{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:39:35Z","timestamp":1793374775911,"version":"4.5.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/19670-0"],"award-info":[{"award-number":["2011\/19670-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/20343-4"],"award-info":[{"award-number":["2011\/20343-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/04237-2"],"award-info":[{"award-number":["2012\/04237-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/08216-2"],"award-info":[{"award-number":["2013\/08216-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.phrs.2016.12.014","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T20:32:46Z","timestamp":1481574766000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis"],"prefix":"10.1016","volume":"117","author":[{"given":"Alexandre","family":"Kanashiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiane","family":"S\u00f4nego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael G.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda V.S.","family":"Castanheira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio A.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa F.","family":"Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele C.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"C\u00f3lon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Alves-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Ulloa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Q.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.phrs.2016.12.014_bib0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.phrs.2016.12.014_bib0010","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jama.2016.0289","article-title":"Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Shankar-Hari","year":"2016","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.phrs.2016.12.014_bib0015","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit. Care Med."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0020","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00134-001-1143-z","article-title":"Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study","volume":"28","author":"Alberti","year":"2002","journal-title":"Intensive Care Med."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.014_bib0025","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/cc8872","article-title":"Sepsis biomarkers: a review","volume":"14","author":"Pierrakos","year":"2010","journal-title":"Crit. Care"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.014_bib0030","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.immuni.2013.10.012","article-title":"Septic shock: on the importance of being tolerant","volume":"39","author":"Medzhitov","year":"2013","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.phrs.2016.12.014_bib0035","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1473-3099(13)70001-X","article-title":"Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"16","key":"10.1016\/j.phrs.2016.12.014_bib0040","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1074\/jbc.274.16.10689","article-title":"Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction","volume":"274","author":"Chow","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.014_bib0045","doi-asserted-by":"crossref","first-page":"e37584","DOI":"10.1371\/journal.pone.0037584","article-title":"TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis","volume":"7","author":"Castoldi","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0050","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.014_bib0055","first-page":"1289","article-title":"Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4","volume":"15","author":"Kato","year":"2004","journal-title":"J. Am. Soc. Nephrol. JASN"},{"issue":"7","key":"10.1016\/j.phrs.2016.12.014_bib0060","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1128\/IAI.70.7.3602-3610.2002","article-title":"Inhibition of leukocyte rolling by nitric oxide during sepsis leads to reduced migration of active microbicidal neutrophils","volume":"70","author":"Benjamim","year":"2002","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.014_bib0065","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0070","doi-asserted-by":"crossref","first-page":"e0148142","DOI":"10.1371\/journal.pone.0148142","article-title":"Neutrophil extracellular traps induce organ damage during experimental and clinical sepsis","volume":"11","author":"Czaikoski","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0075","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1164\/rccm.201003-0416OC","article-title":"Essential role of CCR2 in neutrophil tissue infiltration and multiple organ dysfunction in sepsis","volume":"183","author":"Souto","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0080","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/01.CCM.0000198527.71819.E1","article-title":"Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis","volume":"34","author":"Alves-Filho","year":"2006","journal-title":"Crit. Care Med."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.014_bib0085","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1073\/pnas.0900196106","article-title":"Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis","volume":"106","author":"Alves-Filho","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.014_bib0090","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1097\/CCM.0b013e318258fb70","article-title":"Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome","volume":"40","author":"Trevelin","year":"2012","journal-title":"Crit. Care Med."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.014_bib0095","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd1854","article-title":"Animal models of sepsis: setting the stage","volume":"4","author":"Buras","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.014_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00024382-199801000-00001","article-title":"Animal models of sepsis and shock: a review and lessons learned","volume":"9","author":"Deitch","year":"1998","journal-title":"Shock"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0105","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.014_bib0110","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tim.2011.01.001","article-title":"Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?","volume":"19","author":"Dejager","year":"2011","journal-title":"Trends Microbiol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.014_bib0115","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1089\/sur.2012.105","article-title":"Preclinical sepsis models","volume":"13","author":"van der Poll","year":"2012","journal-title":"Surg. Infect. (Larchmt)"},{"issue":"10","key":"10.1016\/j.phrs.2016.12.014_bib0120","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1172\/JCI39421","article-title":"Animal models of sepsis and sepsis-induced kidney injury","volume":"119","author":"Doi","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.phrs.2016.12.014_bib0125","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.autneu.2014.01.006","article-title":"Autonomic regulation of cellular immune function","volume":"182","author":"Bellinger","year":"2014","journal-title":"Autom. Neurosci. Basic Clin."},{"issue":"1-3","key":"10.1016\/j.phrs.2016.12.014_bib0130","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s12026-015-8718-1","article-title":"Neural circuitry and immunity","volume":"63","author":"Pavlov","year":"2015","journal-title":"Immunol. Res."},{"issue":"10","key":"10.1016\/j.phrs.2016.12.014_bib0135","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.it.2015.08.007","article-title":"The regulation of immunological processes by peripheral neurons in homeostasis and disease","volume":"36","author":"Ordovas-Montanes","year":"2015","journal-title":"Trends Immunol."},{"issue":"6917","key":"10.1016\/j.phrs.2016.12.014_bib0140","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"issue":"1-2","key":"10.1016\/j.phrs.2016.12.014_bib0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-3940(94)11105-R","article-title":"Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication","volume":"183","author":"Watkins","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.phrs.2016.12.014_bib0150","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.bbi.2015.07.012","article-title":"Fever and sickness behavior: friend or foe?","volume":"50","author":"Harden","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"1 Pt 2","key":"10.1016\/j.phrs.2016.12.014_bib0155","first-page":"R63","article-title":"Signaling the brain in systemic inflammation: which vagal branch is involved in fever genesis?","volume":"275","author":"Simons","year":"1998","journal-title":"Am. J. Physiol."},{"issue":"1-2","key":"10.1016\/j.phrs.2016.12.014_bib0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.autneu.2004.11.012","article-title":"Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion","volume":"120","author":"Hosoi","year":"2005","journal-title":"Autom. Neurosci. Basic Clin."},{"issue":"6785","key":"10.1016\/j.phrs.2016.12.014_bib0165","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.phrs.2016.12.014_bib0170","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1084\/jem.20052362","article-title":"Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis","volume":"203","author":"Huston","year":"2006","journal-title":"J. Exp. Med."},{"issue":"31","key":"10.1016\/j.phrs.2016.12.014_bib0175","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0803237105","article-title":"Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia","volume":"105","author":"Rosas-Ballina","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.phrs.2016.12.014_bib0180","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.4049\/jimmunol.1003722","article-title":"Alpha7-cholinergic receptor mediates vagal induction of splenic norepinephrine","volume":"186","author":"Vida","year":"2011","journal-title":"J. Immunol."},{"issue":"6052","key":"10.1016\/j.phrs.2016.12.014_bib0185","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1209985","article-title":"Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit","volume":"334","author":"Rosas-Ballina","year":"2011","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.phrs.2016.12.014_bib0190","first-page":"4476","article-title":"beta2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system","volume":"25","author":"Vida","year":"2011","journal-title":"FASEB J. Off. Pub. Fed. Am. Soc. Exp. Biol."},{"issue":"6921","key":"10.1016\/j.phrs.2016.12.014_bib0195","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.phrs.2016.12.014_bib0200","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1113\/expphysiol.2011.061531","article-title":"Neural regulation of inflammation: no neural connection from the vagus to splenic sympathetic neurons","volume":"97","author":"Bratton","year":"2012","journal-title":"Exp. Physiol."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.014_bib0205","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1172\/JCI83658","article-title":"Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through alpha7nAChR+ splenocytes","volume":"126","author":"Inoue","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.014_bib0210","doi-asserted-by":"crossref","first-page":"e3152","DOI":"10.1371\/journal.pone.0003152","article-title":"Spleen vagal denervation inhibits the production of antibodies to circulating antigens","volume":"3","author":"Buijs","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.phrs.2016.12.014_bib0215","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.autneu.2013.12.007","article-title":"The cholinergic anti-inflammatory pathway: a critical review","volume":"182","author":"Martelli","year":"2014","journal-title":"Auton. Neurosci."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0220","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4049\/jimmunol.1100013","article-title":"Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis","volume":"187","author":"Pena","year":"2011","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.014_bib0225","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/j.1538-7836.2006.02112.x","article-title":"Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats","volume":"4","author":"van Westerloo","year":"2006","journal-title":"J. Throm. Haemost. JTH"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0230","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/SHK.0b013e318299e9c0","article-title":"Vagus nerve stimulation attenuates intestinal epithelial tight junctions disruption in endotoxemic mice through alpha7 nicotinic acetylcholine receptors","volume":"40","author":"Zhou","year":"2013","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.phrs.2016.12.014_bib0235","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10753-010-9204-5","article-title":"Electrical vagus nerve stimulation and nicotine effects in peritonitis-induced acute lung injury in rats","volume":"34","author":"Boland","year":"2011","journal-title":"Inflammation"},{"issue":"12","key":"10.1016\/j.phrs.2016.12.014_bib0240","first-page":"2762","article-title":"Transcutaneous vagus nerve stimulation reduces serum high mobility group Box 1 levels and improves survival in murine sepsis","volume":"35","author":"Huston","year":"2007","journal-title":"Crit. Care Med."},{"issue":"12","key":"10.1016\/j.phrs.2016.12.014_bib0245","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1086\/430323","article-title":"The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis","volume":"191","author":"van Westerloo","year":"2005","journal-title":"J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.phrs.2016.12.014_bib0250","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1086\/590432","article-title":"Deficiency of alpha7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis","volume":"198","author":"Giebelen","year":"2008","journal-title":"J. Infect. Dis."},{"issue":"6","key":"10.1016\/j.phrs.2016.12.014_bib0255","doi-asserted-by":"crossref","first-page":"e67086","DOI":"10.1371\/journal.pone.0067086","article-title":"Impact of anesthetics on immune functions in a rat model of vagus nerve stimulation","volume":"8","author":"Picq","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.phrs.2016.12.014_bib0260","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nm1124","article-title":"Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.014_bib0265","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0014-5793(86)80881-X","article-title":"The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits","volume":"205","author":"Hucho","year":"1986","journal-title":"FEBS Lett."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.014_bib0270","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ni1229","article-title":"Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway","volume":"6","author":"de Jonge","year":"2005","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.014_bib0275","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1365-2249.2006.03169.x","article-title":"Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7","volume":"146","author":"Yoshikawa","year":"2006","journal-title":"Clin. Exp. Immunol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.014_bib0280","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/01.shk.0000228168.86845.60","article-title":"Stimulation of alpha7 nicotinic acetylcholine receptor inhibits CD14 and the toll-like receptor 4 expression in human monocytes","volume":"26","author":"Hamano","year":"2006","journal-title":"Shock"},{"issue":"7-8","key":"10.1016\/j.phrs.2016.12.014_bib0285","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2119\/molmed.2009.00039","article-title":"The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE","volume":"15","author":"Rosas-Ballina","year":"2009","journal-title":"Mol. Med."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.014_bib0290","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/01.CCM.0000259381.56526.96","article-title":"Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis","volume":"35","author":"Pavlov","year":"2007","journal-title":"Crit. Care Med."},{"issue":"9-10","key":"10.1016\/j.phrs.2016.12.014_bib0295","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2119\/2008-00079.Parrish","article-title":"Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling","volume":"14","author":"Parrish","year":"2008","journal-title":"Mol. Med."},{"issue":"3","key":"10.1016\/j.phrs.2016.12.014_bib0300","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0735-1097(02)02820-6","article-title":"Nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats","volume":"41","author":"Suzuki","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.014_bib0305","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10753-010-9228-x","article-title":"Nicotine exerts an anti-inflammatory effect in a murine model of acute lung injury","volume":"34","author":"Mabley","year":"2011","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.phrs.2016.12.014_bib0310","doi-asserted-by":"crossref","first-page":"e35361","DOI":"10.1371\/journal.pone.0035361","article-title":"Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity","volume":"7","author":"Chatterjee","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0315","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/sji.12141","article-title":"The vagus nerve attenuates fulminant hepatitis by activating the Src kinase in Kuppfer cells","volume":"79","author":"Li","year":"2014","journal-title":"Scand. J. Immunol."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.014_bib0320","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000319151","article-title":"Protective effect of nicotine on lipopolysaccharide-induced acute lung injury in mice","volume":"81","author":"Ni","year":"2011","journal-title":"Respiration"},{"issue":"6","key":"10.1016\/j.phrs.2016.12.014_bib0325","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s10517-015-3063-x","article-title":"Effect of alpha7n-Acetylcholine receptor activation and antibodies to TNF-alpha on mortality of mice and concentration of proinflammatory cytokines during early stage of sepsis","volume":"159","author":"Zabrodskii","year":"2015","journal-title":"Bull. Exp. Biol. Med."},{"issue":"8","key":"10.1016\/j.phrs.2016.12.014_bib0330","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1797","article-title":"The vagus nerve and the nicotinic anti-inflammatory pathway","volume":"4","author":"Ulloa","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.phrs.2016.12.014_bib0335","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/infdis\/jiu425","article-title":"Usefulness of alpha7 nicotinic receptor messenger RNA levels in peripheral blood mononuclear cells as a marker for cholinergic antiinflammatory pathway activity in septic patients: results of a pilot study","volume":"211","author":"Cedillo","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0340","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1183\/09031936.00103408","article-title":"Stimulation of acetylcholine receptors impairs host defence during pneumococcal pneumonia","volume":"33","author":"Giebelen","year":"2009","journal-title":"Eur. Respir. J."},{"issue":"11","key":"10.1016\/j.phrs.2016.12.014_bib0345","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.4049\/jimmunol.167.11.6518","article-title":"Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine","volume":"167","author":"Matsunaga","year":"2001","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.phrs.2016.12.014_bib0350","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1902\/jop.1995.66.12.1047","article-title":"Inhibition of neutrophil and monocyte defensive functions by nicotine","volume":"66","author":"Pabst","year":"1995","journal-title":"J. Periodontol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.014_bib0355","doi-asserted-by":"crossref","first-page":"028","DOI":"10.1152\/japplphysiol.90619.2008","article-title":"Nicotine administration and withdrawal affect survival in systemic inflammation models","volume":"105","author":"Steiner","year":"2008","journal-title":"J. Appl. Physiol."},{"issue":"11","key":"10.1016\/j.phrs.2016.12.014_bib0360","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1089\/ars.2010.3555","article-title":"Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction","volume":"14","author":"Tsoyi","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0365","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/01.CCM.0B013E31816208B3","article-title":"Pharmacologic cholinesterase inhibition improves survival in experimental sepsis","volume":"36","author":"Hofer","year":"2008","journal-title":"Crit. Care Med."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.014_bib0370","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1086\/432134","article-title":"Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: key roles for tumor necrosis factor\/phagocytes and interleukin-4\/lymphocytes","volume":"192","author":"Straub","year":"2005","journal-title":"J. Infect. Dis."},{"issue":"6655","key":"10.1016\/j.phrs.2016.12.014_bib0375","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/36362","article-title":"Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A","volume":"390","author":"Daaka","year":"1997","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.phrs.2016.12.014_bib0380","doi-asserted-by":"crossref","first-page":"11406","DOI":"10.1073\/pnas.1936664100","article-title":"Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors","volume":"100","author":"Azzi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.phrs.2016.12.014_bib0385","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1164\/rccm.200903-0332OC","article-title":"Beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock","volume":"181","author":"Nakada","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"11","key":"10.1016\/j.phrs.2016.12.014_bib0390","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.4049\/jimmunol.148.11.3441","article-title":"Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists","volume":"148","author":"Severn","year":"1992","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.phrs.2016.12.014_bib0395","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1189\/jlb.0410186","article-title":"Beta-adrenergic stimulation increases macrophage CD14 expression and E. coli phagocytosis through PKA signaling mechanisms","volume":"88","author":"Muthu","year":"2010","journal-title":"J. Leukoc. Biol."},{"issue":"9","key":"10.1016\/j.phrs.2016.12.014_bib0400","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1681\/ASN.2013010084","article-title":"Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway","volume":"24","author":"Gigliotti","year":"2013","journal-title":"J. Am. Soc. Nephrol. JASN"},{"issue":"3","key":"10.1016\/j.phrs.2016.12.014_bib0405","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nm.3479","article-title":"Dopamine mediates vagal modulation of the immune system by electroacupuncture","volume":"20","author":"Torres-Rosas","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.phrs.2016.12.014_bib0410","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbi.2014.07.010","article-title":"Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation","volume":"44","author":"Rosas-Ballina","year":"2015","journal-title":"Brain Behav. Immun."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816311719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661816311719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T07:45:25Z","timestamp":1692603925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661816311719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":82,"alternative-id":["S1043661816311719"],"URL":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.014","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential and limitations of cholinergic anti-inflammatory pathway in sepsis","name":"articletitle","label":"Article Title"},{"value":"Pharmacological Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phrs.2016.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}