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J. Cancer Res."},{"key":"10.1016\/j.phrs.2015.04.008_bib2570","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.fct.2008.08.023","article-title":"Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3\u2032,4,4\u2032-tetrachlorobiphenyl (PCB-77)","volume":"46","author":"Tharappel","year":"2008","journal-title":"Food Chem. 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Virol."},{"key":"10.1016\/j.phrs.2015.04.008_bib2620","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.antiviral.2005.06.005","article-title":"A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes","volume":"67","author":"Shin","year":"2005","journal-title":"Antiviral Res."},{"key":"10.1016\/j.phrs.2015.04.008_bib2625","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1248\/bpb.31.743","article-title":"Anti-hepatitis B virus activities of Geranium carolinianum L. extracts and identification of the active components","volume":"31","author":"Li","year":"2008","journal-title":"Biol. Pharm. 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Biomed. Mater. Res. B: Appl. Bioomater."},{"key":"10.1016\/j.phrs.2015.04.008_bib2705","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.colsurfb.2013.03.039","article-title":"Ellagic acid encapsulated chitosan nanoparticles for drug delivery system in human oral cancer cell line (KB)","volume":"110","author":"Arulmozhi","year":"2013","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.phrs.2015.04.008_bib2710","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.carbpol.2014.03.093","article-title":"Ellagic acid encapsulated chitosan nanoparticles as anti-hemorrhagic agent","volume":"111","author":"Gopalakrishnan","year":"2014","journal-title":"Carbohydr. 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Perianesthesia Nurs."},{"key":"10.1016\/j.phrs.2015.04.008_bib2735","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.foodchem.2013.09.012","article-title":"Polyphenols in Barringtonia racemosa and their protection against oxidation of LDL, serum and haemoglobin","volume":"146","author":"Kong","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.phrs.2015.04.008_bib2740","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.fct.2013.06.048","article-title":"Evaluation of acute and subacute toxicity and mutagenic activity of the aqueous extract of pecan shells [Carya illinoinensis (Wangenh.) K. Koch]","volume":"59","author":"Porto","year":"2013","journal-title":"Food Chem. 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