{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:50:58Z","timestamp":1790661058397,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC-100-2320-B-400-002-MY3"],"award-info":[{"award-number":["NSC-100-2320-B-400-002-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 DA023905"],"award-info":[{"award-number":["R01 DA023905"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.phrs.2016.05.034","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T00:02:26Z","timestamp":1470268946000},"page":"867-876","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice"],"prefix":"10.1016","volume":"111","author":[{"given":"Pao-Pao","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng-Chang","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-Kuang","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horace H.","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Yee","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao-Luh","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2016.05.034_bib0005","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/1731231a0","article-title":"Stereochemistry of certain analgesics","volume":"173","author":"Beckett","year":"1954","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2016.05.034_bib0010","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.pain.2007.03.022","article-title":"Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain","volume":"132","author":"Nielsen","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2016.05.034_bib0015","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/sj.npp.1301471","article-title":"Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine","volume":"33","author":"Narita","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.phrs.2016.05.034_bib0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00520-004-0731-1","article-title":"Effectiveness and safety of oral extended-release oxymorphone for the treatment of cancer pain: a pilot study","volume":"13","author":"Sloan","year":"2005","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.phrs.2016.05.034_bib0025","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1399-6576.1991.tb03364.x","article-title":"Intravenous morphine and oxycodone for pain after abdominal surgery","volume":"35","author":"Kalso","year":"1991","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/j.phrs.2016.05.034_bib0030","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1200\/JCO.1998.16.10.3222","article-title":"Randomized double-blind, cross-over trial comparing safety and efficacy of oral controlled-release oxycodone with controlled-release morphine in patients with cancer pain","volume":"16","author":"Bruera","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1600-0773.1992.tb00441.x","article-title":"Antinociceptive effects and central nervous system depression caused by oxycodone and morphine in rats","volume":"70","author":"Poyhia","year":"1992","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0040","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0304-3959(90)91131-2","article-title":"Influence of polarity on dose-response relationships of intrathecal opioids in rats","volume":"40","author":"Plummer","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2016.05.034_bib0045","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/0024-3205(94)00849-3","article-title":"The antinociceptive potencies of oxycodone, noroxycodone and morphine after intracerebroventricular administration to rats","volume":"54","author":"Leow","year":"1994","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2016.05.034_bib0050","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/00000542-200610000-00027","article-title":"Antinociception by spinal and systemic oxycodone: why does the route make a difference? In vitro and in vivo studies in rats","volume":"105","author":"Lemberg","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.phrs.2016.05.034_bib0055","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0090-9556(25)08048-1","article-title":"Oxymorphone metabolism and urinary excretion in human, rat, guinea pig, rabbit, and dog","volume":"11","author":"Cone","year":"1983","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phrs.2016.05.034_bib0060","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.clpt.2006.01.009","article-title":"Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites","volume":"79","author":"Lalovic","year":"2006","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2016.05.034_bib0065","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jpain.2005.05.004","article-title":"Trends in abuse of oxycontin and other opioid analgesics in the united states: 2002\u2fff2004","volume":"6","author":"Cicero","year":"2005","journal-title":"J. Pain"},{"key":"10.1016\/j.phrs.2016.05.034_bib0070","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1124\/dmd.32.4.447","article-title":"Quantitative contribution of cyp2d6 and cyp3a to oxycodone metabolism in human liver and intestinal microsomes","volume":"32","author":"Lalovic","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.phrs.2016.05.034_bib0075","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1440-1681.2007.04821.x","article-title":"Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat","volume":"35","author":"Chan","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0009-9236(96)90024-7","article-title":"Pharmacokinetic-pharmacodynamic relationships of controlled-release oxycodone","volume":"59","author":"Kaiko","year":"1996","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2016.05.034_bib0085","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2125.1991.tb03942.x","article-title":"The pharmacokinetics of oxycodone after intravenous injection in adults","volume":"32","author":"Poyhia","year":"1991","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0090","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3959(97)00093-6","article-title":"The intrinsic antinociceptive effects of oxycodone appear to be kappa-opioid receptor mediated","volume":"73","author":"Ross","year":"1997","journal-title":"Pain"},{"key":"10.1016\/j.phrs.2016.05.034_bib0095","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ejphar.2006.02.002","article-title":"Characterization of the antinociceptive effects of oxycodone in diabetic mice","volume":"535","author":"Nozaki","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0100","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/5706","article-title":"Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of mor-1","volume":"2","author":"Schuller","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.phrs.2016.05.034_bib0105","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1476-5381.2010.00873.x","article-title":"Guidelines for reporting experiments involving animals: the arrive guidelines","volume":"160","author":"McGrath","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0110","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: the arrive guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0115","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0160-5402(86)90038-0","article-title":"Intracerebroventricular injections in mice. Some methodological refinements","volume":"16","author":"Laursen","year":"1986","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.phrs.2016.05.034_bib0120","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0022-3565(25)03823-6","article-title":"A method for determining loss of pain sensation","volume":"72","author":"D\u2fffAmour","year":"1941","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2016.05.034_bib0125","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.cellsig.2008.05.004","article-title":"Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins","volume":"20","author":"Chu","year":"2008","journal-title":"Cell Signal."},{"key":"10.1016\/j.phrs.2016.05.034_bib0130","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1213\/01.ane.0000205751.88422.41","article-title":"Morphine oxycodone, methadone and its enantiomers in different models of nociception in the rat","volume":"102","author":"Lemberg","year":"2006","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.phrs.2016.05.034_bib0135","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejphar.2005.09.051","article-title":"Antinociceptive effect of oxycodone in diabetic mice","volume":"524","author":"Nozaki","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0140","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-291X(84)90469-8","article-title":"A very high affinity opioid binding site in rat brain: demonstration by computer modeling","volume":"122","author":"Lutz","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2016.05.034_bib0145","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1111\/bph.13039","article-title":"Enhanced gabaergic synaptic transmission at vlpag neurons and potent modulation by oxycodone in a bone cancer pain model","volume":"172","author":"Takasu","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0014-2999(88)90502-X","article-title":"Naltrindole a highly selective and potent non-peptide delta opioid receptor antagonist","volume":"146","author":"Portoghese","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0155","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s11095-005-6154-y","article-title":"Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: influence of streptozotocin-induced diabetes","volume":"22","author":"Huang","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.phrs.2016.05.034_bib0160","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1365-2125.1992.tb04090.x","article-title":"The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects","volume":"33","author":"Poyhia","year":"1992","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.phrs.2016.05.034_bib0165","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0009-9236(98)90051-0","article-title":"Effects of blocking cyp2d6 on the pharmacokinetics and pharmacodynamics of oxycodone","volume":"64","author":"Heiskanen","year":"1998","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2016.05.034_bib0170","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0091-3057(90)90061-L","article-title":"Pharmacological profile of the potentiation of opioid analgesia by restraint stress","volume":"37","author":"Calcagnetti","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.phrs.2016.05.034_bib0175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0165-6147(88)90195-2","article-title":"Can supraspinal delta-opioid receptors mediate antinociception?","volume":"9","author":"Heyman","year":"1988","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2016.05.034_bib0180","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0031-6997(25)06958-3","article-title":"International union of pharmacology. Xii. Classification of opioid receptors","volume":"48","author":"Dhawan","year":"1996","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phrs.2016.05.034_bib0185","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0165-6147(93)90068-U","article-title":"Delta-opioid receptor subtypes and cross-talk with mu-receptors","volume":"14","author":"Traynor","year":"1993","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2016.05.034_bib0190","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1017\/erm.2012.5","article-title":"Opioid receptor heteromers in analgesia","volume":"14","author":"Costantino","year":"2012","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.phrs.2016.05.034_bib0195","doi-asserted-by":"crossref","first-page":"ra54","DOI":"10.1126\/scisignal.2000807","article-title":"Increased abundance of opioid receptor heteromers after chronic morphine administration","volume":"3","author":"Gupta","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.phrs.2016.05.034_bib0200","doi-asserted-by":"crossref","first-page":"Rc110","DOI":"10.1523\/JNEUROSCI.20-22-j0007.2000","article-title":"Heterodimerization of mu and delta opioid receptors: a role in opiate synergy","volume":"20","author":"Gomes","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phrs.2016.05.034_bib0205","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-291X(82)91981-7","article-title":"Increased biological activity of dimers of oxymorphone and enkephalin: possible role of receptor crosslinking","volume":"104","author":"Hazum","year":"1982","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661815301766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661815301766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T12:16:22Z","timestamp":1749039382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661815301766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":41,"alternative-id":["S1043661815301766"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.05.034","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.05.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}