{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:43:12Z","timestamp":1790239392028,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"French Ministry of Health"},{"name":"Hospital of Limoges"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"},{"name":"Czech Republic"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.phrs.2016.07.012","type":"journal-article","created":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T17:47:31Z","timestamp":1468086451000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Multidrug resistance-associated protein 4 (MRP4) controls ganciclovir intracellular accumulation and contributes to ganciclovir-induced neutropenia in renal transplant patients"],"prefix":"10.1016","volume":"111","author":[{"given":"Pierre-Andr\u00e9","family":"Billat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-1307","authenticated-orcid":false,"given":"Tahani","family":"Ossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Saint-Marcoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Essig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Rerolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassim","family":"Kamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Rostaing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8165-3358","authenticated-orcid":false,"given":"Hannah","family":"Kaminski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabin","family":"Fabre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Otyepka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Woillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Marquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Trouillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2016.07.012_bib0005","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1073\/pnas.82.8.2473","article-title":"Metabolic activation of the nucleoside analog 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus","volume":"82","author":"Biron","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2016.07.012_bib0010","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1097\/00007890-199812270-00019","article-title":"A randomized prospective controlled trial of oral acyclovir versus oral ganciclovir for cytomegalovirus prophylaxis in high-risk kidney transplant recipients","volume":"66","author":"Flechner","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.phrs.2016.07.012_bib0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(95)92110-9","article-title":"Randomised comparison of ganciclovir and high-dose acyclovir for long-term cytomegalovirus prophylaxis in liver-transplant recipients","volume":"346","author":"Winston","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.phrs.2016.07.012_bib0020","first-page":"5","article-title":"Evaluation of ganciclovir for cytomegalovirus disease","volume":"23","author":"Fletcher","year":"1989","journal-title":"DICP Ann. Pharmacother."},{"key":"10.1016\/j.phrs.2016.07.012_bib0025","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1097\/01.TP.0000164512.99703.AD","article-title":"Valganciclovir Solid Organ Transplant Study Group, pharmacodynamics of oral ganciclovir and valganciclovir in solid organ transplant recipients","volume":"79","author":"Wiltshire","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.phrs.2016.07.012_bib0030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/clpt.1986.177","article-title":"Human pharmacokinetics of the antiviral drug DHPG","volume":"40","author":"Fletcher","year":"1986","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2016.07.012_bib0035","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2165\/00003088-200948060-00006","article-title":"Valganciclovir in adult solid organ transplant recipients: pharmacokinetic and pharmacodynamic characteristics and clinical interpretation of plasma concentration measurements","volume":"48","author":"Perrottet","year":"2009","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.phrs.2016.07.012_bib0040","article-title":"Plasma and intracellular exposure to ganciclovir in adult renal transplant recipients: is there an association with haematological toxicity?","author":"Billat","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.phrs.2016.07.012_bib0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0006-2952(91)90485-N","article-title":"Ganciclovir permeation of the human erythrocyte membrane","volume":"41","author":"Mahony","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phrs.2016.07.012_bib0050","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s00424-003-1107-y","article-title":"The concentrative nucleoside transporter family, SLC28","volume":"447","author":"Gray","year":"2004","journal-title":"Pfl\u00fcg. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.phrs.2016.07.012_bib0055","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00424-003-1103-2","article-title":"The equilibrative nucleoside transporter family, SLC29","volume":"447","author":"Baldwin","year":"2004","journal-title":"Pfl\u00fcg. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.phrs.2016.07.012_bib0060","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/sj.clpt.6100275","article-title":"Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics","volume":"83","author":"Shu","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2016.07.012_bib0065","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2307\/2532642","article-title":"Estimating equations for parameters in means and covariances of multivariate discrete and continuous responses","volume":"47","author":"Prentice","year":"1991","journal-title":"Biometrics"},{"key":"10.1016\/j.phrs.2016.07.012_bib0070","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/clpt.2009.205","article-title":"The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics","volume":"87","author":"Picard","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.phrs.2016.07.012_bib0075","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1254\/jphs.08209FP","article-title":"Induction of multiple drug transporters by efavirenz","volume":"109","author":"Weiss","year":"2009","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.phrs.2016.07.012_bib0080","doi-asserted-by":"crossref","DOI":"10.1007\/s00216-015-8554-0","article-title":"Liquid chromatography tandem mass spectrometry quantitation of intracellular concentrations of ganciclovir and its phosphorylated forms","author":"Billat","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.phrs.2016.07.012_bib0085","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1039\/C5CC00636H","article-title":"Synergism of antioxidant action of vitamins E, C and quercetin is related to formation of molecular associations in biomembranes","volume":"51","author":"Fabre","year":"2015","journal-title":"Chem. Commun. Camb. Engl."},{"key":"10.1016\/j.phrs.2016.07.012_bib0090","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1021\/jp4112052","article-title":"Amphiphilic drug-like molecules accumulate in a membrane below the head group region","volume":"118","author":"Palonc\u00fdov\u00e1","year":"2014","journal-title":"J. Phys. Chem. B."},{"key":"10.1016\/j.phrs.2016.07.012_bib0095","first-page":"199","article-title":"Polymorphism in the P-glycoprotein drug transporter MDR1 gene in renal transplant patients treated with cyclosporin A in a Polish population","volume":"59","author":"Kotrych","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.phrs.2016.07.012_bib0100","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bcp.2014.11.006","article-title":"Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen","volume":"93","author":"Cheung","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phrs.2016.07.012_bib0105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1248\/bpb.b14-00588","article-title":"Risk factors for ganciclovir-induced thrombocytopenia and leukopenia","volume":"38","author":"Matsumoto","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phrs.2016.07.012_bib0110","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM199204303261803","article-title":"A controlled trial of ganciclovir to prevent cytomegalovirus disease after heart transplantation","volume":"326","author":"Merigan","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2016.07.012_bib0115","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0140-6736(97)05535-9","article-title":"Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients. The Oral Ganciclovir International Transplantation Study Group [corrected]","volume":"350","author":"Gane","year":"1997","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.phrs.2016.07.012_bib0120","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2165\/00003495-200161080-00016","article-title":"Ganciclovir: an update of its use in the prevention of cytomegalovirus infection and disease in transplant recipients","volume":"61","author":"McGavin","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/j.phrs.2016.07.012_bib0125","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.phrs.2016.07.012_bib0130","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1128\/AAC.00836-08","article-title":"Population pharmacokinetics of ganciclovir in solid-organ transplant recipients receiving oral valganciclovir","volume":"53","author":"Perrottet","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phrs.2016.07.012_bib0135","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1124\/jpet.108.136523","article-title":"The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene","volume":"325","author":"Abla","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2016.07.012_bib0140","doi-asserted-by":"crossref","first-page":"33747","DOI":"10.1074\/jbc.M104833200","article-title":"Transport of cyclic nucleotides and estradiol 17-\u03b2-d-glucuronide by multidrug resistance protein 4 resistance to 6-mercaptopurine and 6-thioguanine","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.07.012_bib0145","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1038\/12487","article-title":"MRP4: a previously unidentified factor in resistance to nucleoside-based antiviral drugs","volume":"5","author":"Schuetz","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2016.07.012_bib0150","doi-asserted-by":"crossref","first-page":"38998","DOI":"10.1074\/jbc.M203262200","article-title":"Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing","volume":"277","author":"Adachi","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"42","key":"10.1016\/j.phrs.2016.07.012_bib0155","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/01.qai.0000225013.53568.69","article-title":"Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study","author":"Anderson","year":"2006","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.phrs.2016.07.012_bib0160","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/QAI.0b013e31815e7478","article-title":"Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients","volume":"47","author":"Kiser","year":"2008","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.phrs.2016.07.012_bib0165","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1182\/blood-2008-11-191098","article-title":"Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia","volume":"114","author":"Ansari","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.phrs.2016.07.012_bib0170","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.tpj.6500451","article-title":"Variability in human hepatic MRP4 expression: influence of cholestasis and genotype","volume":"8","author":"Gradhand","year":"2007","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.phrs.2016.07.012_bib0175","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00280-008-0906-4","article-title":"MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents","volume":"64","author":"Woodahl","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.phrs.2016.07.012_bib0180","doi-asserted-by":"crossref","first-page":"e91555","DOI":"10.1371\/journal.pone.0091555","article-title":"ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines","volume":"9","author":"Dessilly","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2016.07.012_bib0185","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/jps.21169","article-title":"ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel","volume":"97","author":"Gr\u00e9en","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.phrs.2016.07.012_bib0190","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/tpj.2010.79","article-title":"Association of ABCB1 polymorphisms with survival and in vitro cytotoxicty in de novo acute myeloid leukemia with normal karyotype","volume":"12","author":"Gr\u00e9en","year":"2012","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.phrs.2016.07.012_bib0195","doi-asserted-by":"crossref","DOI":"10.1038\/tpj.2014.81","article-title":"Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia","author":"Gregers","year":"2015","journal-title":"Pharmacogenomics J."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816304297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816304297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:40:18Z","timestamp":1657240818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816304297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":39,"alternative-id":["S1043661816304297"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.07.012","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multidrug resistance-associated protein 4 (MRP4) controls ganciclovir intracellular accumulation and contributes to ganciclovir-induced neutropenia in renal transplant patients","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}