{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T12:25:12Z","timestamp":1778070312360,"version":"3.51.4"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.phrs.2016.06.024","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T13:28:42Z","timestamp":1467120522000},"page":"357-373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1"],"prefix":"10.1016","volume":"111","author":[{"given":"Qiurong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2016.06.024_bib0005","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1152\/physrev.1995.75.3.473","article-title":"Pathophysiology of insulin resistance in human disease","volume":"75","author":"Reaven","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.phrs.2016.06.024_bib0010","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.2337\/diabetes.53.11.2735","article-title":"Molecular mechanisms of insulin resistance that impact cardiovascular biology","volume":"53","author":"Wang","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2016.06.024_bib0015","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00125-006-0230-7","article-title":"Cardiac overexpression of catalase rescues cardiac contractile dysfunction induced by insulin resistance: role of oxidative stress, protein carbonyl formation and insulin sensitivity","volume":"49","author":"Dong","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2016.06.024_bib0020","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1007\/s00125-005-1940-y","article-title":"Metallothionein alleviates cardiac contractile dysfunction induced by insulin resistance: role of Akt phosphorylation, PTB1B, PPARgamma and c-Jun","volume":"48","author":"Fang","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2016.06.024_bib0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.freeradbiomed.2013.06.042","article-title":"Folic acid reverses nitric oxide synthase uncoupling and prevents cardiac dysfunction in insulin resistance: role of Ca2+\/calmodulin-activated protein kinase II","volume":"65","author":"Roe","year":"2013","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.phrs.2016.06.024_bib0030","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s12017-013-8275-5","article-title":"Deciphering the roles of trehalose and Hsp104 in the inhibition of aggregation of mutant huntingtin in a yeast model of Huntington's disease","volume":"16","author":"Chaudhary","year":"2014","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.phrs.2016.06.024_bib0035","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1152\/japplphysiol.01412.2009","article-title":"Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs adult rats","volume":"108","author":"Sharma","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0040","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/BST0350231","article-title":"Physiological roles of PKB\/Akt isoforms in development and disease","volume":"35","author":"Dummlerand","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.phrs.2016.06.024_bib0045","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1089\/ars.2006.8.1765","article-title":"The redox regulation of PI 3-kinase-dependent signaling","volume":"8","author":"Leslie","year":"2006","journal-title":"Antioxid. Redox Signaling"},{"key":"10.1016\/j.phrs.2016.06.024_bib0050","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","article-title":"Akt signalling in health and disease","volume":"23","author":"Hers","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.phrs.2016.06.024_bib0055","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1126\/science.292.5522.1728","article-title":"Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)","volume":"292","author":"Cho","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.phrs.2016.06.024_bib0060","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1681\/ASN.2009090900","article-title":"Uremic cardiomyopathy and insulin resistance: a critical role for akt?","volume":"22","author":"Semple","year":"2011","journal-title":"J. Am. Soc. Nephrol.: JASN"},{"key":"10.1016\/j.phrs.2016.06.024_bib0065","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ctrv.2003.07.007","article-title":"PI3K\/Akt signalling pathway and cancer","volume":"30","author":"Fresno Vara","year":"2004","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.phrs.2016.06.024_bib0070","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nm.2686","article-title":"Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1","volume":"18","author":"Lu","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2016.06.024_bib0075","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1126\/science.1096706","article-title":"A family with severe insulin resistance and diabetes due to a mutation in AKT2","volume":"304","author":"George","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.phrs.2016.06.024_bib0080","doi-asserted-by":"crossref","first-page":"851717","DOI":"10.1155\/2012\/851717","article-title":"Short-chain fatty acid propionate alleviates Akt2 knockout-induced myocardial contractile dysfunction","volume":"2012","author":"Li","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.phrs.2016.06.024_bib0085","doi-asserted-by":"crossref","first-page":"R761","DOI":"10.1152\/ajpregu.00327.2013","article-title":"Hydrogen sulfide alleviates cardiac contractile dysfunction in an Akt2-knockout murine model of insulin resistance: role of mitochondrial injury and apoptosis","volume":"306","author":"Hu","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0090","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Autophagy as a regulated pathway of cellular degradation","volume":"290","author":"Klionskyand","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.phrs.2016.06.024_bib0095","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levineand","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.phrs.2016.06.024_bib0100","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2016.06.024_bib0105","doi-asserted-by":"crossref","first-page":"S191","DOI":"10.1161\/CIRCULATIONAHA.108.842252","article-title":"Markers of autophagy are downregulated in failing human heart after mechanical unloading","volume":"120","author":"Kassiotis","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.phrs.2016.06.024_bib0110","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nm1574","article-title":"The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress","volume":"13","author":"Nakai","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2016.06.024_bib0115","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.yjmcc.2011.06.010","article-title":"Autophagy as a therapeutic target in cardiovascular disease","volume":"51","author":"Nemchenko","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0120","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1089\/dna.2014.2755","article-title":"Autophagy in diabetes: beta-cell dysfunction, insulin resistance, and complications","volume":"34","author":"Barlowand","year":"2015","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0125","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2337\/db11-0555","article-title":"Nutrient sensing, autophagy, and diabetic nephropathy","volume":"61","author":"Kume","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2016.06.024_bib0130","doi-asserted-by":"crossref","first-page":"31484","DOI":"10.1074\/jbc.M109.033936","article-title":"Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.06.024_bib0135","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mce.2015.03.009","article-title":"Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway","volume":"409","author":"Shi","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0140","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1042\/BST20130134","article-title":"Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers","volume":"41","author":"Sarkar","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.phrs.2016.06.024_bib0145","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","article-title":"TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0150","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1157535","article-title":"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1","volume":"320","author":"Sancak","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.phrs.2016.06.024_bib0155","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/ncb1753","article-title":"Regulation of TORC1 by Rag GTPases in nutrient response","volume":"10","author":"Kim","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0160","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1074\/jbc.275.2.992","article-title":"Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells","volume":"275","author":"Petiot","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.06.024_bib0165","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.cellsig.2014.08.019","article-title":"The role of PI3K\/AKT\/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration","volume":"26","author":"Heras-Sandoval","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.phrs.2016.06.024_bib0170","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4161\/auto.3710","article-title":"AMP-activated protein kinase and autophagy","volume":"3","author":"Meijerand","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2016.06.024_bib0175","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0180","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","article-title":"AMPK phosphorylation of raptor mediates a metabolic checkpoint","volume":"30","author":"Gwinn","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phrs.2016.06.024_bib0185","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/kfu158","article-title":"AMP-activated protein kinase deficiency rescues paraquat-induced cardiac contractile dysfunction through an autophagy-dependent mechanism","volume":"142","author":"Wang","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.phrs.2016.06.024_bib0190","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1083\/jcb.200504035","article-title":"Lithium induces autophagy by inhibiting inositol monophosphatase","volume":"170","author":"Sarkar","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0195","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nchembio.79","article-title":"Novel targets for Huntington's disease in an mTOR-independent autophagy pathway","volume":"4","author":"Williams","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0200","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molcel.2011.04.029","article-title":"Complex inhibitory effects of nitric oxide on autophagy","volume":"43","author":"Sarkar","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phrs.2016.06.024_bib0205","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1172\/JCI75051","article-title":"p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8(+) T cells","volume":"124","author":"Henson","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2016.06.024_bib0210","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1074\/jbc.M609532200","article-title":"Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein","volume":"282","author":"Sarkar","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.06.024_bib0215","doi-asserted-by":"crossref","first-page":"E667","DOI":"10.1152\/ajpendo.00185.2013","article-title":"Trehalose prevents neural tube defects by correcting maternal diabetes-suppressed autophagy and neurogenesis","volume":"305","author":"Xu","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.phrs.2016.06.024_bib0220","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00213-013-3119-4","article-title":"Trehalose induced antidepressant-like effects and autophagy enhancement in mice","volume":"229","author":"Kara","year":"2013","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.phrs.2016.06.024_bib0225","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.4161\/auto.25188","article-title":"Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons","volume":"9","author":"Castillo","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2016.06.024_bib0230","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/hmg\/ddi422","article-title":"Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy","volume":"15","author":"Davies","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2016.06.024_bib0235","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/sj.ijo.0802389","article-title":"Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes","volume":"27","author":"Hintz","year":"2003","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.phrs.2016.06.024_bib0240","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1097\/CCM.0b013e31817bf925","article-title":"Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts","volume":"36","author":"Ren","year":"2008","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.phrs.2016.06.024_bib0245","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/rej.2007.0552","article-title":"Insulin-like growth factor I deficiency prolongs survival and antagonizes paraquat-induced cardiomyocyte dysfunction: role of oxidative stress","volume":"10","author":"Li","year":"2007","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.phrs.2016.06.024_bib0250","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1128\/MCB.18.4.1844","article-title":"Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction","volume":"18","author":"Hazzalin","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0255","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.taap.2015.09.009","article-title":"Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes","volume":"289","author":"Chien","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0260","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/jmcb\/mjs055","article-title":"Akt2 knockout preserves cardiac function in high-fat diet-induced obesity by rescuing cardiac autophagosome maturation","volume":"5","author":"Xu","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0265","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.1074\/jbc.M308011200","article-title":"Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.06.024_bib0270","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1741-7015-10-40","article-title":"Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3beta and mitochondrial function","volume":"10","author":"Zhang","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.phrs.2016.06.024_bib0275","doi-asserted-by":"crossref","first-page":"e000439","DOI":"10.1161\/JAHA.113.000439","article-title":"Macrophage migration inhibitory factor deficiency augments doxorubicin-induced cardiomyopathy","volume":"2","author":"Xu","year":"2013","journal-title":"J, Am. Heart Assoc."},{"key":"10.1016\/j.phrs.2016.06.024_bib0280","doi-asserted-by":"crossref","first-page":"H828","DOI":"10.1152\/ajpheart.00752.2012","article-title":"Oxidative activation of Ca(2+)\/calmodulin-activated kinase II mediates ER stress-induced cardiac dysfunction and apoptosis","volume":"304","author":"Roeand","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/CBB:42:1:001","article-title":"Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins","volume":"42","author":"Li","year":"2005","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.phrs.2016.06.024_bib0290","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/cvr\/cvq349","article-title":"Insulin says NO to cardiovascular disease","volume":"89","author":"Yu","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.phrs.2016.06.024_bib0295","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ijo.2014.174","article-title":"Macrophage migration inhibitory factor (MIF) knockout preserves cardiac homeostasis through alleviating Akt-mediated myocardial autophagy suppression in high-fat diet-induced obesity","volume":"39","author":"Xuand","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.phrs.2016.06.024_bib0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10741-013-9387-6","article-title":"Animal models of insulin resistance and heart failure","volume":"19","author":"Velez","year":"2014","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.phrs.2016.06.024_bib0305","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1161\/ATVBAHA.111.241984","article-title":"Insulin resistance: metabolic mechanisms and consequences in the heart","volume":"32","author":"Abel","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0310","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1158\/1055-9965.EPI-05-0239","article-title":"Insulin resistance, apoptosis, and colorectal adenoma risk","volume":"14","author":"Keku","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.phrs.2016.06.024_bib0315","doi-asserted-by":"crossref","first-page":"23432","DOI":"10.1074\/jbc.M302674200","article-title":"AKT2 inhibition of cisplatin-induced JNK\/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance","volume":"278","author":"Yuan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.06.024_bib0320","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/sj.cdd.4400919","article-title":"Activation of Akt2 Inhibits anoikis and apoptosis induced by myogenic differentiation","volume":"8","author":"Fujio","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2016.06.024_bib0325","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1128\/MCB.20.1.139-148.2000","article-title":"The phosphoinositide 3-OH kinase\/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis","volume":"20","author":"Jiang","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0330","first-page":"1681","article-title":"AKT2-knockdown suppressed viability with enhanced apoptosis: and attenuated chemoresistance to temozolomide of human glioblastoma cells in vitro and in vivo","volume":"8","author":"Cui","year":"2015","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.phrs.2016.06.024_bib0335","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0340","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbadis.2014.09.002","article-title":"Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy","volume":"1852","author":"Roe","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2016.06.024_bib0345","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/HYPERTENSIONAHA.113.02526","article-title":"Inhibition of mammalian target of rapamycin with rapamycin reverses hypertrophic cardiomyopathy in mice with cardiomyocyte-specific knockout of PTEN","volume":"63","author":"Xu","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2016.06.024_bib0350","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00395-011-0222-8","article-title":"Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy","volume":"106","author":"Hua","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0355","doi-asserted-by":"crossref","first-page":"600","DOI":"10.4161\/auto.6.5.11947","article-title":"Inhibition of autophagy in the heart induces age-related cardiomyopathy","volume":"6","author":"Taneike","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2016.06.024_bib0360","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.yjmcc.2013.11.007","article-title":"Cardiomyocyte autophagy and cancer chemotherapy","volume":"71","author":"Liand","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0365","doi-asserted-by":"crossref","first-page":"e0124524","DOI":"10.1371\/journal.pone.0124524","article-title":"Trehalose-mediated autophagy impairs the anti-viral function of human primary airway epithelial cells","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2016.06.024_bib0370","doi-asserted-by":"crossref","first-page":"588","DOI":"10.4161\/auto.27710","article-title":"MTOR-independent: autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis","volume":"10","author":"Zhang","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2016.06.024_bib0375","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1242\/jeb.01133","article-title":"Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals","volume":"207","author":"Chenand","year":"2004","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.phrs.2016.06.024_bib0380","doi-asserted-by":"crossref","first-page":"e90202","DOI":"10.1371\/journal.pone.0090202","article-title":"Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition","volume":"9","author":"Fernandez-Estevez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2016.06.024_bib0385","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.4161\/auto.21488","article-title":"Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy","volume":"8","author":"Schaefferand","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.phrs.2016.06.024_bib0390","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/hmg\/dds040","article-title":"Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy","volume":"21","author":"Vidal","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.phrs.2016.06.024_bib0395","doi-asserted-by":"crossref","first-page":"20517","DOI":"10.1073\/pnas.0610290104","article-title":"FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases","volume":"104","author":"Ni","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2016.06.024_bib0400","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tem.2005.03.010","article-title":"FoxO proteins in insulin action and metabolism","volume":"16","author":"Barthel","year":"2005","journal-title":"Trends Endocrinol. Metab.: TEM"},{"key":"10.1016\/j.phrs.2016.06.024_bib0405","doi-asserted-by":"crossref","first-page":"10162","DOI":"10.1073\/pnas.1019268108","article-title":"Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor","volume":"108","author":"Gonzalez","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181530270X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S104366181530270X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T09:07:58Z","timestamp":1568106478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S104366181530270X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":81,"alternative-id":["S104366181530270X"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.06.024","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.06.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}