{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:12:54Z","timestamp":1790475174641,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.phrs.2016.09.032","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T06:20:39Z","timestamp":1475130039000},"page":"533-546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"PA","title":["A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and  in vivo"],"prefix":"10.1016","volume":"113","author":[{"given":"Caleb Weihao","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng Teng","family":"Peh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaye","family":"Peh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Dymock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Keith","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1\u20132","key":"10.1016\/j.phrs.2016.09.032_bib0005","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-012-1435-3","article-title":"Exogenous hydrogen sulfide attenuates diabetic myocardial injury through cardiac mitochondrial protection","volume":"371","author":"Zhong","year":"2012","journal-title":"Mol. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.phrs.2016.09.032_bib0010","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1089\/ars.2013.5324","article-title":"Hydrogen sulfide and the pathogenesis of atherosclerosis","volume":"20","author":"Mani","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"6","key":"10.1016\/j.phrs.2016.09.032_bib0015","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1096\/fj.12-226415","article-title":"Polysulfides are possible H2S-derived signaling molecules in rat brain","volume":"27","author":"Kimura","year":"2013","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.phrs.2016.09.032_bib0020","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.freeradbiomed.2006.03.021","article-title":"Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide","volume":"41","author":"Oh","year":"2006","journal-title":"Free Radic. Biol. Med."},{"issue":"18","key":"10.1016\/j.phrs.2016.09.032_bib0025","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.phrs.2016.09.032_bib0030","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"issue":"96","key":"10.1016\/j.phrs.2016.09.032_bib0035","doi-asserted-by":"crossref","first-page":"ra72","DOI":"10.1126\/scisignal.2000464","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"issue":"15","key":"10.1016\/j.phrs.2016.09.032_bib0040","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.phrs.2016.09.032_bib0045","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrd4433","article-title":"Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter","volume":"14","author":"Wallace","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phrs.2016.09.032_bib0050","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.niox.2014.04.008","article-title":"AP39 a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro","volume":"41","author":"Szczesny","year":"2014","journal-title":"Nitric Oxide"},{"issue":"6","key":"10.1016\/j.phrs.2016.09.032_bib0055","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1476-5381.2009.00611.x","article-title":"Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)","volume":"159","author":"Wallace","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.phrs.2016.09.032_bib0060","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.niox.2014.04.006","article-title":"Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer","volume":"41","author":"Elsheikh","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.phrs.2016.09.032_bib0065","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12974-014-0196-1","article-title":"Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice","volume":"11","author":"Campolo","year":"2014","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.phrs.2016.09.032_bib0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/ecp.10.134","article-title":"Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising","volume":"4","author":"Whiteman","year":"2011","journal-title":"Expert Rev. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2016.09.032_bib0075","doi-asserted-by":"crossref","first-page":"R814","DOI":"10.1152\/ajpregu.90524.2008","article-title":"Leukocyte trafficking and pain behavioral responses to a hydrogen sulfide donor in acute monoarthritis","volume":"295","author":"Andruski","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.phrs.2016.09.032_bib0080","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/srep00499","article-title":"Hydrogen sulfide and resolution of acute inflammation: a comparative study utilizing a novel fluorescent probe","volume":"2","author":"Dufton","year":"2012","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.phrs.2016.09.032_bib0085","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.4049\/jimmunol.179.6.4153","article-title":"Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury","volume":"179","author":"Zhang","year":"2007","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2016.09.032_bib0090","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1053\/j.gastro.2009.04.012","article-title":"Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats","volume":"137","author":"Wallace","year":"2009","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.phrs.2016.09.032_bib0095","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1089\/ars.2009.2899","article-title":"The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages","volume":"12","author":"Whiteman","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"16","key":"10.1016\/j.phrs.2016.09.032_bib0100","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1021\/acs.jmedchem.5b00848","article-title":"Discovery of new H2S releasing phosphordithioates and 2,3-dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with improved antiproliferative activity","volume":"58","author":"Feng","year":"2015","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.phrs.2016.09.032_bib0105","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1002\/asia.201402860","article-title":"Highly selective and sensitive near-infrared-fluorescent probes for the detection of cellular hydrogen sulfide and the imaging of H2S in mice","volume":"9","author":"Wu","year":"2014","journal-title":"Chem. Asian J."},{"issue":"1","key":"10.1016\/j.phrs.2016.09.032_bib0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.171.1.35","article-title":"Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages","volume":"171","author":"Shakhov","year":"1990","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.phrs.2016.09.032_bib0115","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1128\/MCB.10.4.1498","article-title":"Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B","volume":"10","author":"Collart","year":"1990","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"10.1016\/j.phrs.2016.09.032_bib0120","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1128\/MCB.10.5.2327","article-title":"Activation of interleukin-6 gene expression through the NF-kappa B transcription factor","volume":"10","author":"Libermann","year":"1990","journal-title":"Mol. Cell. Biol."},{"issue":"10","key":"10.1016\/j.phrs.2016.09.032_bib0125","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.1128\/MCB.13.10.6231","article-title":"Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop","volume":"13","author":"Hiscott","year":"1993","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.phrs.2016.09.032_bib0130","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-kappaB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.phrs.2016.09.032_bib0135","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2016.09.032_bib0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/hr.2014.125","article-title":"Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice","volume":"38","author":"Al-Magableh","year":"2015","journal-title":"Hypertens. Res."},{"issue":"6","key":"10.1016\/j.phrs.2016.09.032_bib0145","doi-asserted-by":"crossref","first-page":"e21077","DOI":"10.1371\/journal.pone.0021077","article-title":"The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.phrs.2016.09.032_bib0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/jcmm.12405","article-title":"Hydrogen sulphide decreases IL-1\u03b2-induced activation of fibroblast-like synoviocytes from patients with osteoarthritis","volume":"19","author":"Sieghart","year":"2015","journal-title":"J. Cell. Mol. Med."},{"issue":"6","key":"10.1016\/j.phrs.2016.09.032_bib0155","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.3892\/ijmm.2015.2176","article-title":"Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling","volume":"35","author":"Rios","year":"2015","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.phrs.2016.09.032_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10895-013-1296-5","article-title":"2,6-dansyl azide as a fluorescent probe for hydrogen sulfide","volume":"24","author":"Wang","year":"2014","journal-title":"J. Fluoresc."},{"issue":"1","key":"10.1016\/j.phrs.2016.09.032_bib0165","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/ars.2011.4401","article-title":"A practical look at the chemistry and biology of hydrogen sulfide","volume":"17","author":"Olson","year":"2012","journal-title":"Antioxid. Redox Signal."},{"issue":"9","key":"10.1016\/j.phrs.2016.09.032_bib0170","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1021\/jf060043k","article-title":"DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kappaB activation in RAW 264.7 macrophages","volume":"54","author":"Liu","year":"2006","journal-title":"J. Agric. Food Chem."},{"issue":"46","key":"10.1016\/j.phrs.2016.09.032_bib0175","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.phrs.2016.09.032_bib0180","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1089\/ars.2009.2899","article-title":"The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages","volume":"12","author":"Whiteman","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.phrs.2016.09.032_bib0185","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.freeradbiomed.2009.04.014","article-title":"GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat","volume":"47","author":"Li","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.phrs.2016.09.032_bib0190","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3892\/ijmm.2014.2036","article-title":"Diallyl trisulfide exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 macrophages by suppressing the Toll-like receptor 4\/nuclear factor-\u03baB pathway","volume":"35","author":"Lee","year":"2015","journal-title":"Int. J. Mol. Med."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816303619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816303619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,15]],"date-time":"2018-07-15T01:34:16Z","timestamp":1531618456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816303619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":38,"alternative-id":["S1043661816303619"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.09.032","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}