{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:14:32Z","timestamp":1790100872075,"version":"4.0.1"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.phrs.2016.11.032","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T23:19:23Z","timestamp":1480029563000},"page":"192-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":148,"special_numbering":"C","title":["Pathophysiology of hemophilic arthropathy and potential targets for therapy"],"prefix":"10.1016","volume":"115","author":[{"given":"Astrid E.","family":"Pulles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Mastbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger E.G.","family":"Schutgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris P.J.G.","family":"Lafeber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lize F.D.","family":"van Vulpen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0005","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2516.2009.02127.x","article-title":"A study of variations in the reported haemophilia A prevalence around the world","volume":"16","author":"Stonebraker","year":"2010","journal-title":"Haemophilia"},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0010","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1111\/j.1365-2516.2011.02588.x","article-title":"A study of variations in the reported haemophilia B prevalence around the world","volume":"18","author":"Stonebraker","year":"2012","journal-title":"Haemophilia"},{"issue":"6161","key":"10.1016\/j.phrs.2016.11.032_bib0015","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/bmj.1.6161.469","article-title":"Patterns of bleeding in adolescents with severe haemophilia A","volume":"1","author":"Aronstam","year":"1979","journal-title":"Br. Med. J."},{"issue":"4","key":"10.1016\/j.phrs.2016.11.032_bib0020","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1538-7836.2011.04214.x","article-title":"A randomized clinical trial of prophylaxis in children with hemophilia A (the ESPRIT Study)","volume":"9","author":"Gringeri","year":"2011","journal-title":"J. Thromb. Haemost."},{"issue":"6","key":"10.1016\/j.phrs.2016.11.032_bib0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1056\/NEJMoa067659","article-title":"Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia","volume":"357","author":"Manco-Johnson","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2796.1992.tb00546.x","article-title":"Twenty-five years\u2019 experience of prophylactic treatment in severe haemophilia A and B","volume":"232","author":"Nilsson","year":"1992","journal-title":"J. Intern. Med."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0035","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1056\/NEJMoa1208024","article-title":"Factor VIII products and inhibitor development in severe hemophilia A","volume":"368","author":"Gouw","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.phrs.2016.11.032_bib0040","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1182\/blood-2003-03-0941","article-title":"Cost of care and quality of life for patients with hemophilia complicated by inhibitors: the COCIS Study Group","volume":"102","author":"Gringeri","year":"2003","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.phrs.2016.11.032_bib0045","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1182\/blood-2012-12-470898","article-title":"Intermediate-dose versus high-dose prophylaxis for severe hemophilia: comparing outcome and costs since the 1970","volume":"122","author":"Fischer","year":"2013","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.phrs.2016.11.032_bib0050","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1182\/blood.V99.7.2337","article-title":"The effects of postponing prophylactic treatment on long-term outcome in patients with severe hemophilia","volume":"99","author":"Fischer","year":"2002","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.phrs.2016.11.032_bib0055","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1046\/j.1365-2141.1999.01463.x","article-title":"Primary prophylaxis in severe haemophilia should be started at an early age but can be individualized","volume":"105","author":"Astermark","year":"1999","journal-title":"Br. J. Haematol."},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0060","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3324\/haematol.2010.029868","article-title":"A modeling approach to evaluate long-term outcome of prophylactic and on demand treatment strategies for severe hemophilia A","volume":"96","author":"Fischer","year":"2011","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.phrs.2016.11.032_bib0065","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2796.1994.tb00815.x","article-title":"A longitudinal study of orthopaedic outcomes for severe factor-VIII-deficient haemophiliacs: the orthopaedic outcome study group","volume":"236","author":"Aledort","year":"1994","journal-title":"J. Intern. Med."},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2516.2005.01065.x","article-title":"Effects of haemophilic arthropathy on health-related quality of life and socio-economic parameters","volume":"11","author":"Fischer","year":"2005","journal-title":"Haemophilia"},{"issue":"6","key":"10.1016\/j.phrs.2016.11.032_bib0075","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.blre.2012.09.002","article-title":"Hemophilic arthropathy in patients with von Willebrand disease","volume":"26","author":"van Galen","year":"2012","journal-title":"Blood Rev."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0080","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1055\/s-0038-1657358","article-title":"Hemarthroses and warfarin: joint destruction with anticoagulation","volume":"49","author":"Andes","year":"1983","journal-title":"Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.phrs.2016.11.032_bib0085","first-page":"462","article-title":"Assessment and management of posttraumatic haemarthrosis of the knee","volume":"69","author":"Shaerf","year":"2008","journal-title":"Br. J. Hosp. Med. (Lond.)"},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.knee.2009.06.008","article-title":"Recurrent haemarthrosis following total knee replacement","volume":"17","author":"Saksena","year":"2010","journal-title":"Knee"},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0095","first-page":"1087","article-title":"Selective cellular expression of tissue factor in human tissues: implications for disorders of hemostasis and thrombosis","volume":"134","author":"Drake","year":"1989","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.phrs.2016.11.032_bib0100","first-page":"313","article-title":"Synthesis of tissue factor pathway inhibitor in human synovial cells and chondrocytes makes joints the predilected site of bleeding in haemophiliacs","volume":"32","author":"Brinkmann","year":"1994","journal-title":"Eur. J. Clin. Chem. Clin. Biochem."},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0105","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1365-2516.2012.02809.x","article-title":"The potential role of synovial thrombomodulin in the pathophysiology of joint bleeds in haemophilia","volume":"18","author":"Dargaud","year":"2012","journal-title":"Haemophilia"},{"issue":"5790","key":"10.1016\/j.phrs.2016.11.032_bib0110","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1136\/bmj.4.5790.812","article-title":"Synovial fibrinolysis and haemophilic haemarthrosis","volume":"4","author":"Storti","year":"1971","journal-title":"Br. Med. J."},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0115","first-page":"173","article-title":"Haemarthrosis stimulates the synovial fibrinolytic system in haemophilic mice","volume":"110","author":"Nieuwenhuizen","year":"2013","journal-title":"Thromb. Haemost."},{"issue":"14 Suppl. (4)","key":"10.1016\/j.phrs.2016.11.032_bib0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2516.2008.01732.x","article-title":"Physiopathology of haemophilic arthropathy","author":"Lafeber","year":"2008","journal-title":"Haemophilia"},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0125","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1365-2516.2011.02669.x","article-title":"Exploring the biological basis of haemophilic joint disease: experimental studies","volume":"18","author":"Valentino","year":"2012","journal-title":"Haemophilia"},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0130","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1046\/j.1365-2559.1999.00608.x","article-title":"Haemophilic arthropathy resembles degenerative rather than inflammatory joint disease","volume":"34","author":"Roosendaal","year":"1999","journal-title":"Histopathology"},{"issue":"8","key":"10.1016\/j.phrs.2016.11.032_bib0135","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1055\/s-0035-1564445","article-title":"Blood-induced arthropathy in hemophilia: mechanisms and heterogeneity","volume":"41","author":"Blobel","year":"2015","journal-title":"Semin. Thromb. Hemost."},{"issue":"9","key":"10.1016\/j.phrs.2016.11.032_bib0140","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/j.1538-7836.2010.03962.x","article-title":"Blood-induced joint disease: the pathophysiology of hemophilic arthropathy","volume":"8","author":"Valentino","year":"2010","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0145","first-page":"275","article-title":"Ultrastructural appearance of human synovial membrane in the reabsorption phase of acute haemarthrosis","volume":"6","author":"Letizia","year":"1980","journal-title":"Ital. J. Orthop. Traumatol."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0150","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1302\/0301-620X.80B3.0800540","article-title":"Iron deposits and catabolic properties of synovial tissue from patients with haemophilia","volume":"80","author":"Roosendaal","year":"1998","journal-title":"J. Bone Joint Surg. Br."},{"issue":"8","key":"10.1016\/j.phrs.2016.11.032_bib0155","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/art.1780280804","article-title":"Release of interleukin-1 from human synovial tissue in vitro","volume":"28","author":"Wood","year":"1985","journal-title":"Arthritis Rheum."},{"issue":"Suppl (2)","key":"10.1016\/j.phrs.2016.11.032_bib0160","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0896-8411(89)90129-7","article-title":"Cytokine production in culture by cells isolated from the synovial membrane","author":"Brennan","year":"1989","journal-title":"J. Autoimmun."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0165","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/jth.12101","article-title":"Nuclear factor (NF)-kappaB and its associated pathways are major molecular regulators of blood-induced joint damage in a murine model of hemophilia","volume":"11","author":"Sen","year":"2013","journal-title":"J. Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0170","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11926-002-0066-1","article-title":"Role of nuclear factor kappaB in synovial inflammation","volume":"4","author":"Muller-Ladner","year":"2002","journal-title":"Curr. Rheumatol. Rep."},{"issue":"24","key":"10.1016\/j.phrs.2016.11.032_bib0175","doi-asserted-by":"crossref","first-page":"17552","DOI":"10.1074\/jbc.M113.453985","article-title":"T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor kappaB signaling","volume":"288","author":"Ma","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0180","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/cei.12054","article-title":"Intra-articular nuclear factor-kappaB blockade ameliorates collagen-induced arthritis in mice by eliciting regulatory T cells and macrophages","volume":"172","author":"Min","year":"2013","journal-title":"Clin. Exp. Immunol."},{"issue":"8","key":"10.1016\/j.phrs.2016.11.032_bib0185","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.3899\/jrheum.120370","article-title":"RANK-RANKL-OPG in hemophilic arthropathy: from clinical and imaging diagnosis to histopathology","volume":"39","author":"Melchiorre","year":"2012","journal-title":"J. Rheumatol."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0190","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1182\/blood-2002-02-0390","article-title":"c-myc Proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide","volume":"100","author":"Wen","year":"2002","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.phrs.2016.11.032_bib0195","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1182\/blood-2003-12-4231","article-title":"Pathobiology of hemophilic synovitis I: overexpression of mdm2 oncogene","volume":"104","author":"Hakobyan","year":"2004","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.phrs.2016.11.032_bib0200","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1182\/blood-2010-05-284653","article-title":"Neoangiogenesis contributes to the development of hemophilic synovitis","volume":"117","author":"Acharya","year":"2011","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0205","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/ejh.12227","article-title":"Angiogenesis is increased in advanced haemophilic joint disease and characterised by normal pericyte coverage","volume":"92","author":"Zetterberg","year":"2014","journal-title":"Eur. J. Haematol."},{"issue":"11","key":"10.1016\/j.phrs.2016.11.032_bib0210","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/ajh.24133","article-title":"Vascular remodeling underlies rebleeding in hemophilic arthropathy","volume":"90","author":"Bhat","year":"2015","journal-title":"Am. J. Hematol."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0215","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-2516.2006.01202.x","article-title":"Current co-ordinated activities of the PEDNET (European paediatric network for haemophilia management)","volume":"12","author":"Donadel-Claeyssens","year":"2006","journal-title":"Haemophilia"},{"issue":"1 Suppl. (1)","key":"10.1016\/j.phrs.2016.11.032_bib0220","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1053\/j.seminhematol.2005.11.026","article-title":"Pathogenesis of hemophilic arthropathy","volume":"43","author":"Hoots","year":"2006","journal-title":"Semin. Hematol."},{"issue":"4","key":"10.1016\/j.phrs.2016.11.032_bib0225","first-page":"554","article-title":"Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response","volume":"26","author":"Furuzawa-Carballeda","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"issue":"9","key":"10.1016\/j.phrs.2016.11.032_bib0230","first-page":"345","article-title":"Articular cartilage degradation and the pathology of haemophilic arthropathy","volume":"54","author":"Rippey","year":"1978","journal-title":"S. Afr. Med. J."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0235","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1172\/JCI117358","article-title":"Studies of thrombin-induced proteoglycan release in the degradation of human and bovine cartilage","volume":"94","author":"Furmaniak-Kazmierczak","year":"1994","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0240","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00441-009-0887-6","article-title":"Proteinases involved in matrix turnover during cartilage and bone breakdown","volume":"339","author":"Cawston","year":"2010","journal-title":"Cell Tissue Res."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0245","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0250","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/hae.12770","article-title":"Silencing of protease-activated receptors attenuates synovitis and cartilage damage following a joint bleed in haemophilic mice","volume":"22","author":"Nieuwenhuizen","year":"2016","journal-title":"Haemophilia"},{"issue":"6","key":"10.1016\/j.phrs.2016.11.032_bib0255","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/rheumatology\/keg220","article-title":"Haemoglobin-derived iron-dependent hydroxyl radical formation in blood-induced joint damage: an in vitro study","volume":"42","author":"Hooiveld","year":"2003","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0260","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/1529-0131(199905)42:5<1025::AID-ANR23>3.0.CO;2-3","article-title":"Blood-induced joint damage: a human in vitro study","volume":"42","author":"Roosendaal","year":"1999","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0265","first-page":"339","article-title":"Blood-induced joint damage: longterm effects in vitro and in vivo","volume":"30","author":"Hooiveld","year":"2003","journal-title":"J. Rheumatol."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0270","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0002-9440(10)63889-8","article-title":"Short-term exposure of cartilage to blood results in chondrocyte apoptosis","volume":"162","author":"Hooiveld","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"9","key":"10.1016\/j.phrs.2016.11.032_bib0275","first-page":"731","article-title":"[Articular manifestations of hemophilia]","volume":"8","author":"Cayla","year":"1967","journal-title":"Cah. Coll. Med. Hop. Paris"},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0280","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00277-009-0759-x","article-title":"Increased bone resorption is implicated in the pathogenesis of bone loss in hemophiliacs: correlations with hemophilic arthropathy and HIV infection","volume":"89","author":"Katsarou","year":"2010","journal-title":"Ann. Hematol."},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0285","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.transci.2007.12.003","article-title":"Hemophilia: low bone mass, and osteopenia\/osteoporosis","volume":"38","author":"Kovacs","year":"2008","journal-title":"Transfus. Apher. Sci."},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0290","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1365-2141.2007.06972.x","article-title":"Inactivity is a risk factor for low bone mineral density among haemophilic children","volume":"140","author":"Tlacuilo-Parra","year":"2008","journal-title":"Br. J. Haematol."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0295","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1542\/peds.114.2.e177","article-title":"Reduced bone density among children with severe hemophilia","volume":"114","author":"Barnes","year":"2004","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0300","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/10245330701383700","article-title":"Evaluation of bone mineral density in children with hemophilia: mansoura University children hospital (MUCH) experience, Mansoura, Egypt","volume":"12","author":"Abdelrazik","year":"2007","journal-title":"Hematology"},{"issue":"6","key":"10.1016\/j.phrs.2016.11.032_bib0305","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ajh.20877","article-title":"Osteoporosis in young haemophiliacs from western India","volume":"82","author":"Nair","year":"2007","journal-title":"Am. J. Hematol."},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0310","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2516.2006.01405.x","article-title":"Osteoporosis in haemophilia\u2014an underestimated comorbidity?","volume":"13","author":"Wallny","year":"2007","journal-title":"Haemophilia"},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0315","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-2516.2008.01963.x","article-title":"Prevalence and risk factors associated with decreased bone mineral density in patients with haemophilia","volume":"15","author":"Gerstner","year":"2009","journal-title":"Haemophilia"},{"key":"10.1016\/j.phrs.2016.11.032_bib0320","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00003086-198006000-00018","article-title":"A radiologic classification of hemophilic arthropathy","volume":"149","author":"Pettersson","year":"1980","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"6","key":"10.1016\/j.phrs.2016.11.032_bib0325","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/jth.13328","article-title":"The F8(-\/-) rat as a model of hemophilic arthropathy","volume":"14","author":"Sorensen","year":"2016","journal-title":"J. Thromb. Haemost."},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0330","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/hae.12399","article-title":"Joint bleeding in factor VIII deficient mice causes an acute loss of trabecular bone and calcification of joint soft tissues which is prevented with aggressive factor replacement","volume":"20","author":"Lau","year":"2014","journal-title":"Haemophilia"},{"issue":"Pt 3","key":"10.1016\/j.phrs.2016.11.032_bib0335","first-page":"411","article-title":"The interrelationship of cell density and cartilage thickness in mammalian articular cartilage","volume":"109","author":"Stockwell","year":"1971","journal-title":"J. Anat."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0340","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00198-003-1529-6","article-title":"Long-term changes in bone metabolism, bone mineral density, quantitative ultrasound parameters, and fracture incidence after spinal cord injury: a cross-sectional observational study in 100 paraplegic men","volume":"15","author":"Zehnder","year":"2004","journal-title":"Osteoporos. Int."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0345","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s11908-006-0012-x","article-title":"Osteopenia and osteoporosis in patients with HIV: a review of current concepts","volume":"8","author":"Brown","year":"2006","journal-title":"Curr. Infect. Dis. Rep."},{"issue":"17","key":"10.1016\/j.phrs.2016.11.032_bib0350","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1097\/QAD.0b013e32801022eb","article-title":"Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review","volume":"20","author":"Brown","year":"2006","journal-title":"AIDS"},{"issue":"12","key":"10.1016\/j.phrs.2016.11.032_bib0355","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.3748\/wjg.v11.i12.1843","article-title":"Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection","volume":"11","author":"Schiefke","year":"2005","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0360","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11914-007-0024-y","article-title":"The RANKL\/RANK\/OPG pathway","volume":"5","author":"Boyce","year":"2007","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.phrs.2016.11.032_bib0365","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-4419-0298-6_6","article-title":"Bone loss in the spondyloarthropathies: role of osteoclast, RANKL, RANK and OPG in the spondyloarthropathies","volume":"649","author":"Anandarajah","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"issue":"10","key":"10.1016\/j.phrs.2016.11.032_bib0370","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/jmv.20938","article-title":"RANKL\/OPG\/TRAIL plasma levels and bone mass loss evaluation in antiretroviral naive HIV-1-positive men","volume":"79","author":"Gibellini","year":"2007","journal-title":"J. Med. Virol."},{"issue":"6","key":"10.1016\/j.phrs.2016.11.032_bib0375","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jhep.2005.05.034","article-title":"The RANKL\/OPG system and bone mineral density in patients with chronic liver disease","volume":"43","author":"Moschen","year":"2005","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.phrs.2016.11.032_bib0380","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2141.2012.09101.x","article-title":"Decreased bone density and bone strength in a mouse model of severe factor VIII deficiency","volume":"158","author":"Liel","year":"2012","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0385","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1160\/TH04-10-0706","article-title":"Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B","volume":"93","author":"Dargaud","year":"2005","journal-title":"Thromb. Haemost."},{"issue":"6\u20137","key":"10.1016\/j.phrs.2016.11.032_bib0390","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.biocel.2007.12.003","article-title":"Protease-activated receptors in the musculoskeletal system","volume":"40","author":"Mackie","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6","key":"10.1016\/j.phrs.2016.11.032_bib0395","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/hae.12195","article-title":"The bone disease associated with factor VIII deficiency in mice is secondary to increased bone resorption","volume":"19","author":"Recht","year":"2013","journal-title":"Haemophilia"},{"issue":"11","key":"10.1016\/j.phrs.2016.11.032_bib0400","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s00402-009-0885-x","article-title":"Preventing blood-induced joint damage with the use of intra-articular iron chelators: an experimental study in rabbits","volume":"129","author":"Kocaoglu","year":"2009","journal-title":"Arch. Orthop. Trauma Surg."},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0405","first-page":"1044","article-title":"Deferasirox limits cartilage damage following haemarthrosis in haemophilic mice","volume":"112","author":"Nieuwenhuizen","year":"2014","journal-title":"Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.phrs.2016.11.032_bib0410","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3324\/haematol.2009.016824","article-title":"Deferasirox is a powerful NF-kappaB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging","volume":"95","author":"Messa","year":"2010","journal-title":"Haematologica"},{"issue":"7","key":"10.1016\/j.phrs.2016.11.032_bib0415","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.joca.2012.04.002","article-title":"IL-4 alone and in combination with IL-10 protects against blood-induced cartilage damage","volume":"20","author":"van Meegeren","year":"2012","journal-title":"Osteoarthr. Cartil."},{"issue":"9","key":"10.1016\/j.phrs.2016.11.032_bib0420","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/rheumatology\/ket005","article-title":"A short time window to profit from protection of blood-induced cartilage damage by IL-4 plus IL-10","volume":"52","author":"van Meegeren","year":"2013","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"10.1016\/j.phrs.2016.11.032_bib0425","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/bjh.12148","article-title":"A single intra-articular injection with IL-4 plus IL-10 ameliorates blood-induced cartilage degeneration in haemophilic mice","volume":"160","author":"van Meegeren","year":"2013","journal-title":"Br. J. Haematol."},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0430","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/jth.12176","article-title":"IL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophilia","volume":"11","author":"Narkbunnam","year":"2013","journal-title":"J. Thromb. Haemost."},{"issue":"19","key":"10.1016\/j.phrs.2016.11.032_bib0435","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1182\/blood-2015-03-635524","article-title":"IL-1beta: in contrast to TNFalpha, is pivotal in blood-induced cartilage damage and is a potential target for therapy","volume":"126","author":"van Vulpen","year":"2015","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.phrs.2016.11.032_bib0440","first-page":"2134","article-title":"Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies","volume":"54","author":"Cavalli","year":"2015","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"10.1016\/j.phrs.2016.11.032_bib0445","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/jclinpath-2015-202967","article-title":"The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia","volume":"68","author":"van Vulpen","year":"2015","journal-title":"J. Clin. Pathol."},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0450","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1136\/annrheumdis-2012-202738","article-title":"Interleukin-1 receptor antagonist in refractory haemochromatosis-related arthritis of the hands","volume":"72","author":"Latourte","year":"2013","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.phrs.2016.11.032_bib0455","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1136\/ard.2008.094284","article-title":"Erosive osteoarthritis of the hand: clinical experience with anakinra","volume":"68","author":"Bacconnier","year":"2009","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.phrs.2016.11.032_bib0460","doi-asserted-by":"crossref","first-page":"R134","DOI":"10.1186\/ar4591","article-title":"Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis","volume":"16","author":"Furman","year":"2014","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0465","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/jth.12467","article-title":"Antiplasmin: but not amiloride, prevents synovitis and cartilage damage following hemarthrosis in hemophilic mice","volume":"12","author":"Nieuwenhuizen","year":"2014","journal-title":"J. Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.phrs.2016.11.032_bib0470","first-page":"257","article-title":"The effect of monthly ibandronate on bone mineral density and bone turnover markers in patients with haemophilia A and B and increased risk for fracture","volume":"110","author":"Anagnostis","year":"2013","journal-title":"Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.phrs.2016.11.032_bib0475","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1056\/NEJMoa044459","article-title":"Denosumab in postmenopausal women with low bone mineral density","volume":"354","author":"McClung","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.phrs.2016.11.032_bib0480","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1056\/NEJMoa1309748","article-title":"Improved survival with bevacizumab in advanced cervical cancer","volume":"370","author":"Tewari","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"10.1016\/j.phrs.2016.11.032_bib0485","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa032691","article-title":"Bevacizumab plus irinotecan: fluorouracil, and leucovorin for metastatic colorectal cancer","volume":"350","author":"Hurwitz","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"28","key":"10.1016\/j.phrs.2016.11.032_bib0490","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1200\/JCO.2008.19.8721","article-title":"Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma","volume":"27","author":"Friedman","year":"2009","journal-title":"J. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.phrs.2016.11.032_bib0495","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1136\/bjo.2009.163576","article-title":"Anti-vascular endothelial growth factor agents for diabetic maculopathy","volume":"94","author":"Salam","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.phrs.2016.11.032_bib0500","article-title":"Anti-vascular endothelial growth factor for neovascular age-related macular degeneration","volume":"8","author":"Solomon","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0505","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2516.2012.02816.x","article-title":"Cartilage restoration in haemophilia: advanced therapies","volume":"18","author":"Liras","year":"2012","journal-title":"Haemophilia"},{"issue":"5","key":"10.1016\/j.phrs.2016.11.032_bib0510","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1365-2516.2012.02805.x","article-title":"Joint distraction results in clinical and structural improvement of haemophilic ankle arthropathy: a series of three cases","volume":"18","author":"Van Meegeren","year":"2012","journal-title":"Haemophilia"},{"issue":"19","key":"10.1016\/j.phrs.2016.11.032_bib0515","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1182\/blood-2015-09-665091","article-title":"Inflammation is key to hemophilic arthropathy","volume":"126","author":"Srivastava","year":"2015","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.phrs.2016.11.032_bib0520","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1258\/jrsm.2011.110180","article-title":"The answer is 17 years, what is the question: understanding time lags in translational research","volume":"104","author":"Morris","year":"2011","journal-title":"J. R. Soc. Med."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816306338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816306338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:41:35Z","timestamp":1657240895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816306338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":104,"alternative-id":["S1043661816306338"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.11.032","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathophysiology of hemophilic arthropathy and potential targets for therapy","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.11.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}