{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:49:40Z","timestamp":1790272180708,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"NIAAA","doi-asserted-by":"crossref","award":["R01 AA020518"],"award-info":[{"award-number":["R01 AA020518"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000027","name":"NIAAA","doi-asserted-by":"crossref","award":["R01 DK102142"],"award-info":[{"award-number":["R01 DK102142"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["5P20RR021940"],"award-info":[{"award-number":["5P20RR021940"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"the National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["8P20 GM103549"],"award-info":[{"award-number":["8P20 GM103549"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"the National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["T32 ES007079"],"award-info":[{"award-number":["T32 ES007079"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Institute of General Medical Sciences of the National Institutes of Health","award":["P20 GM103418"],"award-info":[{"award-number":["P20 GM103418"]}]},{"name":"KUMC Research Institute","award":["UL1TR000001"],"award-info":[{"award-number":["UL1TR000001"]}]},{"name":"KUMC Research Institute","award":["UL1RR033179"],"award-info":[{"award-number":["UL1RR033179"]}]},{"name":"the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health","award":["P20GM104936"],"award-info":[{"award-number":["P20GM104936"]}]},{"name":"the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health","award":["S10RR027564"],"award-info":[{"award-number":["S10RR027564"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.phrs.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,8]],"date-time":"2016-05-08T12:53:40Z","timestamp":1462712020000},"page":"35-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["A cell-based quantitative high-throughput image screening identified novel autophagy modulators"],"prefix":"10.1016","volume":"110","author":[{"given":"Yuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"McGreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7182","key":"10.1016\/j.phrs.2016.05.004_bib0005","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.phrs.2016.05.004_bib0010","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/ncb1007-1102","article-title":"Autophagosome formation: core machinery and adaptations","volume":"9","author":"Xie","year":"2007","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.phrs.2016.05.004_bib0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cr.2013.168","article-title":"The machinery of macroautophagy","volume":"24","author":"Feng","year":"2014","journal-title":"Cell Res."},{"issue":"9","key":"10.1016\/j.phrs.2016.05.004_bib0020","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/ncb0910-823","article-title":"Autophagy in mammalian development and differentiation","volume":"12","author":"Mizushima","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.phrs.2016.05.004_bib0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrd3802","article-title":"Autophagy modulation as a potential therapeutic target for diverse diseases","volume":"11","author":"Rubinsztein","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.phrs.2016.05.004_bib0030","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bbrc.2003.07.023","article-title":"Autophagy a regulated bulk degradation process inside cells","volume":"313","author":"Yoshimori","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.phrs.2016.05.004_bib0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.phrs.2016.05.004_bib0040","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"issue":"7095","key":"10.1016\/j.phrs.2016.05.004_bib0045","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.phrs.2016.05.004_bib0050","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jhep.2014.04.043","article-title":"Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy","volume":"61","author":"Ni","year":"2014","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.phrs.2016.05.004_bib0055","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/hep.24690","article-title":"Activation of autophagy protects against acetaminophen-induced hepatotoxicity","volume":"55","author":"Ni","year":"2012","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.phrs.2016.05.004_bib0060","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.phrs.2016.05.004_bib0065","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.15252\/emmm.201303671","article-title":"Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB","volume":"6","author":"Polito","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.phrs.2016.05.004_bib0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"Tanida","year":"2008","journal-title":"Methods Mol. Biol. (Clifton, NJ)"},{"issue":"2","key":"10.1016\/j.phrs.2016.05.004_bib0075","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4161\/auto.7.2.14181","article-title":"Dissecting the dynamic turnover of GFP-LC3 in the autolysosome","volume":"7","author":"Ni","year":"2011","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.phrs.2016.05.004_bib0080","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1091\/mbc.E03-09-0704","article-title":"In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker","volume":"15","author":"Mizushima","year":"2004","journal-title":"Mol. Biol. Cell"},{"issue":"9","key":"10.1016\/j.phrs.2016.05.004_bib0085","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1158\/1535-7163.MCT-11-0047","article-title":"The role of autophagy in cancer: therapeutic implications","volume":"10","author":"Yang","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.phrs.2016.05.004_bib0090","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1038\/srep05664","article-title":"Profiling of the Tox21 10 K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway","volume":"4","author":"Huang","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phrs.2016.05.004_bib0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/1875397301004010057","article-title":"A grid algorithm for high throughput fitting of dose-response curve data","volume":"4","author":"Wang","year":"2010","journal-title":"Curr. Chem. Genomics"},{"key":"10.1016\/j.phrs.2016.05.004_bib0100","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0076-6879(08)04020-2","article-title":"Analyzing macroautophagy in hepatocytes and the liver","volume":"453","author":"Ding","year":"2009","journal-title":"Methods Enzymol."},{"issue":"7","key":"10.1016\/j.phrs.2016.05.004_bib0105","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1074\/jbc.M609267200","article-title":"Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival","volume":"282","author":"Ding","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.phrs.2016.05.004_bib0110","doi-asserted-by":"crossref","first-page":"e0130953","DOI":"10.1371\/journal.pone.0130953","article-title":"Basal autophagy and feedback activation of akt are associated with resistance to metformin-Induced inhibition of hepatic tumor cell growth","volume":"10","author":"Yang","year":"2015","journal-title":"PLoS One"},{"issue":"48","key":"10.1016\/j.phrs.2016.05.004_bib0115","doi-asserted-by":"crossref","first-page":"19023","DOI":"10.1073\/pnas.0709695104","article-title":"Small molecule regulators of autophagy identified by an image-based high-throughput screen","volume":"104","author":"Zhang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.phrs.2016.05.004_bib0120","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1093\/carcin\/bgt169","article-title":"The antipsychotic agent chlorpromazine induces autophagic cell death by inhibiting the Akt\/mTOR pathway in human U-87MG glioma cells","volume":"34","author":"Shin","year":"2013","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.phrs.2016.05.004_bib0125","doi-asserted-by":"crossref","first-page":"e0122083","DOI":"10.1371\/journal.pone.0122083","article-title":"AMDE-1 is a dual function chemical for autophagy activation and inhibition","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.phrs.2016.05.004_bib0130","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.molcel.2011.04.024","article-title":"Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest","volume":"42","author":"Ganley","year":"2011","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.phrs.2016.05.004_bib0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/jmcc.2001.1495","article-title":"Antioxidant and lysosomotropic properties of acridine-propranolol: protection against oxidative endothelial cell injury","volume":"34","author":"Dickens","year":"2002","journal-title":"J. Mol. Cell Cardiol."},{"issue":"1","key":"10.1016\/j.phrs.2016.05.004_bib0140","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/pr.110.002642","article-title":"The physiology, signaling, and pharmacology of dopamine receptors","volume":"63","author":"Beaulieu","year":"2011","journal-title":"Pharmacol. Rev."},{"issue":"6","key":"10.1016\/j.phrs.2016.05.004_bib0145","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10565-013-9261-2","article-title":"Dopamine- and zinc-induced autophagosome formation facilitates PC12 cell survival","volume":"29","author":"Hung","year":"2013","journal-title":"Cell Biol. Toxicol."},{"issue":"6","key":"10.1016\/j.phrs.2016.05.004_bib0150","first-page":"781","article-title":"LC3-I conversion to LC3-II does not necessarily result in complete autophagy","volume":"22","author":"Gimenez-Xavier","year":"2008","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.phrs.2016.05.004_bib0155","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jcb.24306","article-title":"D2 dopamine receptor antagonist raclopride induces non-canonical autophagy in cardiac myocytes","volume":"114","author":"Yan","year":"2013","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.phrs.2016.05.004_bib0160","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1053\/j.gastro.2010.07.041","article-title":"Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice","volume":"139","author":"Ding","year":"2010","journal-title":"Gastroenterology"},{"issue":"17","key":"10.1016\/j.phrs.2016.05.004_bib0165","doi-asserted-by":"crossref","first-page":"10934","DOI":"10.1074\/jbc.M114.602284","article-title":"Chronic deletion and acute knockdown of parkin have differential responses to acetaminophen-induced mitophagy and liver injury in mice","volume":"290","author":"Williams","year":"2015","journal-title":"J. Biol. Chem."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816300469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816300469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T06:50:56Z","timestamp":1536735056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816300469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":33,"alternative-id":["S1043661816300469"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.05.004","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A cell-based quantitative high-throughput image screening identified novel autophagy modulators","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}