{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:21:48Z","timestamp":1790698908325,"version":"4.1.0"},"reference-count":175,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.phrs.2016.12.001","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T03:15:19Z","timestamp":1481080519000},"page":"275-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"C","title":["Metals and metastasis: Exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents"],"prefix":"10.1016","volume":"115","author":[{"given":"Leyla","family":"Fouani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharleen V.","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mellow","family":"Paulson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Des R.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaklina","family":"Kovacevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17010066","article-title":"The metals in the biological periodic system of the elements: concepts and conjectures","volume":"17","author":"Maret","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0010","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1021\/ja063792r","article-title":"X-ray absorption and EPR spectroscopic studies of the biotransformations of chromium(VI) in mammalian cells. Is chromodulin an artifact of isolation methods?","volume":"129","author":"Levina","year":"2007","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0968-0004(92)90249-9","article-title":"Ribonucleotide reductase: regulation, regulation, regulation","volume":"17","author":"Elledge","year":"1992","journal-title":"Trends Biochem. Sci."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.001_bib0020","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1093\/ajcn\/22.9.1222","article-title":"Zinc metalloenzymes: characteristics and significance in biology and medicine","volume":"22","author":"Parisi","year":"1969","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1056\/NEJM199801223380407","article-title":"Respiratory function of hemoglobin","volume":"338","author":"Hsia","year":"1998","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0030","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.hoc.2015.11.002","article-title":"The global burden of anemia","volume":"30","author":"Kassebaum","year":"2016","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0035","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.bbamcr.2016.01.026","article-title":"Redox cycling metals: pedaling their roles in metabolism and their use in the development of novel therapeutics","volume":"1863","author":"Kalinowski","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0040","doi-asserted-by":"crossref","first-page":"232","DOI":"10.15430\/JCP.2015.20.4.232","article-title":"An overview of carcinogenic heavy metal: molecular toxicity mechanism and prevention","volume":"20","author":"Kim","year":"2015","journal-title":"J. Cancer Prev."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0045","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/toxsci\/kfw064","article-title":"Arsenite and cadmium activate MAPK\/ERK via membrane estrogen receptors and G-protein coupled estrogen receptor signaling in human lung adenocarcinoma cells","volume":"152","author":"Huff","year":"2016","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kfm111","article-title":"Arsenic: extension of its endocrine disruption potential to interference with estrogen receptor-mediated signaling","volume":"98","author":"Watson","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"11","key":"10.1016\/j.phrs.2016.12.001_bib0055","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.freeradbiomed.2004.03.010","article-title":"Cadmium inhibits the electron transfer chain and induces reactive oxygen species","volume":"36","author":"Wang","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0060","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.freeradbiomed.2004.02.003","article-title":"Role of oxidative damage in the genotoxicity of arsenic","volume":"37","author":"Hei","year":"2004","journal-title":"Free Radic. Biol. Med."},{"issue":"Suppl. 5","key":"10.1016\/j.phrs.2016.12.001_bib0065","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1289\/ehp.02110s5797","article-title":"Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms","volume":"110","author":"Hartwig","year":"2002","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbrc.2004.06.102","article-title":"Cadmium inhibits human DNA mismatch repair in vivo","volume":"321","author":"Lutzen","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2016.12.001_bib0075","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/978-94-007-5179-8_15","article-title":"Cadmium and cancer","volume":"11","author":"Hartwig","year":"2013","journal-title":"Met. Ions Life Sci."},{"issue":"22","key":"10.1016\/j.phrs.2016.12.001_bib0080","doi-asserted-by":"crossref","first-page":"18748","DOI":"10.18632\/oncotarget.4349","article-title":"Targeting cancer by binding iron: dissecting cellular signaling pathways","volume":"6","author":"Lui","year":"2015","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0085","first-page":"166","article-title":"Expanding horizons in iron chelation and the treatment of cancer: role of iron in the regulation of ER stress and the epithelial-mesenchymal transition","volume":"1845","author":"Lane","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"Pt. B (10)","key":"10.1016\/j.phrs.2016.12.001_bib0090","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1016\/j.bbamem.2015.06.009","article-title":"Plasma membrane calcium channels in cancer: alterations and consequences for cell proliferation and migration","volume":"1848","author":"Deliot","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2016.12.001_bib0095","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.phrs.2016.05.019","article-title":"The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis","volume":"111","author":"Thakur","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0100","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4161\/cam.4.1.10497","article-title":"Breast cancer metastasis driven by ErbB2 and 14-3-3zeta: a division of labor","volume":"4","author":"Wang","year":"2010","journal-title":"Cell Adh. Migr."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17081308","article-title":"The significance of epithelial-to-mesenchymal transition for circulating tumor cells","volume":"17","author":"Kolbl","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.phrs.2016.12.001_bib0110","doi-asserted-by":"crossref","first-page":"17016","DOI":"10.1074\/jbc.M112.350470","article-title":"The iron chelators Dp44mT and DFO inhibit TGF-beta-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1)","volume":"287","author":"Chen","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"23","key":"10.1016\/j.phrs.2016.12.001_bib0115","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell-cell adhesion molecule E-cadherin","volume":"65","author":"van Roy","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0120","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/emmm.201100190","article-title":"N-myc downstream regulated gene 1 modulates Wnt-beta-catenin signalling and pleiotropically suppresses metastasis","volume":"4","author":"Liu","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.phrs.2016.12.001_bib0125","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s40139-016-0106-6","article-title":"Tight junctions and the tumor microenvironment","volume":"4","author":"Salvador","year":"2016","journal-title":"Curr. Pathobiol. Rep."},{"issue":"24","key":"10.1016\/j.phrs.2016.12.001_bib0130","doi-asserted-by":"crossref","first-page":"9857","DOI":"10.1073\/pnas.1019003108","article-title":"Calcium-dependent dynamics of cadherin interactions at cell-cell junctions","volume":"108","author":"Kim","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1165\/rcmb.2013-0314TR","article-title":"The role of vimentin intermediate filaments in the progression of lung cancer","volume":"50","author":"Kidd","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0140","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/wsbm.110","article-title":"Signaling pathways that control cell migration: models and analysis","volume":"3","author":"Welf","year":"2011","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0145","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/bies.20558","article-title":"GTP-binding proteins of the Rho\/Rac family: regulation, effectors and functions in vivo","volume":"29","author":"Bustelo","year":"2007","journal-title":"Bioessays"},{"issue":"1-2","key":"10.1016\/j.phrs.2016.12.001_bib0150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10555-008-9165-4","article-title":"Signal transduction by focal adhesion kinase in cancer","volume":"28","author":"Zhao","year":"2009","journal-title":"Cancer Metastasis Rev."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0155","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nrc1370","article-title":"Dissecting the metastatic cascade","volume":"4","author":"Pantel","year":"2004","journal-title":"Nat. Rev. Cancer"},{"issue":"31","key":"10.1016\/j.phrs.2016.12.001_bib0160","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0165","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12307-011-0085-4","article-title":"Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases","volume":"5","author":"Chao","year":"2012","journal-title":"Cancer Microenviron."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.001_bib0170","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1210\/me.2004-0342","article-title":"Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via phosphatidylinositol 3 kinase and ligand-independent activation of epidermal growth factor receptor in ovarian cancer cells","volume":"19","author":"Reddy","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.phrs.2016.12.001_bib0175","first-page":"25","article-title":"The effect of iron deficiency on myoglobin iron","volume":"27","author":"Fons","year":"1961","journal-title":"Marquette Med. Rev."},{"issue":"2206","key":"10.1016\/j.phrs.2016.12.001_bib0180","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1126\/science.85.2206.360-a","article-title":"The percentage of iron in hemoglobin","volume":"85","author":"Walker","year":"1937","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0014-5793(81)80429-2","article-title":"Soluble guanylate cyclase purified from bovine lung contains heme and copper","volume":"132","author":"Gerzer","year":"1981","journal-title":"FEBS Lett."},{"key":"10.1016\/j.phrs.2016.12.001_bib0190","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0006-291X(61)90077-8","article-title":"Evidence for a new type of iron containing electron carrier in mitochondria","volume":"5","author":"Beinert","year":"1961","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0195","first-page":"61","article-title":"Changes of iron metabolism in PNH: interrelationships of iron and DNA synthesis","volume":"5","author":"van der Weyden","year":"1972","journal-title":"Ser. Haematol."},{"issue":"7","key":"10.1016\/j.phrs.2016.12.001_bib0200","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.bbamcr.2015.03.009","article-title":"Iron for proliferation of cell lines and hematopoietic progenitors: nailing down the intracellular functional iron concentration","volume":"1853","author":"Pourcelot","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"16","key":"10.1016\/j.phrs.2016.12.001_bib0205","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.4161\/cc.6.16.4603","article-title":"Tuning cell cycle regulation with an iron key","volume":"6","author":"Yu","year":"2007","journal-title":"ABBV Cell Cycle"},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0210","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1182\/blood.V98.3.842","article-title":"The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: the mechanisms involved in inhibiting cell-cycle progression","volume":"98","author":"Gao","year":"2001","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0215","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3109\/10715762.2011.653969","article-title":"Mechanisms of free radical-induced damage to DNA","volume":"46","author":"Dizdaroglu","year":"2012","journal-title":"Free Radic. Res."},{"issue":"Pt. 1 (24)","key":"10.1016\/j.phrs.2016.12.001_bib0220","first-page":"6522","article-title":"Hydroxyl radical production and human DNA damage induced by ferric nitrilotriacetate and hydrogen peroxide","volume":"47","author":"Inoue","year":"1987","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0225","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF00265663","article-title":"Transferrin receptor expression by human bladder transitional cell carcinomas","volume":"15","author":"Seymour","year":"1987","journal-title":"Urol. Res."},{"issue":"8323","key":"10.1016\/j.phrs.2016.12.001_bib0230","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0140-6736(83)92191-8","article-title":"Correlation of transferrin receptor expression with histological class and outcome in non-Hodgkin lymphoma","volume":"1","author":"Habeshaw","year":"1983","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0235","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1040-8428(01)00213-X","article-title":"The iron metabolism of neoplastic cells: alterations that facilitate proliferation?","volume":"42","author":"Kwok","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.phrs.2016.12.001_bib0240","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1046\/j.1523-1755.1999.055Suppl.69131.x","article-title":"Iron therapy and cancer","volume":"69","author":"Weinberg","year":"1999","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.phrs.2016.12.001_bib0245","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00322.2015","article-title":"Iron induces cancer stem cells and aggressive phenotypes in human lung cancer cells","author":"Chanvorachote","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.phrs.2016.12.001_bib0250","doi-asserted-by":"crossref","first-page":"1616781","DOI":"10.1155\/2016\/1616781","article-title":"Reactive oxygen species and targeted therapy for pancreatic cancer","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0255","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1158\/1078-0432.CCR-06-2082","article-title":"Reactive oxygen species: a breath of life or death?","volume":"13","author":"Fruehauf","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.phrs.2016.12.001_bib0260","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1196\/annals.1354.022","article-title":"Mitochondria damage checkpoint, aging, and cancer","volume":"1067","author":"Singh","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1\u20133","key":"10.1016\/j.phrs.2016.12.001_bib0265","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/10715769009109669","article-title":"Oxidative stress and tumour cell proliferation","volume":"11","author":"Burdon","year":"1990","journal-title":"Free Radic. Res. Commun."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0270","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.biopha.2005.03.009","article-title":"Differential modulation of normal and tumor cell proliferation by reactive oxygen species","volume":"59","author":"Nicco","year":"2005","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0275","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2174\/157488810790442813","article-title":"Signaling mechanism(s) of reactive oxygen species in Epithelial-Mesenchymal Transition reminiscent of cancer stem cells in tumor progression","volume":"5","author":"Wang","year":"2010","journal-title":"Curr. Stem Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0280","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/sj.bjc.6605487","article-title":"Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-kappaB signalling pathways in human pancreatic adenocarcinoma cells","volume":"102","author":"Lau","year":"2010","journal-title":"Br. J. Cancer"},{"issue":"9","key":"10.1016\/j.phrs.2016.12.001_bib0285","first-page":"622","article-title":"Tumorigenesis: oncogene detox programme","volume":"11","author":"McCarthy","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.phrs.2016.12.001_bib0290","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1097\/IGC.0b013e318222cfdd","article-title":"Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary","volume":"21","author":"Yamada","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0295","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1089\/ars.2004.6.858","article-title":"Complex role of heme oxygenase-1 in angiogenesis","volume":"6","author":"Dulak","year":"2004","journal-title":"Antioxid. Redox Signal."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0300","doi-asserted-by":"crossref","first-page":"L1029","DOI":"10.1152\/ajplung.2000.279.6.L1029","article-title":"Heme oxygenase: colors of defense against cellular stress","volume":"279","author":"Otterbein","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0305","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/carcin\/bgp012","article-title":"15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS","volume":"30","author":"Kim","year":"2009","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0310","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrc727","article-title":"Role of integrins in cell invasion and migration","volume":"2","author":"Hood","year":"2002","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0315","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1582-4934.2005.tb00355.x","article-title":"Matrix metalloproteinases and angiogenesis","volume":"9","author":"Rundhaug","year":"2005","journal-title":"J. Cell. Mol. Med."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0320","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrc1670","article-title":"Breast cancer metastasis: markers and models","volume":"5","author":"Weigelt","year":"2005","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0325","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1006762425323","article-title":"Specific expression of matrix metalloproteinases 1, 3, 9 and 13 associated with invasiveness of breast cancer cells in vitro","volume":"18","author":"Balduyck","year":"2000","journal-title":"Clin. Exp. Metastasis"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0330","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10549-008-0085-3","article-title":"Matrix metalloproteinase-1 promotes breast cancer angiogenesis and osteolysis in a novel in vivo model","volume":"116","author":"Eck","year":"2009","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.phrs.2016.12.001_bib0335","first-page":"44","article-title":"Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature","volume":"4","author":"Deryugina","year":"2015","journal-title":"Matrix Biol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0340","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s13277-014-2747-6","article-title":"Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review","volume":"36","author":"Wieczorek","year":"2015","journal-title":"Tumour Biol."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.001_bib0345","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1074\/jbc.273.9.5279","volume":"273","author":"Brenneisen","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.phrs.2016.12.001_bib0350","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1158\/0008-5472.CAN-11-1870","article-title":"An iron regulatory gene signature predicts outcome in breast cancer","volume":"71","author":"Miller","year":"2011","journal-title":"Cancer Res."},{"issue":"34","key":"10.1016\/j.phrs.2016.12.001_bib0355","doi-asserted-by":"crossref","first-page":"35522","DOI":"10.18632\/oncotarget.5849","article-title":"The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0360","first-page":"1","article-title":"Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy","volume":"1845","author":"Fang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"10.1016\/j.phrs.2016.12.001_bib0365","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.4155\/fmc.14.80","article-title":"NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis","volume":"6","author":"Sahni","year":"2014","journal-title":"Future Med. Chem."},{"issue":"12","key":"10.1016\/j.phrs.2016.12.001_bib0370","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1093\/carcin\/bgl146","article-title":"The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer","volume":"27","author":"Kovacevic","year":"2006","journal-title":"Carcinogenesis"},{"issue":"9","key":"10.1016\/j.phrs.2016.12.001_bib0375","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1182\/blood-2004-05-1866","article-title":"Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation","volume":"104","author":"Le","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0380","doi-asserted-by":"crossref","first-page":"e57273","DOI":"10.1371\/journal.pone.0057273","article-title":"N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion","volume":"8","author":"Lane","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2016.12.001_bib0385","first-page":"1","article-title":"NDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway","author":"Ai","year":"2016","journal-title":"Cancer Biol. Ther."},{"issue":"Pt. 14","key":"10.1016\/j.phrs.2016.12.001_bib0390","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1242\/jcs.147835","article-title":"The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of beta-catenin through mechanisms involving FRAT1 and PAK4","volume":"127","author":"Jin","year":"2014","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0395","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/bjc.2012.582","article-title":"Dp44mT targets the AKT, TGF-beta and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells","volume":"108","author":"Dixon","year":"2013","journal-title":"Br. J. Cancer"},{"issue":"11","key":"10.1016\/j.phrs.2016.12.001_bib0400","doi-asserted-by":"crossref","first-page":"8851","DOI":"10.18632\/oncotarget.3316","article-title":"The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0405","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1089\/ars.2011.4273","article-title":"The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN and SMAD4 and inhibits the PI3K and ras signaling pathways","volume":"18","author":"Kovacevic","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"12","key":"10.1016\/j.phrs.2016.12.001_bib0410","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1158\/0008-5472.CAN-08-4882","article-title":"N-myc downstream regulated gene 1\/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression","volume":"69","author":"Hosoi","year":"2009","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0415","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1074\/jbc.M115.689653","article-title":"The metastasis suppressor, N-MYC downstream-regulated gene-1 (NDRG1), down-regulates the ErbB family of receptors to inhibit downstream oncogenic signaling pathways","volume":"291","author":"Kovacevic","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.001_bib0420","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1093\/carcin\/bgt163","article-title":"Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors","volume":"34","author":"Sun","year":"2013","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0425","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1124\/mol.112.083097","article-title":"Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1\/pMLC2 signaling pathway","volume":"83","author":"Sun","year":"2013","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0430","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1124\/mol.115.103044","article-title":"Targeting the metastasis suppressor, N-Myc downstream regulated gene-1, with novel di-2-Pyridylketone thiosemicarbazones: suppression of tumor cell migration and cell-collagen adhesion by inhibiting focal adhesion kinase\/paxillin signaling","volume":"89","author":"Wangpu","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2016.12.001_bib0435","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1038\/srep08686","article-title":"WNT-1 inducible signaling pathway protein-1 enhances growth and tumorigenesis in human breast cancer","volume":"5","author":"Chiang","year":"2015","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0440","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.clbc.2011.08.005","article-title":"A phase II study of lipoplatin (liposomal cisplatin)\/vinorelbine combination in HER-2\/neu-negative metastatic breast cancer","volume":"11","author":"Farhat","year":"2011","journal-title":"Clin. Breast Cancer"},{"issue":"11","key":"10.1016\/j.phrs.2016.12.001_bib0445","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1039\/C5MT00149H","article-title":"Targeting copper in cancer therapy: \u2018Copper That Cancer\u2019","volume":"7","author":"Denoyer","year":"2015","journal-title":"Metallomics"},{"issue":"7","key":"10.1016\/j.phrs.2016.12.001_bib0450","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/jn\/129.7.1251","article-title":"A delicate balance: homeostatic control of copper uptake and distribution","volume":"129","author":"Pena","year":"1999","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0455","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ctrv.2008.07.004","article-title":"Elevated copper and oxidative stress in cancer cells as a target for cancer treatment","volume":"35","author":"Gupte","year":"2009","journal-title":"Cancer Treat. Rev."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/BTER:89:1:1","article-title":"Serum and tissue trace elements in patients with breast cancer in Taiwan","volume":"89","author":"Kuo","year":"2002","journal-title":"Biol. Trace Elem. Res."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0465","first-page":"1121","article-title":"Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor","volume":"137","author":"Brem","year":"1990","journal-title":"Am. J. Pathol."},{"issue":"15","key":"10.1016\/j.phrs.2016.12.001_bib0470","doi-asserted-by":"crossref","first-page":"9588","DOI":"10.1074\/jbc.M114.631283","article-title":"Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp)","volume":"290","author":"Jansson","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0475","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1084\/jem.136.2.261","article-title":"Tumor dormancy in vivo by prevention of neovascularization","volume":"136","author":"Gimbrone","year":"1972","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0480","doi-asserted-by":"crossref","first-page":"H1821","DOI":"10.1152\/ajpheart.01015.2001","article-title":"Copper-induced vascular endothelial growth factor expression and wound healing","volume":"282","author":"Sen","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7","key":"10.1016\/j.phrs.2016.12.001_bib0485","doi-asserted-by":"crossref","first-page":"406","DOI":"10.6026\/97320630010406","article-title":"A molecular model of human Lysyl Oxidase (LOX) with optimal copper orientation in the catalytic cavity for induced fit docking studies with potential modulators","volume":"10","author":"Bhuvanasundar","year":"2014","journal-title":"Bioinformation"},{"issue":"31","key":"10.1016\/j.phrs.2016.12.001_bib0490","doi-asserted-by":"crossref","first-page":"19022","DOI":"10.1016\/S0021-9258(17)30618-X","article-title":"Structural and catalytic properties of copper in lysyl oxidase","volume":"265","author":"Gacheru","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0495","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/(SICI)1097-4644(19980601)69:3<326::AID-JCB10>3.0.CO;2-A","article-title":"Copper stimulates proliferation of human endothelial cells under culture","volume":"69","author":"Hu","year":"1998","journal-title":"J. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0500","doi-asserted-by":"crossref","first-page":"909","DOI":"10.4161\/cbt.5.8.3230","article-title":"Lysyl oxidase (LOX) and hypoxia-induced metastases","volume":"5","author":"Sion","year":"2006","journal-title":"Cancer Biol. Ther."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.001_bib0505","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2217\/fon.14.39","article-title":"Lysyl oxidase in cancer research","volume":"10","author":"Perryman","year":"2014","journal-title":"Future Oncol."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.001_bib0510","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2217\/fon.12.105","article-title":"LOXL2 in epithelial cell plasticity and tumor progression","volume":"8","author":"Cano","year":"2012","journal-title":"Future Oncol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0515","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ccr.2008.11.012","article-title":"Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche","volume":"15","author":"Erler","year":"2009","journal-title":"Cancer Cell."},{"key":"10.1016\/j.phrs.2016.12.001_bib0520","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12943-016-0502-x","article-title":"Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications","volume":"15","author":"Serrano-Gomez","year":"2016","journal-title":"Mol. Cancer"},{"issue":"329","key":"10.1016\/j.phrs.2016.12.001_bib0525","doi-asserted-by":"crossref","first-page":"ra56","DOI":"10.1126\/scisignal.2004870","article-title":"Memo is a copper-dependent redox protein with an essential role in migration and metastasis","volume":"7","author":"MacDonald","year":"2014","journal-title":"Sci. Signal."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0530","first-page":"267","article-title":"Zinc deficiency and zinc toxicity","volume":"37","author":"Calesnick","year":"1988","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.phrs.2016.12.001_bib0535","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.bi.61.070192.004341","article-title":"Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins","volume":"61","author":"Coleman","year":"1992","journal-title":"Annu. Rev. Biochem"},{"issue":"13","key":"10.1016\/j.phrs.2016.12.001_bib0540","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1073\/pnas.89.13.6109","article-title":"Atomic structures of wild-type and thermostable mutant recombinant human Cu, Zn superoxide dismutase","volume":"89","author":"Parge","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.001_bib0545","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.3945\/jn.109.106369","article-title":"Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats","volume":"139","author":"Song","year":"2009","journal-title":"J. Nutr."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.001_bib0550","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1093\/carcin\/bgl034","article-title":"Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression","volume":"27","author":"Uzzo","year":"2006","journal-title":"Carcinogenesis"},{"issue":"1-2","key":"10.1016\/j.phrs.2016.12.001_bib0555","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0014-5793(93)80312-I","article-title":"Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the \u2018metzincins'","volume":"331","author":"Bode","year":"1993","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0560","first-page":"1048","article-title":"Reduced angiogenesis and tumor progression in gelatinase A-deficient mice","volume":"58","author":"Itoh","year":"1998","journal-title":"Cancer Res."},{"issue":"1\u20133","key":"10.1016\/j.phrs.2016.12.001_bib0565","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1385\/IJGC:31:1-3:79","article-title":"Regulation of epithelial cell growth by ZBP-89: potential relevance in pancreatic cancer","volume":"31","author":"Bai","year":"2002","journal-title":"Int. J. Gastrointest. Cancer"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0570","first-page":"36","article-title":"Transcription factor ZBP-89 in cancer growth and apoptosis","volume":"1806","author":"Zhang","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0575","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbrc.2016.02.045","article-title":"Zinc-binding protein-89 (ZBP-89) cooperates with NF-kappaB to regulate expression of matrix metalloproteinases (MMPs) in response to inflammatory cytokines","volume":"471","author":"Borghaei","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0580","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.bbrc.2012.08.146","article-title":"High-expression of ZBP-89 correlates with distal metastasis and poor prognosis of patients in clear cell renal cell carcinoma","volume":"426","author":"Cai","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.phrs.2016.12.001_bib0585","doi-asserted-by":"crossref","first-page":"409245","DOI":"10.1155\/2015\/409245","article-title":"Ca2+ signaling in cytoskeletal reorganization, cell migration, and cancer metastasis","volume":"2015","author":"Tsai","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"41","key":"10.1016\/j.phrs.2016.12.001_bib0590","doi-asserted-by":"crossref","first-page":"16176","DOI":"10.1073\/pnas.0707719104","article-title":"Ca2+ influx is an essential component of the positive-feedback loop that maintains leading-edge structure and activity in macrophages","volume":"104","author":"Evans","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Pt. 2","key":"10.1016\/j.phrs.2016.12.001_bib0595","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1242\/jcs.071357","article-title":"Slit-2 repels the migration of olfactory ensheathing cells by triggering Ca2+-dependent cofilin activation and RhoA inhibition","volume":"124","author":"Huang","year":"2011","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0600","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1158\/0008-5472.CAN-13-3058","article-title":"Cofilin drives cell-invasive and metastatic responses to TGF-beta in prostate cancer","volume":"74","author":"Collazo","year":"2014","journal-title":"Cancer Res."},{"issue":"Pt. B (6)","key":"10.1016\/j.phrs.2016.12.001_bib0605","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.bbamcr.2015.11.030","article-title":"The store-operated Ca(2 +) entry-mediated signaling is important for cancer spread","volume":"1863","author":"Chen","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.phrs.2016.12.001_bib0610","doi-asserted-by":"crossref","first-page":"31071","DOI":"10.1038\/srep31071","article-title":"CCBE1 promotes GIST development through enhancing angiogenesis and mediating resistance to imatinib","volume":"6","author":"Tian","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0615","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1089\/ars.2012.4540","article-title":"Novel chelators for cancer treatment: where are we now?","volume":"18","author":"Merlot","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"22","key":"10.1016\/j.phrs.2016.12.001_bib0620","doi-asserted-by":"crossref","first-page":"6510","DOI":"10.1021\/jm0606342","article-title":"Dipyridyl thiosemicarbazone chelators with potent and selective antitumor activity form iron complexes with redox activity","volume":"49","author":"Richardson","year":"2006","journal-title":"J. Med. Chem."},{"issue":"15","key":"10.1016\/j.phrs.2016.12.001_bib0625","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1021\/jm070445z","article-title":"Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents","volume":"50","author":"Kalinowski","year":"2007","journal-title":"J. Med. Chem."},{"issue":"17","key":"10.1016\/j.phrs.2016.12.001_bib0630","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1158\/0008-5472.CAN-11-1218","article-title":"Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes","volume":"71","author":"Lovejoy","year":"2011","journal-title":"Cancer Res."},{"issue":"16","key":"10.1016\/j.phrs.2016.12.001_bib0635","doi-asserted-by":"crossref","first-page":"7230","DOI":"10.1021\/jm300768u","article-title":"Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo","volume":"55","author":"Lovejoy","year":"2012","journal-title":"J. Med. Chem."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0640","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0006-2952(99)00419-0","article-title":"Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity","volume":"59","author":"Finch","year":"2000","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0645","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10637-009-9230-z","article-title":"A phase II trial of triapine (NSC# 663249) and gemcitabine as second line treatment of advanced non-small cell lung cancer: Eastern Cooperative Oncology Group Study 1503","volume":"28","author":"Traynor","year":"2010","journal-title":"Invest. New Drugs"},{"issue":"11","key":"10.1016\/j.phrs.2016.12.001_bib0650","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1182\/blood.V86.11.4295.bloodjournal86114295","article-title":"The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents","volume":"86","author":"Richardson","year":"1995","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0655","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1182\/blood.V89.8.3025","article-title":"The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone","volume":"89","author":"Richardson","year":"1997","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0660","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1182\/blood.V94.2.781","article-title":"The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation","volume":"94","author":"Darnell","year":"1999","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0665","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1182\/blood.V100.2.666","article-title":"Novel hybrid iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells","volume":"100","author":"Lovejoy","year":"2002","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0670","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/sj.bjp.0705089","article-title":"Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents","volume":"138","author":"Becker","year":"2003","journal-title":"Br. J. Pharmacol."},{"issue":"40","key":"10.1016\/j.phrs.2016.12.001_bib0675","doi-asserted-by":"crossref","first-page":"14901","DOI":"10.1073\/pnas.0604979103","article-title":"A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics","volume":"103","author":"Whitnall","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0680","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1182\/blood-2004-03-0868","article-title":"Novel di-2-pyridyl-derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment","volume":"104","author":"Yuan","year":"2004","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0685","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1124\/mol.111.073627","article-title":"Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancer","volume":"80","author":"Kovacevic","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.phrs.2016.12.001_bib0690","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.phrs.2015.08.013","article-title":"The renaissance of polypharmacology in the development of anti-cancer therapeutics: inhibition of the Triad of Death in cancer by Di-2-pyridylketone thiosemicarbazones","volume":"100","author":"Jansson","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0695","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3748\/wjg.v22.i1.221","article-title":"Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma","volume":"22","author":"Wachsmann","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0700","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ijc.10740","article-title":"The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production","volume":"102","author":"Moriguchi","year":"2002","journal-title":"Int. J. Cancer"},{"issue":"10","key":"10.1016\/j.phrs.2016.12.001_bib0705","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1158\/1541-7786.MCR-12-0312","article-title":"Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signaling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells","volume":"10","author":"Parr-Sturgess","year":"2012","journal-title":"Mol. Cancer Res."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0710","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s10585-007-9104-8","article-title":"Soluble cadherins as cancer biomarkers","volume":"24","author":"De Wever","year":"2007","journal-title":"Clin. Exp. Metastasis"},{"issue":"19","key":"10.1016\/j.phrs.2016.12.001_bib0715","doi-asserted-by":"crossref","first-page":"12691","DOI":"10.1074\/jbc.M708887200","article-title":"A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus","volume":"283","author":"Ferber","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0720","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/annonc\/mds654","article-title":"Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse","volume":"24","author":"Jain","year":"2013","journal-title":"Ann. Oncol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0725","first-page":"689","article-title":"Zinc accumulation in N-methyl-N-nitrosourea-induced rat mammary tumors is accompanied by an altered expression of ZnT-1 and metallothionein","volume":"228","author":"Lee","year":"2003","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0730","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.bjc.6605562","article-title":"The role of zinc in the anti-tumour and anti-cachectic activity of D-myo-inositol 1,2,6-triphosphate","volume":"102","author":"Russell","year":"2010","journal-title":"Br. J. Cancer"},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0735","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1006\/scbi.2000.0379","article-title":"Matrix metalloproteinases in tumor invasion and metastasis","volume":"10","author":"Stamenkovic","year":"2000","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0740","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.gendis.2014.12.002","article-title":"Targeting matrix metalloproteinases in cancer: bringing new life to old ideas","volume":"2","author":"Cathcart","year":"2015","journal-title":"Genes Dis."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0745","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/0929867053363243","article-title":"Matrix metalloproteinase inhibitors: a review on pharmacophore mapping and (Q)SARs results","volume":"12","author":"Kontogiorgis","year":"2005","journal-title":"Curr. Med. Chem."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0750","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.plefa.2006.08.004","article-title":"Matrix metalloproteinase inhibitor RO 28-2653 decreases liver metastasis by reduction of MMP-2 and MMP-9 concentration in BOP-induced ductal pancreatic cancer in Syrian Hamsters: inhibition of matrix metalloproteinases in pancreatic cancer","volume":"75","author":"Kilian","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0755","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s10555-014-9530-4","article-title":"New approaches to selectively target cancer-associated matrix metalloproteinase activity","volume":"33","author":"Tauro","year":"2014","journal-title":"Cancer Metastasis Rev."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0760","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1158\/0008-5472.CAN-08-3255","article-title":"Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis","volume":"69","author":"Devy","year":"2009","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0765","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbagen.2006.10.012","article-title":"A monoclonal antibody inhibits gelatinase B\/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains","volume":"1770","author":"Martens","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"14","key":"10.1016\/j.phrs.2016.12.001_bib0770","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1158\/0008-5472.CAN-10-4552","article-title":"Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9","volume":"71","author":"Dufour","year":"2011","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0775","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s12253-016-0071-8","article-title":"NDRG1 controls gastric cancer migration and invasion through regulating MMP-9","volume":"22","author":"Chang","year":"2016","journal-title":"Pathol. Oncol. Res."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0780","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1039\/C5DT03919C","article-title":"Metal-based drugs that break the rules","volume":"45","author":"Allardyce","year":"2016","journal-title":"Dalton Trans."},{"key":"10.1016\/j.phrs.2016.12.001_bib0785","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0790","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.3892\/mmr.2016.5571","article-title":"Effects of cisplatin on the LSD1-mediated invasion and metastasis of prostate cancer cells","volume":"14","author":"Chen","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0795","article-title":"Cisplatin-based chemotherapy options for recurrent and\/or metastatic squamous cell cancer of the head and neck","volume":"2013","author":"Pendleton","year":"2013","journal-title":"Clin. Med. Insights Ther."},{"issue":"21","key":"10.1016\/j.phrs.2016.12.001_bib0800","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1158\/1078-0432.CCR-14-0713","article-title":"Preclinical activity of the liposomal cisplatin lipoplatin in ovarian cancer","volume":"20","author":"Casagrande","year":"2014","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.001_bib0805","first-page":"3031","article-title":"Systemic Lipoplatin infusion results in preferential tumor uptake in human studies","volume":"25","author":"Boulikas","year":"2005","journal-title":"Anticancer Res."},{"key":"10.1016\/j.phrs.2016.12.001_bib0810","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-3-319-24223-1_11","article-title":"Current state of metal-based drugs for the efficient therapy of lung cancers and lung metastases","volume":"893","author":"Biersack","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"23","key":"10.1016\/j.phrs.2016.12.001_bib0815","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1046\/j.1432-1033.2002.03307.x","article-title":"Inhibition of the MEK\/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation","volume":"269","author":"Pintus","year":"2002","journal-title":"Eur. J. Biochem."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0820","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.drup.2006.05.002","article-title":"DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity","volume":"9","author":"Brabec","year":"2006","journal-title":"Drug Resist. Updat."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.001_bib0825","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/CAD.0000000000000327","article-title":"Gold(III) compounds-mediated inhibition of lung cancer cell proliferation","volume":"27","author":"Bostancioglu","year":"2016","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.phrs.2016.12.001_bib0830","article-title":"Gold(III) compounds-mediated inhibition of lung cancer cell line proliferation: potential apoptotic effects for its chemotherapeutic effects","author":"Bostancoglu","year":"2015","journal-title":"Anticancer Drugs"},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0835","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1039\/C5DT01802A","article-title":"In vitro and in vivo evaluation of organometallic gold(I) derivatives as anticancer agents","volume":"45","author":"Garcia-Moreno","year":"2016","journal-title":"Dalton Trans."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.001_bib0840","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3109\/0284186X.2010.537693","article-title":"Gold(III) porphyrin 1a prolongs the survival of melanoma-bearing mice and inhibits angiogenesis","volume":"50","author":"Lum","year":"2011","journal-title":"Acta Oncol."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.001_bib0845","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/cpr.12296","article-title":"Gold nanoparticle-conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR\/VEGFR-2-mediated pathway in breast cancer","volume":"49","author":"Balakrishnan","year":"2016","journal-title":"Cell Prolif."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.001_bib0850","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.4155\/fmc.12.69","article-title":"Gallium-containing anticancer compounds","volume":"4","author":"Chitambar","year":"2012","journal-title":"Future Med. Chem."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.001_bib0855","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.bbamcr.2016.04.027","article-title":"Gallium and its competing roles with iron in biological systems","volume":"1863","author":"Chitambar","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.001_bib0860","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1124\/jpet.105.099044","article-title":"Resistance to the antineoplastic agent gallium nitrate results in marked alterations in intracellular iron and gallium trafficking: identification of novel intermediates","volume":"317","author":"Davies","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.phrs.2016.12.001_bib0865","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bcp.2016.06.020","article-title":"Gallium, a promising candidate to disrupt the vicious cycle driving osteolytic metastases","volume":"116","author":"Strazic-Geljic","year":"2016","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.001_bib0870","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.canlet.2013.02.052","article-title":"Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells","volume":"335","author":"Petanidis","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phrs.2016.12.001_bib0875","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biocel.2016.02.015","article-title":"In vitro and ex vivo vanadium antitumor activity in (TGF-beta)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients","volume":"74","author":"Petanidis","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816312087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816312087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T06:41:22Z","timestamp":1749796882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816312087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":175,"alternative-id":["S1043661816312087"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.001","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metals and metastasis: Exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}