immune response","volume":"108","author":"Berdyshev","year":"2000","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.phrs.2014.05.009_bib0155","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbalip.2008.01.006","article-title":"Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine","volume":"1781","author":"Artmann","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.phrs.2014.05.009_bib0160","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nchembio.86","article-title":"Activation of the endocannabinoid system by organophosphorus nerve agents","volume":"4","author":"Nomura","year":"2008","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.phrs.2014.05.009_bib0165","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1136\/jnnp.2007.139071","article-title":"Abnormalities in the cerebrospinal fluid levels of endocannabinoids in multiple sclerosis","volume":"79","author":"Di Filippo","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.phrs.2014.05.009_bib0170","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ab.2007.09.030","article-title":"An optimized GC\u2013MS method detects nanomolar amounts of anandamide in mouse brain","volume":"373","author":"Muccioli","year":"2008","journal-title":"Anal Biochem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0175","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.lfs.2005.12.028","article-title":"Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat","volume":"79","author":"Murillo-Rodriguez","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.phrs.2014.05.009_bib0180","doi-asserted-by":"crossref","first-page":"20869","DOI":"10.1074\/jbc.M110813200","article-title":"Astrocytes in culture produce anandamide and other acylethanolamides","volume":"277","author":"Walter","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0185","series-title":"Proceedings ICRS 2010 \u2013 20th Annual Symposium of the International Cannabinoid Research Society","article-title":"Perforant pathway transsection induces differential regulation of endocannabinoid levels in organotypic hippocampal slice cultures","author":"Kallendrusch","year":"2010"},{"key":"10.1016\/j.phrs.2014.05.009_bib0190","doi-asserted-by":"crossref","first-page":"7767","DOI":"10.1523\/JNEUROSCI.23-21-07767.2003","article-title":"Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility","volume":"23","author":"Franklin","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.phrs.2014.05.009_bib0195","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0021-9258(19)68203-7","article-title":"Inhibition of permeability-dependent Ca2+ release from mitochondria by N-acylethanolamines, a class of lipids synthesized in ischemic heart tissue","volume":"257","author":"Epps","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0200","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0014-5793(96)00959-3","article-title":"Calcineurin and mitochondrial function in glutamate-induced neuronal cell death","volume":"394","author":"Ankarcrona","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/j.phrs.2014.05.009_bib0205","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0014-5793(88)80169-8","article-title":"Effects of long-chain N-acylethanolamines on lipid peroxidation in cardiac mitochondria","volume":"237","author":"Parinandi","year":"1988","journal-title":"FEBS Lett"},{"key":"10.1016\/j.phrs.2014.05.009_bib0210","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0009-3084(98)00093-0","article-title":"Long-chain N-acylethanolamines inhibit lipid peroxidation in rat liver mitochondria under acute hypoxic hypoxia","volume":"97","author":"Gulaya","year":"1998","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.phrs.2014.05.009_bib0215","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.1021\/ja01577a066","article-title":"The identification of N-(2-hydroxyethyl)-palmitamide as a naturally occurring anti-inflammatory agent","volume":"79","author":"Kuehl","year":"1957","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.phrs.2014.05.009_bib0220","first-page":"395","article-title":"Anti-inflammatory properties of N(2-hydroxyethyl) palmitamide","volume":"39","author":"Perlik","year":"1971","journal-title":"Acta Physiol Hung"},{"key":"10.1016\/j.phrs.2014.05.009_bib0225","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1073\/pnas.92.8.3376","article-title":"Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide","volume":"92","author":"Facci","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.phrs.2014.05.009_bib0230","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0014-2999(97)01007-8","article-title":"Influence of fatty acid ethanolamides and delta9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells","volume":"330","author":"Berdyshev","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.phrs.2014.05.009_bib0235","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0014-2999(00)00437-4","article-title":"Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide","volume":"401","author":"Ross","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.phrs.2014.05.009_bib0240","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1046\/j.1471-4159.1996.66031157.x","article-title":"Mast cell activation causes delayed neurodegeneration in mixed hippocampal cultures via the nitric oxide pathway","volume":"66","author":"Skaper","year":"1996","journal-title":"J Neurochem"},{"key":"10.1016\/j.phrs.2014.05.009_bib0245","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0166-2236(96)10058-8","article-title":"Nerve growth factor: from neurotrophin to neurokine","volume":"19","author":"Levi-Montalcini","year":"1996","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.phrs.2014.05.009_bib0250","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0005-2760(86)90341-3","article-title":"N-acylethanolamine phospholipid metabolism in normal and ischemic rat brain","volume":"878","author":"Natarajan","year":"1986","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.phrs.2014.05.009_bib0255","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.brainres.2008.09.019","article-title":"Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia","volume":"1240","author":"Schomacher","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.phrs.2014.05.009_bib0260","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/sj.bjp.0707478","article-title":"Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism","volume":"152","author":"Sun","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.phrs.2014.05.009_bib0265","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature01921","article-title":"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha","volume":"425","author":"Fu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2014.05.009_bib0270","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.neuropharm.2005.02.013","article-title":"Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats","volume":"48","author":"Fu","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2014.05.009_bib0275","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s11745-008-3217-y","article-title":"Biological functions and metabolism of oleoylethanolamide","volume":"43","author":"Thabuis","year":"2008","journal-title":"Lipids"},{"key":"10.1016\/j.phrs.2014.05.009_bib0280","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.phrs.2003.12.006","article-title":"Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration","volume":"49","author":"Oveisi","year":"2004","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.phrs.2014.05.009_bib0285","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1161\/01.STR.0000023491.63693.18","article-title":"Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study","volume":"33","author":"Schabitz","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.phrs.2014.05.009_bib0290","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuropharm.2012.03.008","article-title":"Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-activated receptor alpha","volume":"63","author":"Zhou","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.phrs.2014.05.009_bib0295","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainres.2012.08.006","article-title":"Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats","volume":"1477","author":"Ahmad","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.phrs.2014.05.009_bib0300","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neulet.2011.01.073","article-title":"Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a rodent model for stroke","volume":"492","author":"Garg","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.phrs.2014.05.009_bib0305","doi-asserted-by":"crossref","first-page":"23341","DOI":"10.3390\/ijms141223341","article-title":"Does the neuroprotective role of anandamide display diurnal variations","volume":"14","author":"Martinez-Vargas","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.phrs.2014.05.009_bib0310","doi-asserted-by":"crossref","first-page":"E298","DOI":"10.1208\/aapsj080234","article-title":"Cannabinoid receptors and endocannabinoids: evidence for new players","volume":"8","author":"Mackie","year":"2006","journal-title":"AAPS J"},{"key":"10.1016\/j.phrs.2014.05.009_bib0315","doi-asserted-by":"crossref","first-page":"PL125","DOI":"10.1016\/S0024-3205(98)00324-5","article-title":"Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice","volume":"63","author":"Berdyshev","year":"1998","journal-title":"Life Sci"},{"key":"10.1016\/j.phrs.2014.05.009_bib0320","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1528-1157.2001.41499.x","article-title":"Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice","volume":"42","author":"Lambert","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.phrs.2014.05.009_bib0325","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/28393","article-title":"Control of pain initiation by endogenous cannabinoids","volume":"394","author":"Calignano","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2014.05.009_bib0330","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00000542-200103000-00023","article-title":"Administration of endocannabinoids prevents a referred hyperalgesia associated with inflammation of the urinary bladder","volume":"94","author":"Farquhar-Smith","year":"2001","journal-title":"Anesthesiology"},{"key":"10.1016\/j.phrs.2014.05.009_bib0335","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.bbi.2012.07.021","article-title":"Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice","volume":"26","author":"Ahmad","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.phrs.2014.05.009_bib0340","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuropharm.2012.11.017","article-title":"Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-alpha receptor activation in a genetic model of absence epilepsy","volume":"69","author":"Citraro","year":"2013","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.phrs.2014.05.009_bib0345","doi-asserted-by":"crossref","first-page":"e41880","DOI":"10.1371\/journal.pone.0041880","article-title":"Neuroprotective activities of palmitoylethanolamide in an animal model of parkinson's disease","volume":"7","author":"Esposito","year":"2012","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.phrs.2014.05.009_bib0350","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1038\/npp.2012.25","article-title":"Palmitoylethanolamide protects against the amyloid-\u03b225-35-induced learning and memory impairment in mice, an experimental model of Alzheimer disease","volume":"37","author":"D\u2019Agostino","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2014.05.009_bib0355","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2012.07.045","article-title":"Endocannabinoids reduce cerebral damage after hypoxic-ischemic injury in perinatal rats","volume":"1474","author":"Lara-Celador","year":"2012","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.phrs.2014.05.009_bib0360","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1254\/jphs.12208FP","article-title":"Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats","volume":"121","author":"Shimizu","year":"2013","journal-title":"J Pharmacol Sci."},{"issue":"5","key":"10.1016\/j.phrs.2014.05.009_bib0365","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/syn.20733","article-title":"Effects of the endogenous PPAR-alpha agonist, oleoylethanolamide on MDMA-induced cognitive deficits in mice","volume":"64","author":"Plaza-Zabala","year":"2010","journal-title":"Synapse"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661814000814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661814000814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T15:50:18Z","timestamp":1649087418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661814000814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":73,"alternative-id":["S1043661814000814"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2014.05.009","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of fatty acid ethanolamides (FAE) in traumatic and ischemic brain injury","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2014.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}