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J"},{"key":"10.1016\/j.phrs.2016.03.023_bib0395","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1042\/bj0181263","article-title":"The chemical constitution of spermine. I. The isolation of spermine from animal tissues, and the preparation of its salts","volume":"18","author":"Dudley","year":"1924","journal-title":"Biochem. J."},{"key":"10.1016\/j.phrs.2016.03.023_bib0400","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000280403","article-title":"The effect of alpha-difluoromethyl-ornithine on tumor growth, acute phase reactants, beta-2-microglobulin and hydroxyproline in kidney and bladder carcinomas","volume":"36","author":"Dunzendorfer","year":"1981","journal-title":"Urol. 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U. S. A."},{"key":"10.1016\/j.phrs.2016.03.023_bib0430","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3940(93)90152-B","article-title":"Polyamine neurotoxicity is antagonized by dizocilpine in cultured chick cortical neurons","volume":"161","author":"Fahey","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2016.03.023_bib0435","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0149-7634(99)00016-0","article-title":"The neuroanatomical and neurochemical basis of conditioned fear","volume":"23","author":"Fendt","year":"1999","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.phrs.2016.03.023_bib0440","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1017\/S1461145709991167","article-title":"Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers","volume":"13","author":"Fiori","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.phrs.2016.03.023_bib0445","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.biopsych.2009.04.002","article-title":"Identification and characterization of spermidine\/spermine N1-acetyltransferase promoter variants in suicide completers","volume":"66","author":"Fiori","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.phrs.2016.03.023_bib0450","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1017\/S1461145711001520","article-title":"Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide","volume":"15","author":"Fiori","year":"2012","journal-title":"Int. J. 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Res."},{"key":"10.1016\/j.phrs.2016.03.023_bib0535","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00213-006-0376-5","article-title":"Nitric oxide is involved in the memory facilitation induced by spermidine in rats","volume":"186","author":"Guerra","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.phrs.2016.03.023_bib0540","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1471-4159.2012.07778.x","article-title":"Spermidine-induced improvement of memory involves a cross-talk between protein kinases C and A","volume":"122","author":"Guerra","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2016.03.023_bib0545","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.nlm.2011.06.007","article-title":"Hippocampal PKA\/CREB pathway is involved in the improvement of memory induced by spermidine in rats","volume":"96","author":"Guerra","year":"2011","journal-title":"Neurobiol. Learn. 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A."},{"key":"10.1016\/j.phrs.2016.03.023_bib0580","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1111\/j.1471-4159.1981.tb00409.x","article-title":"High-affinity uptake of spermine by slices of rat cerebral cortex","volume":"36","author":"Harman","year":"1981","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2016.03.023_bib0585","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0091-3057(01)00565-2","article-title":"MK-801 induced retrieval, but not acquisition, deficits for passive avoidance conditioning","volume":"69","author":"Harrod","year":"2001","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2016.03.023_bib0590","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1471-4159.1992.tb09756.x","article-title":"Involvement of putrescine in the development of kindled seizure in rats","volume":"58","author":"Hayashi","year":"1992","journal-title":"J. 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Res."},{"key":"10.1016\/j.phrs.2016.03.023_bib0680","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0006-8993(99)02388-4","article-title":"Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: the roles of the NMDA receptor and nitric oxide","volume":"857","author":"Johnson","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.phrs.2016.03.023_bib0685","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1432-1033.1988.tb14297.x","article-title":"Characterization of the inducible polyamine transporter in bovine lymphocytes","volume":"176","author":"Kakinuma","year":"1988","journal-title":"Eur. J. 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Lett."},{"key":"10.1016\/j.phrs.2016.03.023_bib0720","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.neurobiolaging.2009.04.005","article-title":"Protection against Abeta-mediated rapid disruption of synaptic plasticity and memory by memantine","volume":"32","author":"Klyubin","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phrs.2016.03.023_bib0725","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1248\/bpb1978.14.407","article-title":"Changes in ingestive behavior induced by intracranial injection of spermine","volume":"14","author":"Kohno","year":"1991","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.phrs.2016.03.023_bib0730","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bj1440021","article-title":"Regulatory effects of polyamines on membrane-bound acetylcholinesterase","volume":"144","author":"Kossorotow","year":"1974","journal-title":"Biochem. 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Biol."},{"key":"10.1016\/j.phrs.2016.03.023_bib0855","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1756-6606-7-33","article-title":"Chronic brain inflammation causes a reduction in GluN2A and GluN2B subunits of NMDA receptors and an increase in the phosphorylation of mitogen-activated protein kinases in the hippocampus","volume":"7","author":"Ma","year":"2014","journal-title":"Mol. Brain"},{"key":"10.1016\/j.phrs.2016.03.023_bib0860","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1021\/cr300222d","article-title":"Cation-pi interaction: its role and relevance in chemistry, biology, and material science","volume":"113","author":"Mahadevi","year":"2013","journal-title":"Chem. Rev."},{"key":"10.1016\/j.phrs.2016.03.023_bib0865","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.brainresbull.2014.10.007","article-title":"Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: modulation by NOS inhibitors","volume":"109","author":"Maher","year":"2014","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.phrs.2016.03.023_bib0870","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1460-9568.2004.03498.x","article-title":"A novel role for polyamines in adult neurogenesis in rodent brain","volume":"20","author":"Malaterre","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.phrs.2016.03.023_bib0875","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.neuro.24.1.897","article-title":"Neurobiology of Pavlovian fear conditioning","volume":"24","author":"Maren","year":"2001","journal-title":"Annu. Rev. 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Chem."},{"key":"10.1016\/j.phrs.2016.03.023_bib0930","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.neuroscience.2007.04.003","article-title":"Acrolein induces selective protein carbonylation in synaptosomes","volume":"147","author":"Mello","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.phrs.2016.03.023_bib0935","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s002130050512","article-title":"Combined stimulation of the glycine and polyamine sites of the NMDA receptor attenuates NMDA blockade-induced learning deficits of rats in a 14-unit T-maze","volume":"135","author":"Meyer","year":"1998","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.phrs.2016.03.023_bib0940","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/JBCPP.2002.13.1.61","article-title":"Effect of multiple ifenprodil or spermidine treatment on social recognition in rats","volume":"13","author":"Mikolajczak","year":"2002","journal-title":"J. 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(Elite Ed.)"},{"key":"10.1016\/j.phrs.2016.03.023_bib0985","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/354031a0","article-title":"Molecular cloning and characterization of the rat NMDA receptor","volume":"354","author":"Moriyoshi","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2016.03.023_bib0990","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1523\/JNEUROSCI.09-09-03040.1989","article-title":"Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-d-aspartate receptor antagonist AP5","volume":"9","author":"Morris","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2016.03.023_bib0995","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0023-9690(81)90020-5","article-title":"Spatial localization does not require the presence of local cues","volume":"12","author":"Morris","year":"1981","journal-title":"Learn. 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Rev."},{"key":"10.1016\/j.phrs.2016.03.023_bib1065","doi-asserted-by":"crossref","first-page":"42041","DOI":"10.1074\/jbc.M406053200","article-title":"Structural analysis of DNA interactions with biogenic polyamines and cobalt(III)hexamine studied by Fourier transform infrared and capillary electrophoresis","volume":"279","author":"Ouameur","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.03.023_bib1070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1037\/h0048023","article-title":"State-dependent or dissociated learning produced with pentobarbital","volume":"57","author":"Overton","year":"1964","journal-title":"J. Comp. Physiol. 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Bull."},{"key":"10.1016\/j.phrs.2016.03.023_bib1120","doi-asserted-by":"crossref","first-page":"32651","DOI":"10.1074\/jbc.M113.475962","article-title":"Spermidine stimulates T cell protein-tyrosine phosphatase-mediated protection of intestinal epithelial barrier function","volume":"288","author":"Penrose","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.03.023_bib1125","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.tips.2010.08.004","article-title":"Gating and permeation of kainate receptors: differences unveiled","volume":"31","author":"Perrais","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2016.03.023_bib1130","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ana.410060307","article-title":"Effects of physostigmine and lecithin on memory in Alzheimer disease","volume":"6","author":"Peters","year":"1979","journal-title":"Ann. 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