{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:41:35Z","timestamp":1791110495483,"version":"4.1.0"},"reference-count":196,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.phrs.2015.05.003","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T02:08:40Z","timestamp":1431655720000},"page":"23-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Ketamine and suicidal ideation in depression: Jumping the gun?"],"prefix":"10.1016","volume":"99","author":[{"given":"R.","family":"Rajkumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.Y.M.","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6119-701X","authenticated-orcid":false,"given":"G.S.","family":"Dawe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2015.05.003_bib0980","series-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.phrs.2015.05.003_bib0985","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jad.2006.05.026","article-title":"Clinical differences among depressed patients with and without a history of suicide attempts: Findings from the star*d trial","volume":"97","author":"Claassen","year":"2007","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.phrs.2015.05.003_bib0990","first-page":"245","article-title":"The role of general practitioners in prevention of depression-related suicides","volume":"14","author":"Rihmer","year":"2012","journal-title":"Neuropsychopharmacol. Hung.: A Magyar Pszichofarmakologiai Egyesulet lapja=Off. J Hung. Assoc. Psychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib0995","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/bdi.12087","article-title":"Epidemiology of suicide in bipolar disorders: a systematic review of the literature","volume":"15","author":"Pompili","year":"2013","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.phrs.2015.05.003_bib1000","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1001\/archpsyc.60.6.610","article-title":"Occurrence and course of suicidality during short-term treatment of late-life depression","volume":"60","author":"Szanto","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1005","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/jama.292.3.338","article-title":"Antidepressants and the risk of suicidal behaviors","volume":"292","author":"Jick","year":"2004","journal-title":"JAMA: J. Am. Med. Assoc."},{"key":"10.1016\/j.phrs.2015.05.003_bib1010","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1176\/appi.ajp.162.5.977","article-title":"Relief of expressed suicidal intent by ECT: a consortium for research in ECT study","volume":"162","author":"Kellner","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1015","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0006-3223(99)00230-9","article-title":"Antidepressant effects of ketamine in depressed patients","volume":"47","author":"Berman","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1020","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","article-title":"A randomized trial of an n-methyl-d-aspartate antagonist in treatment-resistant major depression","volume":"63","author":"Zarate","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1025","doi-asserted-by":"crossref","first-page":"A260","DOI":"10.1136\/ip.2010.029215.925","article-title":"Rapid treatment of suicide states in the emergency department","volume":"16","author":"Larkin","year":"2010","journal-title":"Injury Prev."},{"key":"10.1016\/j.phrs.2015.05.003_bib1030","first-page":"1127","article-title":"A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department","volume":"14","author":"Larkin","year":"2011","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Collegium Int. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1035","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s40263-015-0232-4","article-title":"Does ketamine have anti-suicidal properties? Current status and future directions","volume":"29","author":"Price","year":"2015","journal-title":"CNS Drugs"},{"key":"10.1016\/j.phrs.2015.05.003_bib1040","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40268-015-0081-0","article-title":"Ketamine as a potential treatment for suicidal ideation: a systematic review of the literature","volume":"15","author":"Reinstatler","year":"2015","journal-title":"Drugs in R&D"},{"key":"10.1016\/j.phrs.2015.05.003_bib1045","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archgenpsychiatry.2007.37","article-title":"Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study","volume":"65","author":"Deakin","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1050","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.phrs.2015.05.003_bib1055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neuroscience.2010.12.012","article-title":"Mechanisms underlying ketamine-induced synaptic depression in rat hippocampus-medial prefrontal cortex pathway","volume":"177","author":"Kamiyama","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2015.05.003_bib1060","first-page":"745","article-title":"Vulnerability to psychotogenic effects of ketamine is associated with elevated d2\/3-receptor availability","volume":"16","author":"Vernaleken","year":"2013","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Collegium Int. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1065","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/npp.2013.290","article-title":"Sub-anesthetic ketamine modulates intrinsic bold connectivity within the hippocampal-prefrontal circuit in the rat","volume":"39","author":"Gass","year":"2014","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1070","first-page":"287","article-title":"Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression","volume":"34","author":"Sos","year":"2013","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.phrs.2015.05.003_bib1075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1017\/S109285291300045X","article-title":"Mechanism of action of ketamine","volume":"18","author":"Stahl","year":"2013","journal-title":"CNS Spectr."},{"key":"10.1016\/j.phrs.2015.05.003_bib1080","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fphar.2013.00161","article-title":"Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants","volume":"4","author":"Browne","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1085","article-title":"A low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects","author":"Sanacora","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1090","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pharmthera.2009.02.010","article-title":"Ketamine and the next generation of antidepressants with a rapid onset of action","volume":"123","author":"Machado-Vieira","year":"2009","journal-title":"Pharmacol. Therap."},{"key":"10.1016\/j.phrs.2015.05.003_bib1095","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/nm1210-1384","article-title":"Cracking the moody brain: lifting the mood with ketamine","volume":"16","author":"Murrough","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1100","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1126\/science.1194313","article-title":"A glutamate pathway to faster-acting antidepressants?","volume":"329","author":"Cryan","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.phrs.2015.05.003_bib1105","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1098\/rstb.2011.0357","article-title":"A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists","volume":"367","author":"Duman","year":"2012","journal-title":"Philos. Trans. R. Soc. London Ser. B, Biol. Sci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1110","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00702-013-1130-x","article-title":"Glutamate and its receptors in the pathophysiology and treatment of major depressive disorder","volume":"121","author":"Niciu","year":"2014","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.phrs.2015.05.003_bib1115","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/mp.2013.55","article-title":"Rapid antidepressant effects: moving right along","volume":"18","author":"Martinowich","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.12223","article-title":"New paradigms for treatment-resistant depression","volume":"1292","author":"Zarate","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.coph.2014.11.005","article-title":"How does ketamine elicit a rapid antidepressant response?","volume":"20","author":"Kavalali","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1130","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.conb.2014.12.004","article-title":"Antidepressant actions of ketamine: from molecular mechanisms to clinical practice","volume":"30","author":"Monteggia","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1135","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12264-014-1484-6","article-title":"Rapid-onset antidepressant efficacy of glutamatergic system modulators: the neural plasticity hypothesis of depression","volume":"31","author":"Wang","year":"2015","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.phrs.2015.05.003_bib1140","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/mp.2011.47","article-title":"Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice","volume":"16","author":"Beurel","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12031-014-0277-8","article-title":"Downregulation of neuregulin 1-ErbB4 signaling in parvalbumin interneurons in the rat brain may contribute to the antidepressant properties of ketamine","volume":"54","author":"Wang","year":"2014","journal-title":"J. Mol. Neurosci.: MN"},{"key":"10.1016\/j.phrs.2015.05.003_bib1150","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12031-014-0340-5","article-title":"Downregulation of neuregulin 1-ErbB4 signaling and antidepressant properties of ketamine: ErbB4 expressing pyramidal neurons may play a role","volume":"55","author":"Bernstein","year":"2015","journal-title":"J. Mol. Neurosci.: MN"},{"key":"10.1016\/j.phrs.2015.05.003_bib1155","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3892\/etm.2013.930","article-title":"Ketamine exerts antidepressant effects and reduces IL-1beta and IL-6 levels in rat prefrontal cortex and hippocampus","volume":"5","author":"Yang","year":"2013","journal-title":"Exp. Therap. Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1160","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tins.2009.11.003","article-title":"mTOR signaling: at the crossroads of plasticity, memory and disease","volume":"33","author":"Hoeffer","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1165","doi-asserted-by":"crossref","first-page":"021001","DOI":"10.1088\/1478-3975\/7\/2\/021001","article-title":"Mechanisms governing the control of MRNA translation","volume":"7","author":"Livingstone","year":"2014","journal-title":"Phys. Biol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1170","doi-asserted-by":"crossref","first-page":"e03581","DOI":"10.7554\/eLife.03581","article-title":"Glun2b-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine","volume":"3","author":"Miller","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.phrs.2015.05.003_bib1175","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000356517","article-title":"Akt mediates GSK-3beta phosphorylation in the rat prefrontal cortex during the process of ketamine exerting rapid antidepressant actions","volume":"21","author":"Zhou","year":"2014","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.phrs.2015.05.003_bib1180","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","author":"Autry","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2015.05.003_bib1185","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.biopsych.2012.09.006","article-title":"The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine","volume":"73","author":"Monteggia","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1190","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbr.2013.07.032","article-title":"The activation of adenosine monophosphate-activated protein kinase in rat hippocampus contributes to the rapid antidepressant effect of ketamine","volume":"253","author":"Xu","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.phrs.2015.05.003_bib0001","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s12017-014-8312-z","article-title":"MicroRNA expression profile and functional analysis reveal that miR-206 is a critical novel gene for the expression of BDNF induced by ketamine","volume":"16","author":"Yang","year":"2014","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1195","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1101\/lm.67804","article-title":"Erk1\/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal ca1 pyramidal neurons","volume":"11","author":"Alonso","year":"2004","journal-title":"Learn. Memory"},{"key":"10.1016\/j.phrs.2015.05.003_bib1200","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1523\/JNEUROSCI.5499-06.2007","article-title":"TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation","volume":"27","author":"Amaral","year":"2007","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1205","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.4037-06.2007","article-title":"Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus","volume":"27","author":"Rex","year":"2007","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1210","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuron.2008.11.013","article-title":"Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity","volume":"61","author":"Jaworski","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.phrs.2015.05.003_bib1215","doi-asserted-by":"crossref","first-page":"11288","DOI":"10.1523\/JNEUROSCI.2284-05.2005","article-title":"Regulation of dendritic morphogenesis by ras-pi3k-Akt-mTOR and ras-mapk signaling pathways","volume":"25","author":"Kumar","year":"2005","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1220","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.eurpsy.2013.10.005","article-title":"Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex","volume":"29","author":"Zhou","year":"2014","journal-title":"Eur. Psychiatry: J. Assoc. Eur. Psychiatrists"},{"key":"10.1016\/j.phrs.2015.05.003_bib1225","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00213-013-3153-2","article-title":"Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR","volume":"230","author":"Akinfiresoye","year":"2013","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.phrs.2015.05.003_bib1230","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/WNR.0b013e32836131ad","article-title":"Acute ketamine-induced neuroplasticity: ribosomal protein s6 phosphorylation expression in drug addiction-related rat brain areas","volume":"24","author":"Tedesco","year":"2013","journal-title":"Neuroreport"},{"key":"10.1016\/j.phrs.2015.05.003_bib1235","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s12035-014-8798-2","article-title":"Loss of phenotype of parvalbumin interneurons in rat prefrontal cortex is involved in antidepressant- and propsychotic-like behaviors following acute and repeated ketamine administration","volume":"51","author":"Zhou","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1240","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.pbb.2013.11.033","article-title":"R (\u2212)-ketamine shows greater potency and longer lasting antidepressant effects than s (+)-ketamine","volume":"116","author":"Zhang","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2015.05.003_bib1245","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/15622970701714370","article-title":"Comparison of racemic ketamine and s-ketamine in treatment-resistant major depression: report of two cases","volume":"10","author":"Paul","year":"2009","journal-title":"World J. Biol. Psychiatry: Off. J. World Fed. Soc. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1250","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0730-725X(95)00010-E","article-title":"Visualisation of changes in regional cerebral blood flow (RCBF) produced by ketamine using long the gradient-echo sequences: preliminary results","volume":"13","author":"Burdett","year":"1995","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.phrs.2015.05.003_bib1255","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00213-006-0344-0","article-title":"Mapping the central effects of ketamine in the rat using pharmacological MRI","volume":"186","author":"Littlewood","year":"2006","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.phrs.2015.05.003_bib1260","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1124\/jpet.110.173880","article-title":"Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2\/3 agonist modulation of ketamine-induced blood oxygenation level dependence signals","volume":"336","author":"Chin","year":"2011","journal-title":"J. Pharmacol. Exp. Therap."},{"key":"10.1016\/j.phrs.2015.05.003_bib1265","first-page":"9","article-title":"Ketamine reverses stress-induced depression-like behavior and increased gaba levels in the anterior cingulate: An 11.7t h-mrs study in rats","volume":"51C","author":"Perrine","year":"2013","journal-title":"Progress Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1270","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.4088\/JCP.08m04659","article-title":"Brain-derived neurotrophic factor and initial antidepressant response to an n-methyl-d-aspartate antagonist","volume":"70","author":"Machado-Vieira","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1275","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00213-010-2121-3","article-title":"Chronic ketamine use increases serum levels of brain-derived neurotrophic factor","volume":"215","author":"Ricci","year":"2011","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.phrs.2015.05.003_bib1280","first-page":"301","article-title":"Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder","volume":"16","author":"Duncan","year":"2013","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Collegium Int. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1285","first-page":"331","article-title":"Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression","volume":"17","author":"Haile","year":"2014","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Collegium Int. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1290","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/hup.2271","article-title":"Single ketamine infusion in bipolar depression resistant to antidepressants: are neurotrophins involved?","volume":"28","author":"Rybakowski","year":"2013","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1295","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1124\/jpet.112.201665","article-title":"Quantifying the attenuation of the ketamine pharmacological magnetic resonance imaging response in humans: a validation using antipsychotic and glutamatergic agents","volume":"345","author":"Doyle","year":"2013","journal-title":"J. Pharmacol. Exp. Therap."},{"key":"10.1016\/j.phrs.2015.05.003_bib1300","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuroimage.2012.09.037","article-title":"Test\u2013retest reliability of the bold pharmacological MRI response to ketamine in healthy volunteers","volume":"64","author":"De Simoni","year":"2013","journal-title":"Neuroimage"},{"key":"10.1016\/j.phrs.2015.05.003_bib1305","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.biopsych.2013.02.008","article-title":"Neural correlates of rapid antidepressant response to ketamine in treatment-resistant unipolar depression: a preliminary positron emission tomography study","volume":"73","author":"Carlson","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1310","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/bdi.12118","article-title":"Neural correlates of rapid antidepressant response to ketamine in bipolar disorder","volume":"16","author":"Nugent","year":"2014","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.phrs.2015.05.003_bib1315","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.biopsych.2011.11.006","article-title":"(1)h-[(1)(3)c]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism","volume":"71","author":"Chowdhury","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1320","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1523\/JNEUROSCI.17-08-02921.1997","article-title":"Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex","volume":"17","author":"Moghaddam","year":"1997","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1325","doi-asserted-by":"crossref","first-page":"11496","DOI":"10.1523\/JNEUROSCI.2213-07.2007","article-title":"NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons","volume":"27","author":"Homayoun","year":"2007","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1330","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.schres.2012.01.024","article-title":"Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine","volume":"136","author":"Chan","year":"2012","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.phrs.2015.05.003_bib1335","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.biopsych.2012.03.029","article-title":"Synaptic potentiation is critical for rapid antidepressant response to ketamine in treatment-resistant major depression","volume":"72","author":"Cornwell","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1340","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jad.2014.02.017","article-title":"Do the dissociative side effects of ketamine mediate its antidepressant effects?","volume":"159","author":"Luckenbaugh","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.phrs.2015.05.003_bib1345","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/schbul\/sbr144","article-title":"Subanaesthetic ketamine treatment alters prefrontal cortex connectivity with thalamus and ascending subcortical systems","volume":"39","author":"Dawson","year":"2013","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.phrs.2015.05.003_bib1350","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0893-133X(01)00243-3","article-title":"Effects of ketamine in normal and schizophrenic volunteers","volume":"25","author":"Lahti","year":"2001","journal-title":"Neuropsychopharmacol: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1355","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.4088\/JCP.09m05327blu","article-title":"Rapid resolution of suicidal ideation after a single infusion of an n-methyl-d-aspartate antagonist in patients with treatment-resistant major depressive disorder","volume":"71","author":"DiazGranados","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1360","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/0253-7176.101793","article-title":"Rapid response with ketamine on suicidal cognition in resistant depression","volume":"34","author":"Thakurta","year":"2012","journal-title":"Indian J. Psychol. Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1365","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1001\/archgenpsychiatry.2010.90","article-title":"A randomized add-on trial of an n-methyl-d-aspartate antagonist in treatment-resistant bipolar depression","volume":"67","author":"Diazgranados","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1370","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.biopsych.2011.12.010","article-title":"Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial","volume":"71","author":"Zarate","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1375","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.biopsych.2012.06.022","article-title":"Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression","volume":"74","author":"Murrough","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1380","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/JCP.0b013e3182856865","article-title":"Urgent ketamine infusion rapidly eliminated suicidal ideation for a patient with major depressive disorder: a case report","volume":"33","author":"Zigman","year":"2013","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1385","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/jpm.2010.0499","article-title":"Ketamine alleviates fear, depression, and suicidal ideation in terminally ill patients","volume":"14","author":"Thangathurai","year":"2011","journal-title":"J. Palliat. Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1390","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.biopsych.2009.04.029","article-title":"Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression","volume":"66","author":"Price","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1395","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/10903120590891859","article-title":"Ketamine chemical restraint to facilitate rescue of a combative \u201cjumper\u201d","volume":"9","author":"Hick","year":"2005","journal-title":"Prehospital Emerg. Care: Off. J. Natl. Assoc. EMS Physicians Natl. Assoc. State EMS Direct."},{"key":"10.1016\/j.phrs.2015.05.003_bib1400","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1097\/00005373-200111000-00031","article-title":"Intramuscular ketamine for the rapid tranquilization of the uncontrollable, violent, and dangerous adult patient","volume":"51","author":"Roberts","year":"2001","journal-title":"J. Trauma"},{"key":"10.1016\/j.phrs.2015.05.003_bib1405","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4088\/JCP.10l06447blu","article-title":"A case of sustained remission following an acute course of ketamine in treatment-resistant depression","volume":"72","author":"Murrough","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1410","first-page":"234","article-title":"Intravenous ketamine therapy in a patient with a treatment-resistant major depression","volume":"137","author":"Liebrenz","year":"2007","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.phrs.2015.05.003_bib1415","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/01.yct.0000263257.44539.23","article-title":"Rapid relief of severe major depressive disorder by use of preoperative ketamine and electroconvulsive therapy","volume":"23","author":"Goforth","year":"2007","journal-title":"J. ECT"},{"key":"10.1016\/j.phrs.2015.05.003_bib1420","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1080\/15622970701420481","article-title":"Repeated intravenous ketamine therapy in a patient with treatment-resistant major depression","volume":"10","author":"Liebrenz","year":"2009","journal-title":"World J. Biol. Psychiatry: Off. J. World Fed. Soc. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1425","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1176\/jnp.2010.22.4.442","article-title":"The use of a series of ketamine infusions in two patients with treatment-resistant depression","volume":"22","author":"Messer","year":"2010","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1430","first-page":"460","article-title":"Ketamine in melancholic depression","volume":"172","author":"Bjerre","year":"2010","journal-title":"Ugeskr. Laeger"},{"key":"10.1016\/j.phrs.2015.05.003_bib1435","first-page":"118","article-title":"Effects of ketamine on major depressive disorder in a patient with posttraumatic stress disorder","volume":"81","author":"Womble","year":"2013","journal-title":"AANA J."},{"key":"10.1016\/j.phrs.2015.05.003_bib1440","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1177\/0004867414520754","article-title":"Oral ketamine augmentation for chronic suicidality in treatment-resistant depression","volume":"48","author":"De Gioannis","year":"2014","journal-title":"Austr. New Zeal. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1445","first-page":"E10","article-title":"Treatment-refractory depression: a case of successful treatment with intranasal ketamine 10%","volume":"26","author":"Clark","year":"2014","journal-title":"Ann. Clin. Psychiatry: Off. J. Am. Acad. Clin. Psychiatr."},{"key":"10.1016\/j.phrs.2015.05.003_bib1450","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.biopsych.2013.04.019","article-title":"Transient resolution of treatment-resistant posttraumatic stress disorder following ketamine infusion","volume":"74","author":"D\u2019Andrea","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1455","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/0019-5545.111461","article-title":"Intramuscular ketamine in acute depression: a report on two cases","volume":"55","author":"Harihar","year":"2013","journal-title":"Indian J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1460","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/da.22253","article-title":"Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression","volume":"31","author":"Price","year":"2014","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.phrs.2015.05.003_bib1465","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.biopsych.2009.08.038","article-title":"Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression","volume":"67","author":"Aan Het Rot","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1470","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1176\/appi.ajp.2013.13030392","article-title":"Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial","volume":"170","author":"Murrough","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1475","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.biopsych.2014.03.026","article-title":"A randomized controlled trial of intranasal ketamine in major depressive disorder","volume":"76","author":"Lapidus","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1480","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/npp.2014.298","article-title":"Neurocognitive effects of ketamine and association with antidepressant response in individuals with treatment-resistant depression: a randomized controlled trial","volume":"40","author":"Murrough","year":"2015","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1485","first-page":"1805","article-title":"Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression","volume":"17","author":"Shiroma","year":"2014","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Collegium Int. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1490","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/0269881113486718","article-title":"Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive-compulsive disorder and a history of major depressive disorder","volume":"27","author":"Niciu","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1495","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1089\/jpm.2012.0617","article-title":"Daily oral ketamine for the treatment of depression and anxiety in patients receiving hospice care: a 28-day open-label proof-of-concept trial","volume":"16","author":"Irwin","year":"2013","journal-title":"J. Palliat. Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1500","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1520\/JFS14283J","article-title":"Tissue distribution of ketamine in a mixed drug fatality","volume":"42","author":"Moore","year":"1997","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1505","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/jat\/28.1.71","article-title":"Postmortem blood ketamine distribution in two fatalities","volume":"28","author":"Lalonde","year":"2004","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1510","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1520\/JFS14742J","article-title":"Ketamine in non-hospital and hospital deaths in New York city","volume":"45","author":"Gill","year":"2000","journal-title":"J. Forensic Sci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1515","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1016\/j.forsciint.2010.04.047","article-title":"Suicide by hanging under the influence of ketamine and ethanol","volume":"202","author":"Dinis-Oliveira","year":"2010","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.phrs.2015.05.003_bib1520","doi-asserted-by":"crossref","first-page":"e417","DOI":"10.4088\/JCP.13m08698","article-title":"Clinical predictors of ketamine response in treatment-resistant major depression","volume":"75","author":"Niciu","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1525","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2190\/PM.46.1.b","article-title":"Suicide prevention as a prerequisite for recovery from severe mental illness","volume":"46","author":"Foster","year":"2013","journal-title":"Int. J. Psychiatry Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1530","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2165\/11586450-000000000-00000","article-title":"Managing suicide risk in patients with schizophrenia","volume":"25","author":"Kasckow","year":"2011","journal-title":"CNS Drugs"},{"key":"10.1016\/j.phrs.2015.05.003_bib1535","doi-asserted-by":"crossref","first-page":"S195","DOI":"10.1016\/j.amepre.2014.06.012","article-title":"Existing and novel biological therapeutics in suicide prevention","volume":"47","author":"Griffiths","year":"2014","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1540","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/714858480","article-title":"Antisuicide properties of psychotropic drugs: a critical review","volume":"12","author":"Ernst","year":"2004","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1545","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1017\/S1121189X00000427","article-title":"The role of psychopharmacology in suicide prevention","volume":"18","author":"Saunders","year":"2009","journal-title":"Epidemiol. Psichiatr. Soc."},{"issue":"Suppl. 3","key":"10.1016\/j.phrs.2015.05.003_bib1550","first-page":"15","article-title":"Suicide in schizophrenia: risk factors and clozapine treatment","volume":"59","author":"Meltzer","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1185\/03007999709113338","article-title":"Treatment-resistant schizophrenia \u2013 the role of clozapine","volume":"14","author":"Meltzer","year":"1997","journal-title":"Curr. Med. Res. Opin."},{"issue":"Suppl. 3","key":"10.1016\/j.phrs.2015.05.003_bib1560","first-page":"4","article-title":"The efficacy of atypical antipsychotics in the treatment of depressive symptoms, hostility, and suicidality in patients with schizophrenia","volume":"61","author":"Keck","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1565","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11920-996-0047-6","article-title":"Suicidality in schizophrenia: a review of the evidence for risk factors and treatment options","volume":"4","author":"Meltzer","year":"2002","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.phrs.2015.05.003_bib1570","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coph.2003.09.010","article-title":"What's atypical about atypical antipsychotic drugs?","volume":"4","author":"Meltzer","year":"2004","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1575","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1176\/ajp.152.2.183","article-title":"Reduction of suicidality during clozapine treatment of neuroleptic-resistant schizophrenia: Impact on risk-benefit assessment","volume":"152","author":"Meltzer","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1580","first-page":"245","article-title":"Diminished suicidal and aggressive behavior, high plasma norepinephrine levels, and serum triglyceride levels in chronic neuroleptic-resistant schizophrenic patients maintained on clozapine","volume":"21","author":"Spivak","year":"1998","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1585","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4088\/JCP.v61n0502","article-title":"Clozapine for treatment-refractory schizophrenia, schizoaffective disorder, and psychotic bipolar disorder: a 24-month naturalistic study","volume":"61","author":"Ciapparelli","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1590","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/archpsyc.60.1.82","article-title":"International Suicide Prevention Trial Study G. Clozapine treatment for suicidality in schizophrenia: International suicide prevention trial (intercept)","volume":"60","author":"Meltzer","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1595","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1192\/bjp.182.6.505","article-title":"Modelling the impact of clozapine on suicide in patients with treatment-resistant schizophrenia in the UK","volume":"182","author":"Duggan","year":"2003","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1600","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1176\/ps.49.8.1029","article-title":"Suicide prevention effects associated with clozapine therapy in schizophrenia and schizoaffective disorder","volume":"49","author":"Reid","year":"1998","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/j.phrs.2015.05.003_bib1605","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/pds.3567","article-title":"Mortality, attempted suicide, re-hospitalisation and prescription refill for clozapine and other antipsychotics in Sweden \u2013 a register-based study","volume":"23","author":"Ringback Weitoft","year":"2014","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.phrs.2015.05.003_bib1610","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3371\/CSRP.4.1.4","article-title":"Clozapine for treatment-resistant schizophrenia: National Institute of Clinical Excellence (NICE) guidance in the real world","volume":"4","author":"Mortimer","year":"2010","journal-title":"Clin. Schizophr. Relat. Psychoses."},{"key":"10.1016\/j.phrs.2015.05.003_bib1615","first-page":"65","article-title":"Suicidal obsessions as dose dependent side-effect of clozapine","volume":"44","author":"Aukst-Margetic","year":"2011","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.phrs.2015.05.003_bib1620","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/15563659709001193","article-title":"Nonfatal suicidal intoxication by clozapine","volume":"35","author":"Ishii","year":"1997","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1625","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00004714-200006000-00006","article-title":"Sudden death in patients receiving clozapine treatment: a preliminary investigation","volume":"20","author":"Modai","year":"2000","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1630","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/0006-3223(95)00550-1","article-title":"Immediate recurrence of psychotic symptoms after discontinuation of clozapine: a case report","volume":"39","author":"Tanriverdi","year":"1996","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1635","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.schres.2006.06.032","article-title":"Beware the meta-analysis \u2013 clozapine and suicidal ideation","volume":"86","author":"Haas","year":"2006","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.phrs.2015.05.003_bib1640","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.schres.2004.05.015","article-title":"Suicidal risk during treatment with clozapine: a meta-analysis","volume":"73","author":"Hennen","year":"2005","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.phrs.2015.05.003_bib1645","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1089\/cap.2013.0063","article-title":"Quetiapine monotherapy in adolescents with bipolar disorder comorbid with conduct disorder","volume":"23","author":"Masi","year":"2013","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1650","first-page":"93","article-title":"Quetiapine reduces irritability and risk of suicide in patients with agitated depression","volume":"38","author":"Nishiyama","year":"2013","journal-title":"Tokai J. Exp. Clin. Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1655","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00213-011-2607-7","article-title":"The effect of add-on treatment with quetiapine on measures of depression, aggression, irritability and suicidal tendencies in children and adolescents","volume":"220","author":"Podobnik","year":"2012","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.phrs.2015.05.003_bib1660","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YIC.0000000000000048","article-title":"Lithium in drinking water and suicide prevention: a review of the evidence","volume":"30","author":"Vita","year":"2015","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1665","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.mehy.2009.02.043","article-title":"Even very low but sustained lithium intake can prevent suicide in the general population?","volume":"73","author":"Terao","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.phrs.2015.05.003_bib1670","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4088\/JCP.14m09218","article-title":"Low risk of male suicide and lithium in drinking water","volume":"76","author":"Ishii","year":"2015","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1675","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.3390\/ijerph10116044","article-title":"Lithium in tap water and suicide mortality in Japan","volume":"10","author":"Sugawara","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.phrs.2015.05.003_bib1680","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s12011-013-9815-4","article-title":"Lithium in the public water supply and suicide mortality in Greece","volume":"156","author":"Giotakos","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.phrs.2015.05.003_bib1685","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4081\/gh.2013.81","article-title":"Does altitude moderate the impact of lithium on suicide? A spatial analysis of Austria","volume":"7","author":"Helbich","year":"2013","journal-title":"Geospat. Health"},{"key":"10.1016\/j.phrs.2015.05.003_bib1690","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1192\/bjp.bp.110.091041","article-title":"Lithium in drinking water and suicide mortality","volume":"198","author":"Kapusta","year":"2011","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1695","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1476-072X-11-19","article-title":"Geospatial examination of lithium in drinking water and suicide mortality","volume":"11","author":"Helbich","year":"2012","journal-title":"Int. J. Health Geogr."},{"key":"10.1016\/j.phrs.2015.05.003_bib1700","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jpsychires.2012.12.002","article-title":"Lithium in the public water supply and suicide mortality in Texas","volume":"47","author":"Bluml","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phrs.2015.05.003_bib1705","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1192\/bjp.bp.110.088617","article-title":"Lithium in drinking water and suicide rates across the east of England","volume":"198","author":"Kabacs","year":"2011","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1710","doi-asserted-by":"crossref","first-page":"f3646","DOI":"10.1136\/bmj.f3646","article-title":"Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis","volume":"346","author":"Cipriani","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.phrs.2015.05.003_bib1715","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1399-5618.2006.00344.x","article-title":"Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review","volume":"8","author":"Baldessarini","year":"2006","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.phrs.2015.05.003_bib1720","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1176\/appi.ajp.162.10.1805","article-title":"Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials","volume":"162","author":"Cipriani","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1725","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4088\/JCP.v68n0304","article-title":"Lithium treatment reduces suicide risk in recurrent major depressive disorder","volume":"68","author":"Guzzetta","year":"2007","journal-title":"J. Clin. Psychiatry"},{"issue":"Suppl. 2","key":"10.1016\/j.phrs.2015.05.003_bib1730","doi-asserted-by":"crossref","first-page":"II72","DOI":"10.1007\/BF03035132","article-title":"Arguments for the specificity of the antisuicidal effect of lithium","volume":"251","author":"Muller-Oerlinghausen","year":"2001","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1735","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1176\/appi.ajp.161.8.1494","article-title":"Awareness of disorder and suicide risk in the treatment of schizophrenia: results of the international suicide prevention trial","volume":"161","author":"Bourgeois","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1740","first-page":"489","article-title":"Early onset of action and sleep-improving effect are crucial in decreasing suicide risk: the role of quetiapine XR in the treatment of unipolar and bipolar depression","volume":"47","author":"Pompili","year":"2012","journal-title":"Riv. Psichiatr."},{"key":"10.1016\/j.phrs.2015.05.003_bib1745","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1046\/j.1471-4159.2001.00300.x","article-title":"Reduced activation and expression of erk1\/2 map kinase in the post-mortem brain of depressed suicide subjects","volume":"77","author":"Dwivedi","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2015.05.003_bib1750","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/sj.mp.4001744","article-title":"Erk map kinase signaling in post-mortem brain of suicide subjects: differential regulation of upstream raf kinases raf-1 and b-raf","volume":"11","author":"Dwivedi","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1755","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1046\/j.1471-4159.2003.01987.x","article-title":"Attenuated 5-ht1a receptor signaling in brains of suicide victims: Involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase","volume":"87","author":"Hsiung","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2015.05.003_bib1760","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.biopsych.2006.04.036","article-title":"Alteration in kinase activity but not in protein levels of protein kinase b and glycogen synthase kinase-3beta in ventral prefrontal cortex of depressed suicide victims","volume":"61","author":"Karege","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1765","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1001\/archpsyc.60.8.804","article-title":"Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase b in postmortem brain of suicide subjects","volume":"60","author":"Dwivedi","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1770","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1001\/archgenpsychiatry.2009.201","article-title":"Association of genetic variants in the neurotrophic receptor-encoding gene ntrk2 and a lifetime history of suicide attempts in depressed patients","volume":"67","author":"Kohli","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1775","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/cbf.940","article-title":"Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder","volume":"20","author":"Kuloglu","year":"2002","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.phrs.2015.05.003_bib1780","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12017-008-8056-8","article-title":"Common variations in 4p locus are related to male completed suicide","volume":"11","author":"Must","year":"2009","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1785","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1073\/pnas.0507901102","article-title":"Altered cortical glutamatergic and gabaergic signal transmission with glial involvement in depression","volume":"102","author":"Choudary","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2015.05.003_bib1790","doi-asserted-by":"crossref","first-page":"e33201","DOI":"10.1371\/journal.pone.0033201","article-title":"Microrna expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects","volume":"7","author":"Smalheiser","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2015.05.003_bib1795","first-page":"6760","article-title":"Microrna-34a negatively regulates anesthesia-induced hippocampal apoptosis and memory impairment through fgfr1","volume":"7","author":"Jiang","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1800","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.pnpbp.2011.05.010","article-title":"The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder","volume":"35","author":"Jernigan","year":"2011","journal-title":"Progress Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1805","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.biopsych.2007.03.017","article-title":"Increased levels of glutamate in brains from patients with mood disorders","volume":"62","author":"Hashimoto","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1810","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/sj.npp.1301312","article-title":"Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders","volume":"32","author":"Beneyto","year":"2007","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. College of Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1815","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1176\/appi.ajp.2011.09111607","article-title":"Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)c]abp688 pet and postmortem study","volume":"168","author":"Deschwanden","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1820","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pnpbp.2008.10.005","article-title":"Reduced levels of nr2a and nr2b subunits of NMDA receptor and psd-95 in the prefrontal cortex in major depression","volume":"33","author":"Feyissa","year":"2009","journal-title":"Progress Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1825","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jad.2013.08.009","article-title":"Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims","volume":"151","author":"Sowa-Kucma","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.phrs.2015.05.003_bib1830","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.pnpbp.2009.11.018","article-title":"Elevated level of metabotropic glutamate receptor 2\/3 in the prefrontal cortex in major depression","volume":"34","author":"Feyissa","year":"2010","journal-title":"Progress in Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1835","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jad.2011.10.001","article-title":"AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder","volume":"136","author":"Gibbons","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.phrs.2015.05.003_bib1840","doi-asserted-by":"crossref","first-page":"e6585","DOI":"10.1371\/journal.pone.0006585","article-title":"Global brain gene expression analysis links glutamatergic and gabaergic alterations to suicide and major depression","volume":"4","author":"Sequeira","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.phrs.2015.05.003_bib1845","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1471-4159.2004.02792.x","article-title":"Low nnos protein in the locus coeruleus in major depression","volume":"91","author":"Karolewicz","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2015.05.003_bib1850","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1038\/sj.npp.1300781","article-title":"Elevated levels of the nr2c subunit of the NMDA receptor in the locus coeruleus in depression","volume":"30","author":"Karolewicz","year":"2005","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1855","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jpsychires.2013.04.007","article-title":"Glutamate transporters: a key piece in the glutamate puzzle of major depressive disorder","volume":"47","author":"Medina","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phrs.2015.05.003_bib1860","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/npp.2012.248","article-title":"Connecting inflammation with glutamate agonism in suicidality","volume":"38","author":"Erhardt","year":"2013","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1865","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1001\/archpsyc.60.1.14","article-title":"Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression","volume":"60","author":"Oquendo","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1870","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1001\/jamapsychiatry.2014.2406","article-title":"Positron emission tomography quantification of serotonin(1a) receptor binding in suicide attempters with major depressive disorder","volume":"72","author":"Sullivan","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1875","first-page":"1","article-title":"Incongruent reduction of serotonin transporter associated with suicide attempts in patients with major depressive disorder: A positron emission tomography study with 4-[18f]-adam","volume":"18","author":"Yeh","year":"2014","journal-title":"Int. J. Neuropsychopharmacol.: Off. Sci. J. Collegium Int. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1880","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jad.2011.04.039","article-title":"Striatal and cortical midline activation and connectivity associated with suicidal ideation and depression in bipolar ii disorder","volume":"133","author":"Marchand","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.phrs.2015.05.003_bib1885","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.pnpbp.2011.10.016","article-title":"Striatal and cortical midline circuits in major depression: Implications for suicide and symptom expression","volume":"36","author":"Marchand","year":"2012","journal-title":"Progress in Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1890","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jad.2013.01.028","article-title":"Differences in functional connectivity in major depression versus bipolar ii depression","volume":"150","author":"Marchand","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.phrs.2015.05.003_bib1895","article-title":"Neural correlates of suicidal ideation and its reduction in depression","volume":"18","author":"Ballard","year":"2015","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Collegium Int. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1900","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tips.2009.01.004","article-title":"Animal models of suicide-trait-related behaviors","volume":"30","author":"Malkesman","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2015.05.003_bib1905","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.pnpbp.2010.10.027","article-title":"Animal model and neurobiology of suicide","volume":"35","author":"Preti","year":"2011","journal-title":"Progress in Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2015.05.003_bib1910","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1027\/0227-5910\/a000077","article-title":"Do animals commit suicide? Does it matter?","volume":"32","author":"Preti","year":"2011","journal-title":"Crisis"},{"key":"10.1016\/j.phrs.2015.05.003_bib1915","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1007\/s00213-014-3664-5","article-title":"Ketamine administration in depressive disorders: a systematic review and meta-analysis","volume":"231","author":"Fond","year":"2014","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.phrs.2015.05.003_bib1920","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/2045125313507739","article-title":"Ketamine as the prototype glutamatergic antidepressant: Pharmacodynamic actions, and a systematic review and meta-analysis of efficacy","volume":"4","author":"Caddy","year":"2014","journal-title":"Therap. Adv. Psychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1925","first-page":"1","article-title":"A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes","author":"McGirr","year":"2014","journal-title":"Psychol. Med."},{"key":"10.1016\/j.phrs.2015.05.003_bib1930","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1177\/0269881113478283","article-title":"Serial infusions of low-dose ketamine for major depression","volume":"27","author":"Rasmussen","year":"2013","journal-title":"J. Psychopharmacol. (Oxford)"},{"key":"10.1016\/j.phrs.2015.05.003_bib1935","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jpsychires.2014.07.027","article-title":"Improvement in suicidal ideation after ketamine infusion: Relationship to reductions in depression and anxiety","volume":"58C","author":"Ballard","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.phrs.2015.05.003_bib1940","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/0269881114527361","article-title":"Ketamine infusions for treatment resistant depression: a series of 28 patients treated weekly or twice weekly in an ECT clinic","volume":"28","author":"Diamond","year":"2014","journal-title":"J. Psychopharmacol. (Oxford)"},{"key":"10.1016\/j.phrs.2015.05.003_bib1945","article-title":"Ketamine's antidepressant efficacy is extended for at least four weeks in subjects with a family history of an alcohol use disorder","volume":"18","author":"Niciu","year":"2015","journal-title":"Int. J. Neuropsychopharmacol.\/Off. Sci. J. Collegium Int. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2015.05.003_bib1950","first-page":"7","article-title":"Intensive ketamine use for multiple years: a case report","volume":"24","author":"Liu","year":"2014","journal-title":"Am. J. Addict.\/Am. Acad. Psychiatr. Alcohol. Addict."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661815000870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661815000870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T05:11:20Z","timestamp":1651986680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661815000870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":196,"alternative-id":["S1043661815000870"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2015.05.003","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ketamine and suicidal ideation in depression: Jumping the gun?","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2015.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}