{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:28:37Z","timestamp":1791854917759,"version":"4.3.4"},"reference-count":134,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81073109"],"award-info":[{"award-number":["81073109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102864"],"award-info":[{"award-number":["81102864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["1508085MH179"],"award-info":[{"award-number":["1508085MH179"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chinese Traditional Medical Research of Anhui Province","award":["2016zy08"],"award-info":[{"award-number":["2016zy08"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.phrs.2016.11.004","type":"journal-article","created":{"date-parts":[[2016,11,5]],"date-time":"2016-11-05T17:32:31Z","timestamp":1478367151000},"page":"251-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":183,"special_numbering":"C","title":["Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy"],"prefix":"10.1016","volume":"114","author":[{"given":"Yuan-ye","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-qin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phrs.2016.11.004_bib0005","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1523-1755.2004.00367.x","article-title":"Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury","volume":"65","author":"Chow","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0010","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjmed.2009.12.004","article-title":"Glycemic control and complications in type 2 diabetes mellitus","volume":"123","author":"Stolar","year":"2010","journal-title":"Am. J. Med."},{"key":"10.1016\/j.phrs.2016.11.004_bib0015","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI200525102","article-title":"Inflammation, stress, and diabetes","volume":"115","author":"Wellen","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2016.11.004_bib0020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00125-011-2387-y","article-title":"Innate immunity, insulin resistance and type 2 diabetes","volume":"55","author":"Fernandez-Real","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2016.11.004_bib0025","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1161\/HYPERTENSIONAHA.111.189688","article-title":"Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia","volume":"60","author":"Zhang","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2016.11.004_bib0035","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-beta","volume":"9","author":"Halle","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0040","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/path.2271","article-title":"Nod-like proteins in inflammation and disease","volume":"214","author":"Carneiro","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0045","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.biochem.74.082803.133347","article-title":"NOD-LRR proteins: role in host-microbial interactions and inflammatory disease","volume":"74","author":"Inohara","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.phrs.2016.11.004_bib0050","doi-asserted-by":"crossref","first-page":"e29695","DOI":"10.1371\/journal.pone.0029695","article-title":"TLR2\/MyD88\/NF-kappaB pathway, reactive oxygen species, potassium efflux activates NLRP3\/ASC inflammasome during respiratory syncytial virus infection","volume":"7","author":"Segovia","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2016.11.004_bib0055","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2016.11.004_bib0060","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phrs.2016.11.004_bib0065","doi-asserted-by":"crossref","first-page":"21119","DOI":"10.1074\/jbc.C200179200","article-title":"The PYRIN-CARD protein ASC is an activating adaptor for caspase-1","volume":"277","author":"Srinivasula","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.11.004_bib0070","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.phrs.2016.11.004_bib0075","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.autrev.2012.07.018","article-title":"Autoinflammation and autoimmunity: bridging the divide","volume":"12","author":"Doria","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.phrs.2016.11.004_bib0080","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4049\/jimmunol.0904145","article-title":"NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses","volume":"185","author":"Gris","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0085","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/BOR.0000000000000088","article-title":"The inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis?","volume":"26","author":"Kahlenberg","year":"2014","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0090","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ni.2228","article-title":"A role for the NLRP3 inflammasome in metabolic diseases\u2014did Warburg miss inflammation?","volume":"13","author":"Wen","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0095","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1681\/ASN.2010080798","article-title":"The inflammasomes in kidney disease","volume":"22","author":"Anders","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0100","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/nep.12785","article-title":"The NLRP3 inflammasome in kidney disease and autoimmunity","volume":"21","author":"Hutton","year":"2016","journal-title":"Nephrology"},{"key":"10.1016\/j.phrs.2016.11.004_bib0105","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1089\/ars.2012.4666","article-title":"NADPH oxidase-mediated triggering of inflammasome activation in mouse podocytes and glomeruli during hyperhomocysteinemia","volume":"18","author":"Abais","year":"2013","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.phrs.2016.11.004_bib0110","doi-asserted-by":"crossref","first-page":"e26778","DOI":"10.1371\/journal.pone.0026778","article-title":"Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3\/ASC inflammasome-mediated activation of caspase-1","volume":"6","author":"Lichtnekert","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2016.11.004_bib0115","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/aps.2015.21","article-title":"Involvement of endoplasmic reticulum stress in angiotensin II-induced NLRP3 inflammasome activation in human renal proximal tubular cells in vitro","volume":"36","author":"Wang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.phrs.2016.11.004_bib0120","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0125","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/sj.ki.5002473","article-title":"IL-18 is expressed in the intercalated cell of human kidney","volume":"72","author":"Gauer","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0130","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ki.2014.271","article-title":"Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy","volume":"87","author":"Shahzad","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/BSR20110089","article-title":"Tumour necrosis factor receptor trafficking dysfunction opens the TRAPS door to pro-inflammatory cytokine secretion","volume":"32","author":"Turner","year":"2012","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.phrs.2016.11.004_bib0140","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.mehy.2012.12.041","article-title":"A novel mechanism of NALP3 inducing ischemia reperfusion injury by activating MAPK pathway in acute renal failure","volume":"80","author":"Hao","year":"2013","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.phrs.2016.11.004_bib0145","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/15216540600904885","article-title":"Lysosomal labilization","volume":"58","author":"Terman","year":"2006","journal-title":"IUBMB Life"},{"key":"10.1016\/j.phrs.2016.11.004_bib0150","doi-asserted-by":"crossref","first-page":"19605","DOI":"10.1074\/jbc.M111.221077","article-title":"The NLR adaptor ASC\/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome","volume":"286","author":"Taxman","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.11.004_bib0155","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.cub.2009.06.038","article-title":"ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways","volume":"19","author":"Tao","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0160","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.phrs.2016.11.004_bib0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00011-012-0555-2","article-title":"Lipopolysaccharide\/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1beta secretion","volume":"62","author":"Liao","year":"2013","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.phrs.2016.11.004_bib0170","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1189\/jlb.0607362","article-title":"Detection of immune danger signals by NALP3","volume":"83","author":"Martinon","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0898-6568(99)00071-6","article-title":"The p38 signal transduction pathway: activation and function","volume":"12","author":"Ono","year":"2000","journal-title":"Cell. Signal."},{"key":"10.1016\/j.phrs.2016.11.004_bib0180","doi-asserted-by":"crossref","first-page":"e56316","DOI":"10.1371\/journal.pone.0056316","article-title":"The mitogen-activated protein kinase p38alpha regulates tubular damage in murine anti-glomerular basement membrane nephritis","volume":"8","author":"Muller","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2016.11.004_bib0185","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"Arthur","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0190","doi-asserted-by":"crossref","first-page":"8815","DOI":"10.1073\/pnas.0402800101","article-title":"Differences in signaling pathways by IL-1beta and IL-18","volume":"101","author":"Lee","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2016.11.004_bib0195","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1124\/jpet.103.059600","article-title":"Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells","volume":"308","author":"Donnelly-Roberts","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2016.11.004_bib0200","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1161\/ATVBAHA.115.307312","article-title":"p38delta MAPK: a novel regulator of NLRP3 inflammasome activation with increased expression in coronary atherogenesis","volume":"36","author":"Rajamaki","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0205","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1046\/j.1523-1755.2001.060002543.x","article-title":"p38 MAPK and MAPK kinase 3\/6 mRNA and activities are increased in early diabetic glomeruli","volume":"60","author":"Kang","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0210","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.cellsig.2009.11.020","article-title":"Differential activation of p38MAPK isoforms by MKK6 and MKK3","volume":"22","author":"Remy","year":"2010","journal-title":"Cell. Signal."},{"key":"10.1016\/j.phrs.2016.11.004_bib0215","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/ard.2007.077263","article-title":"Selective p38MAPK isoform expression and activation in antineutrophil cytoplasmatic antibody-associated crescentic glomerulonephritis: role of p38MAPKalpha","volume":"67","author":"Polzer","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phrs.2016.11.004_bib0220","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejphar.2006.08.065","article-title":"Chronic inhibition of p38MAPK improves cardiac and endothelial function in experimental diabetes mellitus","volume":"554","author":"Riad","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0225","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000356673","article-title":"High glucose concentration stimulates NHE-1 activity in distal nephron cells: the role of the Mek\/Erk1\/2\/p90RSK and p38MAPK signaling pathways","volume":"33","author":"da Costa-Pessoa","year":"2014","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.phrs.2016.11.004_bib0230","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1210\/en.2003-0220","article-title":"High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells","volume":"144","author":"Hsieh","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.phrs.2016.11.004_bib0235","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00125-003-1075-y","article-title":"P38 mitogen-activated protein kinase mediates hexosamine-induced TGFbeta1 mRNA expression in human mesangial cells","volume":"46","author":"Burt","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2016.11.004_bib0240","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2337\/diabetes.55.01.06.db05-0894","article-title":"Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy","volume":"55","author":"Susztak","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2016.11.004_bib0245","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1097\/01.ASN.0000099702.16315.DE","article-title":"Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes","volume":"14","author":"Kang","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0250","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/sj.ki.5000033","article-title":"Glucose and diabetes: effects on podocyte and glomerular p38MAPK, heat shock protein 25, and actin cytoskeleton","volume":"69","author":"Dai","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0255","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.2337\/db13-0305","article-title":"Transforming growth factor-beta-induced cross talk between p53 and a microRNA in the pathogenesis of diabetic nephropathy","volume":"62","author":"Deshpande","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2016.11.004_bib0260","first-page":"2268","article-title":"Regulative mechanism of renal inflammatory-related p38MAPK signaling pathway in diabetic nephropathy and interventional effects of Chinese herbal medicine","volume":"38","author":"Chen","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.phrs.2016.11.004_bib0265","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1681\/ASN.2007091048","article-title":"The role of inflammatory cytokines in diabetic nephropathy","volume":"19","author":"Navarro-Gonzalez","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0270","first-page":"1700","article-title":"Regulatory mechanism of p38MAPK signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine","volume":"37","author":"Zhao","year":"2012","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.phrs.2016.11.004_bib0275","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/ndt\/gft332","article-title":"Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis","volume":"29","author":"Lorenz","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.phrs.2016.11.004_bib0280","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4049\/jimmunol.1201959","article-title":"Inflammasome-independent NLRP3 augments TGF-beta signaling in kidney epithelium","volume":"190","author":"Wang","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0285","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ki.1997.346","article-title":"Podocytes are the major source of IL-1 alpha and IL-1 beta in human glomerulonephritides","volume":"52","author":"Niemir","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0290","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/jcp.20626","article-title":"Wound-induced p38MAPK-dependent histone H3 phosphorylation correlates with increased COX-2 expression in enterocytes","volume":"207","author":"Karrasch","year":"2006","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0295","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.7314\/APJCP.2012.13.4.1365","article-title":"HMGB1 promotes the synthesis of pro-IL-1beta and pro-IL-18 by activation of p38 MAPK and NF-kappaB through receptors for advanced glycation end-products in macrophages","volume":"13","author":"He","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.phrs.2016.11.004_bib0300","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1111\/j.1471-4159.2007.04557.x","article-title":"Mitogen-activated protein kinase phosphatase-1 (MKP-1) preferentially dephosphorylates p42\/44MAPK but not p38MAPK in rat pinealocytes","volume":"101","author":"Price","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.phrs.2016.11.004_bib0305","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1038\/sj.onc.1210414","article-title":"The ERK1\/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition","volume":"26","author":"Meloche","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.phrs.2016.11.004_bib0310","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3181\/0705-MR-134","article-title":"Diabetic nephropathy: mechanisms of renal disease progression","volume":"233","author":"Kanwar","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.phrs.2016.11.004_bib0315","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1053\/j.ajkd.2004.08.039","article-title":"Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy","volume":"45","author":"Sakai","year":"2005","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.phrs.2016.11.004_bib0320","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1126\/science.1158398","article-title":"Immunology. How frustration leads to inflammation","volume":"320","author":"O\u2019Neill","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.phrs.2016.11.004_bib0325","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0330","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.4049\/jimmunol.1301974","article-title":"Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function","volume":"192","author":"Ghonime","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0335","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1523-1755.2004.00798.x","article-title":"High expression of PKC-MAPK pathway mRNAs correlates with glomerular lesions in human diabetic nephropathy","volume":"66","author":"Toyoda","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0340","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/bbrc.2001.6138","article-title":"High glucose induced VEGF expression via PKC and ERK in glomerular podocytes","volume":"290","author":"Hoshi","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2016.11.004_bib0345","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0350","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.molimm.2013.05.005","article-title":"Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages","volume":"56","author":"Budai","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0355","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0360","doi-asserted-by":"crossref","first-page":"22131","DOI":"10.1074\/jbc.M111883200","article-title":"Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression","volume":"277","author":"Hsu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.11.004_bib0365","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/01.HYP.0000120964.22281.3e","article-title":"How does angiotensin II cause renal injury?","volume":"43","author":"Long","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.phrs.2016.11.004_bib0370","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1053\/j.gastro.2012.08.048","article-title":"Nod2-induced autocrine interleukin-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines","volume":"143","author":"Hedl","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.phrs.2016.11.004_bib0375","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.5301\/jn.5000089","article-title":"Effect of mitofusin 2 overexpression on the proliferation and apoptosis of high-glucose-induced rat glomerular mesangial cells","volume":"25","author":"Wan-Xin","year":"2012","journal-title":"J. Nephrol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0380","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12079-010-0102-2","article-title":"Mastering a mediator: blockade of CCN-2 shows early promise in human diabetic kidney disease","volume":"4","author":"Twigg","year":"2010","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.phrs.2016.11.004_bib0385","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/ndt\/gfq521","article-title":"Parathyroid hormone-potentiated connective tissue growth factor expression in human renal proximal tubular cells through activating the MAPK and NF-kappaB signalling pathways","volume":"26","author":"Guo","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.phrs.2016.11.004_bib0390","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.yexcr.2012.05.016","article-title":"Spleen tyrosine kinase mediates high glucose-induced transforming growth factor-beta1 up-regulation in proximal tubular epithelial cells","volume":"318","author":"Yang","year":"2012","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.phrs.2016.11.004_bib0395","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1093\/ndt\/gfs260","article-title":"The pathogenic role of the renal proximal tubular cell in diabetic nephropathy","volume":"27","author":"Tang","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.phrs.2016.11.004_bib0400","doi-asserted-by":"crossref","first-page":"32926","DOI":"10.1074\/jbc.M114.579961","article-title":"The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation","volume":"289","author":"Okada","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.11.004_bib0405","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.molcel.2005.04.001","article-title":"Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases","volume":"18","author":"Takekawa","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.phrs.2016.11.004_bib0410","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1126\/science.290.5496.1574","article-title":"Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3","volume":"290","author":"McDonald","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.phrs.2016.11.004_bib0415","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.4049\/jimmunol.0800448","article-title":"Mechanism and repertoire of ASC-mediated gene expression","volume":"182","author":"Hasegawa","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0420","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/sj.icb.7100098","article-title":"Coordinating TLR-activated signaling pathways in cells of the immune system","volume":"85","author":"Banerjee","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0425","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1016\/j.biocel.2008.06.012","article-title":"c-Jun N-terminal kinase pathways in diabetes","volume":"40","author":"Yang","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0430","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.2337\/db13-0927","article-title":"Sustained inflammasome activity in macrophages impairs wound healing in type 2 diabetic humans and mice","volume":"63","author":"Mirza","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2016.11.004_bib0435","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2337\/db08-0057","article-title":"Oxidative stress as a major culprit in kidney disease in diabetes","volume":"57","author":"Forbes","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.phrs.2016.11.004_bib0440","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.phrs.2016.11.004_bib0445","doi-asserted-by":"crossref","first-page":"F420","DOI":"10.1152\/ajprenal.00415.2004","article-title":"Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation","volume":"289","author":"Rosca","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0450","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00281-008-0120-9","article-title":"NOX enzymes and toll-like receptor signaling","volume":"30","author":"Ogier-Denis","year":"2008","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0455","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11046-007-9026-7","article-title":"Review of innate and specific immunity in plants and animals","volume":"164","author":"Iriti","year":"2007","journal-title":"Mycopathologia"},{"key":"10.1016\/j.phrs.2016.11.004_bib0460","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0465","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration","volume":"14","author":"Petrilli","year":"2007","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.phrs.2016.11.004_bib0470","doi-asserted-by":"crossref","first-page":"17548","DOI":"10.1073\/pnas.0607914103","article-title":"SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes","volume":"103","author":"Fay","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2016.11.004_bib0475","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.phrs.2016.11.004_bib0480","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1074\/jbc.M608083200","article-title":"ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages","volume":"282","author":"Cruz","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phrs.2016.11.004_bib0485","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1371\/journal.pmed.0040158","article-title":"TXNIP regulates peripheral glucose metabolism in humans","volume":"4","author":"Parikh","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/j.phrs.2016.11.004_bib0490","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1464-5491.2007.02109.x","article-title":"Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus","volume":"24","author":"van Greevenbroek","year":"2007","journal-title":"Diabet. Med."},{"key":"10.1016\/j.phrs.2016.11.004_bib0495","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/eji.201040331","article-title":"NLR-containing inflammasomes: central mediators of host defense and inflammation","volume":"40","author":"Fitzgerald","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0500","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-016-0414-3","article-title":"Protective effects of asiatic acid against spinal cord injury-induced acute lung injury in rats","author":"Jiang","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.phrs.2016.11.004_bib0505","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/sj.cdd.4402194","article-title":"The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation","volume":"14","author":"Fernandes-Alnemri","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.phrs.2016.11.004_bib0510","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11892-006-0080-1","article-title":"Inflammation and diabetic nephropathy","volume":"6","author":"Mora","year":"2006","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.phrs.2016.11.004_bib0515","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/eji.200940168","article-title":"Signaling by ROS drives inflammasome activation","volume":"40","author":"Martinon","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0520","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4049\/jimmunol.1100613","article-title":"Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome","volume":"187","author":"Bauernfeind","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0525","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrneph.2011.51","article-title":"Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy","volume":"7","author":"Navarro-Gonzalez","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0530","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bbrc.2010.04.084","article-title":"Glycated albumin activates NADPH oxidase in rat mesangial cells through up-regulation of p47phox","volume":"397","author":"Li","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2016.11.004_bib0535","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1111\/j.1523-1755.2005.00274.x","article-title":"Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney","volume":"67","author":"Lee","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0540","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1681\/ASN.2006080895","article-title":"Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production","volume":"18","author":"Prabhakar","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0545","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000157628","article-title":"Normalizing NADPH oxidase contributes to attenuating diabetic nephropathy by the dual endothelin receptor antagonist CPU0213 in rats","volume":"29","author":"Xu","year":"2009","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0550","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000299798","article-title":"Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-kappaB activation","volume":"31","author":"Tumur","year":"2010","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0555","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mce.2010.07.023","article-title":"Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: involvement of NF-kappaB signaling pathway","volume":"331","author":"Jiang","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0560","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1084\/jem.20100050","article-title":"The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer","volume":"207","author":"Allen","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.phrs.2016.11.004_bib0565","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.4049\/jimmunol.1002046","article-title":"IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation","volume":"185","author":"Zaki","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0570","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.lfs.2016.06.002","article-title":"Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-kappaB and NLRP3 inflammasome","volume":"157","author":"Samra","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.phrs.2016.11.004_bib0575","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bbrc.2013.07.065","article-title":"High glucose induces activation of NF-kappaB inflammatory signaling through IkappaBalpha sumoylation in rat mesangial cells","volume":"438","author":"Huang","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2016.11.004_bib0580","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1128\/MCB.01139-10","article-title":"A cytosolic ATM\/NEMO\/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)\/MAPK-activated protein 2 responses to DNA damage","volume":"31","author":"Yang","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0585","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1016\/j.yexcr.2013.10.006","article-title":"Emodin attenuates high glucose-induced TGF-beta1 and fibronectin expression in mesangial cells through inhibition of NF-kappaB pathway","volume":"319","author":"Yang","year":"2013","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.phrs.2016.11.004_bib0590","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00125-013-3115-6","article-title":"Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-kappaB\/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis","volume":"57","author":"Yang","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2016.11.004_bib0595","doi-asserted-by":"crossref","first-page":"e38285","DOI":"10.1371\/journal.pone.0038285","article-title":"Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2016.11.004_bib0600","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1164\/rccm.200808-1274OC","article-title":"Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis","volume":"179","author":"Gasse","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.phrs.2016.11.004_bib0605","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa065213","article-title":"Interleukin-1-receptor antagonist in type 2 diabetes mellitus","volume":"356","author":"Larsen","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.phrs.2016.11.004_bib0610","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/ki.1994.169","article-title":"Leukocyte adhesion molecules and kidney diseases","volume":"45","author":"Brady","year":"1994","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0615","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s001250051567","article-title":"High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent","volume":"43","author":"Park","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2016.11.004_bib0620","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1046\/j.1523-1755.2001.0590051739.x","article-title":"Regulation of renal proximal tubular epithelial cell hyaluronan generation: implications for diabetic nephropathy","volume":"59","author":"Jones","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.phrs.2016.11.004_bib0625","doi-asserted-by":"crossref","first-page":"F1358","DOI":"10.1152\/ajprenal.00332.2011","article-title":"Monocyte\/macrophage chemokine receptor CCR2 mediates diabetic renal injury","volume":"301","author":"Awad","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.phrs.2016.11.004_bib0630","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2174\/187152506777698335","article-title":"Interleukin-1 and occlusive arterial diseases","volume":"4","author":"Kusuhara","year":"2006","journal-title":"Cardiovasc. Hematol. Agents Med. Chem."},{"key":"10.1016\/j.phrs.2016.11.004_bib0635","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar2143","article-title":"A pilot study of IL-1 inhibition by anakinra in acute gout","volume":"9","author":"So","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.phrs.2016.11.004_bib0640","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1136\/ard.2007.073759","article-title":"Management of treatment resistant inflammation of acute on chronic tophaceous gout with anakinra","volume":"66","author":"McGonagle","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phrs.2016.11.004_bib0645","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00125-006-0586-8","article-title":"Predictive impact of elevated serum level of IL-18 for early renal dysfunction in type 2 diabetes: an observational follow-up study","volume":"50","author":"Araki","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.phrs.2016.11.004_bib0650","doi-asserted-by":"crossref","first-page":"e002128","DOI":"10.1161\/JAHA.115.002128","article-title":"Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome","volume":"4","author":"Martinez","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.phrs.2016.11.004_bib0655","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1073\/pnas.1424741112","article-title":"Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance","volume":"112","author":"Carta","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phrs.2016.11.004_bib0660","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.1184003","article-title":"The NLRP3 inflammasome: a sensor for metabolic danger?","volume":"327","author":"Schroder","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.phrs.2016.11.004_bib0665","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/CS20130043","article-title":"NLRP3 inflammasome activation in coronary artery disease: results from prospective and randomized study of treatment with atorvastatin or rosuvastatin","volume":"126","author":"Satoh","year":"2014","journal-title":"Clin. Sci."},{"key":"10.1016\/j.phrs.2016.11.004_bib0670","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.2337\/diacare.28.12.2890","article-title":"Serum interleukin-18 levels are associated with nephropathy and atherosclerosis in Japanese patients with type 2 diabetes","volume":"28","author":"Nakamura","year":"2005","journal-title":"Diabetes Care"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816307058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816307058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T23:26:39Z","timestamp":1536276399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816307058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":134,"alternative-id":["S1043661816307058"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.11.004","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}